Explanipedia

Organ Donor Transmission of Rickettsia typhi to Kidney Transplant Recipients, Texas, USA, 2024 Open

Jeffrey C. Jones, Odalys Cabrera, Julian A. Villalba, Rosa Hinojosa, Marissa Taylor , et al. · 2025

Murine typhus, a fleaborne disease caused by the bacterium Rickettsia typhi, is found throughout temperate and tropical regions of the world. Transmission of R. typhi to humans involves several species of fleas, and most infections result …

Transmission of Ehrlichia chaffeensis From an Organ Donor to a Kidney–Pancreas Transplant Recipient Open

Praveen Gundelly, Eric M. Ransom, Zoe A. Stewart, Brianna Ruch, Arksarapuk Jittirat , et al. · 2025

Donor-Derived Ehrlichiosis Caused by Ehrlichia chaffeensis from Living Donor Kidney Transplant Open

Michael Scolarici, Daniel Kuehler, Rebecca Osborn, Alden Doyle, Elizabeth Schiffman , et al. · 2025

Tickborne infections are challenging to diagnose, particularly among solid organ transplant recipients. We report a US case of donor-derived ehrlichiosis from a living kidney donation that highlights how screening for living donors may mis…

Severe Non–Donor-Derived Lymphocytic Choriomeningitis Virus Infection in 2 Solid Organ Transplant Recipients Open

Leanna Sayyad, K. L. Smith, Katrin S. Sadigh, Caitlin M. Cossaboom, Mary J. Choi , et al. · 2025

Background Lymphocytic choriomeningitis virus (LCMV) infection in immunocompromised hosts can result in disseminated disease, meningoencephalitis, and death. Published cases in transplant recipients have been traced to transmission from in…

Bartonella quintana Infection in Kidney Transplant Recipients from Donor Experiencing Homelessness, United States, 2022 Open

Amy Beeson, Shannan N. Rich, Michael E. Russo, Julu Bhatnagar, Rebecca N. Kumar , et al. · 2024

Bartonella quintana infection can cause severe disease that includes clinical manifestations such as endocarditis, chronic bacteremia, and vasoproliferative lesions of the skin and viscera. B. quintana bacteria is transmitted by the human …

Rickettsia parkeri Rickettsiosis in Kidney Transplant Recipient, North Carolina, USA, 2023 Open

Gautam Phadke, Kiran Gajurel, Jennifer Kasten, Marlene DeLeon-Carnes, Carmen Ramos , et al. · 2024

Spotted fever rickettsiosis is rarely observed in solid organ transplant recipients, and all previously reported cases have been associated with tick bite months to years after transplantation. We describe a kidney transplant recipient in …

Animal vaccine strain Brucella abortus infection in a plateletpheresis donor: A case report Open

Meredith G. Parsons, Daniela Hermelin, Andrew Hennenfent, Rebekah Tiller, Pallavi Annambhotla , et al. · 2024

The authors declare no conflicts of interest.

Second Nationwide Tuberculosis Outbreak Caused by Bone Allografts Containing Live Cells — United States, 2023 Open

Jonathan M. Wortham, Maryam B. Haddad, Rebekah J. Stewart, Pallavi Annambhotla, Sridhar V. Basavaraju , et al. · 2024

During July 7-11, 2023, CDC received reports of two patients in different states with a tuberculosis (TB) diagnosis following spinal surgical procedures that used bone allografts containing live cells from the same deceased donor. An outbr…

Posttransfusion Sepsis Attributable to Bacterial Contamination in Platelet Collection Set Manufacturing Facility, United States Open

Ian Kracalik, Alyssa G. Kent, Carlos H. Villa, Paige Gable, Pallavi Annambhotla , et al. · 2023

During May 2018‒December 2022, we reviewed transfusion-transmitted sepsis cases in the United States attributable to polymicrobial contaminated apheresis platelet components, including Acinetobacter calcoaceticus‒baumannii complex or Staph…

Incomplete tissue product tracing during an investigation of a tissue-derived tuberculosis outbreak Open

Kristen E. Marshall, Rebecca J. Free, Thomas D. Filardo, Noah G. Schwartz, Alfonso C. Hernandez‐Romieu , et al. · 2023

Transmission of yellow fever vaccine virus through blood transfusion and organ transplantation in the USA in 2021: report of an investigation Open

Carolyn V. Gould, Rebecca J. Free, Julu Bhatnagar, Raymond Soto, Tricia Royer , et al. · 2023

US Centers for Disease Control and Prevention (CDC), the Biomedical Advanced Research and Development Authority, and the CDC Epidemiology and Laboratory Capacity Cooperative Agreement for Infectious Diseases.

