Päivi Tossavainen
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View article: Adolescent anorexia nervosa treated in primary care with a family-based method – long-term outcomes
Adolescent anorexia nervosa treated in primary care with a family-based method – long-term outcomes Open
Adolescent anorexia nervosa patients treated mainly in primary care had at least as favourable long-term outcomes as those treated in tertiary care. The results of this study encourage further development of outpatient treatment methods in…
View article: Prevalence of carotid atherosclerosis in 3-92-year-old Finns. The 3-generational cardiovascular risk in young Finns study
Prevalence of carotid atherosclerosis in 3-92-year-old Finns. The 3-generational cardiovascular risk in young Finns study Open
Carotid artery plaques are very prevalent finding among Finnish adults but not observed in children of the general population. High LDL-cholesterol concentration and hypertension are strongly associated with plaques, especially among young…
View article: Association of epicardial adipose tissue thickness and cardiac structure and function in early midlife: the cardiovascular risk in Young Finns Study
Association of epicardial adipose tissue thickness and cardiac structure and function in early midlife: the cardiovascular risk in Young Finns Study Open
Aims Previous studies who have reported associations between higher epicardial adipose tissue (EAT) and alterations in cardiac geometry and function are mainly derived from older adults. In this cross-sectional study, we examined whether t…
View article: Factors related to blood-based biomarkers for neurodegenerative diseases and their intergenerational associations in the Young Finns Study: a cohort study
Factors related to blood-based biomarkers for neurodegenerative diseases and their intergenerational associations in the Young Finns Study: a cohort study Open
View article: Childhood 25-hydroxy-vitamin D levels predict early cardiovascular outcomes in adulthood: the Cardiovascular Risk in Young Finns Study
Childhood 25-hydroxy-vitamin D levels predict early cardiovascular outcomes in adulthood: the Cardiovascular Risk in Young Finns Study Open
View article: Unfolding the Mystery of Autoimmunity: The Environmental Determinants of Diabetes in the Young (TEDDY) Study
Unfolding the Mystery of Autoimmunity: The Environmental Determinants of Diabetes in the Young (TEDDY) Study Open
In 2025, the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) at the National Institutes of Health celebrates 75 years of leadership in diabetes research. The NIDDK serves people of the U.S. affected by or at risk f…
View article: Association of neighbourhood and individual-level socioeconomic disadvantage in childhood and adulthood with cognitive function in mid-adulthood: Cardiovascular Risk in Young Finns Study
Association of neighbourhood and individual-level socioeconomic disadvantage in childhood and adulthood with cognitive function in mid-adulthood: Cardiovascular Risk in Young Finns Study Open
Socioeconomic disadvantage at individual level is associated with poor cognitive outcomes but the link of neighbourhood disadvantage with cognitive function is unclear. We used data from Young Finns Study, a population-based cohort, to exa…
View article: Cohort Profile Update: Expanding the Cardiovascular Risk in Young Finns Study into a multigenerational cohort
Cohort Profile Update: Expanding the Cardiovascular Risk in Young Finns Study into a multigenerational cohort Open
Cardiovascular Risk in Young Finns Study (YFS) is a prospective cohort of 3596 males and females (baseline age 3-18 years) that was established in 1980 to study cardiovascular risk factors in children and adolescents. The YFS has been inst…
View article: Supplementary Table S2 from Association of Ideal Cardiovascular Health in Youth with Cancer Risk in Adulthood: A Cardiovascular Risk in Young Finns Study
Supplementary Table S2 from Association of Ideal Cardiovascular Health in Youth with Cancer Risk in Adulthood: A Cardiovascular Risk in Young Finns Study Open
Supplementary Table S2: Summary Statistics of the Age at Cancer Diagnosis for the 72 Cancer Cases in YFS study Cohort with complete AHA ICH data in 1986
View article: Data from Association of Ideal Cardiovascular Health in Youth with Cancer Risk in Adulthood: A Cardiovascular Risk in Young Finns Study
Data from Association of Ideal Cardiovascular Health in Youth with Cancer Risk in Adulthood: A Cardiovascular Risk in Young Finns Study Open
