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Ravulizumab in treatment-naïve patients with atypical hemolytic uremic syndrome: a real-world case series Open
Introduction: Atypical hemolytic uremic syndrome (aHUS) is a potentially life-threatening condition associatedwith poor clinical outcomes if not treated adequately. Eculizumab has become the standard of care, whereasravulizumab, a second-g…
Dapagliflozin’s Effects on Urinary Albumin and Non-Albumin Proteins in Diabetic and Non-Diabetic Kidney Transplant Recipients Open
Background: SGLT2 inhibitors (SGLT2is) lower glucose and have renoprotective effects, including reducing proteinuria. In kidney transplant recipients (KTRs), proteinuria impacts graft and patient survival. While SGLT2is benefits have been …
View article: Non-Invasive Ventilation Failure in Pediatric ICU: A Machine Learning Driven Prediction
Non-Invasive Ventilation Failure in Pediatric ICU: A Machine Learning Driven Prediction Open
Background/Objectives: Non-invasive ventilation (NIV) has emerged as a possible first-step treatment to avoid invasive intubation in pediatric intensive care units (PICUs) due to its advantages in reducing intubation-associated risks. Howe…
A Resilient Approach to a Test Rig Setup in the Qualification of a Tilt Rotor Carbon Fiber-Reinforced Polymer (CFRP) Wing Open
The evolution of aircraft wing development has seen significant progress since the early days of aviation, with static testing emerging as a crucial aspect for ensuring safety and reliability. This study focused specifically on the enginee…
Virtual Full Scale Static Test of a Civil Tilt Rotor Composite Wing in Non-Linear Regime Open
This study addresses the crucial role of post-buckling behavior analysis in the structural design of composite aeronautical structures. Traditional engineering practices tend to result in oversized composite components, increasing structur…
Non-Linear Analysis in Post-Buckling Regime of a Tilt Rotor Composite Wing Structure Using Detailed Model and Robust Loading Approach Open
The design and development of a wing for a completely brand-new aircraft represents, in aeronautics, one of the highest challenges from an engineering point of view. The present work describes a novel methodology devoted to execute numeric…
Prognostic value of diabetes and metformin use in a real-life population of head and neck cancer patients Open
Introduction Head and neck carcinoma (HNC) is a disease with a poor prognosis despite currently available treatments. The management of patients with this tumor is often complicated by several comorbidities. Among these, diabetes is the se…
Utility of psychotherapy assessed with Kessler scale in a population of cancer patients undergoing systemic oncological treatment: a mono-institutional experience Open
The use of the K10 test is helpful in monitoring the degree of psychological distress of patients facing the diagnosis of cancer and who are about to start oncological treatment. Psychotherapy is effective in reducing the distress of these…
The Art of Counseling in the Treatment of Head and Neck Cancer: Exploratory Investigation among Perceptions of Health Professionals in Southern Italy Open
(1) Background: Recurrent and/or metastatic patients with head and neck squamous cell carcinoma show a poor prognosis, which has not changed significantly in 30 years. Preserving quality of life is a primary goal for this subset of patient…
View article: Primary versus secondary antiemetic prophylaxis with NK1 receptor antagonists in patients affected by gastrointestinal malignancies and treated with a doublet or triplet combination regimen including oxaliplatin and/or irinotecan plus fluoropyrimidines: A propensity score matched analysis
Primary versus secondary antiemetic prophylaxis with NK1 receptor antagonists in patients affected by gastrointestinal malignancies and treated with a doublet or triplet combination regimen including oxaliplatin and/or irinotecan plus fluoropyrimidines: A propensity score matched analysis Open
Aim The aim of the current study is to investigate the impact of primary compared to secondary chemotherapy-induced nausea and vomiting (CINV) prophylaxis with NK1 receptor antagonists (NK1-RA) in patients affected by gastrointestinal mali…
Predictive Biomarkers for a Personalized Approach in Resectable Pancreatic Cancer Open
The mainstay treatment for patients with immediate resectable pancreatic cancer remains upfront surgery, which represents the only potentially curative strategy. Nevertheless, the majority of patients surgically resected for pancreatic can…
View article: Post-Induction Management in Patients With Left-Sided RAS and BRAF Wild-Type Metastatic Colorectal Cancer Treated With First-Line Anti-EGFR-Based Doublet Regimens: A Multicentre Study
Post-Induction Management in Patients With Left-Sided RAS and BRAF Wild-Type Metastatic Colorectal Cancer Treated With First-Line Anti-EGFR-Based Doublet Regimens: A Multicentre Study Open
Background Few data regarding post-induction management following first-line anti-epidermal growth factor receptor (EGFR)-based doublet regimens in patients with left-sided RAS/BRAF wild-type metastatic colorectal cancer (mCRC) are availab…
Retrospective Study of Regorafenib Versus TAS-102 Efficacy and Safety in Chemorefractory Metastatic Colorectal Cancer (mCRC) Patients: A Multi-institution Real Life Clinical Data Open
The present study is the first one to compare the activity of the two agents in a large cohort of chemo-refractory mCRC patients providing more details about the best sequence, to be incorporated in clinical practice.
Development of a Morphing Landing Gear Composite Door for High Speed Compound Rotorcraft Open
In the framework of fast rotorcraft, smoothness and flushness of external aerodynamic surfaces present challenges for high-speed conditions, where aerodynamics is the driver of helicopter performance. For AIRBUS-RACER helicopter the main l…
Evaluation of Second-Line Anti-VEGF after First-Line Anti-EGFR Based Therapy in RAS Wild-Type Metastatic Colorectal Cancer: The Multicenter “SLAVE” Study Open
Background: The optimal anti-angiogenic strategy as second-line treatment in RAS wild-type metastatic colorectal cancer (mCRC) treated with anti-EGFR (Epidermal Growth Factor Receptor) based first-line treatment is still debated. Methods: …
View article: Overview of Current Targeted Anti-Cancer Drugs for Therapy in Onco-Hematology
Overview of Current Targeted Anti-Cancer Drugs for Therapy in Onco-Hematology Open
The upgraded knowledge of tumor biology and microenviroment provides information on differences in neoplastic and normal cells. Thus, the need to target these differences led to the development of novel molecules (targeted therapy) active …
View article: Overview of Targeted Drugs for Mature B-Cell Non-hodgkin Lymphomas
Overview of Targeted Drugs for Mature B-Cell Non-hodgkin Lymphomas Open
The improved knowledge of pathogenetic mechanisms underlying lymphomagenesis and the discovery of the critical role of tumor microenvironments have enabled the design of new drugs against cell targets and pathways. The Food and Drug Admini…
View article: A case report of a severe fluoropyrimidine-related toxicity due to an uncommon DPYD variant
A case report of a severe fluoropyrimidine-related toxicity due to an uncommon DPYD variant Open
Introduction: Fluoropyrimidines such as 5-fluorouracil (5-FU) and its orally active prodrug, capecitabine, are widely used in the treatment of gastrointestinal cancer, including colorectal cancer. Dihydropyrimidine dehydrogenase (DPD) play…
AXL has a prognostic role in metastatic colorectal cancer (mCRC) and is a predictive biomarker of lack of efficacy of chemotherapy (CT) + cetuximab in RAS wild type (WT) patients (pts) Open
Background: AXL expression promotes tumour growth, angiogenesis, epithelial to mesenchymal transition (EMT), resistance to CT and targeted agents. AXL is overexpressed in CRC. We aimed to evaluate AXL expression in mCRC pts and to correlat…