Panos N. Papapanou
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View article: Cerebrospinal fluid microbiome revisited: no evidence of resident bacteria in archived samples
Cerebrospinal fluid microbiome revisited: no evidence of resident bacteria in archived samples Open
DNA from oral bacteria has been detected in the cerebrospinal fluid (CSF) of patients with Alzheimer’s disease and related dementias (AD/ADRD). We hypothesized that examination of archived CSF samples from donors with variable cognitive st…
View article: Consensus Report of the 20th European Workshop on Periodontology: Contemporary and Emerging Technologies in Periodontal Diagnosis
Consensus Report of the 20th European Workshop on Periodontology: Contemporary and Emerging Technologies in Periodontal Diagnosis Open
Background This Consensus Workshop dealt with diagnostic methodologies in the context of surveillance, screening, assessment of stage and grade, prognosis, monitoring and prediction of periodontal status. Several elements provided the impe…
View article: Association Between Dietary Patterns and Subgingival Microbiota: Results From the Oral Infections, Glucose Intolerance, and Insulin Resistance Study (<scp>ORIGINS</scp>)
Association Between Dietary Patterns and Subgingival Microbiota: Results From the Oral Infections, Glucose Intolerance, and Insulin Resistance Study (<span>ORIGINS</span>) Open
Objective To study the association between dietary patterns and subgingival microbiota. Methods Participants ( n = 651) who were enrolled in the Oral Infections, Glucose Intolerance, and Insulin Resistance Study (ORIGINS) with subgingival …
View article: Consensus report of the second European Consensus Workshop on Education in Periodontology
Consensus report of the second European Consensus Workshop on Education in Periodontology Open
Background The second European Consensus Workshop on Education in Periodontology was commissioned, as a result of the changes in the discipline and the advances in educational methods/technology, to update the 2009 Consensus report of the …
View article: Dietary nitrate intake and net nitrite-generating capacity of the oral microbiome interact to enhance cardiometabolic health: Results from the Oral Infections Glucose Intolerance and Insulin Resistance Study (ORIGINS)
Dietary nitrate intake and net nitrite-generating capacity of the oral microbiome interact to enhance cardiometabolic health: Results from the Oral Infections Glucose Intolerance and Insulin Resistance Study (ORIGINS) Open
Background We investigated the association between dietary nitrate intake and early clinical cardiometabolic risk biomarkers, and explored whether the oral microbiome modifies the association between dietary nitrate intake and cardiometabo…
View article: <scp>ACES</scp>: A new framework for the application of the 2018 periodontal status classification scheme to epidemiological survey data
<span>ACES</span>: A new framework for the application of the 2018 periodontal status classification scheme to epidemiological survey data Open
Aim To propose a framework for consistently applying the 2018 periodontal status classification scheme to epidemiological surveys (Application of the 2018 periodontal status Classification to Epidemiological Survey data, ACES). Proposed Fr…
View article: Clinical attachment loss is cross‐sectionally associated with elevated glucose among adults without diabetes
Clinical attachment loss is cross‐sectionally associated with elevated glucose among adults without diabetes Open
Aim We investigated whether periodontal measures are cross‐sectionally associated with prediabetes and cardiometabolic biomarkers among non‐diabetic younger adults. Materials and Methods One thousand seventy‐one participants (mean age = 32…
View article: Periodontitis and brain magnetic resonance imaging markers of Alzheimer's disease and cognitive aging
Periodontitis and brain magnetic resonance imaging markers of Alzheimer's disease and cognitive aging Open
INTRODUCTION We examined the association of clinical, microbiological, and host response features of periodontitis with MRI markers of atrophy/cerebrovascular disease in the Washington Heights Inwood Columbia Aging Project (WHICAP) Ancilla…
View article: Experimentally Induced Peripheral Venous Congestion Exacerbates Inflammation, Oxidative Stress, and Neurohormonal and Endothelial Cell Activation in Patients With Systolic Heart Failure
Experimentally Induced Peripheral Venous Congestion Exacerbates Inflammation, Oxidative Stress, and Neurohormonal and Endothelial Cell Activation in Patients With Systolic Heart Failure Open
View article: Prevention and treatment of peri‐implant diseases—The <scp>EFP S3</scp> level clinical practice guideline
Prevention and treatment of peri‐implant diseases—The <span>EFP S3</span> level clinical practice guideline Open
Background The recently published Clinical Practice Guidelines (CPGs) for the treatment of stages I–IV periodontitis provided evidence‐based recommendations for treating periodontitis patients, defined according to the 2018 classification.…
View article: Editorial: Core outcome sets and measures for clinical trials in implant dentistry
Editorial: Core outcome sets and measures for clinical trials in implant dentistry Open
It is well established that the validity of clinical recommendations relies heavily on the quality of clinical trials that investigate therapeutic procedures, and on the accurate reporting of treatment outcomes, complication rates and pati…
View article: Relevant domains, core outcome sets and measurements for implant dentistry clinical trials: The Implant Dentistry Core Outcome Set and Measurement (<scp>ID‐COSM)</scp> international consensus report
Relevant domains, core outcome sets and measurements for implant dentistry clinical trials: The Implant Dentistry Core Outcome Set and Measurement (<span>ID‐COSM)</span> international consensus report Open
Aim Lack of consistently reported outcomes limits progress in evidence‐based implant dentistry and quality of care. The objective of this initiative was to develop a core outcome set (COS) and measurements for implant dentistry clinical tr…
View article: Editorial: Core outcome sets and measures for clinical trials in implant dentistry
