Palwinder Singh
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View article: Small Peptides Targeting BACE-1, AChE, and A-β Reversing Scopolamine-Induced Memory Impairment: A Multitarget Approach against Alzheimer’s Disease
Small Peptides Targeting BACE-1, AChE, and A-β Reversing Scopolamine-Induced Memory Impairment: A Multitarget Approach against Alzheimer’s Disease Open
Based on the biochemical understanding of Alzheimer's disease, here, we report the design, synthesis, and biological screening of a series of compounds against this neuro-disorder. Adopting the multitarget approach, the catalytic processes…
View article: Sensitising natural wool with green and brown coffee using a facile extraction method to optimise dye process parameters
Sensitising natural wool with green and brown coffee using a facile extraction method to optimise dye process parameters Open
Green coffee powder is the raw powder of coffee cherries and all coffee’s potential components are held within this green powder. A new natural colourant was extracted from Green Coffee using water as an extractant. To obtain a green-color…
View article: Targeting aromatase to restrain oestrogen production and developing efficacious interventions against ER-positive cancer
Targeting aromatase to restrain oestrogen production and developing efficacious interventions against ER-positive cancer Open
View article: Structure and ligand based design for identification of highly potent molecules against 5-LOX
Structure and ligand based design for identification of highly potent molecules against 5-LOX Open
View article: Proline based rationally designed peptide esters against dipeptidyl peptidase-4: Highly potent anti-diabetic agents
Proline based rationally designed peptide esters against dipeptidyl peptidase-4: Highly potent anti-diabetic agents Open
View article: Referee report. For: Anti-inflammatory activity and toxicity evaluation of 1,3-bis(p-hydroxyphenyl)urea [version 1; peer review: 1 not approved]
Referee report. For: Anti-inflammatory activity and toxicity evaluation of 1,3-bis(p-hydroxyphenyl)urea [version 1; peer review: 1 not approved] Open
View article: Design, Synthesis, and Activity Evaluation of Stereoconfigured Tartarate Derivatives as Potential Anti-inflammatory Agents <i>In Vitro</i> and <i>In Vivo</i>
Design, Synthesis, and Activity Evaluation of Stereoconfigured Tartarate Derivatives as Potential Anti-inflammatory Agents <i>In Vitro</i> and <i>In Vivo</i> Open
Preclinical and clinical data reveal that inflammation is strongly correlated with the pathogenesis of a number of diseases including those of cancer, Alzheimer, and diabetes. The inflammatory cascade involves a multitude of cytokines endi…
View article: Rationally designed TNF-α inhibitors: Identification of promising cytotoxic agents
Rationally designed TNF-α inhibitors: Identification of promising cytotoxic agents Open
View article: Biological Evaluation of <i>Aegle marmelos</i> Fruit Extract and Isolated Aegeline in Alleviating Pain<b>–</b>Depression Dyad: In Silico Analysis of Aegeline on MAO-A and iNOS
Biological Evaluation of <i>Aegle marmelos</i> Fruit Extract and Isolated Aegeline in Alleviating Pain<b>–</b>Depression Dyad: In Silico Analysis of Aegeline on MAO-A and iNOS Open
[Image: see text] Pain and depression have been assessed to co-occur in up to 80% of patients, and this comorbidity is more debilitating and pricier for the patients as compared to either of these disorders alone. Aegle marmelos is a well-…
View article: Role of water in cyclooxygenase catalysis and design of anti-inflammatory agents targeting two sites of the enzyme
Role of water in cyclooxygenase catalysis and design of anti-inflammatory agents targeting two sites of the enzyme Open
View article: <i>In</i> <i>Silico</i> Studies and <i>In Vivo</i> MAO<sub>A</sub> Inhibitory Activity of Coumarins Isolated from <i>Angelica archangelica</i> Extract: An Approach toward Antidepressant Activity
<i>In</i> <i>Silico</i> Studies and <i>In Vivo</i> MAO<sub>A</sub> Inhibitory Activity of Coumarins Isolated from <i>Angelica archangelica</i> Extract: An Approach toward Antidepressant Activity Open
