Pandurangan Vijayanand
YOU?
Author Swipe
View article: T cell monocyte complexes exhibit distinct immune signatures during infection
T cell monocyte complexes exhibit distinct immune signatures during infection Open
Communication between immune cells through direct contact is a critical feature of immune responses. Here, we developed an innovative high-throughput workflow to study the transcriptome and adaptive immune receptor repertoire of single cel…
View article: Evolution of SARS-CoV-2 T cell responses as a function of multiple COVID-19 boosters
Evolution of SARS-CoV-2 T cell responses as a function of multiple COVID-19 boosters Open
We investigate the long-term impact of repeated COVID-19 vaccinations on adaptive immunity through a 3-year study of 78 individuals without reported symptomatic infections. We observe distinct dynamics in spike-specific responses across mu…
View article: Single-cell transcriptional analysis reveals allergen-specific signatures in human γδ T cells
Single-cell transcriptional analysis reveals allergen-specific signatures in human γδ T cells Open
The role of gamma-delta T (γδ T) cells in immune responses to common allergens is poorly understood. Here, we utilized single-cell (sc) transcriptomic analysis of allergen-reactive γδ T cells in humans to characterize the transcriptional l…
View article: Crohn’s Disease-associated variant in laccase domain containing 1 (LACC1) modulates T cell gene expression, metabolism and T cell function
Crohn’s Disease-associated variant in laccase domain containing 1 (LACC1) modulates T cell gene expression, metabolism and T cell function Open
View article: A novel method for characterizing cell-cell interactions at single-cell resolution reveals unique signatures in blood T cell-monocyte complexes during infection
A novel method for characterizing cell-cell interactions at single-cell resolution reveals unique signatures in blood T cell-monocyte complexes during infection Open
Communication between immune cells through direct contact is a critical feature of immune responses. Here, we developed a novel high-throughput method to study the transcriptome and adaptive immune receptor repertoire of single cells formi…
View article: Stem-like T cells are associated with the pathogenesis of ulcerative colitis in humans
Stem-like T cells are associated with the pathogenesis of ulcerative colitis in humans Open
View article: High-resolution African HLA resource uncovers HLA-DRB1 expression effects underlying vaccine response
High-resolution African HLA resource uncovers HLA-DRB1 expression effects underlying vaccine response Open
View article: Intra-tumoral T cells in pediatric brain tumors display clonal expansion and effector properties
Intra-tumoral T cells in pediatric brain tumors display clonal expansion and effector properties Open
View article: How Does Mild Asthma Differ Phenotypically from Difficult-to-Treat Asthma?
How Does Mild Asthma Differ Phenotypically from Difficult-to-Treat Asthma? Open
Phenotypic characterisation of mild asthma identified early-onset disease with high prevalence of current smokers, T2-high inflammation and significant multimorbidity burden. Early comprehensive assessment of mild asthma patients could hel…
View article: Transcriptomes and metabolism define mouse and human MAIT cell populations
Transcriptomes and metabolism define mouse and human MAIT cell populations Open
Mucosal-associated invariant T (MAIT) cells are a subset of T lymphocytes that respond to microbial metabolites. We defined MAIT cell populations in different organs and characterized the developmental pathway of mouse and human MAIT cells…
View article: Distinct use of super-enhancer elements controls cell type–specific CD25 transcription and function
Distinct use of super-enhancer elements controls cell type–specific CD25 transcription and function Open
The IL-2 receptor α chain (IL-2Rα/CD25) is constitutively expressed on double-negative (DN2/DN3 thymocytes and regulatory T cells (T regs ) but induced by IL-2 on T and natural killer (NK) cells, with Il2ra expression regulated by a STAT5-…
View article: Human CD79b+ neutrophils in the blood are associated with early-stage melanoma
Human CD79b+ neutrophils in the blood are associated with early-stage melanoma Open
Purpose Due to their abundance in the blood, low RNA content, and short lifespan, neutrophils have been classically considered to be one homogenous pool. However, recent work has found that mature neutrophils and neutrophil progenitors are…
View article: Divergent metabolic programmes control two populations of MAIT cells that protect the lung
Divergent metabolic programmes control two populations of MAIT cells that protect the lung Open
View article: Germline modifiers of the tumor immune microenvironment implicate drivers of cancer risk and immunotherapy response
Germline modifiers of the tumor immune microenvironment implicate drivers of cancer risk and immunotherapy response Open
With the continued promise of immunotherapy for treating cancer, understanding how host genetics contributes to the tumor immune microenvironment (TIME) is essential to tailoring cancer screening and treatment strategies. Here, we study 10…
View article: Bio-active lipids protect against immune-related adverse events due to immune checkpoint blockade therapy
Bio-active lipids protect against immune-related adverse events due to immune checkpoint blockade therapy Open
Introduction Immune checkpoint blockade (ICB) therapy has been revolutionary in its ability to treat advanced malignancies. Yet many patients receiving ICB develop Immune related adverse events (IRAEs), a leading cause for patients to disc…
View article: High-resolution African HLA resource uncovers<i>HLA-DRB1</i>expression effects underlying vaccine response
