Panyu Chen
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View article: Novel multifunctional degraders of EP300/CBP and IKZF1/3 with potent anti-myeloma activity
Novel multifunctional degraders of EP300/CBP and IKZF1/3 with potent anti-myeloma activity Open
Immunomodulatory imide drugs (IMiDs) are well-established therapies for patients with multiple myeloma (MM) (Hartley-Brown 2024). The primary mechanism of IMiD action occurs through binding to the E3 ligase cereblon and allosterically enab…
View article: Infertile women with a history of fertility-sparing surgery for borderline ovarian tumors: IVF outcomes and the association between IVF and tumor recurrence
Infertile women with a history of fertility-sparing surgery for borderline ovarian tumors: IVF outcomes and the association between IVF and tumor recurrence Open
Not applicable.
View article: HPD-Kit: a comprehensive toolkit for pathogen detection and analysis
HPD-Kit: a comprehensive toolkit for pathogen detection and analysis Open
Introduction Unbiased metagenomic sequencing (mNGS) is crucial for infectious disease diagnosis and epidemiological surveillance. However, its analysis requires specialized bioinformatics skills, creating barriers for clinicians. We develo…
View article: RBM15-mediated metabolic reprogramming boosts immune response in colorectal cancer
RBM15-mediated metabolic reprogramming boosts immune response in colorectal cancer Open
Introduction Immune checkpoint blockade (ICB) therapy has shown promise in treating advanced colorectal cancer, particularly in patients with microsatellite instability-high (MSI-H) tumors. However, only a subset of these patients responds…
View article: <i>In vivo</i> validation of the palmitoylation cycle as a therapeutic target in <i>NRAS</i>-mutant cancer
<i>In vivo</i> validation of the palmitoylation cycle as a therapeutic target in <i>NRAS</i>-mutant cancer Open
SUMMARY Normal and oncogenic Ras proteins are functionally dependent on one or more lipid modifications 1,2 . Whereas K-Ras4b farnesylation is sufficient for stable association with the plasma membrane, farnesylated H-Ras, K-Ras4a, and N-R…
View article: Quality Assessment and Identification of Key Areas for Ecological Conservation Projects in Inner Mongolia
Quality Assessment and Identification of Key Areas for Ecological Conservation Projects in Inner Mongolia Open
In the context of global climate change, implementing ecological projects in China is critical for improving ecosystem quality, conservation, and sustainable development. Despite progress, ecological engineering areas remain vulnerable to …
View article: Mood disorders influencing endometriosis and adenomyosis: Mendelian randomisation study
Mood disorders influencing endometriosis and adenomyosis: Mendelian randomisation study Open
Background Many studies have found an association between mood-disorder-related traits and endometriosis and adenomyosis. However, the cause–effect relationship remains unclear. Aims We conducted Mendelian randomisation analyses to evaluat…
View article: Kuaiji: the First Chinese Accounting Large Language Model
Kuaiji: the First Chinese Accounting Large Language Model Open
Large Language Models (LLMs) like ChatGPT and GPT-4 have demonstrated impressive proficiency in comprehending and generating natural language. However, they encounter difficulties when tasked with adapting to specialized domains such as ac…
View article: Antibiotic resistance profiles of gut microbiota across various primate species in Guangxi
Antibiotic resistance profiles of gut microbiota across various primate species in Guangxi Open
Introduction Understanding the gut microbiota and antibiotic resistance gene (ARG) profiles in non-human primates (NHPs) is crucial for evaluating their potential impact on human health and the environment. Methods In this study, we perfor…
View article: Antibiotic Resistance Profiles of Gut Microbiota Across Various Primate Species in Guangxi
Antibiotic Resistance Profiles of Gut Microbiota Across Various Primate Species in Guangxi Open
Understanding the gut microbiota and antibiotic resistance gene (ARG) profiles in non-human primates (NHPs) is crucial for evaluating their potential impact on human health and the environment. In this study, we performed metagenomic analy…
View article: Structural and functional analyses of a germline KRAS T50I mutation provide insights into Raf activation
Structural and functional analyses of a germline KRAS T50I mutation provide insights into Raf activation Open
