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View article: Prompt’s Evolution for Language Model-Driven Data Generation
Prompt’s Evolution for Language Model-Driven Data Generation Open
In the era of data, data generation continues to grow day by day, posing new challenges for processing systems due to the dynamism of its volume, variety, and velocity. To process data in real time, stream processing systems (SPS) serve as…
View article: Electromigration of Aquaporins Controls Water-Driven Electrotaxis
Electromigration of Aquaporins Controls Water-Driven Electrotaxis Open
Cell motility is a process central to life and is undoubtedly influenced by mechanical and chemical signals. Even so, other stimuli are also involved in controlling cell migration in vivo and in vitro. Among these, electric fields have bee…
View article: Competing signaling pathways controls electrotaxis
Competing signaling pathways controls electrotaxis Open
Understanding how cells migrate following exogenous cues is one of the most fundamental questions for biology, medicine, and bioengineering. Growing evidence shows that electrotaxis, the directed cell migration toward electric potential gr…
View article: Cell response to extracellular matrix viscous energy dissipation outweighs high-rigidity sensing
Cell response to extracellular matrix viscous energy dissipation outweighs high-rigidity sensing Open
The mechanics of the extracellular matrix (ECM) determine cell activity and fate through mechanoresponsive proteins including Yes-associated protein 1 (YAP). Rigidity and viscous relaxation have emerged as the main mechanical properties of…
View article: Active interfacial degradation/deposition of an elastic matrix by a fluid inclusion: Theory and pattern formation
Active interfacial degradation/deposition of an elastic matrix by a fluid inclusion: Theory and pattern formation Open
During collective invasion in 3D, cohesive cellular tissues migrate within a fibrous extracellular matrix (ECM). This process requires significant remodeling of the ECM by cells, notably proteolysis at the cell–ECM interface by specialized…
View article: The laminin–keratin link shields the nucleus from mechanical deformation and signalling
The laminin–keratin link shields the nucleus from mechanical deformation and signalling Open
The mechanical properties of the extracellular matrix dictate tissue behaviour. In epithelial tissues, laminin is a very abundant extracellular matrix component and a key supporting element. Here we show that laminin hinders the mechanores…
View article: A computational model for early cell spreading, migration, and competing taxis
A computational model for early cell spreading, migration, and competing taxis Open
© 2023 Elsevier. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
View article: A multi-scale clutch model for adhesion complex mechanics
A multi-scale clutch model for adhesion complex mechanics Open
Cell-matrix adhesion is a central mechanical function to a large number of phenomena in physiology and disease, including morphogenesis, wound healing, and tumor cell invasion. Today, how single cells respond to different extracellular cue…
View article: A multi-scale clutch model for adhesion complex mechanics
A multi-scale clutch model for adhesion complex mechanics Open
Cell-matrix adhesion is a central mechanical function to a large number of phenomena in physiology and disease, including morphogenesis, wound healing and tumor cell invasion. Today, how single cells responds to different extracellular cue…
View article: Positive, negative and controlled durotaxis
Positive, negative and controlled durotaxis Open
Durotaxis is a physical process central to life, including embryogenesis, tissue regeneration, and tumor growth. This work proposes a mechanistic rationale for durotaxis based on the clutch hypothesis and active gels.
View article: Cell response to extracellular matrix energy dissipation outweighs rigidity sensing
Cell response to extracellular matrix energy dissipation outweighs rigidity sensing Open
The mechanical properties of the extracellular matrix (ECM) determine cell differentiation, proliferation and migration through mechanoresponsive proteins including YAP. However, how different mechanical signals cooperate, synergize or com…
View article: Brain tissue mechanics is governed by microscale relations of the tissue constituents
Brain tissue mechanics is governed by microscale relations of the tissue constituents Open
Local mechanical tissue properties are a critical regulator of cell function in the central nervous system (CNS) during development and disorder. However, we still don’t fully understand how the mechanical properties of individual tissue c…
View article: Emergent oscillations during cellular directional decision-making on junctions
Emergent oscillations during cellular directional decision-making on junctions Open
Motile cells inside living tissues often encounter junctions, where their path branches into several alternative directions of migration. We present a theoretical model of cellular polarization for cells migrating along one-dimensional lin…
View article: A full computational model of cell motility: Early spreading, cell migration and competing taxis
A full computational model of cell motility: Early spreading, cell migration and competing taxis Open
Cell motility represents one of the most fundamental function in mechanobiology. Cell motility is directly implicated in development, cancer or tissue regeneration, but it also plays a key role in the future of tissue and biomedical engine…
View article: Positive, negative and engineered durotaxis
Positive, negative and engineered durotaxis Open
Cell migration is a physical process central to life. Among others, it regulates embryogenesis, tissue regeneration and tumor growth. Therefore, understanding and controlling cell migration represent fundamental challenges in science. Spec…
View article: The laminin-keratin link shields the nucleus from mechanical deformation and signalling
The laminin-keratin link shields the nucleus from mechanical deformation and signalling Open
The mechanical properties of the extracellular matrix (ECM) dictate tissue behaviour. In epithelial tissues, laminin is both a very abundant ECM component, and a key supporting element. Here we show that laminin hinders the mechanoresponse…
View article: Mechanotransmission of haemodynamic forces by the endothelial glycocalyx in a full-scale arterial model
Mechanotransmission of haemodynamic forces by the endothelial glycocalyx in a full-scale arterial model Open
The glycocalyx has been identified as a key mechano-sensor of the shear forces exerted by streaming blood onto the vascular endothelial lining. Although the biochemical reaction to the blood flow has been extensively studied, the mechanism…
View article: Optimal bounds for Büchi's problem in modular arithmetic II
Optimal bounds for Büchi's problem in modular arithmetic II Open
Given a prime $p\ge5$ and an integer $s\ge1$, we show that there exists an integer $M$ such that for any quadratic polynomial $f$ with coefficients in the ring of integers modulo $p^s$, such that $f$ is not a square, if a sequence $(f(1),\…
View article: Fully coupled numerical model of actin treadmilling in the lamellipodium of the cell
Fully coupled numerical model of actin treadmilling in the lamellipodium of the cell Open
Cells rely on an interplay of subcellular elements for motility and migration. Certain regions of motile cells, such as the lamellipodium, are made of a complex mixture of actin monomers and filaments, which polymerize at the front of the …