Paola Bontempo
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View article: Editor’s Note: RIP1–HAT1–SIRT Complex Identification and Targeting in Treatment and Prevention of Cancer
Editor’s Note: RIP1–HAT1–SIRT Complex Identification and Targeting in Treatment and Prevention of Cancer Open
View article: Correlation between clinical and sonographic assessment of the fetal head station in the second stage of labor: a prospective observational study
Correlation between clinical and sonographic assessment of the fetal head station in the second stage of labor: a prospective observational study Open
Findings from our study show a moderate-to-fair correlation between clinical and sonographic head station. An agreement between clinical and sonographic diagnosis of head station occurs in less than one-in-three cases overall and particula…
View article: Standardization of the sonographic measurement of the head to perineum distance: A pilot study comparing techniques with and without perineal compression
Standardization of the sonographic measurement of the head to perineum distance: A pilot study comparing techniques with and without perineal compression Open
In this pilot study, we developed a regression model using restricted cubic splines to convert between both HPD measurements. BMI did not seem to significantly influence the relationship between the two HPD measurements, suggesting the mod…
View article: Synergistic Effects of a Novel Combination of Natural Compounds Prevent H2O2-Induced Oxidative Stress in Red Blood Cells
Synergistic Effects of a Novel Combination of Natural Compounds Prevent H2O2-Induced Oxidative Stress in Red Blood Cells Open
Novel strategies to prevent the “storage lesions” of red blood cells (RBCs) are needed to prevent the risk of adverse effects after blood transfusion. One option could be the supplementation of stored blood bags with natural compounds that…
View article: Epigallocatechin Gallate (EGCG): Pharmacological Properties, Biological Activities and Therapeutic Potential
Epigallocatechin Gallate (EGCG): Pharmacological Properties, Biological Activities and Therapeutic Potential Open
Epigallocatechin gallate (EGCG), the predominant catechin in green tea, comprises approximately 50% of its total polyphenol content and has garnered widespread recognition for its significant therapeutic potential. As the principal bioacti…
View article: Vacuum extraction is successful in 95% of cases with an occiput posterior position: the results of a prospective, multicenter study
Vacuum extraction is successful in 95% of cases with an occiput posterior position: the results of a prospective, multicenter study Open
View article: Editorial Expression of Concern: Tumor-selective action of HDAC inhibitors involves TRAIL induction in acute myeloid leukemia cells
Editorial Expression of Concern: Tumor-selective action of HDAC inhibitors involves TRAIL induction in acute myeloid leukemia cells Open
View article: Health-Promoting Effects, Phytochemical Constituents and Molecular Genetic Profile of the Purple Carrot ‘Purple Sun’ (Daucus carota L.)
Health-Promoting Effects, Phytochemical Constituents and Molecular Genetic Profile of the Purple Carrot ‘Purple Sun’ (Daucus carota L.) Open
The purple carrot cultivar ‘Purple Sun’ (Daucus carota L.) is characterized by a relevant content of phenolic compounds and anthocyanins, which may play an important role in reducing the risk of chronic diseases and in the treatment of met…
View article: Therapeutic Potential of Natural Compounds Acting through Epigenetic Mechanisms in Cardiovascular Diseases: Current Findings and Future Directions
Therapeutic Potential of Natural Compounds Acting through Epigenetic Mechanisms in Cardiovascular Diseases: Current Findings and Future Directions Open
Cardiovascular diseases (CVDs) remain a leading global cause of morbidity and mortality. These diseases have a multifaceted nature being influenced by a multitude of biochemical, genetic, environmental, and behavioral factors. Epigenetic m…
View article: Phytochemical Characterization, Antioxidant, and Anti-Proliferative Activities of Wild and Cultivated Nigella damascena Species Collected in Sicily (Italy)
Phytochemical Characterization, Antioxidant, and Anti-Proliferative Activities of Wild and Cultivated Nigella damascena Species Collected in Sicily (Italy) Open
The use of Nigella damascena seeds in the culinary field or as aerial parts infusions in the pharmaceutical and cosmetic fields is widely reported. The biological activity of this plant, as demonstrated over the years, is closely related t…
View article: OP01.02: Does fetal occiput position affect the ultrasonographic prediction of vaginal delivery in prolonged second stage of labour?
