D. Palm
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View article: Morphometric analysis of rat hearts (therapy-study).
Morphometric analysis of rat hearts (therapy-study). Open
Morphometric data of rat hearts harvested at the end of the therapy-study were obtained by computer-aided analysis of H&E-stained; mid-ventricular 2 μm cross-sections as previously described in detail [18]. Parameters given are (from top t…
View article: Novel Receptor-Derived Cyclopeptides to Treat Heart Failure Caused by Anti-β1-Adrenoceptor Antibodies in a Human-Analogous Rat Model
Novel Receptor-Derived Cyclopeptides to Treat Heart Failure Caused by Anti-β1-Adrenoceptor Antibodies in a Human-Analogous Rat Model Open
Despite recent therapeutic advances the prognosis of heart failure remains poor. Recent research suggests that heart failure is a heterogeneous syndrome and that many patients have stimulating auto-antibodies directed against the second ex…
View article: Tripeptides of RS1 (RSC1A1) Inhibit a Monosaccharide-dependent Exocytotic Pathway of Na+-d-Glucose Cotransporter SGLT1 with High Affinity
Tripeptides of RS1 (RSC1A1) Inhibit a Monosaccharide-dependent Exocytotic Pathway of Na+-d-Glucose Cotransporter SGLT1 with High Affinity Open
The human gene RSC1A1 codes for a 67-kDa protein named RS1 that mediates transcriptional and post-transcriptional regulation of Na(+)-D-glucose cotransporter SGLT1. The post-transcriptional regulation occurs at the trans-Golgi network (TGN…
View article: Turn-on switch in parathyroid hormone receptor by a two-step parathyroid hormone binding mechanism
Turn-on switch in parathyroid hormone receptor by a two-step parathyroid hormone binding mechanism Open
Parathyroid hormone (PTH) and its related receptor (PTHR) are essential regulators of calcium homeostasis and bone physiology. PTH activates PTHR by interacting with a ligand-binding site localized within the N-terminal extracellular domai…
View article: High molecular weight hyaluronic acid inhibits advanced glycation endproduct‐induced NF‐κB activation and cytokine expression
High molecular weight hyaluronic acid inhibits advanced glycation endproduct‐induced NF‐κB activation and cytokine expression Open
Advanced glycation endproducts (AGEs), which accumulate on long‐lived proteins and protein deposits (amyloids), induce the expression of proinflammatory cytokines through NF‐κB‐dependent pathways. Hyaluronic acid with a molecular weight ab…
View article: 3pK, a Novel Mitogen-Activated Protein (MAP) Kinase-Activated Protein Kinase, Is Targeted by Three MAP Kinase Pathways
3pK, a Novel Mitogen-Activated Protein (MAP) Kinase-Activated Protein Kinase, Is Targeted by Three MAP Kinase Pathways Open
Recently we have identified a mitogen-activated protein kinase (MAPK)-activated protein kinase, named 3pK (G. Sithanandam, F. Latif, U. Smola, R. A. Bernal, F.-M. Duh, H. Li, I. Kuzmin, V. Wixler, L. Geil, S. Shresta, P. A. Lloyd, S. Bader…
View article: Reproducibility and consistency of the responses to supine bicycle ergometry; evaluation in conjunction with beta 1‐adrenoceptor occupancies.
Reproducibility and consistency of the responses to supine bicycle ergometry; evaluation in conjunction with beta 1‐adrenoceptor occupancies. Open
A protocol is presented for supine bicycle ergometry in healthy subjects, which aims for a target increase of heart rate (HR = 140 beats min‐1) after 4 min cycling under constant load. The required load is selected from a pre‐study ergomet…
View article: cAMP- and cGMP-dependent protein kinase phosphorylation sites of the focal adhesion vasodilator-stimulated phosphoprotein (VASP) in vitro and in intact human platelets.
cAMP- and cGMP-dependent protein kinase phosphorylation sites of the focal adhesion vasodilator-stimulated phosphoprotein (VASP) in vitro and in intact human platelets. Open
The vasodilator-stimulated phosphoprotein (VASP) is a major substrate for cAMP-dependent- (cAK) and cGMP-dependent protein kinase (cGK) in human platelets and other cardiovascular cells. To identify the VASP phosphorylation sites, purified…
View article: Author Index
Author Index Open
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View article: Dissecting differential binding in the forward and reverse reaction of Escherichia coli maltodextrin phosphorylase using 2-deoxyglucosyl substrates.
