Paola Borgia
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View article: Diagnosis, Treatment, and Follow-Up of Tracheo/Bronchomalacia in Children: The Italian Multicenter Experience
Diagnosis, Treatment, and Follow-Up of Tracheo/Bronchomalacia in Children: The Italian Multicenter Experience Open
Background: In pediatric age, the central airways are more flexible and mobile, with tracheal and bronchial walls easily tending to collapse, allowing partial or complete occlusion of the lumen: a situation described as tracheobronchomalac…
View article: Tracheo/Bronchomalacia in Children: Clinical Presentation, Diagnostic Tests, Surgical Treatments, Follow Up and Respiratory Assistance
Tracheo/Bronchomalacia in Children: Clinical Presentation, Diagnostic Tests, Surgical Treatments, Follow Up and Respiratory Assistance Open
Background: In pediatric age, the central airways are more flexible and mobile, with tracheal and bronchial walls easly tending to collapse, allowing partial or complete occlusion of the lumen: a situation described as tracheobronchomalaci…
View article: Primary Lung Tumors in Children: Insights from a Single-Center Case Series
Primary Lung Tumors in Children: Insights from a Single-Center Case Series Open
Background: Primary lung tumors in pediatric patients are rare, predominantly malignant, and present diagnostic challenges due to symptom overlap with more common conditions such as inflammatory processes or asthma. Evidence-based approach…
View article: Dermatologic Effects of Selumetinib in Pediatric Patients with Neurofibromatosis Type 1: Clinical Challenges and Therapeutic Management
Dermatologic Effects of Selumetinib in Pediatric Patients with Neurofibromatosis Type 1: Clinical Challenges and Therapeutic Management Open
Background: Plexiform neurofibromas (pNFs) are benign neoplasms, primarily originating from Schwann cells, posing challenges in patients with type 1 neurofibromatosis (NF1) due to pain, disfigurement, compression of vital structures and po…
View article: Histopathologic features of selumetinib‐induced paronychia in a child with neurofibromatosis type 1
Histopathologic features of selumetinib‐induced paronychia in a child with neurofibromatosis type 1 Open
We report a 4‐year‐old girl developing therapy refractory paronychia induced by selumetinib, an oral selective inhibitor of mitogen‐activated protein kinase 1/2 prescribed for a large submandibular plexiform neurofibroma. Although this cut…
View article: Changes in the Use of Antibiotics for Methicillin-Resistant Staphylococcus aureus Bloodstream Infections in Children: A 5-Year Retrospective, Single Center Study
Changes in the Use of Antibiotics for Methicillin-Resistant Staphylococcus aureus Bloodstream Infections in Children: A 5-Year Retrospective, Single Center Study Open
Monitoring antibiotic use in the pediatric population is a challenge, especially when determining a relationship between specific pathogens, infections, and antibiotic use. We retrospectively analyzed the consumption of anti-methicillin-re…
View article: Chemotherapy-associated paronychia: Do not forget the children
Chemotherapy-associated paronychia: Do not forget the children Open
View article: Genotype–phenotype correlations and disease mechanisms in PEX13-related Zellweger spectrum disorders
Genotype–phenotype correlations and disease mechanisms in PEX13-related Zellweger spectrum disorders Open
View article: A sharply marginated erythematous dermatitis in a toddler
A sharply marginated erythematous dermatitis in a toddler Open
A 33-month-old boy was referred for a 2-month history of a diffuse rash, unsuccessfully treated with oral dexamethasone and fluconazole. He was delivered at term with normal birthweight. His immunizations were up-to-date. According to his …
View article: My White Orchids
My White Orchids Open
This poem is dedicated to Nella (fictional name) who recently died at age 50 from a glioblastoma. During the last months of her life, she had frequent episodes of memory loss. One day she told me: "I'm used to observing my white orchids ev…
View article: Kidney Involvement in PSTPIP1 Associated Inflammatory Diseases (PAID): A Case Report and Review of the Literature
Kidney Involvement in PSTPIP1 Associated Inflammatory Diseases (PAID): A Case Report and Review of the Literature Open
Pyogenic arthritis, pyoderma gangrenosum and acne (PAPA) syndrome, and the proline-serine-threonine phosphatase-interacting protein 1 (PSTPIP1)-associated myeloid-related proteinemia inflammatory (PAMI) syndrome are two distinct clinical c…
View article: Lo iodio nell’alimentazione dell’età evolutiva
Lo iodio nell’alimentazione dell’età evolutiva Open
View article: Neuromuscular and Neuroendocrinological Features Associated With ZC4H2-Related Arthrogryposis Multiplex Congenita in a Sicilian Family: A Case Report
Neuromuscular and Neuroendocrinological Features Associated With ZC4H2-Related Arthrogryposis Multiplex Congenita in a Sicilian Family: A Case Report Open
Wieacker-Wolff syndrome (WWS) is an X-linked Arthrogryposis Multiplex Congenita (AMC) disorder associated with broad neurodevelopmental impairment. The genetic basis of WWS lies in hemizygous pathogenic variants in ZC4H2 , encoding a C4H2 …
View article: “Thyroid nodular disease and PTEN mutation in a multicentre series of children with PTEN hamartoma tumor syndrome (PHTS)”
“Thyroid nodular disease and PTEN mutation in a multicentre series of children with PTEN hamartoma tumor syndrome (PHTS)” Open
Purpose To report the incidence of 4–12% of differentiated thyroid cancer (DTC) and up to 50% of benign thyroid nodular disease and to describe nodular thyroid disease in a multicentre pediatric population with PTEN mutations. Methods: Ret…
View article: Update on the Classification and Pathophysiological Mechanisms of Pediatric Cardiorenal Syndromes
Update on the Classification and Pathophysiological Mechanisms of Pediatric Cardiorenal Syndromes Open
Cardiorenal syndrome (CRS) is defined as a disorder resulting from the abnormal interaction between the heart and kidney, in which acute or chronic dysfunction of one organ may lead to acute and/or chronic dysfunction of the other. The fun…