Palanimuthu Thangaraju Sivakumar
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View article: Efficacy of Transdiagnostic Cognitive-behavioural Intervention in Older Adults with Common Mental Disorders and Its Impact on Sleep and Metabolic Outcomes: A Randomised Controlled Trial Protocol
Efficacy of Transdiagnostic Cognitive-behavioural Intervention in Older Adults with Common Mental Disorders and Its Impact on Sleep and Metabolic Outcomes: A Randomised Controlled Trial Protocol Open
Background: Common mental disorders (CMDs) in older adults contribute to considerable disease burden and are associated with significant multimorbidity. With the increase in population ageing, the concerns related to multimorbidity are lik…
View article: Development and validation of fluorine-18[18F]-NAV4694 for imaging amyloid plaques in AD
Development and validation of fluorine-18[18F]-NAV4694 for imaging amyloid plaques in AD Open
View article: Home-based Transcranial Electrical Stimulation (tES) for the Management of Psychiatric Disorders: A Scoping Review
Home-based Transcranial Electrical Stimulation (tES) for the Management of Psychiatric Disorders: A Scoping Review Open
Background: Transcranial electrical stimulation (tES) is a non-invasive neuromodulation technique increasingly recognized for its therapeutic potential in psychiatric disorders. Recent advances have enabled its administration in home setti…
View article: Personalized Transcranial Direct Current Stimulation for Behavioral and Neurophysiologic Outcomes
Personalized Transcranial Direct Current Stimulation for Behavioral and Neurophysiologic Outcomes Open
Importance Transcranial direct current stimulation (tDCS) is emerging as a home-based intervention for neuropsychiatric conditions and cognitive enhancement. However, its effectiveness is limited by interindividual variability, as fixed-do…
View article: The role of structural and functional parameters in designing pathology-specific tDCS protocols for primary progressive aphasia
The role of structural and functional parameters in designing pathology-specific tDCS protocols for primary progressive aphasia Open
The study identifies the frontal montage as the most suitable for nfvPPA and the ventral montage for svPPA. This study highlights the importance of pathology-specific tDCS montage selection, emphasizing the need for variant-based modulatio…
View article: Identifying target regions for non-invasive brain stimulation of the language network in primary progressive aphasia: A narrative review
Identifying target regions for non-invasive brain stimulation of the language network in primary progressive aphasia: A narrative review Open
Primary progressive aphasia (PPA) is a heterogeneous neurodegenerative condition characterized by loss of language function. The present review discusses that Non-invasive brain stimulation (NIBS) holds the potential to benefit these patie…
View article: Follow-up Study of Treatment Adherence and Mortality in Alzheimer’s Disease
Follow-up Study of Treatment Adherence and Mortality in Alzheimer’s Disease Open
Introduction: Alzheimer’s disease (AD) has a heterogeneous course and there is a dearth of long-term follow-up data on treatment adherence and mortality in AD patients from India. Materials and Methods: A total of 99 AD patients consecutiv…
View article: Efficacy and Safety of Haloperidol in the Prevention and Management of Delirium in Medical Inpatients: An Umbrella Review of Systematic Reviews
Efficacy and Safety of Haloperidol in the Prevention and Management of Delirium in Medical Inpatients: An Umbrella Review of Systematic Reviews Open
Objective: Delirium occurs in up to 31% of general hospital patients in the medical, surgical, or critical care wards. Agitation is common during hyperactive delirium, which poses a risk to themselves, other patients, or staff. Evidence fo…
View article: Caregiver-driven cognitive training program for dementia: a treatment development and feasibility study protocol in Indian population
Caregiver-driven cognitive training program for dementia: a treatment development and feasibility study protocol in Indian population Open
Background: Cognitive training (CT) is an efficacious intervention for promoting experience-dependent neuroplasticity, especially in modifying cognitive decline in neurodegenerative conditions. Despite its immense potential, there exist cl…
View article: A functional MRI and magnetoencephalography study of the cognitive modulatory effect of transcranial direct current stimulation in early Alzheimer’s disease
A functional MRI and magnetoencephalography study of the cognitive modulatory effect of transcranial direct current stimulation in early Alzheimer’s disease Open
