Explanipedia

2-Cyclopropanecarboxamido- 6-carboxamide substituted benzothiazoles: Synthesis, in vitro and in vivo evaluation of their antiproliferative and anti-tumorigenic activity Open

Yakinthi Batsi, Γεωργία Αντωνοπούλου, Constantinos Galatis-Vaxovanos, Maria Goulielmaki, Kassandra Koumaki , et al. · 2025

To expand our structure-activity relationship studies exploiting substituted benzothiazoles as potential antiproliferative and antitumor agents, we developed a new class of benzothiazole derivatives by coupling of 2-(cyclopropanecarboxamid…

In vitro fermentation of whole matrix, digested products and β-glucan enriched extract of Pleurotus eryngii mushrooms distinctively impact the fecal microbiota of healthy older adults Open

Evangelia N. Kerezoudi, Marigoula Vlassopoulou, Evdokia K. Mitsou, Georgia Saxami, Georgios Koutrotsios , et al. · 2025

Pleurotus eryngii (PE), an edible mushroom rich in bioactive compounds, has been shown to exert immunomodulatory, anti-inflammatory, antioxidant, anti-carcinogenic, anti-microbial, antihepatotoxic and hypolipidemic activities, all importan…

2-Cyclopropanecarboxamido- 6-Carboxamide Substituted Benzothiazoles: Synthesis, in Vitro and in Vivo Evaluation of Their Antiproliferative and Anti-Tumorigenic Activity Open

Yakinthi Batsi, Γεωργία Αντωνοπούλου, Constantinos Galatis-Vaxovanos, Maria Goulielmaki, Kassandra Koumaki , et al. · 2025

Supporting the working life exposome: Annotating occupational exposure for enhanced literature search Open

Paul Thompson, Sophia Ananiadou, Ioannis Basinas, Bendik C. Brinchmann, Christine Cramer , et al. · 2024

An individual’s likelihood of developing non-communicable diseases is often influenced by the types, intensities and duration of exposures at work. Job exposure matrices provide exposure estimates associated with different occupations. How…

Innovative Biomarkers for Obesity and Type 1 Diabetes Based on Bifidobacterium and Metabolomic Profiling Open

Angelica Nobili, Marco Pane, М. И. Скворцова, Meryam Ben Salem, Stephan Morgenthaler , et al. · 2024

The role of Bifidobacterium species and microbial metabolites such as short-chain fatty acids (SCFAs) and human milk oligosaccharides in controlling intestinal inflammation and the pathogenesis of obesity and type 1 diabetes (T1D) has been…

A Computational Approach for the Discovery of Novel DNA Methyltransferase Inhibitors Open

Eftichia Kritsi, Paris Christodoulou, Thalia Tsiaka, Panagiotis Georgiadis, María Zervoú · 2024

Nowadays, the explosion of knowledge in the field of epigenetics has revealed new pathways toward the treatment of multifactorial diseases, rendering the key players of the epigenetic machinery the focus of today’s pharmaceutical landscape…

Design and Synthesis of Novel 2‐Acetamido, 6‐Carboxamide Substituted Benzothiazoles as Potential BRAFV600E Inhibitors – <i>In vitro</i> Evaluation of their Antiproliferative Activity Open

Yakinthi Batsi, Γεωργία Αντωνοπούλου, Theano Fotopoulou, Kassandra Koumaki, Eftichia Kritsi , et al. · 2023

The oncogenic BRAFV600E kinase leads to abnormal activation of the MAPK signaling pathway and thus, uncontrolled cellular proliferation and cancer development. Based on our previous virtual screening studies which issued 2‐acetamido‐1,3 be…

Correction: Boulaka et al. Genoprotective Properties and Metabolites of β-Glucan-Rich Edible Mushrooms Following Their In Vitro Fermentation by Human Faecal Microbiota. Molecules 2020, 25, 3554 Open

Athina Boulaka, Paris Christodoulou, Marigoula Vlassopoulou, Georgios Koutrotsios, Georgios Bekiaris , et al. · 2023

The authors wish to add the following information to the Authors and Affiliation section of our paper published in Molecules [...]

