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View article: Targeting bacterial and human levodopa decarboxylases for improved drug treatment of Parkinson's disease: Discovery and characterization of new inhibitors
Targeting bacterial and human levodopa decarboxylases for improved drug treatment of Parkinson's disease: Discovery and characterization of new inhibitors Open
Parkinson's disease (PD) is a common neurodegenerative disease, typically treated with levodopa, which alleviates the motor symptoms of the disease. However, levodopa metabolism in peripheral tissues hampers its bioavailability and leads t…
View article: Crotoscheffleriolides, ent-clerodane diterpenoids from Kenyan Croton scheffleri
Crotoscheffleriolides, ent-clerodane diterpenoids from Kenyan Croton scheffleri Open
Kenyan Croton scheffleri has yielded nineteen compounds. The stem bark gave six undescribed ent-clerodane diterpenoids (1-4, 6 and 7), three undescribed sesquiterpene lactones (9, 11 and 12) and four known compounds (5, 8, 10 and 13). From…
View article: Sustainable multifunctional foams for cold-chain packaging: Stabilizing polyethylene glycol with cellulose and pomegranate peel for antibacterial protection and temperature control
Sustainable multifunctional foams for cold-chain packaging: Stabilizing polyethylene glycol with cellulose and pomegranate peel for antibacterial protection and temperature control Open
View article: A Systematic Study of <i>Staphylococcus aureus</i> Biofilm Formation on Thiol‐Ene Polymers: Toward the Development of Microfluidic Bacterial Biofilm Models
A Systematic Study of <i>Staphylococcus aureus</i> Biofilm Formation on Thiol‐Ene Polymers: Toward the Development of Microfluidic Bacterial Biofilm Models Open
Global antimicrobial resistance poses a major threat to human health and is largely driven by bacterial biofilms, which demonstrate significantly greater antibiotic resistance than planktonic bacteria. While most biofilm research targets t…
View article: Structure-property correlations and environmental impact assessment of sustainable antibacterial food packaging films reinforced with fungal chitin nanofibrils
Structure-property correlations and environmental impact assessment of sustainable antibacterial food packaging films reinforced with fungal chitin nanofibrils Open
View article: Functionalized cellulose nanocrystals reinforced PLA-gelatin electrospun fibers for potential antibacterial wound dressing and coating applications
Functionalized cellulose nanocrystals reinforced PLA-gelatin electrospun fibers for potential antibacterial wound dressing and coating applications Open
This study addresses the critical need for effective antibacterial materials by exploring the innovative integration of dimethyloctadecyl [3-(trimethoxysilyl)propyl] ammonium chloride (DTSACl) onto cellulose nanocrystal (CNC), followed by …
View article: Cryptophytes as potential source of natural antimicrobials for food preservation
Cryptophytes as potential source of natural antimicrobials for food preservation Open
Cryptophytes are a promising source of bioactive compounds that have not been fully explored. This research investigated the antimicrobial activity of total phenolic compounds (TPC) and exopolysaccharides (EPS) extracted from several crypt…
View article: Improved N-phenylpyrrolamide inhibitors of DNA gyrase as antibacterial agents for high-priority bacterial strains
Improved N-phenylpyrrolamide inhibitors of DNA gyrase as antibacterial agents for high-priority bacterial strains Open
In this work, we describe an improved series of N-phenylpyrrolamide inhibitors that exhibit potent activity against DNA gyrase and are highly effective against high-priority gram-positive bacteria. The most potent compounds show low nanomo…
View article: Bioprospecting of inhibitors of EPEC virulence from metabolites of marine actinobacteria from the Arctic Sea
Bioprospecting of inhibitors of EPEC virulence from metabolites of marine actinobacteria from the Arctic Sea Open
A considerable number of antibacterial agents are derived from bacterial metabolites. Similarly, numerous known compounds that impede bacterial virulence stem from bacterial metabolites. Enteropathogenic Escherichia coli (EPEC) is a notabl…
View article: Development and characterization of pomegranate peel extract-infused carboxymethyl cellulose composite films for functional, sustainable food packaging