Fatal Invasive Mold Infections after Transplantation of Organs Recovered from Drowned Donors, United States, 2011–2021 Open

Karen Wu, Pallavi Annambhotla, Rebecca J. Free, Jana M. Ritter, Brooke Leitgeb , et al. · 2023

Drowned organ donors can be exposed to environmental molds through the aspiration of water; transplantation of exposed organs can cause invasive mold infections in recipients. We describe 4 rapidly fatal cases of potentially donor-derived …

Investigation of donor‐derived Strongyloides stercoralis infection in multiple solid organ transplant recipients—California, Michigan, Ohio, 2022 Open

AdeSubomi Adeyemo, Susan P. Montgomery, Rebecca J. Chancey, Pallavi Annambhotla, Lilly Barba , et al. · 2023

Background The Centers for Disease Control and Prevention led an investigation to determine if Strongyloides infection in a right kidney recipient was an existing chronic infection, or if the infection was transmitted from an infected orga…

Nationwide tuberculosis outbreak in the USA linked to a bone graft product: an outbreak report Open

Noah G. Schwartz, Alfonso C. Hernandez‐Romieu, Pallavi Annambhotla, Thomas D. Filardo, Sandy Althomsons , et al. · 2022

Risk of Severe Acute Respiratory Syndrome Coronavirus 2 Transmission Through Solid Organ Transplantation and Outcomes of Coronavirus Disease 2019 Among Recent Transplant Recipients Open

Rebecca J. Free, Pallavi Annambhotla, Ricardo M. La Hoz, Lara Danziger‐Isakov, Jefferson M. Jones , et al. · 2022

Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is transmissible through lung transplantation, and outcomes among infected organ recipients may be severe. Transmission risk to extrapulmonary organ recipients and rec…

West Nile Virus Transmission by Solid Organ Transplantation and Considerations for Organ Donor Screening Practices, United States Open

Raymond Soto, Emily G. McDonald, Pallavi Annambhotla, Jason O. Velez, Janeen Laven , et al. · 2021

West Nile virus (WNV) is the most common domestic arbovirus in the United States. During 2018, WNV was transmitted through solid organ transplantation to 2 recipients who had neuroinvasive disease develop. Because of increased illness and …

Notes from the Field:Tuberculosis Outbreak Linked to a Contaminated Bone Graft Product Used in Spinal Surgery — Delaware, March–June 2021 Open

Ruoran Li, Wendy Wilson, Noah G. Schwartz, Alfonso C. Hernandez‐Romieu, Janet Glowicz , et al. · 2021

Unexpected Hepatitis B Virus Infection After Liver Transplantation — United States, 2014–2019 Open

Danae Bixler, Pallavi Annambhotla, Martha P. Montgomery, Tonya Mixon-Hayden, Benjamin A. Kupronis , et al. · 2021

Unexpected donor-derived hepatitis B virus (HBV) infection is defined as a new HBV infection in a recipient of a transplanted organ from a donor who tested negative for total antihepatitis B core antibody (total anti-HBc), hepatitis B surf…

Donor-derived human herpesvirus 8 and development of Kaposi sarcoma among 6 recipients of organs from donors with high-risk sexual and substance use behavior Open

Sheila C. Dollard, Pallavi Annambhotla, Phili Wong, Katherine Meneses, Minal M. Amin , et al. · 2020

Powassan Virus Infection Likely Acquired Through Blood Transfusion Presenting as Encephalitis in a Kidney Transplant Recipient Open

Lindsay Taylor, Taryn Condon, Eric Destrampe, Jennifer A. Brown, Jeanette McGavic , et al. · 2020

A kidney transplant patient without known tick exposure developed encephalitis 3 weeks after transplantation. During the transplant hospitalization, the patient had received a blood transfusion from an asymptomatic donor later discovered t…