Anodal transcranial direct current stimulation(tDCS) is known to improve cognition in patients with mild cognitive impairment (MCI) and Alzheimer’s disease(mild AD). We aimed to examine the brain functional alterations accompanying improve…
View article: Production of Fluorine-18[18f]-Nav4694 on an Fx2n Synthesis Module for Imaging Amyloid Plaques
Production of Fluorine-18[18f]-Nav4694 on an Fx2n Synthesis Module for Imaging Amyloid Plaques Open
View article: Geriatric Mental Health Nursing in India: Need and Scope
Geriatric Mental Health Nursing in India: Need and Scope Open
A BSTRACT India’s aging population is witnessing a surge in geriatric mental health concerns, with conditions like depression and dementia affecting a significant proportion of older adults. Geriatric mental health nursing (GMHN) plays a c…
View article: Challenges in diagnosis and management in elderly presenting with very late-onset psychiatric symptoms and N-methyl-D-aspartate receptor autoimmune encephalitis
Challenges in diagnosis and management in elderly presenting with very late-onset psychiatric symptoms and N-methyl-D-aspartate receptor autoimmune encephalitis Open
N-methyl-D-aspartate receptor (NMDAR) encephalitis presents with psychiatric and neurological symptoms at various stages of the disease course. We present the case of a 70-year-old elderly woman with hypertension, diabetes mellitus, and a …
View article: Caregivers’ experiences, challenges, and needs in caring for people with dementia in India: a scoping review
Caregivers’ experiences, challenges, and needs in caring for people with dementia in India: a scoping review Open
Background As the world’s most populous country, India faces a growing challenge in addressing dementia, in which advancing age remains the strongest risk factor. Approximately 8.8 million Indians over the age of 60 are currently affected …
View article: Does Apolipoprotein E polymorphism play a role in familial Alzheimer’s Dementia
Does Apolipoprotein E polymorphism play a role in familial Alzheimer’s Dementia Open
Background Apo E4 is the best studied genetic risk factor for sporadic Alzheimer’s disease. Apo E2 homozygosity is associated with a lower risk of Alzheimer’s disease. While rare and common variants in genes encoding APP metabolism are str…
View article: Resting‐state functional connectivity correlates of cognitive function in Mild Cognitive Impairment on functional Near Infrared Spectroscopy
Resting‐state functional connectivity correlates of cognitive function in Mild Cognitive Impairment on functional Near Infrared Spectroscopy Open
Background Mild cognitive impairment(MCI) is characterized by an impairment in one or more cognitive domains greater than expected for a person’s age and educational background with preserved functional independence. Functional Near Infra‐…
View article: Training of formal caregivers in geriatric mental health and dementia care: Experiences and challenges from the Indian context
Training of formal caregivers in geriatric mental health and dementia care: Experiences and challenges from the Indian context Open
The population of older adults in India is projected to increase from the current estimate of 150 million to 350 million by the year 2050. The prevalence of older adults with mental health problems including dementia is also increasing rap…
View article: Efficacy of Transcranial Direct Current Stimulation on Cognitive Function in Dementia and Mild Cognitive Impairment Secondary to Neurodegenerative Etiology: A Systematic Review and Meta-Analysis
Efficacy of Transcranial Direct Current Stimulation on Cognitive Function in Dementia and Mild Cognitive Impairment Secondary to Neurodegenerative Etiology: A Systematic Review and Meta-Analysis Open
Background: Dementia is a chronic progressive illness with significant impairment in a person’s functioning ability. The currently available treatment options for dementia are limited in modifying disease progression. Non-invasive brain st…
View article: Cross‐cultural adaption of the computerized assessment of information processing battery (COGNITO) for an Indian longitudinal study on rural elderly
Cross‐cultural adaption of the computerized assessment of information processing battery (COGNITO) for an Indian longitudinal study on rural elderly Open
Introduction Testing cognitive functions in Indians with low literacy and linguistic diversity is challenging. We describe the adaptation process of a comprehensive neurocognitive test battery to suit both literate and illiterate aging rur…
View article: Auditory Event-related Potentials for Word Stimuli in Kannada Language Among Native Kannada Speakers with Dementia
Auditory Event-related Potentials for Word Stimuli in Kannada Language Among Native Kannada Speakers with Dementia Open
