Pablo Vieyra-Garcia
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View article: Modulation of the skin microbiome in cutaneous T-cell lymphoma delays tumour growth and increases survival in the murine EL4 model
Modulation of the skin microbiome in cutaneous T-cell lymphoma delays tumour growth and increases survival in the murine EL4 model Open
Cutaneous T-cell lymphomas (CTCL) are a group of lymphoproliferative disorders of skin-homing T cells causing chronic inflammation. These disorders cause impairment of the immune environment, which leads to severe infections and/or sepsis …
View article: Riboswitch-controlled IL-12 gene therapy reduces hepatocellular cancer in mice
Riboswitch-controlled IL-12 gene therapy reduces hepatocellular cancer in mice Open
Hepatocellular carcinoma (HCC) and solid cancers with liver metastases are indications with high unmet medical need. Interleukin-12 (IL-12) is a proinflammatory cytokine with substantial anti-tumor properties, but its therapeutic potential…
View article: Phototherapy Restores Deficient Type I IFN Production and Enhances Antitumor Responses in Mycosis Fungoides
Phototherapy Restores Deficient Type I IFN Production and Enhances Antitumor Responses in Mycosis Fungoides Open
View article: Data from STAT3/5-Dependent IL9 Overexpression Contributes to Neoplastic Cell Survival in Mycosis Fungoides
Data from STAT3/5-Dependent IL9 Overexpression Contributes to Neoplastic Cell Survival in Mycosis Fungoides Open
Purpose: Sustained inflammation is a key feature of mycosis fungoides (MF), the most common form of cutaneous T-cell lymphoma (CTCL). Resident IL9–producing T cells have been found in skin infections and certain inflammatory skin di…
View article: Data from STAT3/5-Dependent IL9 Overexpression Contributes to Neoplastic Cell Survival in Mycosis Fungoides
Data from STAT3/5-Dependent IL9 Overexpression Contributes to Neoplastic Cell Survival in Mycosis Fungoides Open
Purpose: Sustained inflammation is a key feature of mycosis fungoides (MF), the most common form of cutaneous T-cell lymphoma (CTCL). Resident IL9–producing T cells have been found in skin infections and certain inflammatory skin di…
View article: Supplementary material from STAT3/5-Dependent IL9 Overexpression Contributes to Neoplastic Cell Survival in Mycosis Fungoides
Supplementary material from STAT3/5-Dependent IL9 Overexpression Contributes to Neoplastic Cell Survival in Mycosis Fungoides Open
Primer list Patient detailed information Supplementary table 1: Primer list Supplementary table 2: Set of samples from archived materials Supplementary table 3: Set of samples from clinical PUVA trial (NCT0168659) Supplementary Figure 1. A…
View article: Supplementary material from STAT3/5-Dependent IL9 Overexpression Contributes to Neoplastic Cell Survival in Mycosis Fungoides
Supplementary material from STAT3/5-Dependent IL9 Overexpression Contributes to Neoplastic Cell Survival in Mycosis Fungoides Open
Primer list Patient detailed information Supplementary table 1: Primer list Supplementary table 2: Set of samples from archived materials Supplementary table 3: Set of samples from clinical PUVA trial (NCT0168659) Supplementary Figure 1. A…
View article: Blocking <scp>STAT3</scp>/5 through direct or upstream kinase targeting in leukemic cutaneous T‐cell lymphoma
Blocking <span>STAT3</span>/5 through direct or upstream kinase targeting in leukemic cutaneous T‐cell lymphoma Open
View article: IL-32 Supports the Survival of Malignant T Cells in Cutaneous T-cell Lymphoma
IL-32 Supports the Survival of Malignant T Cells in Cutaneous T-cell Lymphoma Open
View article: The molecular and phenotypic makeup of fetal human skin T lymphocytes
The molecular and phenotypic makeup of fetal human skin T lymphocytes Open
The adult human skin contains a vast number of T cells that are essential for skin homeostasis and pathogen defense. T cells are first observed in the skin at the early stages of gestation; however, our understanding of their contribution …
View article: αβγδ T cells play a vital role in fetal human skin development and immunity
αβγδ T cells play a vital role in fetal human skin development and immunity Open
T cells in human skin play an important role in the immune defense against pathogens and tumors. T cells are present already in fetal skin, where little is known about their cellular phenotype and biological function. Using single-cell ana…
View article: Long-term skin-resident memory T cells proliferate in situ and are involved in human graft-versus-host disease
Long-term skin-resident memory T cells proliferate in situ and are involved in human graft-versus-host disease Open
GVHD includes an autoinflammatory host-versus-graft component from recipient-derived skin-resident memory T cells.