Editorial: Core outcome sets and measures for clinical trials in implant dentistry Open
View article: Relevant domains, core outcome sets and measurements for implant dentistry clinical trials: The Implant Dentistry Core Outcome Set and Measurement (<scp>ID‐COSM)</scp> international consensus report
Relevant domains, core outcome sets and measurements for implant dentistry clinical trials: The Implant Dentistry Core Outcome Set and Measurement (<span>ID‐COSM)</span> international consensus report Open
Aim Lack of consistently reported outcomes limits progress in evidence‐based implant dentistry and quality of care. The objective of this initiative was to develop a core outcome set (COS) and measurements for implant dentistry clinical tr…
View article: Phenotype Harmonization in the GLIDE2 Oral Health Genomics Consortium
Phenotype Harmonization in the GLIDE2 Oral Health Genomics Consortium Open
Genetic risk factors play important roles in the etiology of oral, dental, and craniofacial diseases. Identifying the relevant risk loci and understanding their molecular biology could highlight new prevention and management avenues. Our c…
View article: Periodontal Status, C-Reactive Protein, NT-proBNP, and Incident Heart Failure
Periodontal Status, C-Reactive Protein, NT-proBNP, and Incident Heart Failure Open
View article: Nitrite Generating and Depleting Capacity of the Oral Microbiome and Cardiometabolic Risk: Results from ORIGINS
Nitrite Generating and Depleting Capacity of the Oral Microbiome and Cardiometabolic Risk: Results from ORIGINS Open
Background The enterosalivary nitrate–nitrite–nitric oxide (NO 3 –NO 2 –NO) pathway generates NO following oral microbiota‐mediated production of salivary nitrite, potentially linking the oral microbiota to reduced cardiometabolic risk. Ni…
View article: Early microbial markers of periodontal and cardiometabolic diseases in ORIGINS
Early microbial markers of periodontal and cardiometabolic diseases in ORIGINS Open
Periodontitis affects up to 50% of individuals worldwide, and 8.5% are diagnosed with diabetes. The high-comorbidity rate of these diseases may suggest, at least in part, a shared etiology and pathophysiology. Changes in oral microbial com…
View article: Replication of gene polymorphisms associated with periodontitis‐related traits in an elderly cohort: the <scp>Washington Heights/Inwood</scp> Community Aging Project Ancillary Study of Oral Health
Replication of gene polymorphisms associated with periodontitis‐related traits in an elderly cohort: the <span>Washington Heights/Inwood</span> Community Aging Project Ancillary Study of Oral Health Open
Aim We sought to replicate findings from published genome‐wide association studies (GWAS), linking specific candidate gene loci with periodontitis‐related clinical/microbial traits. Materials and Methods In the published GWAS, a total of 2…
View article: Peri-Implant Health and the Knowing-Doing Gap—A Digital Survey on Procedures and Therapies
Peri-Implant Health and the Knowing-Doing Gap—A Digital Survey on Procedures and Therapies Open
Objectives: Peri-implant tissue maintenance and treatment is becoming a serious challenge in implantology. With increasing numbers of implants being placed, more cases of peri-implant mucositis and peri-implantitis is seen. A digital surve…
View article: C3-targeted therapy in periodontal disease: moving closer to the clinic
C3-targeted therapy in periodontal disease: moving closer to the clinic Open
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ISSUE INFORMATION Open
The facial mucosal margin level of immediately placed implants with either immediate provisionalization or
View article: <i>Fusobacterium nucleatum</i> secretes amyloid‐like FadA to enhance pathogenicity
<i>Fusobacterium nucleatum</i> secretes amyloid‐like FadA to enhance pathogenicity Open
View article: Differential <scp>DNA</scp> methylation and <scp>mRNA</scp> transcription in gingival tissues in periodontal health and disease
Differential <span>DNA</span> methylation and <span>mRNA</span> transcription in gingival tissues in periodontal health and disease Open
Aim We investigated differential DNA methylation in gingival tissues in periodontal health, gingivitis, and periodontitis, and its association with differential mRNA expression. Materials and methods Gingival tissues were harvested from in…
View article: Diet quality and periodontal disease: Results from the oral infections, glucose intolerance and insulin resistance study (ORIGINS)
Diet quality and periodontal disease: Results from the oral infections, glucose intolerance and insulin resistance study (ORIGINS) Open
Aims This study examined the cross‐sectional association between diet quality and periodontal disease. Materials and methods In the Oral Infections, Glucose Intolerance and Insulin Resistance Study (ORIGINS), 923 individuals completed the …
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ISSUE INFORMATION Open
A new system for classification and clinical management is proposed for non-proximal gingival recession defects.
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ISSUE INFORMATION Open
In addition to the number of cigarettes consumed, nicotine dependence level influenced the diagnosis of periodontitis severity.
View article: Cell Type–Specific Decomposition of Gingival Tissue Transcriptomes
Cell Type–Specific Decomposition of Gingival Tissue Transcriptomes Open
Genome-wide transcriptomic analyses in whole tissues reflect the aggregate gene expression in heterogeneous cell populations comprising resident and migratory cells, and they are unable to identify cell type–specific information. We used a…
View article: Repeated delivery of chlorhexidine chips for the treatment of peri‐implantitis: A multicenter, randomized, comparative clinical trial
Repeated delivery of chlorhexidine chips for the treatment of peri‐implantitis: A multicenter, randomized, comparative clinical trial Open
Background Peri‐implantitis is a challenging condition to manage and is frequently treated using non‐surgical debridement. The local delivery of antimicrobial agents has demonstrated benefit in mild to moderate cases of peri‐implantitis. T…
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ISSUE INFORMATION Open