Ping Chen
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View article: RAD51B-EZH2 axis as a potential therapeutic target for TNBC through cell fate conversion
RAD51B-EZH2 axis as a potential therapeutic target for TNBC through cell fate conversion Open
Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer with higher histologic grade, poorer prognosis, and fewer treatment options due to the lack of reliable and effective molecular targets. Using a functiona…
View article: Attributes Influencing Visitors’ Experiences in Conservation Centers with Different Social Identities: A Topic Modeling Approach
Attributes Influencing Visitors’ Experiences in Conservation Centers with Different Social Identities: A Topic Modeling Approach Open
The importance of charismatic flagship species (CFSs) in efforts to raise public awareness of conservation has been widely recognized. However, the effect of differences in social identities on shaping visitors’ experiences remains underex…
View article: P-778 Disruption of Male Reproductive Function in Offspring Following In Utero Exposure to Hexavalent Chromium
P-778 Disruption of Male Reproductive Function in Offspring Following In Utero Exposure to Hexavalent Chromium Open
Study question How does in utero hexavalent chromium(Cr(VI)) exposure impact embryonic testes development and androgen secretion, both pivotal for adult spermatogenesis? Summary answer Prenatal Cr(VI) exposure, even at environmental levels…
View article: Classification and Hemodynamic Characteristics of Uterine Artery Blood Flow in Recurrent Spontaneous Abortion
Classification and Hemodynamic Characteristics of Uterine Artery Blood Flow in Recurrent Spontaneous Abortion Open
Introduction: Recurrent spontaneous abortion (RSA) demonstrates a complex pathogenesis. The uterine artery (UtA) Doppler ultrasound monitoring is clinically valuable for predicting RSA risk. Objective: This study aimed to assess the type o…
View article: In vitro susceptibility profiles of invasive Candida bloodstream isolates to ten antifungal drugs in a southern area of China
In vitro susceptibility profiles of invasive Candida bloodstream isolates to ten antifungal drugs in a southern area of China Open
Introduction. In recent years, with the increase of drug resistance of Candida , the incidence rate and mortality of candidemia have gradually increased, which has brought a huge economic and health burden to people. Gap Statement. The epi…
View article: Clinical features and genetic analysis of a family with t(5;9) (p15;p24) balanced translocation leading to Cri-du-chat syndrome in offspring
Clinical features and genetic analysis of a family with t(5;9) (p15;p24) balanced translocation leading to Cri-du-chat syndrome in offspring Open
Background Balanced translocations are common chromosomal structural abnormalities that usually do not involve a gain or loss of genetic material; and carriers usually display normal phenotypes and intelligence. However, unbalanced rearran…
View article: Parecoxib sequential with imrecoxib for occurrence and remission of severe acute pancreatitis: a multicentre, double-blind, randomised, placebo-controlled trial
Parecoxib sequential with imrecoxib for occurrence and remission of severe acute pancreatitis: a multicentre, double-blind, randomised, placebo-controlled trial Open
Background There is no effective drug treatment for the organ failure (OF) caused by severe acute pancreatitis (SAP). Objective We aimed to evaluate the efficacy of cyclooxygenase-2 inhibitors (COX-2-Is) on the treatment of SAP and its saf…
View article: Assessment of the Effects of Single-Domain Anti-Idiotypic Distribution Enhancers on the Disposition of Trastuzumab and on the Efficacy of a PE24-Trastuzumab Immunotoxin
Assessment of the Effects of Single-Domain Anti-Idiotypic Distribution Enhancers on the Disposition of Trastuzumab and on the Efficacy of a PE24-Trastuzumab Immunotoxin Open
Background/Objectives: Antibody-based therapies often exhibit limited distribution within solid tumors due to the “binding-site barrier” (BSB). Our group has developed and validated the use of anti-idiotypic distribution enhancers (AIDEs),…
View article: The Radiosensitizing Effect of Tumor-Derived Microparticles Co-Loaded with Sorafenib and Gold Nanoparticles on Hepatocellular Carcinoma
The Radiosensitizing Effect of Tumor-Derived Microparticles Co-Loaded with Sorafenib and Gold Nanoparticles on Hepatocellular Carcinoma Open
This study offers a promising treatment approach for malignant tumors such as HCC by using MP co-loaded and delivered with anti-tumor drugs and AuNP in combination with radiotherapy.