Development and characterization of pomegranate peel extract-infused carboxymethyl cellulose composite films for functional, sustainable food packaging Open
View article: High-throughput combination assay for studying biofilm formation of uropathogenic Escherichia coli
High-throughput combination assay for studying biofilm formation of uropathogenic Escherichia coli Open
Uropathogenic Escherichia coli , the most common cause for urinary tract infections, forms biofilm enhancing its antibiotic resistance. To assess the effects of compounds on biofilm formation of uropathogenic Escherichia coli UMN026 strain…
View article: Highly scalable and standardized organ-on-chip platform with TEER for biological barrier modeling
Highly scalable and standardized organ-on-chip platform with TEER for biological barrier modeling Open
The development of new therapies is hampered by the lack of predictive, and patient-relevant in vitro models. Organ-on-chip (OOC) technologies can potentially recreate physiological features and hold great promise for tissue and disease mo…
View article: Drug repurposing platform for deciphering the druggable SARS-CoV-2 interactome
Drug repurposing platform for deciphering the druggable SARS-CoV-2 interactome Open
The coronavirus disease 2019 (COVID-19) pandemic has heavily challenged the global healthcare system. Despite the vaccination programs, the new virus variants are circulating. Further research is required for understanding of the biology o…
View article: Benzothiazole DNA gyrase inhibitors and their conjugates with siderophore mimics: design, synthesis and evaluation
Benzothiazole DNA gyrase inhibitors and their conjugates with siderophore mimics: design, synthesis and evaluation Open
Potent DNA gyrase and topoisomerase IV inhibitor bearing a siderophore mimic moiety displays improved antibacterial activity against Escherichia coli under iron-depleted conditions.
View article: New <i>N</i>-phenylpyrrolamide inhibitors of DNA gyrase with improved antibacterial activity
New <i>N</i>-phenylpyrrolamide inhibitors of DNA gyrase with improved antibacterial activity Open
New N -phenylpyrrolamide inhibitors of DNA gyrase were developed with excellent on-target activity and improved antibacterial activity.
View article: Crotoscheffleriolides, Ent-Clerodane Diterpenoids from Kenyan Croton Scheffleri
Crotoscheffleriolides, Ent-Clerodane Diterpenoids from Kenyan Croton Scheffleri Open
View article: Virtual Screening Assisted Search for Inhibitors of the Translocated Intimin Receptor of Enteropathogenic <i>Escherichia Coli</i>
Virtual Screening Assisted Search for Inhibitors of the Translocated Intimin Receptor of Enteropathogenic <i>Escherichia Coli</i> Open
This study aimed to identify inhibitors of the translocated intimin receptor (Tir) of enteropathogenic Escherichia coli (EPEC). EPEC is an intestinal pathogen that causes diarrhea and is a major health concern worldwide. Because Tir is a k…
View article: Natural Product – Drug Interactions and Their Evaluation Using a Caco-2 Cell Culture Model
Natural Product – Drug Interactions and Their Evaluation Using a Caco-2 Cell Culture Model Open
Natural products, such as herbal medicinal products, food supplements, and functional food, are widely used to support well-being and for promoting health. In general, the effects of using these products are desired and beneficial, but une…
View article: Biochemometry identifies ostruthin as pluripotent antimicrobial and anthelmintic agent from masterwort
Biochemometry identifies ostruthin as pluripotent antimicrobial and anthelmintic agent from masterwort Open
The root extract of Peucedanum ostruthium (PO-E) was identified as a promising antibacterial source from a screening of 158 extracts against Staphylococcus aureus. It has also recently been shown to significantly decrease the…
View article: Willow Bark-Derived Material with Antibacterial and Antibiofilm Properties for Potential Wound Dressing Applications
Willow Bark-Derived Material with Antibacterial and Antibiofilm Properties for Potential Wound Dressing Applications Open
Tree stems contain wood in addition to 10-20% bark, which remains one of the largest underutilized biomasses on earth. Unique macromolecules (like lignin, suberin, pectin, and tannin), extractives, and sclerenchyma fibers form the main par…
