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View article: Myocardial ketone body oxidation contributes to empagliflozin‐induced improvements in cardiac contractility in murine heart failure
Myocardial ketone body oxidation contributes to empagliflozin‐induced improvements in cardiac contractility in murine heart failure Open
Aims Sodium–glucose cotransporter 2 inhibitors (SGLT2i) improve cardiac performance and clinical outcomes in patients with heart failure, yet mechanisms underlying these beneficial effects remain incompletely understood. We sought to deter…
View article: Atpif-1 Knockout Attenuates Mitochondrial Mptp Opening But Does Not Diminish Cardiac Ischemic/Reperfusion Injury
Atpif-1 Knockout Attenuates Mitochondrial Mptp Opening But Does Not Diminish Cardiac Ischemic/Reperfusion Injury Open
View article: ATPIF-1 knockout attenuates mitochondrial mPTP opening but does not diminish cardiac ischemic/reperfusion injury.
ATPIF-1 knockout attenuates mitochondrial mPTP opening but does not diminish cardiac ischemic/reperfusion injury. Open
Ischemic conditions can flip the action of mitochondrial ATP-synthase from an ATP producing to an ATP consuming enzyme. The mitochondrial protein ATPase inhibitory factor 1 (ATPIF-1) prevents ATP-synthase reversal, thereby preserving ATP d…
View article: A Kinase Interacting Protein 1 regulates mitochondrial protein levels in energy metabolism and promotes mitochondrial turnover after exercise
A Kinase Interacting Protein 1 regulates mitochondrial protein levels in energy metabolism and promotes mitochondrial turnover after exercise Open
View article: Exercising heart failure patients: cardiac protection through preservation of mitochondrial function and substrate utilization?
Exercising heart failure patients: cardiac protection through preservation of mitochondrial function and substrate utilization? Open
View article: A Kinase Interacting Protein 1 (AKIP1) promotes cardiomyocyte elongation and physiological cardiac remodelling
A Kinase Interacting Protein 1 (AKIP1) promotes cardiomyocyte elongation and physiological cardiac remodelling Open
View article: IGF-1 boosts mitochondrial function by a Ca2+ uptake-dependent mechanism in cultured human and rat cardiomyocytes
IGF-1 boosts mitochondrial function by a Ca2+ uptake-dependent mechanism in cultured human and rat cardiomyocytes Open
A physiological increase in cardiac workload results in adaptive cardiac remodeling, characterized by increased oxidative metabolism and improvements in cardiac performance. Insulin-like growth factor-1 (IGF-1) has been identified as a cri…
View article: Could SGLT2 Inhibitors Improve Exercise Intolerance in Chronic Heart Failure?
Could SGLT2 Inhibitors Improve Exercise Intolerance in Chronic Heart Failure? Open
Despite the constant improvement of therapeutical options, heart failure (HF) remains associated with high mortality and morbidity. While new developments in guideline-recommended therapies can prolong survival and postpone HF hospitalizat…
View article: Exercise: a molecular tool to boost muscle growth and mitochondrial performance in heart failure?