OP01.02: Does fetal occiput position affect the ultrasonographic prediction of vaginal delivery in prolonged second stage of labour? Open
To investigate whether head–perineum distance (HPD) and angle of progression (AoP) measured by transperineal ultrasound are predictive of vaginal delivery in women with prolonged second stage of labour according to fetal occiput position. …
View article: EP25.06: Clinical and sonographic characteristics and outcome of vacuum extractions in occiput posterior fetuses: a retrospective cohort study
EP25.06: Clinical and sonographic characteristics and outcome of vacuum extractions in occiput posterior fetuses: a retrospective cohort study Open
Objectives: Accurate prediction of the time to delivery (TTD) is an important clinical significance in the obstetric field.The objective of this study is to predict the time to delivery through the rate of increase in angle of progress wit…
View article: EP25.10: Description of the sonographic pattern of head descent on the mid‐sagittal plane in relation to the fetal occiput position: a quantitative approach
EP25.10: Description of the sonographic pattern of head descent on the mid‐sagittal plane in relation to the fetal occiput position: a quantitative approach Open
the surrounding colour Doppler flow imaging (CDFI) signals were noted.The entire process of CEUS was recorded in real-time, the imaging models of the lesion were continuously observed for 2-3 min, and the imaging process was stored on a ha…
View article: SIRT1 activation promotes energy homeostasis and reprograms liver cancer metabolism
SIRT1 activation promotes energy homeostasis and reprograms liver cancer metabolism Open
View article: Prediction of persistent occiput posterior position by sonographic assessment of fetal head attitude at start of second stage of labor: prospective study
Prediction of persistent occiput posterior position by sonographic assessment of fetal head attitude at start of second stage of labor: prospective study Open
Objectives To evaluate the relationship between the attitude of the fetal head quantified by means of the chin‐to‐chest angle (CCA) in fetuses in occiput posterior (OP) position at the beginning of the second stage of labor, and persistent…
View article: SIRT1 activation promotes energy homeostasis and reprograms liver cancer metabolism
SIRT1 activation promotes energy homeostasis and reprograms liver cancer metabolism Open
Background Cancer cells are characterized by uncontrolled cell proliferation and impaired bioenergetics. Sirtuins are a family of highly conserved enzymes that play a fundamental role in energy metabolism regulation. SIRT1, in particular, …
View article: Functional Properties of Natural Products and Human Health
Functional Properties of Natural Products and Human Health Open
Natural products (NPs), broadly defined as chemicals produced by living organisms including microbes, marine organisms, animals, fungi and plants, are widely used as therapeutic agents for treating diseases and maintaining health and “well…
View article: Sirtuin Inhibitor Cambinol Induces Cell Differentiation and Differently Interferes with SIRT1 and 2 at the Substrate Binding Site
Sirtuin Inhibitor Cambinol Induces Cell Differentiation and Differently Interferes with SIRT1 and 2 at the Substrate Binding Site Open
Epigenetic mechanisms finely regulate gene expression and represent potential therapeutic targets. Cambinol is a synthetic heterocyclic compound that inhibits class III histone deacetylases known as sirtuins (SIRTs). The acetylating action…
View article: Data from RIP1–HAT1–SIRT Complex Identification and Targeting in Treatment and Prevention of Cancer
Data from RIP1–HAT1–SIRT Complex Identification and Targeting in Treatment and Prevention of Cancer Open
Purpose: Alteration in cell death is a hallmark of cancer. A functional role regulating survival, apoptosis, and necroptosis has been attributed to RIP1/3 complexes.Experimental Design: We have investigated the role of RIP1 a…
