Jingye Pan
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View article: Impact of transcutaneous electrical acupoint stimulation on postoperative recovery in older adults following pterygium excision: a prospective randomized controlled trial
Impact of transcutaneous electrical acupoint stimulation on postoperative recovery in older adults following pterygium excision: a prospective randomized controlled trial Open
Objective The aim of this study is to evaluate the effect of transcutaneous electrical acupoint stimulation (TEAS) during the perioperative period on the quality of postoperative recovery among patients undergoing pterygium excision. Metho…
View article: Deep Learning in Digital Breast Tomosynthesis: Current Status, Challenges, and Future Trends
Deep Learning in Digital Breast Tomosynthesis: Current Status, Challenges, and Future Trends Open
The high‐resolution three‐dimensional (3D) images generated with digital breast tomosynthesis (DBT) in the screening of breast cancer offer new possibilities for early disease diagnosis. Early detection is especially important as the incid…
View article: Embedding narrative medicine in primary healthcare: Exploration and practice from a medical humanities perspective
Embedding narrative medicine in primary healthcare: Exploration and practice from a medical humanities perspective Open
This study examines the integration of narrative medicine (NM) into primary healthcare (PHC) settings, evaluating its role in enhancing medical humanities education within grassroots healthcare institutions. Through a comprehensive literat…
View article: Carbon Nanotube Reinforced Carbonized Cellulose Aerogels for Enhanced Hemostasis and Accelerated Skin Wound Healing
Carbon Nanotube Reinforced Carbonized Cellulose Aerogels for Enhanced Hemostasis and Accelerated Skin Wound Healing Open
Trauma from car accidents and other causes can result in severe bleeding and significant skin defects. Current biomaterials still face challenges in achieving rapid hemostasis to stabilize life‐threatening conditions and subsequently promo…
View article: Multifunctional Co‐Delivery Systems with Downregulation of the Novel Target PIM1 in Macrophages to Ameliorate TF‐Mediated Coagulopathy in Sepsis
Multifunctional Co‐Delivery Systems with Downregulation of the Novel Target PIM1 in Macrophages to Ameliorate TF‐Mediated Coagulopathy in Sepsis Open
Disordered coagulation is an independent risk factor for mortality in patients with sepsis and currently lacks effective therapeutic strategies. In this study, PIM1, a novel target predominantly expressed in macrophages during sepsis, is i…
View article: Inhibition of LOX-1 ameliorates coagulation and inflammation in sepsis by suppressing the JAK2/STAT3 pathway
Inhibition of LOX-1 ameliorates coagulation and inflammation in sepsis by suppressing the JAK2/STAT3 pathway Open
Lectin-like oxidised low-density lipoprotein receptor-1 (LOX-1) is a transmembrane protein that belongs to the C-type lectin family and plays a significant role in various diseases by promoting the release of inflammatory mediators and enh…
View article: Triglyceride-glucose index is associated with all-cause mortality in critically ill patients with alcohol use disorder: a retrospective cohort study
Triglyceride-glucose index is associated with all-cause mortality in critically ill patients with alcohol use disorder: a retrospective cohort study Open
BACKGROUND: The relationship between Triglyceride-glucose (TyG) index and clinical outcomes in patients with alcohol use disorder (AUD) is unclear. The aim of this study was to evaluate the association between TyG index and all-cause morta…
View article: Decoding the mechanism of Qingjie formula in the prevention of COVID-19 based on network pharmacology and molecular docking
Decoding the mechanism of Qingjie formula in the prevention of COVID-19 based on network pharmacology and molecular docking Open
Traditional Chinese medicine (TCM) has played a positive role in preventing and controlling the coronavirus disease 2019 (COVID-19) epidemic. Qingjie formula (QJF) developed to prevent COVID-19 is widely used in Wenzhou, Zhejiang province,…
View article: Identification of a novel intronic variant in COL4A2 gene associated with fetal severe cerebral encephalomalacia and subdural hemorrhage
Identification of a novel intronic variant in COL4A2 gene associated with fetal severe cerebral encephalomalacia and subdural hemorrhage Open
Our study demonstrated that c.549 + 5G > A in COL4A2 gene is a disease-causing variant by aberrant splicing. This finding enriches the variant spectrum of COL4A2 gene, which not only improves the understanding of the fetal neurological dis…
View article: Exploring the mechanism of Pim-1 upregulation of tissue factor to initiate hypercoagulable state in sepsis
Exploring the mechanism of Pim-1 upregulation of tissue factor to initiate hypercoagulable state in sepsis Open
Background During sepsis-induced coagulopathy (SIC), the balance of coagulation, anticoagulation, and fibrinolysis is disrupted, and endothelial dysfunction plays a key role in the disease progression. Current studies have indicated that t…
View article: The spectrum of factor XI deficiency in Southeast China: four recurrent variants can explain most of the deficiencies
The spectrum of factor XI deficiency in Southeast China: four recurrent variants can explain most of the deficiencies Open
Background Factor XI (FXI) deficiency is an autosomal hemorrhagic disorder characterized by reduced plasma FXI levels. Multiple ancestral variants in the F11 gene have been identified in Ashkenazi Jews and other selected European populatio…