View article: Quality of Life, Anxiety, and Depression in Patients With Early-Stage Mycosis Fungoides and the Effect of Oral Psoralen Plus UV-A (PUVA) Photochemotherapy on it
Quality of Life, Anxiety, and Depression in Patients With Early-Stage Mycosis Fungoides and the Effect of Oral Psoralen Plus UV-A (PUVA) Photochemotherapy on it Open
Background: Little is known about psychological discomfort and quality of life (QoL) in early stage mycosis fungoides (MF) and the effect of psoralen plus UV-A (PUVA) on it. Objective: To evaluate QoL, anxiety, and depression…
View article: Extracorporeal Photopheresis: A Case of Immunotherapy Ahead of Its Time
Extracorporeal Photopheresis: A Case of Immunotherapy Ahead of Its Time Open
Extracorporeal photopheresis (ECP) is a cell-based immunotherapy that involves the reinfusion of autologous leukocytes after exposure to psoralen and UVA. The treatment has been used for over 30 years, at first on patients with cutaneous T…
View article: Numeric Errors in Results and Discussion and Errors in Figure 3
Numeric Errors in Results and Discussion and Errors in Figure 3 Open
Pablo Vieyra-Garcia, PhD; Regina Fink-Puches, MD; Stefanie Porkert, MD; Roland Lang, PhD; Sophie Pöchlauer, MD; Gudrun Ratzinger, MD; Adrian Tanew, MD; Sylvia Selhofer, MD; Sator Paul-Gunther, MD; Angelika Hofer, MD; Alexandra Gruber-Wacke…
View article: Clarification of Skin Cream Function
Clarification of Skin Cream Function Open
tial response in induction phase in panel B. In addition, because of percentage miscalculations, the percentage of the 3 patients without an MF score reduction erroneously reported as "23%" should be "12%," and the percentage calculation f…
View article: <scp>CD</scp> 11b <sup>+</sup> cells markedly express the itch cytokine interleukin‐31 in polymorphic light eruption
<span>CD</span> 11b <sup>+</sup> cells markedly express the itch cytokine interleukin‐31 in polymorphic light eruption Open
View article: Evaluation of Low-Dose, Low-Frequency Oral Psoralen–UV-A Treatment With or Without Maintenance on Early-Stage Mycosis Fungoides
Evaluation of Low-Dose, Low-Frequency Oral Psoralen–UV-A Treatment With or Without Maintenance on Early-Stage Mycosis Fungoides Open
ClinicalTrials.gov identifier: NCT01686594.
View article: Benign T cells drive clinical skin inflammation in cutaneous T cell lymphoma
Benign T cells drive clinical skin inflammation in cutaneous T cell lymphoma Open
Psoralen plus UVA (PUVA) is an effective therapy for mycosis fungoides (MF), the skin-limited variant of cutaneous T cell lymphoma (CTCL). In low-burden patients, PUVA reduced or eradicated malignant T cells and induced clonal expansion of…
View article: From Early Immunomodulatory Triggers to Immunosuppressive Outcome: Therapeutic Implications of the Complex Interplay Between the Wavebands of Sunlight and the Skin
From Early Immunomodulatory Triggers to Immunosuppressive Outcome: Therapeutic Implications of the Complex Interplay Between the Wavebands of Sunlight and the Skin Open
Phototherapy is an efficient treatment for many cutaneous diseases that involve the activation of inflammatory pathways or the overgrowth of cells with aberrant phenotype. In this review, we discuss recent advances in photoimmunology, focu…
View article: Cbl-b deficiency provides protection against UVB-induced skin damage by modulating inflammatory gene signature
Cbl-b deficiency provides protection against UVB-induced skin damage by modulating inflammatory gene signature Open
Exposure of skin to ultraviolet (UV) radiation induces DNA damage, inflammation, and immune suppression that ultimately lead to skin cancer. However, some of the pathways that regulate these events are poorly understood. We exposed mice to…
View article: 591 PUVA induces a shift in systemic T-cell function and Treg activity in lesional skin of MF patients
591 PUVA induces a shift in systemic T-cell function and Treg activity in lesional skin of MF patients Open
View article: 459 Understanding benign T-cell infiltration in mycosis fungoides: Malignant clones are not alone
459 Understanding benign T-cell infiltration in mycosis fungoides: Malignant clones are not alone Open
View article: STAT3/5-Dependent IL9 Overexpression Contributes to Neoplastic Cell Survival in Mycosis Fungoides
STAT3/5-Dependent IL9 Overexpression Contributes to Neoplastic Cell Survival in Mycosis Fungoides Open
Purpose: Sustained inflammation is a key feature of mycosis fungoides (MF), the most common form of cutaneous T-cell lymphoma (CTCL). Resident IL9–producing T cells have been found in skin infections and certain inflammatory skin diseases,…