View article: CCDC 2195742: Experimental Crystal Structure Determination
CCDC 2195742: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Antibacterial and antibiofilm activity of permanently ionized quaternary ammonium fluoroquinolones
Antibacterial and antibiofilm activity of permanently ionized quaternary ammonium fluoroquinolones Open
A series of quaternary ammonium fluoroquinolones was obtained by exhaustive methylation of the amine groups present at the 7-position of fluoroquinolones, including ciprofloxacin, enoxacin, gatifloxacin, lomefloxacin, and norfloxacin. The …
View article: Selected strategies to fight pathogenic bacteria
Selected strategies to fight pathogenic bacteria Open
Natural products and analogues are a source of antibacterial drug discovery. Considering drug resistance levels emerging for antibiotics, identification of bacterial metalloenzymes and the synthesis of selective inhibitors are interesting …
View article: Synthesis, Structure and Biological Activity of Novel 4,5-dihydro-1H-imidazol-2-yl-phthalazine Derivatives and Their Copper(II) Complexes
Synthesis, Structure and Biological Activity of Novel 4,5-dihydro-1H-imidazol-2-yl-phthalazine Derivatives and Their Copper(II) Complexes Open
As a continuation of our previous investigations aimed at the synthesis of novel nitrogen-containing heterocycles and their metal complexes, we have now prepared two series of compounds incorporating a phthalazine ring at the position C2 o…
View article: Effect of Hybrid Type and Harvesting Season on Phytochemistry and Antibacterial Activity of Extracted Metabolites from <i>Salix</i> Bark
Effect of Hybrid Type and Harvesting Season on Phytochemistry and Antibacterial Activity of Extracted Metabolites from <i>Salix</i> Bark Open
Hundreds of different fast-growing Salix hybrids have been developed mainly for energy crops. In this paper, we studied water extracts from the bark of 15 willow hybrids and species as potential antimicrobial additives. Treatment of…
View article: Compounding Parenteral Products in Pediatric Wards—Effect of Environment and Aseptic Technique on Product Sterility
Compounding Parenteral Products in Pediatric Wards—Effect of Environment and Aseptic Technique on Product Sterility Open
Parenteral products must be compounded using an aseptic technique to ensure sterility of the medicine. We compared the effect of three clinical environments as compounding areas as well as different aseptic techniques on the sterility of t…
View article: Synthesis and Cytotoxicity Evaluation of Spirocyclic Bromotyrosine Clavatadine C Analogs
Synthesis and Cytotoxicity Evaluation of Spirocyclic Bromotyrosine Clavatadine C Analogs Open
Marine-originated spirocyclic bromotyrosines are considered as promising scaffolds for new anticancer drugs. In a continuation of our research to develop potent and more selective anticancer compounds, we synthesized a library of 32 spiroc…
View article: Development and validation of a high-content screening assay for inhibitors of enteropathogenic E. coli adhesion
Development and validation of a high-content screening assay for inhibitors of enteropathogenic E. coli adhesion Open
Enteropathogenic E. coli (EPEC) causes intestinal infections leading to severe diarrhea. EPEC attaches to the host cell causing lesions to the intestinal epithelium coupled with the effacement of microvilli. In the process, actin accumulat…
View article: Separation of fiber bundles from willow bark using sodium bicarbonate and their novel use in yarns for superior UV protection and antibacterial performance
Separation of fiber bundles from willow bark using sodium bicarbonate and their novel use in yarns for superior UV protection and antibacterial performance Open
View article: Discovery of Substituted (2-Aminooxazol-4-yl)Isoxazole-3-carboxylic Acids as Inhibitors of Bacterial Serine Acetyltransferase in the Quest for Novel Potential Antibacterial Adjuvants
Discovery of Substituted (2-Aminooxazol-4-yl)Isoxazole-3-carboxylic Acids as Inhibitors of Bacterial Serine Acetyltransferase in the Quest for Novel Potential Antibacterial Adjuvants Open
Many bacteria and actinomycetales use L-cysteine biosynthesis to increase their tolerance to antibacterial treatment and establish a long-lasting infection. In turn, this might lead to the onset of antimicrobial resistance that currently r…