Padma Kadiyala
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View article: Fibroblast STAT3 Activation Drives Organ-Specific Premetastatic Niche Formation
Fibroblast STAT3 Activation Drives Organ-Specific Premetastatic Niche Formation Open
Pancreatic cancer is associated with a high rate of metastasis and poor prognosis. The formation of a premetastatic niche (PMN) facilitates cancer cell spread and contributes to cancer mortality. Using murine pancreatic cancer models based…
View article: Autophagy Upregulation in Mutant Isocitrate Dehydrogenase 1 (IDH1) Glioma Uncovers a Novel Therapeutic Target
Autophagy Upregulation in Mutant Isocitrate Dehydrogenase 1 (IDH1) Glioma Uncovers a Novel Therapeutic Target Open
Mutant isocitrate dehydrogenase 1 (mIDH1) catalyzes 2-hydroxyglutarate production which leads to epigenetic reprogramming. RNA-seq, scRNA-seq, and ChIP-seq analysis revealed that human and mouse mIDH1 gliomas exhibit downregulated gene ont…
View article: Aryl Hydrocarbon Receptor Ligands Drive Pancreatic Cancer Initiation and Progression through Protumorigenic T-cell Polarization
Aryl Hydrocarbon Receptor Ligands Drive Pancreatic Cancer Initiation and Progression through Protumorigenic T-cell Polarization Open
Although smoking is a risk factor for pancreatic adenocarcinoma (PDAC), the underlying mechanisms promoting tumorigenesis and progression are unknown. In this study, we show that aryl hydrocarbon receptor (AHR) ligands found in cigarette s…
View article: Primary and metastatic cellular landscapes in human pancreatic cancer
Primary and metastatic cellular landscapes in human pancreatic cancer Open
View article: Spatial analysis of IPMNs defines a paradoxical KRT17-positive, low-grade epithelial population harboring malignant features
Spatial analysis of IPMNs defines a paradoxical KRT17-positive, low-grade epithelial population harboring malignant features Open
Background & Aims Intraductal papillary mucinous neoplasms (IPMNs) are pancreatic cysts that represent one of the few radiologically identifiable precursors to pancreatic ductal adenocarcinoma (PDAC). Though the IPMN-bearing patient popula…
View article: Supplementary Figure S7 from Oncogenic KRAS-Dependent Stromal Interleukin-33 Directs the Pancreatic Microenvironment to Promote Tumor Growth
Supplementary Figure S7 from Oncogenic KRAS-Dependent Stromal Interleukin-33 Directs the Pancreatic Microenvironment to Promote Tumor Growth Open
Figure S7: Tumor cell-initiated autocrine signaling drives IL-33 upregulation in pancreatic fibroblasts.
View article: Data from Oncogenic KRAS-Dependent Stromal Interleukin-33 Directs the Pancreatic Microenvironment to Promote Tumor Growth
Data from Oncogenic KRAS-Dependent Stromal Interleukin-33 Directs the Pancreatic Microenvironment to Promote Tumor Growth Open
Pancreatic cancer is characterized by an extensive fibroinflammatory microenvironment. During carcinogenesis, normal stromal cells are converted to cytokine-high cancer-associated fibroblasts (CAF). The mechanisms underlying this conversio…
View article: Supplementary Table S2 from Oncogenic KRAS-Dependent Stromal Interleukin-33 Directs the Pancreatic Microenvironment to Promote Tumor Growth
Supplementary Table S2 from Oncogenic KRAS-Dependent Stromal Interleukin-33 Directs the Pancreatic Microenvironment to Promote Tumor Growth Open
Table S2. Primer sequences used in qRT-PCR
View article: Supplementary Figure S1 from Oncogenic KRAS-Dependent Stromal Interleukin-33 Directs the Pancreatic Microenvironment to Promote Tumor Growth
Supplementary Figure S1 from Oncogenic KRAS-Dependent Stromal Interleukin-33 Directs the Pancreatic Microenvironment to Promote Tumor Growth Open
Figure S1: IL-33+ stromal cells are abundant in human and mouse PDA.
