Explanipedia

A multi-omics approach reveals impaired lipid metabolism and oxidative stress in a zebrafish model of Alexander disease Open

Deianira Bellitto, Matteo Bozzo, Silvia Ravera, Nadia Bertola, Francesca Rosamilia , et al. · 2025

Alexander disease (AxD) is a rare leukodystrophy caused by heterozygous mutations in the GFAP gene. To date, several in vitro and in vivo models have been generated in an attempt to unravel the main mechanisms underlying this complex disea…

A Proteomics Approach Identifies RREB1 as a Crucial Molecular Target of Imidazo–Pyrazole Treatment in SKMEL-28 Melanoma Cells Open

Erika Iervasi, Gabriela Coronel Vargas, Tiziana Bachetti, Kateryna Tkachenko, Andrea Spallarossa , et al. · 2024

Cutaneous melanoma is the most dangerous and deadly form of human skin malignancy. Despite its rarity, it accounts for a staggering 80% of deaths attributed to cutaneous cancers overall. Moreover, its final stages often exhibit resistance …

Identification of Molecular Markers Associated with Prostate Cancer Subtypes: An Integrative Bioinformatics Approach Open

Ilaria Granata, Paola Barboro · 2024

Prostate cancer (PCa) is characterised by androgen dependency. Unfortunately, under anti-androgen treatment pressure, castration-resistant prostate cancer (CRPC) emerges, characterised by heterogeneous cell populations that, over time, lea…

Fraisinib: a calixpyrrole derivative reducing A549 cell-derived NSCLC tumor in vivo acts as a ligand of the glycine-tRNA synthase, a new molecular target in oncology Open

Imène Ben Toumia, Tiziana Bachetti, Leila Chekir‐Ghedira, Aldo Profumo, Marco Ponassi , et al. · 2024

Background and purpose: Lung cancer is the leading cause of death in both men and women, constituting a major public health problem worldwide. Non-small-cell lung cancer accounts for 85%–90% of all lung cancers. We propose a compound that …

Identification of Molecular Markers Associated with Prostate Cancer Subtypes: An Integrative Bioinformatics Approach Open

Ilaria Granata, Paola Barboro · 2023

Prostate cancer (PCa) is characterised by androgen-dependency. Unfortunately, under anti-androgen treatment pressure, castration-resistant prostate cancer (CRPC) emerges, characterised by heterogeneous cell populations that, over time, lea…

Untargeted lipidomics reveal association of elevated plasma C18 ceramide levels with reduced survival in metastatic castration-resistant prostate cancer patients Open

Carlo Cattrini, Marcello Manfredi, Paola Barboro, Marco Ghirimoldi, Alessia Mennitto , et al. · 2023

Gene’s expression underpinning the divergent predictive value of [18F]F-fluorodeoxyglucose and prostate-specific membrane antigen positron emission tomography in primary prostate cancer: a bioinformatic and experimental study Open

Matteo Bauckneht, Cecilia Marini, Vanessa Cossu, Cristina Campi, Mattia Riondato , et al. · 2023

Background Positron Emission Tomography (PET) imaging with Prostate-Specific Membrane Antigen (PSMA) and Fluorodeoxyglucose (FDG) represent promising biomarkers for risk-stratification of Prostate Cancer (PCa). We verified whether the expr…

Two calix[4]pyrroles as potential therapeutics for castration-resistant prostate cancer Open

Imène Ben Toumia, Marco Ponassi, Paola Barboro, Erika Iervasi, Gabriela Coronel Vargas , et al. · 2022

The prognostic value of aspartate beta-hydroxylase in early breast cancer Open

Paola Barboro, A. Rubagotti, Silvia Poddine, Federica Grillo, Luca Mastracci , et al. · 2022

Purpose Aspartate beta-hydroxylase (ASPH) is a transmembrane protein involved in cancer progression, which has been shown to imply a worse prognosis in several solid tumors. The aim of the present study was to further investigate the progn…

Epidemiological Characteristics and Survival in Patients with De Novo Metastatic Prostate Cancer Open

Carlo Cattrini, Davide Soldato, A. Rubagotti, Linda Zinoli, Elisa Zanardi , et al. · 2020

