Paloma R. Tuttle
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View article: Covalent adduct Grob fragmentation underlies LSD1 demethylase-specific inhibitor mechanism of action and resistance
Covalent adduct Grob fragmentation underlies LSD1 demethylase-specific inhibitor mechanism of action and resistance Open
View article: Jump-Starting Global Grid Decarbonization: US-Dutch Partnerships Energize Utility-Scale Battery Deployment
Jump-Starting Global Grid Decarbonization: US-Dutch Partnerships Energize Utility-Scale Battery Deployment Open
The United States and the Netherlands heavily invest in renewable energy as part of their individual commitments to net zero emissions by 2050. Weather-dependent fluctuations in wind and solar power, along with limitations in legacy infras…
View article: Fluorescent 5-Pyrimidine and 8-Purine Nucleosides Modified with an <i>N</i>-Unsubstituted 1,2,3-Triazol-4-yl Moiety
Fluorescent 5-Pyrimidine and 8-Purine Nucleosides Modified with an <i>N</i>-Unsubstituted 1,2,3-Triazol-4-yl Moiety Open
The Cu(I)- or Ag(I)-catalyzed cycloaddition between 8-ethynyladenine or guanine nucleosides and TMSN3 gave 8-(1- H-1,2,3-triazol-4-yl) nucleosides in good yields. On the other hand, reactions of 5-ethynyluracil or cytosine nucle…
View article: Electron-Mediated Aminyl and Iminyl Radicals from C5 Azido-Modified Pyrimidine Nucleosides Augment Radiation Damage to Cancer Cells
Electron-Mediated Aminyl and Iminyl Radicals from C5 Azido-Modified Pyrimidine Nucleosides Augment Radiation Damage to Cancer Cells Open
Two classes of azido-modified pyrimidine nucleosides were synthesized as potential radiosensitizers; one class is 5-azidomethyl-2'-deoxyuridine (AmdU) and cytidine (AmdC), while the second class is 5-(1-azidovinyl)-2'-deoxyuridine (AvdU) a…