Paola Castillo
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View article: Cancer stem cell biomarkers in locally advanced head and neck squamous cell carcinoma
Cancer stem cell biomarkers in locally advanced head and neck squamous cell carcinoma Open
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View article: Understanding anatomy of dermoscopy of melanocytic skin tumors: correlation in vivo with line-field optical coherence tomography
Understanding anatomy of dermoscopy of melanocytic skin tumors: correlation in vivo with line-field optical coherence tomography Open
View article: A pilot study evaluating the 3D morphology of melanocytic lesions with LC-OCT and correlating findings to histopathology and RCM
A pilot study evaluating the 3D morphology of melanocytic lesions with LC-OCT and correlating findings to histopathology and RCM Open
View article: Melanocytic Clefting Observed Using LC-OCT
Melanocytic Clefting Observed Using LC-OCT Open
View article: Criteria for melanocytic lesions in LC-OCT
Criteria for melanocytic lesions in LC-OCT Open
View article: First detection of V410L kdr mutation in Aedes aegypti populations of Argentina and its correlation with the toxicological evidence
First detection of V410L kdr mutation in Aedes aegypti populations of Argentina and its correlation with the toxicological evidence Open
BACKGROUND Aedes aegypti (L.) is the main vector of dengue, yellow fever, Zika and chikungunya viruses in many parts of the world impacting millions of people worldwide each year. Insecticide-based interventions have been effective in cont…
View article: Cutaneous Adverse Reactions to Apalutamide: Case Series with Clinical and Pathological Correlations
Cutaneous Adverse Reactions to Apalutamide: Case Series with Clinical and Pathological Correlations Open
is missing (Short communication)
View article: Walking one hour per day and the derived neutrophil-to-lymphocyte ratio are associated with outcome in palliative second-line immunotherapy for patients with recurrent and/or metastatic squamous cell carcinoma of head and neck
Walking one hour per day and the derived neutrophil-to-lymphocyte ratio are associated with outcome in palliative second-line immunotherapy for patients with recurrent and/or metastatic squamous cell carcinoma of head and neck Open
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View article: First detection of V410L kdr mutation in Aedes aegypti populations of Argentina supported by toxicological evidence
First detection of V410L kdr mutation in Aedes aegypti populations of Argentina supported by toxicological evidence Open
View article: Perianal Basal Cell Carcinoma: A Diagnostic Challenge
Perianal Basal Cell Carcinoma: A Diagnostic Challenge Open
View article: Feasibility and Impact of Embedding an Extended DNA and RNA Tissue-Based Sequencing Panel for the Routine Care of Patients with Advanced Melanoma in Spain
Feasibility and Impact of Embedding an Extended DNA and RNA Tissue-Based Sequencing Panel for the Routine Care of Patients with Advanced Melanoma in Spain Open
Targeted NGS allows a fast and efficient multi-gene analysis and the detection of key gene aberrations in melanoma. In this study, we aim to describe the genetic alterations in a series of 87 melanoma cases using the oncomine focus assay (…
View article: Combined WNT-activated deep-penetrating/plexiform melanocytoma: insights into clinicopathological and molecular characterization
Combined WNT-activated deep-penetrating/plexiform melanocytoma: insights into clinicopathological and molecular characterization Open
Background A combined deep-penetrating tumour redefined as WNT-activated deep-penetrating/plexiform melanocytoma (DPM), may pose challenging clinical and histological diagnoses. Objectives To review the clinicopathological characteristics …
View article: Spanish cohort of VEXAS syndrome: clinical manifestations, outcome of treatments and novel evidences about UBA1 mosaicism
Spanish cohort of VEXAS syndrome: clinical manifestations, outcome of treatments and novel evidences about UBA1 mosaicism Open
Thirty patients with adult-onset AID were definitively diagnosed with VEXAS syndrome through genetic analyses. Despite minor interindividual differences, their main characteristics were in concordance with previous reports. We detected for…
View article: Margin control of lentigo maligna with <scp>SOX10</scp>‐frozen section immunostaining: A case series
Margin control of lentigo maligna with <span>SOX10</span>‐frozen section immunostaining: A case series Open
Mohs micrographic surgery is associated with an improved overall survival rate in patients with melanoma of the head and neck.1 However, visualizing melanocytes on frozen sections may be challenging. Although permanent section analyses are…
View article: Isolated bone marrow amyloid light chain amyloidosis coexisting with multiple myeloma
Isolated bone marrow amyloid light chain amyloidosis coexisting with multiple myeloma Open
A 62-year-old woman was diagnosed with Bence-Jones protein multiple myeloma in another hospital. She referred sternum pain and a clavicle fracture. Nuclear magnetic resonance showed multiple lytic lesions in clavicle, rib, vertebra, humeru…
View article: Correction to: Recommendations for the use of biomarkers for head and neck cancer, including salivary gland tumours: a consensus of the Spanish Society of Medical Oncology and the Spanish Society of Pathology
Correction to: Recommendations for the use of biomarkers for head and neck cancer, including salivary gland tumours: a consensus of the Spanish Society of Medical Oncology and the Spanish Society of Pathology Open
View article: A Xanthomatous Eruption in a Patient with Jaundice and Constitutional Symptoms
A Xanthomatous Eruption in a Patient with Jaundice and Constitutional Symptoms Open