The real-world outcomes of patients with metastatic prostate cancer (mPCa) are largely unexplored. We investigated the trends in overall survival (OS) and cancer-specific survival (CSS) in patients with de novo mPCa according to distinct t…

Epidemiological Characteristics and Survival in Patients with de novo Metastatic Prostate Cancer. Open

Carlo Cattrini, Davide Soldato, A. Rubagotti, Linda Zinoli, Elisa Zanardi , et al. · 2020

The real-world outcomes of patients with metastatic prostate cancer (mPCa) are largely unexplored. We investigated the improvements in overall survival (OS) and cancer-specific survival (CSS) in patients with de novo mPCa in latest years. …

Etoposide and topoisomerase II inhibition for aggressive prostate cancer: data from a translational study. Open

Carlo Cattrini, Matteo Capaia, Francesco Boccardo, Paola Barboro · 2020

Background. Etoposide phosphate (VP-16) is a topoisomerase 2 (TOP2) inhibitor that demonstrated limited activity in patients with metastatic castration-resistant prostate cancer (mCRPC). In our study, we investigated the sensitivity of pro…

Aspartate β-hydroxylase targeting in castration-resistant prostate cancer modulates the NOTCH/HIF1α/GSK3β crosstalk Open

Paola Barboro, Roberto Benelli, Francesca Tosetti, Delfina Costa, Matteo Capaia , et al. · 2020

Castration-resistant prostate cancer (CRPC) is an incurable stage of the disease. A multivariate principal component analysis on CRPC in vitro models identified aspartyl (asparaginyl) β hydrolase (ASPH) as the most relevant molecule associ…

Integrative Analysis of Periostin in Primary and Advanced Prostate Cancer Open

Carlo Cattrini, Paola Barboro, A. Rubagotti, Linda Zinoli, Elisa Zanardi , et al. · 2020

Erratum: Benelli, R., et al. Aspartate-β-Hydroxylase: A Promising Target to Limit the Local Invasiveness of Colorectal Cancer. Cancers 2020, 12, 971 Open

Roberto Benelli, Delfina Costa, Luca Mastracci, Federica Grillo, Mark Olsen , et al. · 2020

The authors wish to make the following corrections to this paper [...]

Aspartate-β-Hydroxylase: A Promising Target to Limit the Local Invasiveness of Colorectal Cancer Open

Roberto Benelli, Delfina Costa, Luca Mastracci, Federica Grillo, Mark Olsen , et al. · 2020

Colorectal cancer’s (CRC) ability to invade local tissues and lymph nodes and generate distant metastases is the key for TNM classification. Aspartate-β-hydroxylase (ASPH), a transmembrane protein that catalyzes Notch receptors and ligand …

Etoposide and topoisomerase II inhibition for aggressive prostate cancer: Data from a translational study. Open

Carlo Cattrini, Matteo Capaia, Francesco Boccardo, Paola Barboro · 2020

Multifocal Signal Modulation Therapy by Celecoxib: A Strategy for Managing Castration-Resistant Prostate Cancer Open

Roberto Benelli, Paola Barboro, Delfina Costa, Simonetta Astigiano, Ottavia Barbieri , et al. · 2019

Background: Prostate cancer (PCa) is a significant health concern throughout the world. Standard therapy for advanced disease consists of anti-androgens, however, almost all prostate tumors become castration resistant (CRPC). Progression f…

Role of Circulating Tumor Cells (CTC), Androgen Receptor Full Length (AR-FL) and Androgen Receptor Splice Variant 7 (AR-V7) in a Prospective Cohort of Castration-Resistant Metastatic Prostate Cancer Patients Open

Carlo Cattrini, A. Rubagotti, Linda Zinoli, Luigi Cerbone, Elisa Zanardi , et al. · 2019

Background: Circulating tumor cells (CTC), androgen receptor full-length (AR-FL), and androgen receptor splice variant 7 (AR-V7) are prognostic in patients (pts) with metastatic castration-resistant prostate cancer (mCRPC). AR-V7 seems to …

Chromatin Nanoscale Organization Investigated by FLIM-FRET and STED Superresolution Microscopy Open