[Image: see text] The current investigation was aimed at in vivo MAO(A) inhibitory activity of coumarins angelicin, bergapten, and scopoletin isolated from the roots of Angelica archangelica. The isolated compounds were screened for MAO(A)…
View article: Identification of Metabolites using 1H NMR in Polycystic Ovary Syndrome Cases from North India
Identification of Metabolites using 1H NMR in Polycystic Ovary Syndrome Cases from North India Open
Polycystic Ovary Syndrome (PCOS) is a common, heterogenous endocrine disorder in women of reproductive age. Alterations in numerous metabolic pathways have been implicated in its pathophysiology. The systemic changes in PCOS initate not on…
View article: Modification of the lead molecule: Tryptophan and piperidine appended triazines reversing inflammation and hyeperalgesia in rats
Modification of the lead molecule: Tryptophan and piperidine appended triazines reversing inflammation and hyeperalgesia in rats Open
View article: Structural tuning of acridones for developing anticancer agents targeting dihydrofolate reductase
Structural tuning of acridones for developing anticancer agents targeting dihydrofolate reductase Open
View article: Engineered Substrate for Cyclooxygenase-2: A Pentapeptide Isoconformational to Arachidonic Acid for Managing Inflammation
Engineered Substrate for Cyclooxygenase-2: A Pentapeptide Isoconformational to Arachidonic Acid for Managing Inflammation Open
Beyond the conventional mode of working of anti-inflammatory agents through enzyme inhibition, herein, COX-2 was provided with an alternate substrate. A proline-centered pentapeptide isoconformational to arachidonic acid, which exhibited a…
View article: Tailoring the Substitution Pattern on 1,3,5-Triazine for Targeting Cyclooxygenase-2: Discovery and Structure–Activity Relationship of Triazine–4-Aminophenylmorpholin-3-one Hybrids that Reverse Algesia and Inflammation in Swiss Albino Mice
Tailoring the Substitution Pattern on 1,3,5-Triazine for Targeting Cyclooxygenase-2: Discovery and Structure–Activity Relationship of Triazine–4-Aminophenylmorpholin-3-one Hybrids that Reverse Algesia and Inflammation in Swiss Albino Mice Open
Here, we report analgesic and anti-inflammatory activity of a series of compounds obtained by appending 4-aminophenylmorpholin-3-one and acyclic, cyclic, or heterocyclic moieties on 1,3,5-triazine. The structures of compounds 4b and 6b are…
View article: Rationally Designed Circularly Arranged Sextuple Molecule with Dimethoxyphenolic Tentacles for Ample Hunting of Cyanide
Rationally Designed Circularly Arranged Sextuple Molecule with Dimethoxyphenolic Tentacles for Ample Hunting of Cyanide Open
Herein, we report the design, synthesis, and cyanide-scavenging behavior of circularly arranged sextuple molecule 4. The six syringaldehyde units carrying equal number of dimethoxyphenolic moieties projecting at the periphery make the mole…
View article: Synergy of Physico-chemical and Biological Experiments for Developing a Cyclooxygenase-2 Inhibitor
Synergy of Physico-chemical and Biological Experiments for Developing a Cyclooxygenase-2 Inhibitor Open
View article: The relationship between feeding and nutritional status: a prospective and observational study conducted in northern region of India
The relationship between feeding and nutritional status: a prospective and observational study conducted in northern region of India Open
Background: The health of Infants to a great extent depends upon the feeding practices and its awareness among the mothers. This study was conducted in Tertiary care hospital to find the correlation between feeding pattern with nutritional…
View article: Design and Synthesis of Aza-/Oxa Heterocycle-Based Conjugates as Novel Anti-Inflammatory Agents Targeting Cyclooxygenase-2
Design and Synthesis of Aza-/Oxa Heterocycle-Based Conjugates as Novel Anti-Inflammatory Agents Targeting Cyclooxygenase-2 Open
A library of hybrid molecules was procured by the combination of triazine-indole adduct with morpholine/piperidine/pyrrolidine and pyrazole/pyrimidine/oxindole moieties. Enzyme immunoassays on cyclooxygenase-1 (COX-1) and cyclooxygenase-2 …
