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View article: Orco regulates the circadian activity of pheromone-sensitive olfactory receptor neurons in hawkmoths
Orco regulates the circadian activity of pheromone-sensitive olfactory receptor neurons in hawkmoths Open
The mating behavior of nocturnal Manduca sexta hawkmoths is under strict temporal control. It is orchestrated via circadian- and ultradian oscillations in sex-pheromone stimuli as social zeitgeber. The extremely sensitive pheromone-detecti…
View article: Orco regulates the circadian activity of pheromone-sensitive olfactory receptor neurons in hawkmoths
Orco regulates the circadian activity of pheromone-sensitive olfactory receptor neurons in hawkmoths Open
The mating behavior of nocturnal Manduca sexta hawkmoths is under strict temporal control. It is orchestrated via circadian- and ultradian oscillations in sex-pheromone stimuli as social zeitgeber. The extremely sensitive pheromone-detecti…
View article: Usefulness of Tissue Biomarkers versus Prostate-Specific Membrane Antigen-Positron Emission Tomography for Prostate Cancer Biochemical Recurrence after Radical Prostatectomy
Usefulness of Tissue Biomarkers versus Prostate-Specific Membrane Antigen-Positron Emission Tomography for Prostate Cancer Biochemical Recurrence after Radical Prostatectomy Open
Despite curative-intent local therapy, approximately 27% to 53% of prostate cancer (PCa) patients experience prostate-specific antigen (PSA) recurrence, known as biochemical recurrence (BCR). BCR significantly raises the risk of PCa-relate…
View article: Usefulness of Tissue Biomarkers versus Prostate-Spcific Membrane Antigen-Positron Emission Tomography for Prostate Cancer Biochemical Recurrence after Radical Prostatectomy
Usefulness of Tissue Biomarkers versus Prostate-Spcific Membrane Antigen-Positron Emission Tomography for Prostate Cancer Biochemical Recurrence after Radical Prostatectomy Open
Despite curative-intent local therapy, approximately 27% to 53% of prostate cancer (PCa) patients experience prostate-specific antigen (PSA) recurrence, known as biochemical recurrence (BCR). BCR significantly raises the risk of PCa-relate…
View article: Biological Rhythms Generated by a Single Activator-Repressor Loop with Inhomogeneity and Diffusion
Biological Rhythms Generated by a Single Activator-Repressor Loop with Inhomogeneity and Diffusion Open
Common models of circadian rhythms are typically constructed as compartmental reactions of well-mixed biochemicals, incorporating a negative-feedback loop consisting of several intermediate reaction steps essentially required to produce os…
View article: Dramatic Differences between the Structural Susceptibility of the S1 Pre- and S2 Postfusion States of the SARS-CoV-2 Spike Protein to External Electric Fields Revealed by Molecular Dynamics Simulations
Dramatic Differences between the Structural Susceptibility of the S1 Pre- and S2 Postfusion States of the SARS-CoV-2 Spike Protein to External Electric Fields Revealed by Molecular Dynamics Simulations Open
In its prefusion state, the SARS-CoV-2 spike protein (similarly to other class I viral fusion proteins) is metastable, which is considered to be an important feature for optimizing or regulating its functions. After the binding process of …
View article: Dramatic Differences between the Structural Stability of the Pre- and Postfusion States of the SARS-CoV-2 Spike Protein under External Electric Fields Revealed by Molecular Dynamics Simulations
Dramatic Differences between the Structural Stability of the Pre- and Postfusion States of the SARS-CoV-2 Spike Protein under External Electric Fields Revealed by Molecular Dynamics Simulations Open
In its prefusion state, the SARS-CoV-2 Spike protein (similarly to other class I viral fusion proteins) is metastable, which is considered to be an important feature for optimizing or regulating their functions. After the binding process o…
View article: Can We Predict Prostate Cancer Metastasis Based on Biomarkers? Where Are We Now?
Can We Predict Prostate Cancer Metastasis Based on Biomarkers? Where Are We Now? Open
The incidence of prostate cancer (PC) has risen annually. PC mortality is explained by the metastatic disease (mPC). There is an intermediate scenario in which patients have non-mPC but have initiated a metastatic cascade through epithelia…
View article: Can We Predict Prostate Cancer Metastasis Based on Biomarkers? Where Are We Now?
Can We Predict Prostate Cancer Metastasis Based on Biomarkers? Where Are We Now? Open
Background: The incidence of prostate cancer (PC) has been risen annually. Despite the diagnosis is made mainly with non-metastatic PC, mortality is explained by the metastatic disease (mPC). Without a doubt there is an intermediate scenar…
View article: Can We Predict Prostate Cancer Clinical Metastasis Based on Biomarkers? Where Are We Now?
Can We Predict Prostate Cancer Clinical Metastasis Based on Biomarkers? Where Are We Now? Open
Background: The incidence of prostate cancer (PC) has been risen annually. Despite the diagnosis is made mainly with non-metastatic PC, mortality is explained by the metastatic disease (mPC). Without a doubt there is an intermediate scenar…
View article: Figure S2 from Dietary Fructose Promotes Prostate Cancer Growth
Figure S2 from Dietary Fructose Promotes Prostate Cancer Growth Open
Glut(s) expression PC-3 cell line-derived xenograft model.