Donor‐derived transmission through lung transplantation of carbapenem‐resistant Acinetobacter baumannii producing the OXA‐23 carbapenemase during an ongoing healthcare facility outbreak Open

Ana C. Bardossy, Emily A. Snavely, Elizabeth Nazarian, Pallavi Annambhotla, Sridhar V. Basavaraju , et al. · 2020

We describe a rare instance of donor‐derived OXA‐23‐producing carbapenem‐resistant Acinetobacter baumannii transmission during lung transplantation and the subsequent public health response. This investigation highlights how transplantatio…

Sepsis Attributed to Bacterial Contamination of Platelets Associated with a Potential Common Source — Multiple States, 2018 Open

Sydney Jones, Jefferson M. Jones, Vivian Leung, Allyn K. Nakashima, Kelly F. Oakeson , et al. · 2019

During May-October 2018, four patients from three states experienced sepsis after transfusion of apheresis platelets contaminated with Acinetobacter calcoaceticus-baumannii complex (ACBC) and Staphylococcus saprophyticus; one patient died.…

Quantifying the risk of undetected HIV, hepatitis B virus, or hepatitis C virus infection in Public Health Service increased risk donors Open

Jefferson M. Jones, Brian M. Gurbaxani, Alice Asher, Stephanie L. Sansom, Pallavi Annambhotla , et al. · 2019

Characteristics of deceased solid organ donors and screening results for hepatitis B, C, and human immunodeficiency viruses — United States, 2010–2017 Open

Winston E. Abara, Melissa G. Collier, Anne C. Moorman, Danae Bixler, Jefferson M. Jones , et al. · 2019

Francisella tularensisTransmission by Solid Organ Transplantation, 20171 Open

Christina A. Nelson, Christian Murua, Jefferson M. Jones, Kelli Mohler, Ying Zhang , et al. · 2019

In July 2017, fever and sepsis developed in 3 recipients of solid organs (1 heart and 2 kidneys) from a common donor in the United States; 1 of the kidney recipients died. Tularemia was suspected only after blood cultures from the survivin…

Characteristics of Deceased Solid Organ Donors and Screening Results for Hepatitis B, C, and Human Immunodeficiency Viruses — United States, 2010–2017 Open

Winston E. Abara, Melissa G. Collier, Anne C. Moorman, Danae Bixler, Jefferson M. Jones , et al. · 2019

The ongoing U.S. opioid crisis has resulted in an increase in drug overdose deaths and acute hepatitis C virus (HCV) infections, with young persons (who might be eligible organ donors) most affected.*^,^† In 2013, the P…

Solid Organ Transplant–Transmitted Tuberculosis Linked to a Community Outbreak — California, 2015 Open

Alexander Kay, Pennan M. Barry, Pallavi Annambhotla, Carol L. Greene, Martin Cilnis , et al. · 2017

This report highlights the association of donor-derived tuberculosis with a community outbreak of tuberculosis. This report highlights the association of donor-derived tuberculosis with a community outbreak of tuberculosis. Weekly/August 4…

St. Louis encephalitis virus possibly transmitted through blood transfusion—Arizona, 2015 Open

Heather Venkat, Laura E. Adams, Rebecca Sunenshine, Elisabeth Krow‐Lucal, Craig Levy , et al. · 2017

BACKGROUND St. Louis encephalitis virus is a mosquito‐borne flavivirus that infrequently causes epidemic central nervous system infections. In the United States, blood donors are not screened for St. Louis encephalitis virus infection, and…

Solid Organ Transplant–Transmitted Tuberculosis Linked to a Community Outbreak — California, 2015 Open

Alexander Kay, Pennan M. Barry, Pallavi Annambhotla, Carol L. Greene, Martin Cilnis , et al. · 2017

In the spring of 2015, a local health department (LHD) in county A notified the California Department of Public Health (CDPH) about three adults with close ties to one another and a congregate community site who had received diagnoses of t…

Mycoplasma hominis Infections Transmitted Through Amniotic Tissue Product Open

Shannon Novosad, Sridhar V. Basavaraju, Pallavi Annambhotla, Marika Mohr, Alison Laufer Halpin , et al. · 2017

Mycoplasma hominis was transmitted through amniotic tissue from a single donor to 2 recipients. Current routine donor screening and product testing does not detect all potential pathogens. Clinicians should be aware that M. hominis can cau…

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