View article: Supplementary Figure S4 from Oncogenic KRAS-Dependent Stromal Interleukin-33 Directs the Pancreatic Microenvironment to Promote Tumor Growth
Supplementary Figure S4 from Oncogenic KRAS-Dependent Stromal Interleukin-33 Directs the Pancreatic Microenvironment to Promote Tumor Growth Open
Figure S4: Loss of stromal IL-33 alters the ST2+ immune cell secretome, resulting in a shift in CAF differentiation.
View article: Supplementary Figure S6 from Oncogenic KRAS-Dependent Stromal Interleukin-33 Directs the Pancreatic Microenvironment to Promote Tumor Growth
Supplementary Figure S6 from Oncogenic KRAS-Dependent Stromal Interleukin-33 Directs the Pancreatic Microenvironment to Promote Tumor Growth Open
Figure S6: Expression of fibroblast IL-33 is extrinsically induced by epithelial KrasG12D and requires JAK1/2-STAT3 activation throughout tumorigenesis.
View article: Supplementary Figure S3 from Oncogenic KRAS-Dependent Stromal Interleukin-33 Directs the Pancreatic Microenvironment to Promote Tumor Growth
Supplementary Figure S3 from Oncogenic KRAS-Dependent Stromal Interleukin-33 Directs the Pancreatic Microenvironment to Promote Tumor Growth Open
Figure S3: Pancreatic fibroblasts secrete IL-33 in response to oxidative stress.
View article: Supplementary Figure S5 from Oncogenic KRAS-Dependent Stromal Interleukin-33 Directs the Pancreatic Microenvironment to Promote Tumor Growth
Supplementary Figure S5 from Oncogenic KRAS-Dependent Stromal Interleukin-33 Directs the Pancreatic Microenvironment to Promote Tumor Growth Open
Figure S5: Inactivation of stromal IL-33 enables cytotoxic T cell activity.
View article: Supplementary Table S1 from Oncogenic KRAS-Dependent Stromal Interleukin-33 Directs the Pancreatic Microenvironment to Promote Tumor Growth
Supplementary Table S1 from Oncogenic KRAS-Dependent Stromal Interleukin-33 Directs the Pancreatic Microenvironment to Promote Tumor Growth Open
Table S1. Single cell RNA sequencing datasets.
View article: Supplementary Figure S2 from Oncogenic KRAS-Dependent Stromal Interleukin-33 Directs the Pancreatic Microenvironment to Promote Tumor Growth
Supplementary Figure S2 from Oncogenic KRAS-Dependent Stromal Interleukin-33 Directs the Pancreatic Microenvironment to Promote Tumor Growth Open
Figure S2: Stromal IL-33 promotes PDA growth.
View article: Supplementary Figures Part 1 from Analysis of donor pancreata defines the transcriptomic signature and microenvironment of early neoplastic lesions.
Supplementary Figures Part 1 from Analysis of donor pancreata defines the transcriptomic signature and microenvironment of early neoplastic lesions. Open
Supplementary Figures 1-10 and associated legends
View article: Supplementary Figures Part 1 from Analysis of donor pancreata defines the transcriptomic signature and microenvironment of early neoplastic lesions.
Supplementary Figures Part 1 from Analysis of donor pancreata defines the transcriptomic signature and microenvironment of early neoplastic lesions. Open
Supplementary Figures 1-10 and associated legends
View article: Supplementary Tables from Analysis of donor pancreata defines the transcriptomic signature and microenvironment of early neoplastic lesions.
Supplementary Tables from Analysis of donor pancreata defines the transcriptomic signature and microenvironment of early neoplastic lesions. Open
Supplemental Table 1: Demographics and clinical data for donor Gife of Life Samples Supplemental Table 2: Putative Ligand-Receptor pairs comparing all cell types from single cell sequencing of tumor samples compared to healthy samples. Sup…
View article: Supplementary Figures Part 1 from Analysis of donor pancreata defines the transcriptomic signature and microenvironment of early neoplastic lesions.
Supplementary Figures Part 1 from Analysis of donor pancreata defines the transcriptomic signature and microenvironment of early neoplastic lesions. Open
Supplementary Figures 1-10 and associated legends
View article: Supplementary Figures Part 1 from Analysis of donor pancreata defines the transcriptomic signature and microenvironment of early neoplastic lesions.