View article: Figure S3 from Dietary Fructose Promotes Prostate Cancer Growth
Figure S3 from Dietary Fructose Promotes Prostate Cancer Growth Open
Gene Set Enrichment Analysis (GSEA) from RNA sequencing data of PC3 cells stimulated with fructose or glucose.
View article: Table S1 from Dietary Fructose Promotes Prostate Cancer Growth
Table S1 from Dietary Fructose Promotes Prostate Cancer Growth Open
Biological/clinical parameters (patient age, PSA levels, Gleason score) and glucose and fructose levels in benign and PCa patients.
View article: Figure S1 from Dietary Fructose Promotes Prostate Cancer Growth
Figure S1 from Dietary Fructose Promotes Prostate Cancer Growth Open
Downregulation of Glut-5 expression in PC-3 cells using the siRNA methodology.
View article: Table S1 from Dietary Fructose Promotes Prostate Cancer Growth
Table S1 from Dietary Fructose Promotes Prostate Cancer Growth Open
Biological/clinical parameters (patient age, PSA levels, Gleason score) and glucose and fructose levels in benign and PCa patients.
View article: Figure S2 from Dietary Fructose Promotes Prostate Cancer Growth
Figure S2 from Dietary Fructose Promotes Prostate Cancer Growth Open
Glut(s) expression PC-3 cell line-derived xenograft model.
View article: Figure S1 from Dietary Fructose Promotes Prostate Cancer Growth
Figure S1 from Dietary Fructose Promotes Prostate Cancer Growth Open
Downregulation of Glut-5 expression in PC-3 cells using the siRNA methodology.
View article: Data from Dietary Fructose Promotes Prostate Cancer Growth
Data from Dietary Fructose Promotes Prostate Cancer Growth Open
Clinical localization of primary tumors and sites of metastasis by PET is based on the enhanced cellular uptake of 2-deoxy-2-[18F]-fluoro-D-glucose (FDG). In prostate cancer, however, PET-FDG imaging has shown limited clinical applicabilit…
View article: Data from Dietary Fructose Promotes Prostate Cancer Growth
Data from Dietary Fructose Promotes Prostate Cancer Growth Open
Clinical localization of primary tumors and sites of metastasis by PET is based on the enhanced cellular uptake of 2-deoxy-2-[18F]-fluoro-D-glucose (FDG). In prostate cancer, however, PET-FDG imaging has shown limited clinical applicabilit…
View article: Figure S3 from Dietary Fructose Promotes Prostate Cancer Growth
Figure S3 from Dietary Fructose Promotes Prostate Cancer Growth Open
Gene Set Enrichment Analysis (GSEA) from RNA sequencing data of PC3 cells stimulated with fructose or glucose.
View article: Contralateral necrotizing fascitis after left nephrectomy for emphysematous pyelonephritis
Contralateral necrotizing fascitis after left nephrectomy for emphysematous pyelonephritis Open
Introduction Emphysematous pyelonephritis is an acute necrotizing infection of the renal parenchyma. The management is variable, extending to total nephrectomy in severe or refractory cases. Post‐nephrectomy complications are numerous and …
View article: MD simulations of SARS-CoV-2 Spike Protein under static electric fields
MD simulations of SARS-CoV-2 Spike Protein under static electric fields Open
This dataset contains trajectories corresponding to all-atom MD simulations of segments of the SARS-CoV-2 Spike Protein, and in-silico mutations, under the influence of moderate external electric fields. The final structures of some of the…
View article: MD simulations of SARS-CoV-2 Spike Protein under static electric fields
MD simulations of SARS-CoV-2 Spike Protein under static electric fields Open
This dataset contains trajectories corresponding to all-atom MD simulations of segments of the SARS-CoV-2 Spike Protein, and in-silico mutations, under the influence of moderate external electric fields. The final structures of some of the…
View article: Changes in Clinical Presentation and Perioperative Management of Pheochromocytomas and Paragangliomas: A Four-Decade Experience in a Academic Center
Changes in Clinical Presentation and Perioperative Management of Pheochromocytomas and Paragangliomas: A Four-Decade Experience in a Academic Center Open
Objective: Latin American reports on pheochromocytomas and paragangliomas (PPGL) are scarce. Recent studies have shown changes in both clinical presentation and management of these patients. We aimed to assess the main characteristics of P…
View article: Clinical Presentation and Perioperative Management of Pheochromocytomas and Paragangliomas: A 4-Decade Experience
Clinical Presentation and Perioperative Management of Pheochromocytomas and Paragangliomas: A 4-Decade Experience Open
Purpose Latin American reports on pheochromocytomas and paragangliomas (PPGLs) are scarce. Recent studies demonstrate changes in clinical presentation and management of these patients. Herein, we assessed the main characteristics of PPGL p…
View article: Explant Cultures From Prostate Needle Biopsies as A Model to Obtain Highly Enriched Populations of Benign and Carcinoma-Associated Fibroblasts
Explant Cultures From Prostate Needle Biopsies as A Model to Obtain Highly Enriched Populations of Benign and Carcinoma-Associated Fibroblasts Open
Prostate cancer (PCa) is a multifocal neoplasm in which different cancer foci can be found within a single organ. This feature represents a technical difficulty when obtaining highly-enriched primary cultures of human prostate stroma cells…