In Vitro Fermentation of Pleurotus eryngii Mushrooms by Human Fecal Microbiota: Metataxonomic Analysis and Metabolomic Profiling of Fermentation Products Open

Paris Christodoulou, Marigoula Vlassopoulou, María Zervoú, Evangelos Xanthakos, Panagiotis Moulos , et al. · 2023

Edible mushrooms contain biologically active compounds with antioxidant, antimicrobial, immunomodulatory and anticancer properties. The link between their anticancer and immunomodulatory properties with their possible prebiotic activity on…

Genoprotective activity of the Pleurotus eryngii mushrooms following their in vitro and in vivo fermentation by fecal microbiota Open

Athina Boulaka, Panagiota Mantellou, Gabriela-Monica Stanc, Efthymia Souka, Christoς Valavanis , et al. · 2022

Pleurotus eryngii mushrooms are commercially cultivated and widely consumed due to their organoleptic properties, and the low caloric and high nutritional value. In addition, they contain various biologically active and health-promoting co…

Immunomodulating Activity of Pleurotus eryngii Mushrooms Following Their In Vitro Fermentation by Human Fecal Microbiota Open

Marigoula Vlassopoulou, Nikolaos Paschalidis, Alexandros L. Savvides, Georgia Saxami, Evdokia K. Mitsou , et al. · 2022

Recent studies have revealed the crucial role of several edible mushrooms and fungal compounds, mainly polysaccharides, in human health and disease. The investigation of the immunomodulating effects of mushroom polysaccharides, especially …

Replacement of Nitrite in Meat Products by Natural Bioactive Compounds Results in Reduced Exposure to N‐Nitroso Compounds: The PHYTOME Project Open

Simone G. van Breda, Karen Mathijs, Harm‐Jan Pieters, Virág Sági‐Kiss, Gunter Kuhnle , et al. · 2021

Scope It has been proposed that endogenously form N‐nitroso compounds (NOCs) are partly responsible for the link between red meat consumption and colorectal cancer (CRC) risk. As nitrite has been indicated as critical factor in the formati…

A Non-Invasive Photonics-Based Device for Monitoring of Diabetic Foot Ulcers: Architectural/Sensorial Components & Technical Specifications Open

Anastasios Doulamis, Nikolaos Doulamis, Aikaterini Angeli, Andreas Lazaris, Siri Luthman , et al. · 2021

This paper proposes a new photonic-based non-invasive device for managing of Diabetic Foot Ulcers (DFUs) for people suffering from diabetes. DFUs are one of the main severe complications of diabetes, which may lead to major disabilities, s…

Effects of processed meat and drinking water nitrate on oral and fecal microbial populations in a controlled feeding study Open

Rashmi Sinha, Ni Zhao, James J. Goedert, Doratha A. Byrd, Yunhu Wan , et al. · 2021

Genoprotective Properties and Metabolites of β-Glucan-Rich Edible Mushrooms Following Their In Vitro Fermentation by Human Faecal Microbiota Open

Athina Boulaka, Paris Christodoulou, Marigoula Vlassopoulou, Georgios Koutrotsios, Georgios Bekiaris , et al. · 2020

A variety of bioactive compounds, constituents of edible mushrooms, in particular β-glucans, i.e., a group of β-d-glucose polysaccharides abundant in the fungal cell walls, have been linked to immunomodulating, anticancer and prebiotic act…

A Multi-omics Approach to Investigate the Inflammatory Response to Life Course Socioeconomic Position Open

Raphaële Castagné, Michelle Kelly‐Irving, Vittorio Krogh, Domenico Palli, Salvatore Panico , et al. · 2020

Aim: Inflammation represents a potential pathway through which socioeconomic position (SEP) is biologically embedded. Materials & methods: We analyzed inflammatory biomarkers in response to life course SEP by integrating mult…

An intrinsic role of IL-33 in Treg cell–mediated tumor immunoevasion Open

Aikaterini Hatzioannou, Aggelos Banos, Theodore Sakelaropoulos, Constantinos Fedonidis, Maria-Sophia Vidali , et al. · 2019

DNA methylation profiling implicates exposure to PCBs in the pathogenesis of B-cell chronic lymphocytic leukemia Open

Panagiotis Georgiadis, Marios Gavriil, Panu Rantakokko, Efthymios Ladoukakis, Maria Botsivali , et al. · 2019

Identification of Sex-Specific Transcriptome Responses to Polychlorinated Biphenyls (PCBs) Open

