Pandian Sokkar
YOU?
Author Swipe
View article: The effect of double (S238F/W159H) mutations on the structure and dynamics of PET degrading enzyme
The effect of double (S238F/W159H) mutations on the structure and dynamics of PET degrading enzyme Open
Polyethylene terephthalate (PET) is one of the highly produced synthetic polymers worldwide and had acquired attention due to its impact resistance, high clarity, and light weight. PET has become the first choice in making disposable bottl…
View article: Effect of Substituents on the Photodynamic Action of Anthraquinones: EPR, Computational and <i>In Vitro</i> Studies
Effect of Substituents on the Photodynamic Action of Anthraquinones: EPR, Computational and <i>In Vitro</i> Studies Open
Anthraquinone class of compounds possesses a broad spectrum of therapeutic applications. Cancer cell targeting ability, together with photogeneration of reactive oxygen species, renders anthraquinones an interesting class of photosensitize…
View article: Rational prioritization strategy allows the design of macrolide derivatives that overcome antibiotic resistance
Rational prioritization strategy allows the design of macrolide derivatives that overcome antibiotic resistance Open
Significance Due to the development of resistance against commonly used antibiotics, new derivatives that avoid resistance mechanisms need to be developed. To address this problem, a rational prioritization strategy is outlined for macroli…
View article: Computational modeling and experimental validation of the EPI-X4/CXCR4 complex allows rational design of small peptide antagonists
Computational modeling and experimental validation of the EPI-X4/CXCR4 complex allows rational design of small peptide antagonists Open
View article: An optimized derivative of an endogenous CXCR4 antagonist prevents atopic dermatitis and airway inflammation
An optimized derivative of an endogenous CXCR4 antagonist prevents atopic dermatitis and airway inflammation Open
Aberrant CXCR4/CXCL12 signaling is involved in many pathophysiological processes such as cancer and inflammatory diseases. A natural fragment of serum albumin, named EPI-X4, has previously been identified as endogenous peptide antagonist a…
View article: Biomolecular models of EPI-X4 binding to CXCR4 allow the rational optimization of peptides with therapeutic potential
Biomolecular models of EPI-X4 binding to CXCR4 allow the rational optimization of peptides with therapeutic potential Open
The Endogenous Peptide Inhibitor of CXCR4 (EPI-X4) is a body-own fragment of albumin and specific antagonist of the CXC-motif-chemokine receptor 4 (CXCR4). CXCR4 signaling is induced by its sole chemokine ligand CXCL12 and is involved in a…
View article: An optimized derivative of an endogenous CXCR4 antagonist prevents atopic dermatitis and airway inflammation
An optimized derivative of an endogenous CXCR4 antagonist prevents atopic dermatitis and airway inflammation Open
Background Aberrant CXCR4/CXCL12 signaling is involved in many pathophysiological processes including chronic inflammatory diseases. Thus, the chemokine receptor CXCR4 is a promising target for the therapy of inflammatory disorders, such a…
View article: Solvent‐Enhanced Conformational Flexibility of Cyclic Tetrapeptides
Solvent‐Enhanced Conformational Flexibility of Cyclic Tetrapeptides Open
The front cover artwork is provided by the groups of Prof. Wolfram Sander (Ruhr‐Universität Bochum) and Prof. Elsa Sanchez‐Garcia (University of Duisburg‐Essen). The image shows the structure of a cyclic tetrapeptide in solution. The dynam…
View article: Front Cover: Solvent‐Enhanced Conformational Flexibility of Cyclic Tetrapeptides (ChemPhysChem 13/2019)
Front Cover: Solvent‐Enhanced Conformational Flexibility of Cyclic Tetrapeptides (ChemPhysChem 13/2019) Open
The Front Cover the structure of a cyclic tetrapeptide in solution. The dynamics of the peptide in explicit solvent was investigated using several computational and experimental techniques at different temperatures. More information can be…
View article: The Interaction Modes of Haloimidazolium Salts in Solution
The Interaction Modes of Haloimidazolium Salts in Solution Open
Invited for the cover of this issue is the group of Elsa Sanchez‐Garcia at the Universität Duisburg‐Essen and Stefan M. Huber at the Ruhr‐University Bochum. The image depicts the crystal structure of an iodoimidazolium salt showing one of …
View article: Front Cover: The Interaction Modes of Haloimidazolium Salts in Solution (Chem. Eur. J. 14/2018)
Front Cover: The Interaction Modes of Haloimidazolium Salts in Solution (Chem. Eur. J. 14/2018) Open
Haloimidazolium salts have gained importance as halogen-bond donors—halogen-based Lewis acids—in many applications including anion recognition and organocatalysis. However, little is known so far about their binding mode to anions in solut…
View article: CCDC 1580300: Experimental Crystal Structure Determination
CCDC 1580300: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1580299: Experimental Crystal Structure Determination
CCDC 1580299: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1580298: Experimental Crystal Structure Determination
CCDC 1580298: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1580548: Experimental Crystal Structure Determination
CCDC 1580548: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1580296: Experimental Crystal Structure Determination
CCDC 1580296: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1580302: Experimental Crystal Structure Determination
CCDC 1580302: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1580295: Experimental Crystal Structure Determination
CCDC 1580295: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1580301: Experimental Crystal Structure Determination
CCDC 1580301: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1580297: Experimental Crystal Structure Determination
CCDC 1580297: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Competitive solvent-molecule interactions govern primary processes of diphenylcarbene in solvent mixtures
Competitive solvent-molecule interactions govern primary processes of diphenylcarbene in solvent mixtures Open
Photochemical reactions in solution often proceed via competing reaction pathways comprising intermediates that capture a solvent molecule. A disclosure of the underlying reaction mechanisms is challenging due to the rapid nature of these …