Hongkui Wang
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View article: Dynamic molecular landscape in dorsal root ganglion for peripheral nerve regeneration promoted by tissue engineered nerve graft
Dynamic molecular landscape in dorsal root ganglion for peripheral nerve regeneration promoted by tissue engineered nerve graft Open
This integrated approach demonstrates the potential of combining biomaterial scaffolds, cellular therapy, and omics technologies for developing effective strategies to repair peripheral nerve injuries. The findings provide a robust preclin…
View article: Chitooligosaccharides accelarate myelin clearance by Wipi1 mediated Schwann cell autophagy promoting peripheral nerve regeneration
Chitooligosaccharides accelarate myelin clearance by Wipi1 mediated Schwann cell autophagy promoting peripheral nerve regeneration Open
As the most feasible method to reconstruct long-distance peripheral nerve injuries, tissue-engineered nerves rely on biomaterials as a key driving factor. Chitooligosaccharides, intermediate products of chitosan degradation, have the abili…
View article: Unveiling the molecular blueprint of SKP-SCs-mediated tissue engineering-enhanced neuroregeneration
Unveiling the molecular blueprint of SKP-SCs-mediated tissue engineering-enhanced neuroregeneration Open
Peripheral nerve injury poses a significant challenge to the nervous system's regenerative capacity. We previously described a novel approach to construct a chitosan/silk fibroin nerve graft with skin-derived precursor-induced Schwann cell…
View article: EZH2-dependent myelination following sciatic nerve injury
EZH2-dependent myelination following sciatic nerve injury Open
JOURNAL/nrgr/04.03/01300535-202508000-00028/figure1/v/2024-09-30T120553Z/r/image-tiff Demyelination and remyelination have been major focal points in the study of peripheral nerve regeneration following peripheral nerve injury. Notably, th…
View article: Skin derived precursors induced Schwann cells mediated tissue engineering-aided neuroregeneration across sciatic nerve defect
Skin derived precursors induced Schwann cells mediated tissue engineering-aided neuroregeneration across sciatic nerve defect Open
A central question in neural tissue engineering is how the tissue-engineered nerve (TEN) translates detailed transcriptional signals associated with peripheral nerve regeneration into meaningful biological processes. Here, we report a skin…
View article: Corrigendum: Transcription factor SS18L1 regulates the proliferation, migration and differentiation of Schwann cells in peripheral nerve injury
Corrigendum: Transcription factor SS18L1 regulates the proliferation, migration and differentiation of Schwann cells in peripheral nerve injury Open
[This corrects the article DOI: 10.3389/fvets.2022.936620.].
View article: Mechanisms underlying the cell-matrixed nerve grafts repairing peripheral nerve defects
Mechanisms underlying the cell-matrixed nerve grafts repairing peripheral nerve defects Open
Decellularized extracellular matrix (dECM), with its distinct biological properties, has gained significant attention as a natural biomaterial. Leveraging its potentials, we successfully developed a three-dimensional matrix-based oriented …
View article: Blood vessel remodeling in late stage of vascular network reconstruction is essential for peripheral nerve regeneration
Blood vessel remodeling in late stage of vascular network reconstruction is essential for peripheral nerve regeneration Open
One of the bottlenecks of advanced study on tissue engineering in regenerative medicine is rapid and functional vascularization. For a deeper comprehension of vascularization, the exhaustive, dynamic, and three‐dimensional depiction of per…
View article: Protective effects and molecular mechanisms of Achyranthes bidentata polypeptide k on Schwann cells
Protective effects and molecular mechanisms of Achyranthes bidentata polypeptide k on Schwann cells Open
Using high-throughput sequencing technology, our work unveiled the protective effects of ABPPk on Schwann cells after serum deprivation in a more comprehensive manner. These results further enrich the positive functions and molecular mecha…
View article: Gene set enrichment analysis and protein-protein interaction network analysis after sciatic nerve injury
Gene set enrichment analysis and protein-protein interaction network analysis after sciatic nerve injury Open
The combined use of GSEA and PPI networks serves as a valuable way to identify potential therapeutic targets for neuroregeneration.
