Pamela Dalton
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View article: Ambient Air Pollution and Smell Function: Evidence from the National Geographic Smell Survey
Ambient Air Pollution and Smell Function: Evidence from the National Geographic Smell Survey Open
Background Olfactory sensory neurons are located outside the brain, allowing them to detect environmental chemicals. However, this comes at the cost of exposure to potential toxins, which may decrease olfactory function. Methods We sought …
View article: Plasmablastic lymphoma presenting as sino-nasal mass in a child: a case report
Plasmablastic lymphoma presenting as sino-nasal mass in a child: a case report Open
Background: Plasmablastic lymphoma (PBL) is a very aggressive non-Hodgkin lymphoma that mostly occurs in immunocompromised individuals, especially those affected with human immunodeficiency virus (HIV) infection, and is rarely reported in …
View article: Towards Universal Chemosensory Testing: Needs, Barriers and Opportunities
Towards Universal Chemosensory Testing: Needs, Barriers and Opportunities Open
Millions of people in the United States experience a reduced or distorted ability to smell or taste. Chemosensory disorders such as anosmia (the inability to smell), parosmia (distorted smell), or dysgeusia (altered taste) have major impac…
View article: Towards universal chemosensory testing: needs, barriers, and opportunities
Towards universal chemosensory testing: needs, barriers, and opportunities Open
Millions of people in the United States experience a reduced or distorted ability to smell or taste. Chemosensory disorders such as anosmia (the inability to smell), parosmia (distorted smell), or dysgeusia (altered taste) have major impac…
View article: Treatment Outcomes in Acute Promyelocytic Leukemia Patients Using a Uniform ATRA + ATO Consolidation Therapy Regimen across All Risk Groups: A Single Centre Study from India
Treatment Outcomes in Acute Promyelocytic Leukemia Patients Using a Uniform ATRA + ATO Consolidation Therapy Regimen across All Risk Groups: A Single Centre Study from India Open
INTRODUCTION Acute Promyelocytic Leukemia (APL) is a particularly aggressive subtype of acute myeloid leukemia associated with high risk of early mortality due to coagulopathy & bleeding. The current standard induction therapy for APL comp…
View article: Real-World Data of Molecular Response Using Different Dosage of Upfront Generic Dasatinib in Chronic Phase Chronic Myeloid Leukemia: Single-Center Experience from India
Real-World Data of Molecular Response Using Different Dosage of Upfront Generic Dasatinib in Chronic Phase Chronic Myeloid Leukemia: Single-Center Experience from India Open
Introduction The 2nd generation tyrosine kinase inhibitor (TKI) agent dasatinib is approved for upfront therapy in newly diagnosed chronic phase chronic myeloid leukemia (CML-CP) patients. The recommended dasatinib dose of 100mg/day is fre…
View article: Integrating the Patient’s Voice into the Research Agenda for Treatment of Chemosensory Disorders
Integrating the Patient’s Voice into the Research Agenda for Treatment of Chemosensory Disorders Open
World-wide some 658 million people were infected with COVID-19 and millions suffer from chemosensory impairment associated with long COVID. Current treatments for taste and smell disorders are limited. Involving patients has the potential …
View article: Topical platelet‐rich plasma as a possible treatment for olfactory dysfunction—A randomized controlled trial
Topical platelet‐rich plasma as a possible treatment for olfactory dysfunction—A randomized controlled trial Open
Background Olfactory dysfunction (OD) affects many survivors of COVID‐19. Prior studies have investigated the use of platelet‐rich plasma (PRP) injections for OD. We describe the first randomized controlled trial investigating topical PRP …
View article: Remote olfactory assessment using the NIH Toolbox Odor Identification test and the brain health registry
Remote olfactory assessment using the NIH Toolbox Odor Identification test and the brain health registry Open
Background Early identification of deficits in our ability to perceive odors is important as many normal (i.e., aging) and pathological (i.e., sinusitis, viral, neurodegeneration) processes can result in diminished olfactory function. To r…
View article: Using SCENTinel® to predict SARS-CoV-2 infection: insights from a community sample during dominance of Delta and Omicron variants
Using SCENTinel® to predict SARS-CoV-2 infection: insights from a community sample during dominance of Delta and Omicron variants Open
Introduction Based on a large body of previous research suggesting that smell loss was a predictor of COVID-19, we investigated the ability of SCENTinel®, a newly validated rapid olfactory test that assesses odor detection, intensity, and …
View article: Patient Insights into the Diagnosis of Smell and Taste Disorders in the United States
Patient Insights into the Diagnosis of Smell and Taste Disorders in the United States Open
OBJECTIVES Diagnosis of smell/taste dysfunction is necessary for appropriate medical care. This study examines factors affecting testing and diagnosis of smell/taste disorders. METHODS The online USA Smell and Taste Patient Survey was made…
View article: Exploring Olfactory Dysfunction as a Marker of Frailty and Postoperative Outcomes in Head and Neck Cancer
Exploring Olfactory Dysfunction as a Marker of Frailty and Postoperative Outcomes in Head and Neck Cancer Open