A T50I substitution in the K-Ras interswitch domain causes Noonan syndrome and emerged as a third-site mutation that restored the in vivo transforming activity and constitutive MAPK pathway activation by an attenuated KrasG12D,E37G oncogen…
View article: Clinicopathological and prognostic value of epithelial cell adhesion molecule in solid tumours: a meta-analysis
Clinicopathological and prognostic value of epithelial cell adhesion molecule in solid tumours: a meta-analysis Open
Background Malignant tumors, mainly solid tumors, are a significant obstacle to the improvement of life expectancy at present. Epithelial cell adhesion molecule (EpCAM), a cancer stem cell biomarker, showed widespread expression in most no…
View article: Machine learning-based prediction of pregnancy outcomes in couples with non-obstructive azoospermia using micro-TESE for ICSI: a retrospective cohort study
Machine learning-based prediction of pregnancy outcomes in couples with non-obstructive azoospermia using micro-TESE for ICSI: a retrospective cohort study Open
Objective: To develop a clinically applicable tool for predicting clinical pregnancy, providing individualized patient counseling, and helping couples with non-obstructive azoospermia (NOA) decide whether to use fresh or cryopreserved sper…
View article: Association between monoaromatic hydrocarbons exposure and vaginal microbiota disorder in recurrent implantation failure
Association between monoaromatic hydrocarbons exposure and vaginal microbiota disorder in recurrent implantation failure Open
Recurrent implantation failure (RIF) is a significant challenge facing population development, with the impact of monoaromatic hydrocarbons (MACHs) exposure on embryo implantation and reproductive hazards remaining largely unclear. As such…
View article: Supplementary Figures S1-S9 and List of Supplementary Tables from Adaptive and Reversible Resistance to Kras Inhibition in Pancreatic Cancer Cells
Supplementary Figures S1-S9 and List of Supplementary Tables from Adaptive and Reversible Resistance to Kras Inhibition in Pancreatic Cancer Cells Open
Figures showing on-target effects of Kras knockdown in murine and human PDAC cells in vitro and in vivo, Gpr56 knockdown, SILAC and iTRAQ workflow and additional proteomics data, pharmacological inhibition of Src and FAK, and genetic inhib…
View article: Data from Adaptive and Reversible Resistance to Kras Inhibition in Pancreatic Cancer Cells
Data from Adaptive and Reversible Resistance to Kras Inhibition in Pancreatic Cancer Cells Open
Activating mutations in KRAS are the hallmark genetic alterations in pancreatic ductal adenocarcinoma (PDAC) and the key drivers of its initiation and progression. Longstanding efforts to develop novel KRAS inhibitors have been based on th…
View article: Data from Adaptive and Reversible Resistance to Kras Inhibition in Pancreatic Cancer Cells
Data from Adaptive and Reversible Resistance to Kras Inhibition in Pancreatic Cancer Cells Open
Activating mutations in KRAS are the hallmark genetic alterations in pancreatic ductal adenocarcinoma (PDAC) and the key drivers of its initiation and progression. Longstanding efforts to develop novel KRAS inhibitors have been based on th…
View article: Supplementary Tables 1-10 from Adaptive and Reversible Resistance to Kras Inhibition in Pancreatic Cancer Cells
Supplementary Tables 1-10 from Adaptive and Reversible Resistance to Kras Inhibition in Pancreatic Cancer Cells Open
Detailed information on shRNA and primer sequences, tumor initiating frequency of Kras-inhibited cells, RNA-Seq data, and phosphoproteomic data.
View article: Supplementary Tables 1-10 from Adaptive and Reversible Resistance to Kras Inhibition in Pancreatic Cancer Cells
Supplementary Tables 1-10 from Adaptive and Reversible Resistance to Kras Inhibition in Pancreatic Cancer Cells Open
Detailed information on shRNA and primer sequences, tumor initiating frequency of Kras-inhibited cells, RNA-Seq data, and phosphoproteomic data.
View article: Supplementary Figures S1-S9 and List of Supplementary Tables from Adaptive and Reversible Resistance to Kras Inhibition in Pancreatic Cancer Cells
Supplementary Figures S1-S9 and List of Supplementary Tables from Adaptive and Reversible Resistance to Kras Inhibition in Pancreatic Cancer Cells Open
Figures showing on-target effects of Kras knockdown in murine and human PDAC cells in vitro and in vivo, Gpr56 knockdown, SILAC and iTRAQ workflow and additional proteomics data, pharmacological inhibition of Src and FAK, and genetic inhib…