View article: Construction of Dual-Biofunctionalized Chitosan/Collagen Scaffolds for Simultaneous Neovascularization and Nerve Regeneration
Construction of Dual-Biofunctionalized Chitosan/Collagen Scaffolds for Simultaneous Neovascularization and Nerve Regeneration Open
Biofunctionalization of artificial nerve implants by incorporation of specific bioactive factors has greatly enhanced the success of grafting procedures for peripheral nerve regeneration. However, most studies on novel biofunctionalized im…
View article: MOESM1 of Matrix metalloproteinase 7 promoted Schwann cell migration and myelination after rat sciatic nerve injury
MOESM1 of Matrix metalloproteinase 7 promoted Schwann cell migration and myelination after rat sciatic nerve injury Open
Additional file 1: Table S1. List of differentially expressed genes in MMP7-treated Schwann cells. Gene ID, symbol, reads, p-value, FDR, gene description, and involved GO terms and KEGG pathways of differentially expressed genes were liste…
View article: Achyranthes bidentata Polypeptide Protects Schwann Cells From Apoptosis in Hydrogen Peroxide-Induced Oxidative Stress
Achyranthes bidentata Polypeptide Protects Schwann Cells From Apoptosis in Hydrogen Peroxide-Induced Oxidative Stress Open
ABPPk, the active ingredient separated from Achyranthes bidentata polypeptides, is a traditional Chinese medicine with multiple pharmaceutical properties. In this study, we investigated the molecular mechanisms of ABPPk in protecting Schwa…
View article: Transcriptomic Landscapes of Immune Response and Axonal Regeneration by Integrative Analysis of Molecular Pathways and Interactive Networks Post-sciatic Nerve Transection
Transcriptomic Landscapes of Immune Response and Axonal Regeneration by Integrative Analysis of Molecular Pathways and Interactive Networks Post-sciatic Nerve Transection Open
Potential interaction between immune response and axonal regeneration has recently attracted much attention in peripheral nervous system (PNS). Previously, global mRNA expression changes in proximal nerve segments were profiled and merely …
View article: Transcriptional Repression of p53 by PAX3 Contributes to Gliomagenesis and Differentiation of Glioma Stem Cells
Transcriptional Repression of p53 by PAX3 Contributes to Gliomagenesis and Differentiation of Glioma Stem Cells Open
Although there are available therapies as surgery, chemotherapy and radiation, glioblastoma (GBM) still has been considered as the most common and overwhelming primary tumor of brain. In GBM, the brain glioma stem cells (BGSCs) were identi…
View article: Overlapping Mechanisms of Peripheral Nerve Regeneration and Angiogenesis Following Sciatic Nerve Transection
Overlapping Mechanisms of Peripheral Nerve Regeneration and Angiogenesis Following Sciatic Nerve Transection Open
Peripheral nervous system owns the ability of self-regeneration, mainly in its regenerative microenvironment including vascular network reconstruction. More recently, more attentions have been given to the close relationship between tissue…
View article: Angiogenesis in tissue-engineered nerves evaluated objectively using MICROFIL perfusion and micro-CT scanning
Angiogenesis in tissue-engineered nerves evaluated objectively using MICROFIL perfusion and micro-CT scanning Open
Angiogenesis is a key process in regenerative medicine generally, as well as in the specific field of nerve regeneration. However, no convenient and objective method for evaluating the angiogenesis of tissue-engineered nerves has been repo…
View article: Blood vessel three-dimensional reconstruction of a tissue engineering nerve bridging rat sciatic nerve injury
Blood vessel three-dimensional reconstruction of a tissue engineering nerve bridging rat sciatic nerve injury Open
Event Abstract Back to Event Blood vessel three-dimensional reconstruction of a tissue engineering nerve bridging rat sciatic nerve injury Hongkui Wang1, Yaxian Wang1, Leilei Gong1, Sheng Yi1 and Xiaosong Gu1 1 Nantong University, Jiangsu …