Exercise: a molecular tool to boost muscle growth and mitochondrial performance in heart failure? Open
Impaired exercise capacity is the key symptom of heart failure (HF) and is associated with reduced quality of life and higher mortality rates. Unfortunately, current therapies, although generally lifesaving, have only small or marginal eff…
View article: Activation of the NLRP3 Inflammasome Increases the IL-1β Level and Decreases GLUT4 Translocation in Skeletal Muscle during Insulin Resistance
Activation of the NLRP3 Inflammasome Increases the IL-1β Level and Decreases GLUT4 Translocation in Skeletal Muscle during Insulin Resistance Open
Low-grade chronic inflammation plays a pivotal role in the pathogenesis of insulin resistance (IR), and skeletal muscle has a central role in this condition. NLRP3 inflammasome activation pathways promote low-grade chronic inflammation in …
View article: ATPase Inhibitory Factor-1 Disrupts Mitochondrial Ca2+ Handling and Promotes Pathological Cardiac Hypertrophy through CaMKIIδ
ATPase Inhibitory Factor-1 Disrupts Mitochondrial Ca2+ Handling and Promotes Pathological Cardiac Hypertrophy through CaMKIIδ Open
ATPase inhibitory factor-1 (IF1) preserves cellular ATP under conditions of respiratory collapse, yet the function of IF1 under normal respiring conditions is unresolved. We tested the hypothesis that IF1 promotes mitochondrial dysfunction…
View article: ATPase Inhibitor Factor-1 Disrupts Mitochondrial Ca2+ Handling and Promotes Pathological Cardiac Hypertrophy through CaMKIIδ
ATPase Inhibitor Factor-1 Disrupts Mitochondrial Ca2+ Handling and Promotes Pathological Cardiac Hypertrophy through CaMKIIδ Open
Background : ATPase inhibitor factor-1 (IF1) preserves cellular ATP under conditions of respiratory collapse, yet the function of IF1 under normal respiring conditions is unresolved. We tested the hypothesis that IF1 promotes mitochondrial…
View article: Is Mitochondrial Dysfunction a Common Root of Noncommunicable Chronic Diseases?
Is Mitochondrial Dysfunction a Common Root of Noncommunicable Chronic Diseases? Open
Mitochondrial damage is implicated as a major contributing factor for a number of noncommunicable chronic diseases such as cardiovascular diseases, cancer, obesity, and insulin resistance/type 2 diabetes. Here, we discuss the role of mitoc…
View article: Sarcoplasmic reticulum and calcium signaling in muscle cells: Homeostasis and disease
Sarcoplasmic reticulum and calcium signaling in muscle cells: Homeostasis and disease Open
View article: Sarcoplasmic reticulum and calcium signaling in muscle cells : Homeostasis and disease
Sarcoplasmic reticulum and calcium signaling in muscle cells : Homeostasis and disease Open
The sarco/endoplasmic reticulum is an extensive, dynamic and heterogeneous membranous network that fulfills multiple homeostatic functions. Among them, it compartmentalizes, stores and releases calcium within the intracellular space. In th…
View article: Eccentric resistance training reduces both non-response to exercise and cardiovascular risk factors in adult with overweight or obesity
Eccentric resistance training reduces both non-response to exercise and cardiovascular risk factors in adult with overweight or obesity Open
© 2018 Elsevier Masson SAS Objectives: The aim of this study was to compare the effect of concentric or eccentric resistance training on different cardiovascular risk factors and the prevalence of non-response to exercise. Materials and me…
View article: Membrane Cholesterol in Skeletal Muscle: A Novel Player in Excitation-Contraction Coupling and Insulin Resistance
Membrane Cholesterol in Skeletal Muscle: A Novel Player in Excitation-Contraction Coupling and Insulin Resistance Open
Membrane cholesterol is critical for signaling processes in a variety of tissues. We will address here current evidence supporting an emerging role of cholesterol on excitation-contraction coupling and glucose transport in skeletal muscle.…
View article: Entrenamiento aeróbico de alta intensidad: Historia y fisiología clínica del ejercicio
Entrenamiento aeróbico de alta intensidad: Historia y fisiología clínica del ejercicio Open
"La transición epidemiológica observada en las últimas décadas ha implicado un aumento creciente de enfermedades crónicas, fenómeno asociados con el estilo de vida de la población, al modelo alimentario y al sedentarismo, lo que predispone…
View article: Plazas activas: ¿Quién prescribe y dosifica el ejercicio?
Plazas activas: ¿Quién prescribe y dosifica el ejercicio? Open
View article: Análisis de variabilidad del ritmo cardiaco y su relación con la sensibilidad insulínica en pacientes obesos y con sobrepeso
Análisis de variabilidad del ritmo cardiaco y su relación con la sensibilidad insulínica en pacientes obesos y con sobrepeso Open
There is an association between spectral and fractal values of heart rate variability and HOMA-IR. These results may indicate a predominance of sympathetic control of heart rate among obese subjects.