View article: Recommendations for the use of biomarkers for head and neck cancer, including salivary gland tumours: a consensus of the Spanish Society of Medical Oncology and the Spanish Society of Pathology
Recommendations for the use of biomarkers for head and neck cancer, including salivary gland tumours: a consensus of the Spanish Society of Medical Oncology and the Spanish Society of Pathology Open
View article: Sinonasal mucosal melanomas: defining profiles for better survival outcomes
Sinonasal mucosal melanomas: defining profiles for better survival outcomes Open
Background: Sinonasal mucosal melanoma is an aggressive malignancy with a 5-year survival rate ranging from 20% to 39%. Despite the evolving surgical and radiotherapy techniques, and introduction of immune-checkpoint inhibitor therapy, ove…
View article: First report of CART treatment in AL amyloidosis and relapsed/refractory multiple myeloma
First report of CART treatment in AL amyloidosis and relapsed/refractory multiple myeloma Open
Multiple myeloma (MM) remains incurable despite the number of novel therapies that have become available in recent years. Occasionally, a patient with MM will develop an amyloid light-chain (AL) amyloidosis with organ dysfunction. Chimeric…
View article: Accuracy of liquid-based brush cytology and HPV detection for the diagnosis and management of patients with oropharyngeal and oral cancer
Accuracy of liquid-based brush cytology and HPV detection for the diagnosis and management of patients with oropharyngeal and oral cancer Open
Objectives This study aims to evaluate the usefulness of liquid-based brush cytology for malignancy diagnosis and HPV detection in patients with suspected oropharyngeal and oral carcinomas, as well as for the diagnosis of tumoral persisten…
View article: First Description of <scp>Late‐Onset</scp> Autoinflammatory Disease Due to Somatic <scp><i>NLRC4</i></scp> Mosaicism
First Description of <span>Late‐Onset</span> Autoinflammatory Disease Due to Somatic <span><i>NLRC4</i></span> Mosaicism Open
Objective Autoinflammatory diseases are inherited disorders of innate immunity that usually start during childhood. However, several recent reports have described an increasing number of patients with autoinflammatory disease starting in a…
View article: Minimally Invasive Tissue Sampling Findings in 12 Patients With Coronavirus Disease 2019
Minimally Invasive Tissue Sampling Findings in 12 Patients With Coronavirus Disease 2019 Open
Background Minimally invasive tissue sampling (MITS), a postmortem procedure that uses core needle biopsy samples and does not require opening the body, may be a valid alternative to complete autopsy (CA) in highly infectious diseases such…
View article: Transoral laser microsurgery in locally advanced laryngeal cancer: Prognostic impact of anterior versus posterior compartments
Transoral laser microsurgery in locally advanced laryngeal cancer: Prognostic impact of anterior versus posterior compartments Open
Background To evaluate the importance of larynx compartments in the prognosis of T3‐T4a laryngeal cancer treated with transoral laser microsurgery. Methods Two hundred and two consecutive pT3‐T4a larynx carcinomas. Pre‐epiglottic space inv…
View article: Molecular Markers and Targets in Melanoma
Molecular Markers and Targets in Melanoma Open
Melanoma develops as a result of several genetic alterations, with UV radiation often acting as a mutagenic risk factor. Deep knowledge of the molecular signaling pathways of different types of melanoma allows better characterization and p…
View article: High within-host diversity found from direct genotyping on post-mortem tuberculosis specimens in a high-burden setting
High within-host diversity found from direct genotyping on post-mortem tuberculosis specimens in a high-burden setting Open
Direct MTB genotyping from post-mortem tissue samples revealed a frequent within-host Mycobacterium tuberculosis diversity, including mixed and polyclonal infections. Most of this diversity would have been overlooked if only standard analy…
View article: Limitations to current methods to estimate cause of death: a validation study of a verbal autopsy model
Limitations to current methods to estimate cause of death: a validation study of a verbal autopsy model Open
Background: Accurate information on causes of death (CoD) is essential to estimate burden of disease, track global progress, prioritize cost-effective interventions, and inform policies to reduce mortality. In low-income settings, where a …
View article: High prevalence and mortality due to Histoplasma capsulatum in the Brazilian Amazon: An autopsy study
High prevalence and mortality due to Histoplasma capsulatum in the Brazilian Amazon: An autopsy study Open
Background Histoplasmosis is acquired by inhalation of spores of the dimorphic fungus Histoplasma spp . Although this pathogen is distributed worldwide, it is more prevalent in the Americas. However, the real burden of histoplasmosis remai…
View article: Minimally Invasive Autopsy Practice in COVID-19 Cases: Biosafety and Findings
Minimally Invasive Autopsy Practice in COVID-19 Cases: Biosafety and Findings Open
Postmortem studies are crucial for providing insight into emergent diseases. However, a complete autopsy is frequently not feasible in highly transmissible diseases due to biohazard challenges. Minimally invasive autopsy (MIA) is a needle-…
View article: Succinate Pathway in Head and Neck Squamous Cell Carcinoma: Potential as a Diagnostic and Prognostic Marker
Succinate Pathway in Head and Neck Squamous Cell Carcinoma: Potential as a Diagnostic and Prognostic Marker Open
Head and neck squamous cell carcinoma (HNSCC) is characterized by high rates of mortality and treatment-related morbidity, underscoring the urgent need for innovative and safe treatment strategies and diagnosis practices. Mitochondrial dys…