Dissecting differential binding in the forward and reverse reaction of Escherichia coli maltodextrin phosphorylase using 2-deoxyglucosyl substrates. Open
Substrate analogs are used in combination with site-directed mutagenesis to probe specific interactions between substrate and enzyme in the forward and reverse direction of the Escherichia coli maltodextrin phosphorylase reaction. In the p…
View article: Reaction of imidazole‐citrate‐deformed glycogen phosphorylase with amino acids
Reaction of imidazole‐citrate‐deformed glycogen phosphorylase with amino acids Open
Incubation of phosphorylase with l ‐valine in the presence of 0.4 M imidazole citrate results in a time‐dependent decrease in the absorption of the enzyme‐bound cofactor pyridoxal 5′‐phosphate at 333 nm and the generation of a new absorpti…
View article: Two sites in the third inner loop of the dopamine D<sub>2</sub> receptor are involved in functional G protein‐mediated coupling to adenylate cyclase
Two sites in the third inner loop of the dopamine D<sub>2</sub> receptor are involved in functional G protein‐mediated coupling to adenylate cyclase Open
Synthetic peptides, corresponding to the amino acid sequences of the N‐ and C‐terminal parts of the 3rd intracellular loop of the dopamine D 2 receptor, attenuate dopaminergic adenylate cyclase inhibition in membranes. Both peptides also a…
View article: Multisite contacts involved in coupling of the β‐adrenergic receptor with the stimulatory guanine‐nucleotide‐binding regulatory protein
Multisite contacts involved in coupling of the β‐adrenergic receptor with the stimulatory guanine‐nucleotide‐binding regulatory protein Open
Synthetic peptides, 12–22 amino acid residues long, comprising the presumed coupling sites of the β‐adrenergic receptor with the stimulatory guanine‐nucleotide‐binding regulatory protein (G s ), were examined for their ability to modulate …
View article: Monoclonal antibodies against various forms of the adenylyl cyclase catalytic subunit and associated proteins
Monoclonal antibodies against various forms of the adenylyl cyclase catalytic subunit and associated proteins Open
Monoclonal antibodies against partially purified adenylyl cyclase from bovine brain cortex were raised in mice. Three types of antibody were obtained. Type I was specific for the calmodulin‐sensitive enzyme. Type II also recognized this en…
View article: Mapping of β‐adrenoceptor coupling domains to G<sub>s</sub>‐protein by site‐specific synthetic peptides
Mapping of β‐adrenoceptor coupling domains to G<sub>s</sub>‐protein by site‐specific synthetic peptides Open
Peptides corresponding to the known sequence of turkey erythrocyte β 1 ‐adrenergic receptor were synthesized and the effects on receptor‐mediated cyclase activation were measured. Peptides corresponding to the first and second intracellula…
View article: E. coli Maltodextrin Phosphorylase: Primary Structure and Deletion Mapping of the C-Terminal Site
E. coli Maltodextrin Phosphorylase: Primary Structure and Deletion Mapping of the C-Terminal Site Open
The complete 796 residue amino acid sequence of maltodextrin phosphorylase was deduced from the E. coli malP nucleotide sequence. The calculated molecular weight of 90 500, including pyridoxal phosphate, is significantly larger than experi…
View article: Mechanism of the phosphorylase reaction. Utilization of d-gluco-hept-1-enitol in the absence of primer
Mechanism of the phosphorylase reaction. Utilization of d-gluco-hept-1-enitol in the absence of primer Open
alpha-Glucan phosphorylases from rabbit skeletal muscle, potato tubers and Escherichia coli catalyze the utilization of 2,6-anhydro-1-deoxy-D-gluco-hept-1-enitol (heptenitol) in the presence of arsenate or phosphate. 1H-NMR analysis in the…
View article: Untersuchungen zur Reaktion der Alkoholdehydrogenasen mit Tritium-markierten Substraten
Untersuchungen zur Reaktion der Alkoholdehydrogenasen mit Tritium-markierten Substraten Open
[1,1-T]-ethanol,:1,1-T]-propanol and [1,1-T]-butanol exhibit small isotope effects (kH/kT=1.3-1.8) in the liver alcohol dehydrogenase catalyzed reaction NAD® + alcohol ⇌aldehyde +NADH+H®. Presence of semicarbazide (with [1,1-T] -ethanol) o…
View article: Untersuchungen zur Reaktion der Alkoholdehydrogenase mit Tritium-markierten Substraten
Untersuchungen zur Reaktion der Alkoholdehydrogenase mit Tritium-markierten Substraten Open
Unexpectedly, the isotope effect of ethanol-1-Τ as a substrate of yeast alcohol dehydrogenase, increases with rising temperature from k H /k T = 3.2 at 5 —15°C to 3.8—4.7 at 20 —35 °C. This suggests a change of the rate controlling step as…
View article: Untersuchungen zur Reaktion der Alkoholdehydrogenase mit Tritium -markierten Substraten
Untersuchungen zur Reaktion der Alkoholdehydrogenase mit Tritium -markierten Substraten Open
The temperature dependence of the kinetic isotope effect of NADH-T in the acetaldehyde reduction by yeast alcohol dehydrogenase showed a discontinuity which can be explained by a change of the rate controlling step. The magnitude of the is…