Background: The P300 is a positive auditory event-related potential appearing around 300 msec post-oddball stimulus onset. Tone and monosyllabic stimuli have been widely used in P300 research, providing valuable insights into auditory perc…
View article: Potential Utility of Plasma Biomarker Panels in Differential Diagnosis of Alzheimer’s Disease
Potential Utility of Plasma Biomarker Panels in Differential Diagnosis of Alzheimer’s Disease Open
Blood tests are in need, in the clinical diagnosis of Alzheimer’s disease (AD) as minimally invasive and less expensive alternatives to cerebrospinal fluid and neuroimaging methods. On these lines, single molecule array (Simoa) analysis of…
View article: Association between severity of dementia, wandering behavior, and caregiver burden among caregivers of persons living with dementia
Association between severity of dementia, wandering behavior, and caregiver burden among caregivers of persons living with dementia Open
Introduction: In dementia, wandering is a challenging and distressing behavioral problem. The caregiver burden will differ between the group of persons with dementia with or without wandering behavior. Understanding the difference in careg…
View article: Clinical practice guidelines for promoting mental health and well-being of older adults: A special focus on strategies for coping with social isolation and loneliness
Clinical practice guidelines for promoting mental health and well-being of older adults: A special focus on strategies for coping with social isolation and loneliness Open
INTRODUCTION The focus of mental health care is undergoing a paradigm shift over the past few decades, with an emphasis on promoting mental health and well-being apart from the treatment and care of people with mental disorders. Recognitio…
View article: Efficacy of Psychosocial Care Training Programme for the Staff Working in Old Age Homes
Efficacy of Psychosocial Care Training Programme for the Staff Working in Old Age Homes Open
Background: Training the old-age home staff is essential in raising geriatric mental health care standards in India. Inadequate knowledge on ageing and psychosocial interventions is a significant issue in old-age homes. Old-age home staff …
View article: Diagnosis and care challenges in a patient with early onset familial dementia due to Kufs disease
Diagnosis and care challenges in a patient with early onset familial dementia due to Kufs disease Open
Evaluation of early onset dementia comes with a set of unique challenges. The pathway to a specific diagnosis of a rare genetic disorder like adult onset Kufs disease presents additional challenges. Kufs disease is an adult‐onset Neuronal …
View article: Caregivers journey through experiences of people living with dementia and history of wandering behaviour
Caregivers journey through experiences of people living with dementia and history of wandering behaviour Open
Introduction Wandering is one of the major behavioural symptoms of dementia. It leads to the high level of caregiver burden. Understanding the caregivers’ difficulties and management strategies will help the mental health professionals to …
View article: Epidemiological analysis of mental health morbidity in Tamil Nadu
Epidemiological analysis of mental health morbidity in Tamil Nadu Open
Background: Existing psychiatric epidemiological studies from Tamil Nadu with methodological limitations and variations had under-reported the prevalence of mental morbidity. Robust data from a representative population-based epidemiologic…
View article: Promoting Workforce for dementia care in India
Promoting Workforce for dementia care in India Open
The population of older adults in India is increasing rapidly with the recent population estimate in 2022 indicating the population of older adults aged 60 years and above in India as 142 million. The prevalence of dementia in India is est…
View article: Recruitment of caregivers of persons living with dementia for an Online Support Group Programme– Learnings from India
Recruitment of caregivers of persons living with dementia for an Online Support Group Programme– Learnings from India Open
Background Caregivers of persons living with dementia (CGPwD) tend to have limited access to dementia care‐oriented support group and relevant resources. The disparity in the ratio of mental health professionals available and the number of…
View article: Impact of APOE ε4 allele on familial aggregation and cerebrovascular disease in Alzheimer’s Dementia: A cross‐sectional pilot study from India
Impact of APOE ε4 allele on familial aggregation and cerebrovascular disease in Alzheimer’s Dementia: A cross‐sectional pilot study from India Open
Background The ε4 variant of the apolipoprotein E gene (APOE4) is associated with the risk of Alzheimer’s dementia (AD). Previous studies have reported APOE4 status association with familial loading and vascular changes in AD. With a diver…