View article: Glucocorticoid therapy for sepsis in the AI era: a survey on current and future approaches
Glucocorticoid therapy for sepsis in the AI era: a survey on current and future approaches Open
Sepsis, a life-threatening medical condition, manifests as new or worsening organ failures due to a dysregulated host response to infection. Many patients with sepsis have manifested a hyperinflammatory phenotype leading to the identificat…
View article: Prognostic value of poly-microorganisms detected by droplet digital PCR and pathogen load kinetics in sepsis patients: a multi-center prospective cohort study
Prognostic value of poly-microorganisms detected by droplet digital PCR and pathogen load kinetics in sepsis patients: a multi-center prospective cohort study Open
This study aimed to investigate the prognostic value of a novel droplet digital polymerase chain reaction (DDPCR) assay in sepsis patients. In this prospective cohort study, univariable and multivariable Cox regressions were used to assess…
View article: Carbonized Cellulose Aerogel Derived from Waste Pomelo Peel for Rapid Hemostasis of Trauma‐Induced Bleeding
Carbonized Cellulose Aerogel Derived from Waste Pomelo Peel for Rapid Hemostasis of Trauma‐Induced Bleeding Open
Uncontrollable massive bleeding caused by trauma will cause the patient to lose a large amount of blood and drop body temperature quickly, resulting in hemorrhagic shock. This study aims to develop a hemostatic product for hemorrhage manag…
View article: DEVELOPMENT AND INTERNAL-EXTERNAL VALIDATION OF THE ACCI-SOFA MODEL FOR PREDICTING IN-HOSPITAL MORTALITY OF PATIENTS WITH SEPSIS-3 IN THE ICU: A MULTICENTER RETROSPECTIVE COHORT STUDY
DEVELOPMENT AND INTERNAL-EXTERNAL VALIDATION OF THE ACCI-SOFA MODEL FOR PREDICTING IN-HOSPITAL MORTALITY OF PATIENTS WITH SEPSIS-3 IN THE ICU: A MULTICENTER RETROSPECTIVE COHORT STUDY Open
Objective: To achieve a better prediction of in-hospital mortality, the Sequential Organ Failure Assessment (SOFA) score needs to be adjusted and combined with comorbidities. This study aims to enhance the prediction of SOFA score for in-h…
View article: FIB‐4 index is associated with mortality in critically ill patients with alcohol use disorder: Analysis from the MIMIC‐IV database
FIB‐4 index is associated with mortality in critically ill patients with alcohol use disorder: Analysis from the MIMIC‐IV database Open
Background The relationship between fibrosis‐4 (FIB‐4) index and all‐cause mortality in critically ill patients with alcohol use disorder (AUD) is unclear. The present study aimed to investigate the predictive ability of FIB‐4 for all‐caus…
View article: Fabp5 is a common gene between a high-cholesterol diet and acute pancreatitis
Fabp5 is a common gene between a high-cholesterol diet and acute pancreatitis Open
Background and aims Hypercholesterolemia has been identified as risk factor for severe acute pancreatitis (AP). We aimed to identify the common differentially expressed genes (DEGs) between a high-cholesterol diet and AP. Methods We retriv…
View article: Assessing the impact of transfusion thresholds in patients with septic acute kidney injury: a retrospective study
Assessing the impact of transfusion thresholds in patients with septic acute kidney injury: a retrospective study Open
Background Sepsis is a severe condition that often leads to complications such as acute kidney injury, which significantly increases morbidity and mortality rates. Septic AKI (S-AKI) is common in ICU patients and is associated with poor ou…
View article: Smart Enzyme‐Like Polyphenol‐Copper Spray for Enhanced Bacteria‐Infected Diabetic Wound Healing
Smart Enzyme‐Like Polyphenol‐Copper Spray for Enhanced Bacteria‐Infected Diabetic Wound Healing Open
Developing functional medical materials is urgent to treat diabetic wounds with a high risk of bacterial infections, high glucose levels and oxidative stress. Here, a smart copper‐based nanocomposite acidic spray has been specifically desi…
View article: Prevotella histicola activates the Wnt/beta-catenin signaling pathway through the gut–bone axis and promotes osteoblastic differentiation of mesenchymal stem cells to alleviate estrogen-deficient osteoporosis
Prevotella histicola activates the Wnt/beta-catenin signaling pathway through the gut–bone axis and promotes osteoblastic differentiation of mesenchymal stem cells to alleviate estrogen-deficient osteoporosis Open
Postmenopausal osteoporosis (PMO) is characterized by dysregulated bone metabolism owing to estrogen insufficiency. Our previous clinical study revealed that postmenopausal women afflicted with osteoporosis exhibited notably diminished lev…
View article: Association between triglyceride-glucose index and in-hospital mortality in critically ill patients with sepsis: analysis of the MIMIC-IV database
Association between triglyceride-glucose index and in-hospital mortality in critically ill patients with sepsis: analysis of the MIMIC-IV database Open
Background This study aimed to explore the association between the triglyceride-glucose (TyG) index and the risk of in-hospital mortality in critically ill patients with sepsis. Methods This was a retrospective observational cohort study a…
View article: Revolutionizing Infection Risk Scoring: An Ensemble “From Weak to Strong” Deduction Strategy and Enhanced Point‐of‐Care Testing Tools
Revolutionizing Infection Risk Scoring: An Ensemble “From Weak to Strong” Deduction Strategy and Enhanced Point‐of‐Care Testing Tools Open
The COVID‐19 pandemic exacerbates challenges faced by human immunodeficiency virus patients, who are at heightened risk for infection due to compromised immune systems. This study aims to develop a reliable, home‐based point‐of‐care testin…