View article: A Pedigree With <i>LHX4</i> and <i>SOX3</i> Gene Variants Resulting in Gonadal Dysplasia
A Pedigree With <i>LHX4</i> and <i>SOX3</i> Gene Variants Resulting in Gonadal Dysplasia Open
Pituitary stalk interruption syndrome is a disease with multiple hormone deficiencies caused by pituitary stalk interruption. Identification of the pathogenic gene variant is helpful for early diagnosis. Early hormone replacement therapy i…
View article: Evolution, Structural and Functional Characteristics of the MADS-box Gene Family and Gene Expression Through Methyl Jasmonate Regulation in Panax ginseng C.A. Meyer
Evolution, Structural and Functional Characteristics of the MADS-box Gene Family and Gene Expression Through Methyl Jasmonate Regulation in Panax ginseng C.A. Meyer Open
MADS-box genes are essential for plant development and secondary metabolism. The majority of genes within a genome exist in a gene family, each with specific functions. Ginseng is an herb used in medicine for its potential health benefits.…
View article: Case report: Identification of a novel TOR1AIP2::ETV6 transcript with FLT3-ITD mutation in acute myeloid leukemia progressed from myelodysplastic syndrome
Case report: Identification of a novel TOR1AIP2::ETV6 transcript with FLT3-ITD mutation in acute myeloid leukemia progressed from myelodysplastic syndrome Open
Acute myeloid leukemia (AML), which is most common in adults, is a challenging hematological malignancy. The occurrence and the progression of AML are often accompanied by various gene fusions and/or mutations. Herein, we report the first …
View article: Development of a Stringent Ex Vivo-Burned Porcine Skin Wound Model to Screen Topical Antimicrobial Agents
Development of a Stringent Ex Vivo-Burned Porcine Skin Wound Model to Screen Topical Antimicrobial Agents Open
Background: Due to rising antibiotic-resistant microorganisms, there is a pressing need to screen approved drugs for repurposing and to develop new antibiotics for controlling infections. Current in vitro and ex vivo models have mostly bee…
View article: Modulation of gut microbiota by probiotics to improve the efficacy of immunotherapy in hepatocellular carcinoma
Modulation of gut microbiota by probiotics to improve the efficacy of immunotherapy in hepatocellular carcinoma Open
Hepatocellular carcinoma, a common malignancy of the digestive system, typically progresses through a sequence of hepatitis, liver fibrosis, cirrhosis and ultimately, tumor. The interaction between gut microbiota, the portal venous system …
View article: MiRNA29a-3p negatively regulates ISL1–Integrin β1 axis to suppress gastric cancer progression
MiRNA29a-3p negatively regulates ISL1–Integrin β1 axis to suppress gastric cancer progression Open
Insulin gene enhancer protein 1 (ISL1) belongs to the LIM homeodomain transcription factor family, which is closely related to the development of several cancers. We previously found that abnormally high ISL1 expression is involved in gast…
View article: SALIRI‐based (raltitrexed plus irinotecan) therapy as a second‐line treatment for patients with metastatic colorectal cancer (SALLY): A prospective, multicenter, non‐interventional, registry study
SALIRI‐based (raltitrexed plus irinotecan) therapy as a second‐line treatment for patients with metastatic colorectal cancer (SALLY): A prospective, multicenter, non‐interventional, registry study Open
Primary chemotherapy options for colorectal cancer (CRC) involve four key drugs: fluorouracils (5-FU), oxaliplatin, irinotecan and raltitrexed. The first-line regimen consists of 5-FU and leucovorin combined with oxaliplatin (FOLFOX), whil…
View article: Maintenance therapy with anlotinib after induction therapy with platinum-based chemotherapy for advanced non-small-cell lung cancer: A pooled analysis of 2 single-arm trials
Maintenance therapy with anlotinib after induction therapy with platinum-based chemotherapy for advanced non-small-cell lung cancer: A pooled analysis of 2 single-arm trials Open
Background: Maintenance therapy could significantly improve the prognosis of patients with advanced non-small cell lung cancer (NSCLC) receiving chemotherapy. Anlotinib is effective, tolerable, and convenient in administration as a third-l…
View article: Two doses of fosaprepitant included prophylactic treatment for the three-day cisplatin-based chemotherapy induced nausea and vomiting
Two doses of fosaprepitant included prophylactic treatment for the three-day cisplatin-based chemotherapy induced nausea and vomiting Open
Purpose Neurokinin 1 receptor antagonists included prophylactic treatment was recommended for patients who receive one-day cisplatin chemotherapy. It is unclear whether the prolonged administration of fosaprepitant is effective for three-d…
View article: Drug screening on digital microfluidics for cancer precision medicine
Drug screening on digital microfluidics for cancer precision medicine Open
Drug screening based on in-vitro primary tumor cell culture has demonstrated potential in personalized cancer diagnosis. However, the limited number of tumor cells, especially from patients with early stage cancer, has hindered the widespr…
View article: Integrated clinical and prognostic analyses of mTOR/Hippo pathway core genes in hepatocellular carcinoma
Integrated clinical and prognostic analyses of mTOR/Hippo pathway core genes in hepatocellular carcinoma Open
Hepatocellular carcinoma (HCC) is one of the most aggressive and dismal cancers globally. Emerging evidence has established that mTOR and Hippo pathways are oncogenic drivers of HCC. However, the prognostic value of these pathways in HCC r…