View article: Supplementary Tables from RIP1–HAT1–SIRT Complex Identification and Targeting in Treatment and Prevention of Cancer
Supplementary Tables from RIP1–HAT1–SIRT Complex Identification and Targeting in Treatment and Prevention of Cancer Open
Supplementary Tables
View article: On line Materials and Methods from RIP1–HAT1–SIRT Complex Identification and Targeting in Treatment and Prevention of Cancer
On line Materials and Methods from RIP1–HAT1–SIRT Complex Identification and Targeting in Treatment and Prevention of Cancer Open
On line Materials and Methods
View article: On line Materials and Methods from RIP1–HAT1–SIRT Complex Identification and Targeting in Treatment and Prevention of Cancer
On line Materials and Methods from RIP1–HAT1–SIRT Complex Identification and Targeting in Treatment and Prevention of Cancer Open
On line Materials and Methods
View article: Supplementary note from RIP1–HAT1–SIRT Complex Identification and Targeting in Treatment and Prevention of Cancer
Supplementary note from RIP1–HAT1–SIRT Complex Identification and Targeting in Treatment and Prevention of Cancer Open
supplementary chemistry
View article: Supplementary note from RIP1–HAT1–SIRT Complex Identification and Targeting in Treatment and Prevention of Cancer
Supplementary note from RIP1–HAT1–SIRT Complex Identification and Targeting in Treatment and Prevention of Cancer Open
supplementary chemistry
View article: Supplementary Figures from RIP1–HAT1–SIRT Complex Identification and Targeting in Treatment and Prevention of Cancer
Supplementary Figures from RIP1–HAT1–SIRT Complex Identification and Targeting in Treatment and Prevention of Cancer Open
Supplementary Figures
View article: Data from RIP1–HAT1–SIRT Complex Identification and Targeting in Treatment and Prevention of Cancer
Data from RIP1–HAT1–SIRT Complex Identification and Targeting in Treatment and Prevention of Cancer Open
Purpose: Alteration in cell death is a hallmark of cancer. A functional role regulating survival, apoptosis, and necroptosis has been attributed to RIP1/3 complexes.Experimental Design: We have investigated the role of RIP1 a…
View article: Supplementary Figures from RIP1–HAT1–SIRT Complex Identification and Targeting in Treatment and Prevention of Cancer
Supplementary Figures from RIP1–HAT1–SIRT Complex Identification and Targeting in Treatment and Prevention of Cancer Open
Supplementary Figures
View article: Supplementary Tables from RIP1–HAT1–SIRT Complex Identification and Targeting in Treatment and Prevention of Cancer
Supplementary Tables from RIP1–HAT1–SIRT Complex Identification and Targeting in Treatment and Prevention of Cancer Open
Supplementary Tables
View article: Chemical Composition of Thymus leucotrichus var. creticus Essential Oil and Its Protective Effects on Both Damage and Oxidative Stress in Leptodictyum riparium Hedw. Induced by Cadmium
Chemical Composition of Thymus leucotrichus var. creticus Essential Oil and Its Protective Effects on Both Damage and Oxidative Stress in Leptodictyum riparium Hedw. Induced by Cadmium Open
The chemical profile of the essential oil (EO) of the aerial parts of Thymus leucotrichus var. creticus (Lamiaceae), a taxon not previously studied, was investigated by GC–MS analysis, using a DB–Wax polar column. Oxygenated monoterpenes a…
View article: Association Between Circulating CD4+ T Cell Methylation Signatures of Network-Oriented SOCS3 Gene and Hemodynamics in Patients Suffering Pulmonary Arterial Hypertension
Association Between Circulating CD4+ T Cell Methylation Signatures of Network-Oriented SOCS3 Gene and Hemodynamics in Patients Suffering Pulmonary Arterial Hypertension Open
Pathogenic DNA methylation changes may be involved in pulmonary arterial hypertension (PAH) onset and its progression, but there is no data on potential associations with patient-derived hemodynamic parameters. The reduced representation b…