Supplementary Figures Part 1 from Analysis of donor pancreata defines the transcriptomic signature and microenvironment of early neoplastic lesions. Open
Supplementary Figures 1-10 and associated legends
View article: Data from Analysis of donor pancreata defines the transcriptomic signature and microenvironment of early neoplastic lesions.
Data from Analysis of donor pancreata defines the transcriptomic signature and microenvironment of early neoplastic lesions. Open
The adult healthy human pancreas has been poorly studied given lack of indication to obtain tissue from the pancreas in the absence of disease and rapid postmortem degradation. We obtained pancreata from brain dead donors thus avoiding any…
View article: Supplementary Tables from Analysis of donor pancreata defines the transcriptomic signature and microenvironment of early neoplastic lesions.
Supplementary Tables from Analysis of donor pancreata defines the transcriptomic signature and microenvironment of early neoplastic lesions. Open
Supplemental Table 1: Demographics and clinical data for donor Gife of Life Samples Supplemental Table 2: Putative Ligand-Receptor pairs comparing all cell types from single cell sequencing of tumor samples compared to healthy samples. Sup…
View article: Data from Analysis of donor pancreata defines the transcriptomic signature and microenvironment of early neoplastic lesions.
Data from Analysis of donor pancreata defines the transcriptomic signature and microenvironment of early neoplastic lesions. Open
The adult healthy human pancreas has been poorly studied given lack of indication to obtain tissue from the pancreas in the absence of disease and rapid postmortem degradation. We obtained pancreata from brain dead donors thus avoiding any…
View article: Supplementary Tables from Analysis of donor pancreata defines the transcriptomic signature and microenvironment of early neoplastic lesions.
Supplementary Tables from Analysis of donor pancreata defines the transcriptomic signature and microenvironment of early neoplastic lesions. Open
Supplemental Table 1: Demographics and clinical data for donor Gife of Life Samples Supplemental Table 2: Putative Ligand-Receptor pairs comparing all cell types from single cell sequencing of tumor samples compared to healthy samples. Sup…
View article: Supplementary Figures Part 2 from Analysis of donor pancreata defines the transcriptomic signature and microenvironment of early neoplastic lesions.
Supplementary Figures Part 2 from Analysis of donor pancreata defines the transcriptomic signature and microenvironment of early neoplastic lesions. Open
Supplementary Figures 11-14 and associated legends.
View article: Supplementary Tables from Analysis of donor pancreata defines the transcriptomic signature and microenvironment of early neoplastic lesions.
Supplementary Tables from Analysis of donor pancreata defines the transcriptomic signature and microenvironment of early neoplastic lesions. Open
Supplemental Table 1: Demographics and clinical data for donor Gife of Life Samples Supplemental Table 2: Putative Ligand-Receptor pairs comparing all cell types from single cell sequencing of tumor samples compared to healthy samples. Sup…
View article: Supplementary Figures Part 2 from Analysis of donor pancreata defines the transcriptomic signature and microenvironment of early neoplastic lesions.
Supplementary Figures Part 2 from Analysis of donor pancreata defines the transcriptomic signature and microenvironment of early neoplastic lesions. Open
Supplementary Figures 11-14 and associated legends.
View article: Supplementary Figures Part 2 from Analysis of donor pancreata defines the transcriptomic signature and microenvironment of early neoplastic lesions.
Supplementary Figures Part 2 from Analysis of donor pancreata defines the transcriptomic signature and microenvironment of early neoplastic lesions. Open
Supplementary Figures 11-14 and associated legends.
View article: Supplementary Figures Part 2 from Analysis of donor pancreata defines the transcriptomic signature and microenvironment of early neoplastic lesions.
Supplementary Figures Part 2 from Analysis of donor pancreata defines the transcriptomic signature and microenvironment of early neoplastic lesions. Open
Supplementary Figures 11-14 and associated legends.
View article: Metabolic landscape of the healthy pancreas and pancreatic tumor microenvironment
Metabolic landscape of the healthy pancreas and pancreatic tumor microenvironment Open
Pancreatic cancer, one of the deadliest human malignancies, is characterized by a fibro-inflammatory tumor microenvironment and wide array of metabolic alterations. To comprehensively map metabolism in a cell type-specific manner, we harne…