Importance Olfactory dysfunction (OD) is increasingly recognized as a robust marker of frailty and mortality. Despite broad recognition of frailty as a critical component of head and neck cancer (HNC) care, there is no standardized frailty…
View article: More spice, less salt: how capsaicin affects liking for and perceived saltiness of foods in people with smell loss
More spice, less salt: how capsaicin affects liking for and perceived saltiness of foods in people with smell loss Open
People who lose their sense of smell self-report consuming more salt to compensate for a lack of flavor and enhance eating enjoyment. However, this can contribute to excess sodium intake and a poor diet. Capsaicin may help increase salt ta…
View article: Low to moderate genetic influences on the rapid smell test SCENTinel™
Low to moderate genetic influences on the rapid smell test SCENTinel™ Open
SCENTinel ™ - a rapid, inexpensive smell test that measures odor detection, intensity, identification, and pleasantness - was developed for population-wide screening of smell function. SCENTinel ™ was previously found to screen for multipl…
View article: Characterization of Ethyl Butyrate–Induced Cough Before and After Breath Control Techniques in Healthy Adults
Characterization of Ethyl Butyrate–Induced Cough Before and After Breath Control Techniques in Healthy Adults Open
Purpose: Methods for cough elicitation frequently involve aerosolized tussive agents. Here, we sought to determine whether healthy individuals demonstrate a quantifiable cough response after inhaling a volatile ester and if breath control …
View article: Environmental chamber studies of eye and respiratory irritation from use of a peracetic acid–based hospital surface disinfectant
Environmental chamber studies of eye and respiratory irritation from use of a peracetic acid–based hospital surface disinfectant Open
Objective: To characterize personal exposures and measures of eye and respiratory tract irritation in controlled environmental chamber studies of 44 healthy adult volunteers simulating upper-bound use of peracetic acid (PAA)–based surface …
View article: Proof-of-concept: SCENTinel 1.1 rapidly discriminates COVID-19-related olfactory disorders
Proof-of-concept: SCENTinel 1.1 rapidly discriminates COVID-19-related olfactory disorders Open
It is estimated that 20%–67% of those with COVID-19 develop olfactory disorders, depending on the SARS-CoV-2 variant. However, there is an absence of quick, population-wide olfactory tests to screen for olfactory disorders. The purpose of …
View article: Proof-of-concept: SCENTinel 1.1 rapidly discriminates COVID-19 related olfactory disorders
Proof-of-concept: SCENTinel 1.1 rapidly discriminates COVID-19 related olfactory disorders Open
It is estimated that 20-67% of those with COVID-19 develop olfactory disorders, depending on the SARS-CoV-2 variant. However, there is an absence of quick, population-wide olfactory tests to screen for olfactory disorders. The purpose of t…
View article: NCS Assessments of the Motor, Sensory, and Physical Health Domains
NCS Assessments of the Motor, Sensory, and Physical Health Domains Open
As part of the National Children's Study (NCS) comprehensive and longitudinal assessment of the health status of the whole child, scientific teams were convened to recommend assessment measures for the NCS. This manuscript documents the wo…
View article: Odorization of Natural Gas: What are the Challenges?
Odorization of Natural Gas: What are the Challenges? Open
Modern natural gas (NG) has little or no odor, so other compounds, usually mercaptans and thiols, are added as warning odorants. Federal regulations state that NG must be odorized so that it is readily detectable by people with normal sens…
View article: E-Cigarettes and Cardiopulmonary Health
E-Cigarettes and Cardiopulmonary Health Open
E-cigarettes have surged in popularity over the last few years, particularly among youth and young adults. These battery-powered devices aerosolize e-liquids, comprised of propylene glycol and vegetable glycerin, typically with nicotine, f…
View article: Perception of Racial Discrimination in the Workplace and Its Impact on Job Satisfaction and Job Security
Perception of Racial Discrimination in the Workplace and Its Impact on Job Satisfaction and Job Security Open
The purpose of this study is to determine if the perception of racial discrimination in the workplace (discrimination and everyday discrimination) impacts job satisfaction and job security among adults. The participants in this study were …
View article: <i>SCENTinel 1.0</i> : Development of a Rapid Test to Screen for Smell Loss
<i>SCENTinel 1.0</i> : Development of a Rapid Test to Screen for Smell Loss Open
Commercially available smell tests are primarily used in research or in-depth clinical evaluations and are too costly and time-consuming for population surveillance in health emergencies like COVID-19. To address this need, we developed th…
View article: Remote olfactory assessment using the NIH Toolbox Odor Identification Test and the Brain Health Registry
Remote olfactory assessment using the NIH Toolbox Odor Identification Test and the Brain Health Registry Open
Objective: Early identification of deficits in our ability to perceive odors is important as many normal (i.e., aging) and pathological (i.e., sinusitis, viral, neurodegeneration) processes can result in diminished olfactory function. Howe…