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View article: Process modeling and control for additive manufacturing of Ti-6Al-4V using plasma arc welding - methodology and experimental validation
Process modeling and control for additive manufacturing of Ti-6Al-4V using plasma arc welding - methodology and experimental validation Open
Wire Arc Additive Manufacturing (WAAM) offers significant potential for producing large, complex components with short lead times. While progress in WAAM technology has primarily been made in the field of gas metal arc welding (GMAW), plas…
View article: Investigation of the scattering and attenuation properties of cataracts formed in mouse eyes with 1060-nm and 1310-nm swept-source optical coherence tomography
Investigation of the scattering and attenuation properties of cataracts formed in mouse eyes with 1060-nm and 1310-nm swept-source optical coherence tomography Open
Cataracts are the leading cause of blindness worldwide. Here we propose optical coherence tomography (OCT) as a quantitative method for investigating cataracts. OCT provides volumetric and non-invasive access to the lens and makes it possi…
View article: High-resolution, depth-resolved vascular leakage measurements using contrast-enhanced, correlation-gated optical coherence tomography in mice
High-resolution, depth-resolved vascular leakage measurements using contrast-enhanced, correlation-gated optical coherence tomography in mice Open
Vascular leakage plays a key role in vision-threatening retinal diseases such as diabetic retinopathy and age-related macular degeneration. Fluorescence angiography is the current gold standard for identification of leaky vasculature in vi…
View article: Improved accuracy of quantitative birefringence imaging by polarization sensitive <scp>OCT</scp> with simple noise correction and its application to neuroimaging
Improved accuracy of quantitative birefringence imaging by polarization sensitive <span>OCT</span> with simple noise correction and its application to neuroimaging Open
Polarization‐sensitive optical coherence tomography (PS‐OCT) enables three‐dimensional imaging of biological tissues based on the inherent contrast provided by scattering and polarization properties. In fibrous tissue such as the white mat…
View article: Improved Diagnostic Imaging of Brain Tumors by Multimodal Microscopy and Deep Learning
Improved Diagnostic Imaging of Brain Tumors by Multimodal Microscopy and Deep Learning Open
Fluorescence-guided surgery is a state-of-the-art approach for intraoperative imaging during neurosurgical removal of tumor tissue. While the visualization of high-grade gliomas is reliable, lower grade glioma often lack visible fluorescen…
View article: Three-dimensional visualization of opacifications in the murine crystalline lens by in vivo optical coherence tomography
Three-dimensional visualization of opacifications in the murine crystalline lens by in vivo optical coherence tomography Open
Diagnostic classification techniques used to diagnose cataracts, the world’s leading cause of blindness, are currently based on subjective methods. Here, we present optical coherence tomography as a noninvasive tool for volumetric visualiz…
View article: Retinal analysis of a mouse model of Alzheimer’s disease with multicontrast optical coherence tomography
Retinal analysis of a mouse model of Alzheimer’s disease with multicontrast optical coherence tomography Open
Significance. Recent Alzheimer's disease (AD) patient studies have focused on retinal analysis, as the retina is the only part of the central nervous system that can be imaged noninvasively by optical methods. However, as this is a relativ…
View article: Attenuation coefficient as a quantitative parameter for analyzing cataracts with optical coherence tomography
Attenuation coefficient as a quantitative parameter for analyzing cataracts with optical coherence tomography Open
Crystalline lenses of mice were imaged in vivo with a custom-made swept-source optical coherence tomography system. The use of the attenuation coefficient as a quantitative parameter for investigating the lens opacities magnitude is propos…
View article: Hyperspectral optical coherence tomography for in vivo visualization of melanin in the retinal pigment epithelium
Hyperspectral optical coherence tomography for in vivo visualization of melanin in the retinal pigment epithelium Open
Previous studies for melanin visualization in the retinal pigment epithelium (RPE) have exploited either its absorption properties (using photoacoustic tomography or photothermal optical coherence tomography [OCT]) or its depolarization pr…
View article: Revealing brain pathologies with multimodal visible light optical coherence microscopy and fluorescence imaging
Revealing brain pathologies with multimodal visible light optical coherence microscopy and fluorescence imaging Open
We present a multimodal visible light optical coherence microscopy (OCM) and fluorescence imaging (FI) setup. Specification and phantom measurements were performed to characterize the system. Two applications in neuroimaging were investiga…
View article: Comparison of Intensity- and Polarization-based Contrast in Amyloid-beta Plaques as Observed by Optical Coherence Tomography
Comparison of Intensity- and Polarization-based Contrast in Amyloid-beta Plaques as Observed by Optical Coherence Tomography Open
One key hallmark of Alzheimer’s disease (AD) is the accumulation of extracellular amyloid-beta protein in cortical regions of the brain. For a definitive diagnosis of AD, post-mortem histological analysis, including sectioning and staining…
View article: Polarization-sensitive optical coherence tomography imaging of the anterior mouse eye
Polarization-sensitive optical coherence tomography imaging of the anterior mouse eye Open
Polarization-sensitive optical coherence tomography (PS-OCT) enables noninvasive, high-resolution imaging of tissue polarization properties. In the anterior segments of human eyes, PS-OCT allows the visualization of birefringent and depola…
View article: Assessment of pathological features in Alzheimer’s disease brain tissue with a large field-of-view visible-light optical coherence microscope
Assessment of pathological features in Alzheimer’s disease brain tissue with a large field-of-view visible-light optical coherence microscope Open
We implemented a wide field-of-view visible-light optical coherence microscope (OCM) for investigating ex-vivo brain tissue of patients diagnosed with Alzheimer's disease (AD) and of a mouse model of AD. A submicrometer axial resolution in…
View article: White light polarization sensitive optical coherence tomography for sub-micron axial resolution and spectroscopic contrast in the murine retina
White light polarization sensitive optical coherence tomography for sub-micron axial resolution and spectroscopic contrast in the murine retina Open
A white light polarization sensitive optical coherence tomography system has been developed, using a supercontinuum laser as the light source. By detecting backscattered light from 400 - 700 nm, an axial resolution of 1.0 µm in air was ach…
View article: Spectroscopic imaging with spectral domain visible light optical coherence microscopy in Alzheimer’s disease brain samples
Spectroscopic imaging with spectral domain visible light optical coherence microscopy in Alzheimer’s disease brain samples Open
A visible light spectral domain optical coherence microscopy system was developed. A high axial resolution of 0.88 μm in tissue was achieved using a broad visible light spectrum (425 - 685 nm). Healthy human brain tissue was imaged to quan…