Almudena Espín-Pérez, Dennie G.A.J. Hebels, Hannu Kiviranta, Panu Rantakokko, Panagiotis Georgiadis , et al. · 2019

WaterSpy: A High Sensitivity, Portable Photonic Device for Pervasive Water Quality Analysis Open

Nikolaos Doulamis, Athanasios Voulodimos, Anastasios Doulamis, Matthaios Bimpas, Aikaterini Angeli , et al. · 2018

In this paper, we present WaterSpy, a project developing an innovative, compact, cost-effective photonic device for pervasive water quality sensing, operating in the mid-IR spectral range. The approach combines the use of advanced Quantum …

Association between low-grade inflammation and Breast cancer and B-cell Myeloma and Non-Hodgkin Lymphoma: findings from two prospective cohorts Open

Éloïse Berger, Cyrille Delpierre, Fatemeh Saberi Hosnijeh, Michelle Kelly‐Irving, Lützen Portengen , et al. · 2018

Epigenome-wide association study of adiposity and future risk of obesity-related diseases Open

Gianluca Campanella, Marc J. Gunter, Silvia Polidoro, Vittorio Krogh, Domenico Palli , et al. · 2018

Pre‐diagnostic blood immune markers, incidence and progression of B‐cell lymphoma and multiple myeloma: Univariate and functionally informed multivariate analyses Open

Roel Vermeulen, Fatemeh Saberi Hosnijeh, Barbara Bodinier, Lützen Portengen, Benoît Liquet , et al. · 2018

Recent prospective studies have shown that dysregulation of the immune system may precede the development of B‐cell lymphomas (BCL) in immunocompetent individuals. However, to date, the studies were restricted to a few immune markers, whic…

Social adversity and epigenetic aging: a multi-cohort study on socioeconomic differences in peripheral blood DNA methylation Open

Giovanni Fiorito, Silvia Polidoro, Pierre‐Antoine Dugué, Mika Kivimäki, Erica Ponzi , et al. · 2017

Evolving DNA methylation and gene expression markers of B-cell chronic lymphocytic leukemia are present in pre-diagnostic blood samples more than 10 years prior to diagnosis Open

Panagiotis Georgiadis, Irene Liampa, Dennie G.A.J. Hebels, Julian Krauskopf, Aristotelis Chatziioannou , et al. · 2017

DNA methylation and exposure to ambient air pollution in two prospective cohorts Open

Michelle Plusquin, Florence Guida, Silvia Polidoro, Roel Vermeulen, Ole Raaschou‐Nielsen , et al. · 2017

Tea and coffee consumption in relation to DNA methylation in four European cohorts Open

Weronica E. Ek, Elmar W. Tobi, Muhammad Ahsan, Erik Lampa, Erica Ponzi , et al. · 2017

Lifestyle factors, such as food choices and exposure to chemicals, can alter DNA methylation and lead to changes in gene activity. Two such exposures with pharmacologically active components are coffee and tea consumption. Both coffee and …

Blood-based omic profiling supports female susceptibility to tobacco smoke-induced cardiovascular diseases Open

Aristotelis Chatziioannou, Panagiotis Georgiadis, Dennie G.A.J. Hebels, Irene Liampa, Ioannis Valavanis , et al. · 2017

Associations Between Genome-wide Gene Expression and Ambient Nitrogen Oxides Open

Nahid Mostafavi, Jelle Vlaanderen, Lützen Portengen, Marc Chadeau‐Hyam, Lars Modig , et al. · 2017

This study provides evidence of subtle changes in gene expression related to exposure to long-term NOx. On a global level, the observed changes in the transcriptome may indicate similarities between air pollution and tobacco induced change…

Additional file 2: Table S1. of Evolving DNA methylation and gene expression markers of B-cell chronic lymphocytic leukemia are present in pre-diagnostic blood samples more than 10 years prior to diagnosis Open

Panagiotis Georgiadis, Irene Liampa, Dennie G.A.J. Hebels, Julian Krauskopf, Aristotelis Chatziioannou , et al. · 2017

Relative risk and TtD of case sub-groups with different B-cell fraction. Table S2. Numbers of differential signals observed in different subject groups. Table S3. Top 100 DM CpGs. Table S4. Genes and CGI’s with at least three DM CpG sites …

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