High-resolution African HLA resource uncovers<i>HLA-DRB1</i>expression effects underlying vaccine response Open
How human genetic variation contributes to vaccine immunogenicity and effectiveness is unclear, particularly in infants from Africa. We undertook genome-wide association analyses of eight vaccine antibody responses in 2,499 infants from th…
View article: High-resolution African HLA resource uncovers HLA-DRB1 expression effects underlying vaccine response: summary statistics
High-resolution African HLA resource uncovers HLA-DRB1 expression effects underlying vaccine response: summary statistics Open
How human genetic variation contributes to vaccine immunogenicity and effectiveness is unclear, particularly in infants from Africa. We undertook genome-wide association analyses of eight vaccine antibody responses in 2,499 infants from th…
View article: High-resolution African HLA resource uncovers HLA-DRB1 expression effects underlying vaccine response: summary statistics
High-resolution African HLA resource uncovers HLA-DRB1 expression effects underlying vaccine response: summary statistics Open
How human genetic variation contributes to vaccine immunogenicity and effectiveness is unclear, particularly in infants from Africa. We undertook genome-wide association analyses of eight vaccine antibody responses in 2,499 infants from th…
View article: Intermittent PI3Kδ inhibition sustains anti-tumour immunity and curbs irAEs
Intermittent PI3Kδ inhibition sustains anti-tumour immunity and curbs irAEs Open
View article: Transcriptomics of Acute DENV-Specific CD8+ T Cells Does Not Support Qualitative Differences as Drivers of Disease Severity
Transcriptomics of Acute DENV-Specific CD8+ T Cells Does Not Support Qualitative Differences as Drivers of Disease Severity Open
While several lines of evidence suggest a protective role of T cells against disease associated with Dengue virus (DENV) infection, their potential contribution to immunopathology in the acute phase of DENV infection remains controversial,…
View article: Single-cell eQTL analysis of activated T cell subsets reveals activation and cell type–dependent effects of disease-risk variants
Single-cell eQTL analysis of activated T cell subsets reveals activation and cell type–dependent effects of disease-risk variants Open
The impact of genetic variants on cells challenged in biologically relevant contexts has not been fully explored. Here, we activated CD4 + T cells from 89 healthy donors and performed a single-cell RNA sequencing assay with >1 million cell…
View article: Tumor-infiltrating NK cell subsets associated with the magnitude of T cell response in human lung cancer
Tumor-infiltrating NK cell subsets associated with the magnitude of T cell response in human lung cancer Open
NK cells are the predominant innate lymphocyte subset that contribute to anti-tumor immunity. The molecular profile of human tumor-infiltrating NK cells, and particularly, their characteristics in relation to CD8 + cytotoxic T lymphocyte (…
View article: Transcriptomes and metabolism define mouse and human MAIT cell heterogeneity
Transcriptomes and metabolism define mouse and human MAIT cell heterogeneity Open
Mucosal-associated invariant T (MAIT) cells are a subpopulation of T lymphocytes that respond to microbial metabolites. We performed single-cell RNA sequencing and metabolic analyses of MAIT cell subsets in thymus and peripheral tissues fr…
View article: CD4+CCR6+ T cells dominate the BCG-induced transcriptional signature
CD4+CCR6+ T cells dominate the BCG-induced transcriptional signature Open
View article: COVID-19 genetic risk variants are associated with expression of multiple genes in diverse immune cell types
COVID-19 genetic risk variants are associated with expression of multiple genes in diverse immune cell types Open
View article: Thymus-Derived CD4+CD8+ Cells Reside in Mediastinal Adipose Tissue and the Aortic Arch
Thymus-Derived CD4+CD8+ Cells Reside in Mediastinal Adipose Tissue and the Aortic Arch Open
Double-positive CD4+CD8αβ+ (DP) cells are thought to reside as T cell progenitors exclusively within the thymus. We recently discovered an unexpected CD4+ and CD8αβ+ immune cell population in healthy and atherosclerotic mice by single-cell…
View article: CD4+CCR6+ T cells dominate the BCG-induced transcriptional signature
CD4+CCR6+ T cells dominate the BCG-induced transcriptional signature Open
The century-old Mycobacterium bovis Bacillus Calmette-Guerin (BCG) remains the only licensed vaccine against tuberculosis (TB). Despite this, there is still a lot to learn about the immune response induced by BCG, both in terms of phenotyp…
View article: HLA-DR Marks Recently Divided Antigen-Specific Effector CD4 T Cells in Active Tuberculosis Patients
HLA-DR Marks Recently Divided Antigen-Specific Effector CD4 T Cells in Active Tuberculosis Patients Open
Upon Ag encounter, T cells can rapidly divide and form an effector population, which plays an important role in fighting acute infections. In humans, little is known about the molecular markers that distinguish such effector cells from oth…
View article: Intratumoral follicular regulatory T cells curtail anti-PD-1 treatment efficacy
Intratumoral follicular regulatory T cells curtail anti-PD-1 treatment efficacy Open
View article: Immunomodulatory effects of PI3Kδ inhibition in solid tumors – evaluation in a randomized phase II trial
Immunomodulatory effects of PI3Kδ inhibition in solid tumors – evaluation in a randomized phase II trial Open
Phosphoinositide 3-kinase δ (PI3Kδ) plays a key role in lymphocytes and inhibitors targeting this PI3K have been approved for hematological malignancies. While studies in hematological and solid tumor models in mice have demonstrated that …