View article: Utility of Transcutaneous Bilirubinometer in Tertiary Care Hospital
Utility of Transcutaneous Bilirubinometer in Tertiary Care Hospital Open
Introduction: Hyperbilirubinemia is one of the most vexing problems that may occur in 60% of term and 80% of preterm neonates. In order to reduce the risk of developing serious hyperbilirubinemia, it is vital to identify jaundiced infants …
View article: Bacteriological Profile and Antibiogram of Community Acquired Neonatal Sepsis in a Tertiary Care Hospital; A Prospective Study
Bacteriological Profile and Antibiogram of Community Acquired Neonatal Sepsis in a Tertiary Care Hospital; A Prospective Study Open
View article: Changing trends in the clinical and hematological profile of Plasmodium vivax mono infection
Changing trends in the clinical and hematological profile of Plasmodium vivax mono infection Open
Background: Malaria continues to be a major public health problem in South East Asia.Plasmodium vivax is the most widely distributed human malaria parasite with an at-risk population of 2.5 billion persons.With the implementation of molecu…
View article: Incidence, etiological risk factors and outcome of glucose-6 phosphate dehydrogenase deficiency (G6PDD) among neonates presenting with hyperbilirubinemia in tertiary care hospital, Punjab.
Incidence, etiological risk factors and outcome of glucose-6 phosphate dehydrogenase deficiency (G6PDD) among neonates presenting with hyperbilirubinemia in tertiary care hospital, Punjab. Open
Objectives:The aim of this study was to analyse the incidence and outcome of G6PD deficiency(G6PDD) among neonates presenting with hyperbilirubinemia and to evaluate other etiological risk factors associated with hyperbilirubinemia.Methods…
View article: Thyroid profile in multi transfused children of beta Thalassemia major and its correlation with serum ferritin levels
Thyroid profile in multi transfused children of beta Thalassemia major and its correlation with serum ferritin levels Open
Background: Thalassemia major is a hereditary anemia which is caused by defective synthesis of hemoglobin, ineffective erythropoiesis and rapid erythrocyte breakdown.Transfusions in beta thalassemia major are necessary for survival of thes…
View article: Benzoflavones as cholesterol esterase inhibitors: Synthesis, biological evaluation and docking studies
Benzoflavones as cholesterol esterase inhibitors: Synthesis, biological evaluation and docking studies Open
View article: Hybrid molecules: The privileged scaffolds for various pharmaceuticals
Hybrid molecules: The privileged scaffolds for various pharmaceuticals Open
View article: Rational Design of Small Peptides for Optimal Inhibition of Cyclooxygenase-2: Development of a Highly Effective Anti-Inflammatory Agent
Rational Design of Small Peptides for Optimal Inhibition of Cyclooxygenase-2: Development of a Highly Effective Anti-Inflammatory Agent Open
Among the small peptides 2-31, (H)Gly-Gly-Phe-Leu(OMe) (30) reduced prostaglandin production of COX-2 with an IC50 of 60 nM relative to 6000 nM for COX-1. The 5 mg kg(-1) dose of compound 30 rescued albino mice by 80% from capsaicin-induce…
View article: Rational modification of the lead molecule: Enhancement in the anticancer and dihydrofolate reductase inhibitory activity
Rational modification of the lead molecule: Enhancement in the anticancer and dihydrofolate reductase inhibitory activity Open
View article: The Effect of Exclusive Breastfeeding on Hospital Stay and Morbidity due to Various Diseases in Infants under 6 Months of Age: A Prospective Observational Study
The Effect of Exclusive Breastfeeding on Hospital Stay and Morbidity due to Various Diseases in Infants under 6 Months of Age: A Prospective Observational Study Open
Background . Mother’s milk is the best for the babies. Protective and preventive role of breast milk was evaluated in this study by assessing the relation of type of feeding and duration of hospital stay or morbidity. Methods . This prospe…