Simone Pelicci, Michele Oneto, Melody Di Bona, Isotta Cainero, Paola Barboro , et al. · 2019

A hnRNP K–AR-Related Signature Reflects Progression toward Castration-Resistant Prostate Cancer Open

Matteo Capaia, Ilaria Granata, Mario Rosario Guarracino, Andrea Petretto, Elvira Inglese , et al. · 2018

The major challenge in castration-resistant prostate cancer (CRPC) remains the ability to predict the clinical responses to improve patient selection for appropriate treatments. The finding that androgen deprivation therapy (ADT) induces a…

PO-445 The phenotypic plasticity of castration-resistant prostate cancer: from challenge to opportunity Open

Carlo Cattrini, Matteo Capaia, Francesco Boccardo, Paola Barboro · 2018

Introduction We have previously reported on the development of two in vitro models (PDB and MDB) of castration-resistant prostate cancer (CRPC) (Ferrari et al. Cell Comm Sign. 2017 8;15( 1 :51). These cell lines are resistant to bical…

Proteomics study of silver nanoparticles on Caco-2 cells Open

Sabrina Gioria, Patricia Urbán, Marián Hajdúch, Paola Barboro, Noelia Cabaleiro , et al. · 2018

Silver nanoparticles (AgNPs) have been incorporated into several consumer products. While these advances in technology are promising and exciting, the effects of these nanoparticles have not equally been studied. Due to the size, AgNPs can…

A Liquid Tunable Microscope as a New Paradigm in Optical Microscopy to Paint 4D Chromatin Organisation in the Cell Nucleus Open

Alberto Diaspro, Isotta Cainero, Luca Lanzanò, Paolo Bianchini, Giuseppe Vicidomini , et al. · 2018

Adaptive phenotype drives resistance to androgen deprivation therapy in prostate cancer Open

Nicoletta Ferrari, Ilaria Granata, Matteo Capaia, Marina Piccirillo, Mario Rosario Guarracino , et al. · 2017

Our models suggest that environmental factors and epigenetic modulation can activate processes of phenotypic adaptation driving drug-resistance. The identified key proteins of these adaptive phenotypes could be eligible targets for innovat…

Targeting androgen-independent pathways: new chances for patients with prostate cancer? Open

Carlo Cattrini, Elisa Zanardi, Giacomo Vallome, Alessia Cavo, Luigi Cerbone , et al. · 2017

A combined proteomics and metabolomics approach to assess the effects of gold nanoparticles in vitro Open

Sabrina Gioria, Joana Lobo Vicente, Paola Barboro, Rita La Spina, Giorgio Tomasi , et al. · 2016

Omics technologies, such as proteomics or metabolomics, have to date been applied in the field of nanomaterial safety assessment to a limited extent. To address this dearth, we developed an integrated approach combining the two techniques …

A combined proteomics and metabolomics approach to assess the effects of gold nanoparticlesin vitro Open

Sabrina Gioria, Joana Lobo Vicente, Paola Barboro, Rita La Spina, Giorgio Tomasi , et al. · 2015

Omics technologies, such as proteomics or metabolomics, have to date been applied in the field of nanomaterial safety assessment to a limited extent. To address this dearth, we developed an integrated approach combining the two techniques …

Expression of nuclear matrix proteins binding matrix attachment regions in prostate cancer. PARP‐1: New player in tumor progression Open

Paola Barboro, Nicoletta Ferrari, Matteo Capaia, Andrea Petretto, Sandra Salvi , et al. · 2015

Prostate cancer (PCa) displays infrequent point mutations, whereas genomic rearrangements are highly prevalent. In eukaryotes, the genome is compartmentalized into chromatin loop domains by the attachment to the nuclear matrix (NM), and it…

A combined proteomics and metabolomics approach to assess the effects of gold nanoparticles in vitro. Open

Sabrina Gioria, Paola Barboro, Patricia Urbán, Agnieszka Kinsner‐Ovaskainen, François Rossi , et al. · 2015

Omics technologies, such as proteomics or metabolomics, have to date been applied in the field of nanomaterial safety assessment to a limited extent. To address this dearth, we developed an integrated approach combining the two techniques …

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