Background:Lifestyle factors may affect cancer risk. This study aimed to identify whether the American Heart Association ideal cardiovascular health (ICH) score and its individual variables in youth are associated with subsequent cancer in…
View article: Supplementary Table S3 from Association of Ideal Cardiovascular Health in Youth with Cancer Risk in Adulthood: A Cardiovascular Risk in Young Finns Study
Supplementary Table S3 from Association of Ideal Cardiovascular Health in Youth with Cancer Risk in Adulthood: A Cardiovascular Risk in Young Finns Study Open
Supplementary Table S3: The association of weekly Hours of moderate to vigorous Physical Activity in 1986 with subsequent Cancer Incidence
View article: Supplementary Table S3 from Association of Ideal Cardiovascular Health in Youth with Cancer Risk in Adulthood: A Cardiovascular Risk in Young Finns Study
Supplementary Table S3 from Association of Ideal Cardiovascular Health in Youth with Cancer Risk in Adulthood: A Cardiovascular Risk in Young Finns Study Open
Supplementary Table S3: The association of weekly Hours of moderate to vigorous Physical Activity in 1986 with subsequent Cancer Incidence
View article: Supplementary Table S1 from Association of Ideal Cardiovascular Health in Youth with Cancer Risk in Adulthood: A Cardiovascular Risk in Young Finns Study
Supplementary Table S1 from Association of Ideal Cardiovascular Health in Youth with Cancer Risk in Adulthood: A Cardiovascular Risk in Young Finns Study Open
Supplementary Table S1: Proportion of Cancers by different Cancer Subtypes among Participants with complete AHA ICH Data in 1986
View article: Data from Association of Ideal Cardiovascular Health in Youth with Cancer Risk in Adulthood: A Cardiovascular Risk in Young Finns Study
Data from Association of Ideal Cardiovascular Health in Youth with Cancer Risk in Adulthood: A Cardiovascular Risk in Young Finns Study Open
Background:Lifestyle factors may affect cancer risk. This study aimed to identify whether the American Heart Association ideal cardiovascular health (ICH) score and its individual variables in youth are associated with subsequent cancer in…
View article: Supplementary Table S2 from Association of Ideal Cardiovascular Health in Youth with Cancer Risk in Adulthood: A Cardiovascular Risk in Young Finns Study
Supplementary Table S2 from Association of Ideal Cardiovascular Health in Youth with Cancer Risk in Adulthood: A Cardiovascular Risk in Young Finns Study Open
Supplementary Table S2: Summary Statistics of the Age at Cancer Diagnosis for the 72 Cancer Cases in YFS study Cohort with complete AHA ICH data in 1986
View article: Supplementary Table S1 from Association of Ideal Cardiovascular Health in Youth with Cancer Risk in Adulthood: A Cardiovascular Risk in Young Finns Study
Supplementary Table S1 from Association of Ideal Cardiovascular Health in Youth with Cancer Risk in Adulthood: A Cardiovascular Risk in Young Finns Study Open
Supplementary Table S1: Proportion of Cancers by different Cancer Subtypes among Participants with complete AHA ICH Data in 1986
View article: Intake of B vitamins and the risk of developing islet autoimmunity and type 1 diabetes in the TEDDY study
Intake of B vitamins and the risk of developing islet autoimmunity and type 1 diabetes in the TEDDY study Open
View article: Metformin Versus Insulin for Gestational Diabetes: Cognitive and Neuropsychological Profiles of Children Aged 9 years
Metformin Versus Insulin for Gestational Diabetes: Cognitive and Neuropsychological Profiles of Children Aged 9 years Open
Objective: We compared cognitive profile and neuropsychological performance in 9-year-old offspring of mothers who were treated with metformin or insulin for gestational diabetes mellitus (GDM). Methods: A total of 172 children whose mothe…
View article: Metformin versus insulin for gestational diabetes: Adiposity variables and adipocytokines in offspring at age of 9 years
Metformin versus insulin for gestational diabetes: Adiposity variables and adipocytokines in offspring at age of 9 years Open
Maternal metformin treatment for GDM had no effects on adiposity, body composition, liver fat, or inflammation markers in prepubertal offspring compared to maternal insulin treatment but was associated with higher adiponectin concentration…
View article: Childhood Dyslipidemia and Carotid Atherosclerotic Plaque in Adulthood: The Cardiovascular Risk in Young Finns Study
Childhood Dyslipidemia and Carotid Atherosclerotic Plaque in Adulthood: The Cardiovascular Risk in Young Finns Study Open
Background Childhood exposure to dyslipidemia is associated with adult atherosclerosis, but it is unclear whether the long‐term risk associated with dyslipidemia is attenuated on its resolution by adulthood. We aimed to address this questi…
View article: Interaction Between Dietary Iron Intake and Genetically Determined Iron Overload: Risk of Islet Autoimmunity and Progression to Type 1 Diabetes in the TEDDY Study
Interaction Between Dietary Iron Intake and Genetically Determined Iron Overload: Risk of Islet Autoimmunity and Progression to Type 1 Diabetes in the TEDDY Study Open
OBJECTIVE To examine whether iron intake and genetically determined iron overload interact in predisposing to the development of childhood islet autoimmunity (IA) and type 1 diabetes (T1D). RESEARCH DESIGN AND METHODS In The Environmental …
View article: Pancreatic Islet Β-Cell Function in Individuals with Multiple Islet Autoantibodies and Effects of Gluten-Free Diet
Pancreatic Islet Β-Cell Function in Individuals with Multiple Islet Autoantibodies and Effects of Gluten-Free Diet Open
View article: Use of antibiotics and risk of type 2 diabetes, overweight and obesity: the Cardiovascular Risk in Young Finns Study and the national FINRISK study
Use of antibiotics and risk of type 2 diabetes, overweight and obesity: the Cardiovascular Risk in Young Finns Study and the national FINRISK study Open
View article: Child type 1 diabetes associated with mother vaginal bacteriome and mycobiome
Child type 1 diabetes associated with mother vaginal bacteriome and mycobiome Open
Mother vaginal microbes contribute to microbiome of vaginally delivered neonates. Child microbiome can be associated with autoimmune diseases, such as type 1 diabetes (T1D). We collected vaginal DNA samples from 25 mothers with a vaginally…
View article: Targeted Exome Sequencing of Genes Involved in Rare CNVs in Early-Onset Severe Obesity
Targeted Exome Sequencing of Genes Involved in Rare CNVs in Early-Onset Severe Obesity Open
Context: Rare copy number variants (CNVs) have been associated with the development of severe obesity. However, the potential disease-causing contribution of individual genes within the region of CNVs is often not known. Objective: Screeni…
View article: Is staff consistency important to parents’ satisfaction in a longitudinal study of children at risk for type 1 diabetes: the TEDDY study
Is staff consistency important to parents’ satisfaction in a longitudinal study of children at risk for type 1 diabetes: the TEDDY study Open
Background Participants’ study satisfaction is important for both compliance with study protocols and retention, but research on parent study satisfaction is rare. This study sought to identify factors associated with parent study satisfac…
View article: Supplementary Material for: Risk Factor Profile in Youth, Genetic Risk and Adulthood Cognitive Function: The Cardiovascular Risk in Young Finns Study
Supplementary Material for: Risk Factor Profile in Youth, Genetic Risk and Adulthood Cognitive Function: The Cardiovascular Risk in Young Finns Study Open
Introduction: The role of risk factor profile in childhood and adolescence on adulthood cognitive function and whether it differs by genetic risk is still obscure. To bring this evidence, we determined cognitive domain specific youth risk …
View article: Dynamic changes in immune gene co-expression networks predict development of type 1 diabetes
Dynamic changes in immune gene co-expression networks predict development of type 1 diabetes Open
View article: Metformin versus insulin therapy for gestational diabetes: Effects on offspring anthropometrics and metabolism at the age of 9 years: A follow‐up study of two open‐label, randomized controlled trials
Metformin versus insulin therapy for gestational diabetes: Effects on offspring anthropometrics and metabolism at the age of 9 years: A follow‐up study of two open‐label, randomized controlled trials Open
Aims To compare anthropometrics, and lipid and glucose metabolism in the 9‐year‐old offspring of mothers treated with metformin or insulin for gestational diabetes mellitus (GDM). Materials and Methods This was a Finnish two‐centre, 9‐year…
View article: Author response for "Metformin versus insulin therapy for gestational diabetes: Effects on offspring anthropometrics and metabolism at the age of 9 years—A follow‐up study of two open‐label, randomised, controlled trials"
Author response for "Metformin versus insulin therapy for gestational diabetes: Effects on offspring anthropometrics and metabolism at the age of 9 years—A follow‐up study of two open‐label, randomised, controlled trials" Open