Paola Coccetti
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View article: Modulating the serine metabolism in human differentiated astrocytes: an integrated multi omics approach
Modulating the serine metabolism in human differentiated astrocytes: an integrated multi omics approach Open
Introduction Astrocytes are the major source of L-serine (L-Ser) in the brain: the glycolytic intermediate D-3-phosphoglycerate is converted into L-Ser through the phosphorylated pathway (PP) made up of three enzymes, phosphoglycerate dehy…
View article: NF-κB-mediated cytokine secretion and glutamate metabolic reprogramming converge in breast cancer brain tropism
NF-κB-mediated cytokine secretion and glutamate metabolic reprogramming converge in breast cancer brain tropism Open
Brain metastases are an increasingly common and life-threatening complication of breast cancer. Here, we report that breast cancer cells with a propensity for cerebral colonization (BrM cells) display a distinct imbalance in the NF-κB path…
View article: Exploring c arbon s ource r elated l ocalization and p hosphorylation in the Snf1/Mig1 n etwork using p opulation and s ingle c ell-based a pproaches
Exploring c arbon s ource r elated l ocalization and p hosphorylation in the Snf1/Mig1 n etwork using p opulation and s ingle c ell-based a pproaches Open
The AMPK/SNF1 pathway governs energy balance in eukaryotic cells, notably influencing glucose de-repression. In S. cerevisiae , Snf1 is phosphorylated and hence activated upon glucose depletion. This activation is required but is not suffi…
View article: Exploiting Natural Niches with Neuroprotective Properties: A Comprehensive Review
Exploiting Natural Niches with Neuroprotective Properties: A Comprehensive Review Open
Natural products from mushrooms, plants, microalgae, and cyanobacteria have been intensively explored and studied for their preventive or therapeutic potential. Among age-related pathologies, neurodegenerative diseases (such as Alzheimer’s…
View article: Exploring Influence of Production Area and Harvest Time on Specialized Metabolite Content of Glycyrrhiza glabra Leaves and Evaluation of Antioxidant and Anti-Aging Properties
Exploring Influence of Production Area and Harvest Time on Specialized Metabolite Content of Glycyrrhiza glabra Leaves and Evaluation of Antioxidant and Anti-Aging Properties Open
Calabrian Glycyrrhiza glabra is one of the most appreciated licorice varieties worldwide, and its leaves are emerging as a valuable source of bioactive compounds. Nevertheless, this biomass is usually discarded, and its valorization could …
View article: Serine metabolism during differentiation of human <scp>iPSC</scp>‐derived astrocytes
Serine metabolism during differentiation of human <span>iPSC</span>‐derived astrocytes Open
Astrocytes are essential players in development and functions, being particularly relevant as regulators of brain energy metabolism, ionic homeostasis and synaptic transmission. They are also the major source of l ‐serine in the brain, whi…
View article: Industrial Production of Proteins with Pichia pastoris—Komagataella phaffii
Industrial Production of Proteins with Pichia pastoris—Komagataella phaffii Open
Since the mid-1960s, methylotrophic yeast Komagataella phaffii (previously described as Pichia pastoris) has received increasing scientific attention. The interest for the industrial production of proteins for different applications (e.g.,…
View article: Snf1/AMPK fine-tunes TORC1 signaling in response to glucose starvation
Snf1/AMPK fine-tunes TORC1 signaling in response to glucose starvation Open
The AMP-activated protein kinase (AMPK) and the target of rapamycin complex 1 (TORC1) are central kinase modules of two opposing signaling pathways that control eukaryotic cell growth and metabolism in response to the availability of energ…
View article: Author response: Snf1/AMPK fine-tunes TORC1 signaling in response to glucose starvation
Author response: Snf1/AMPK fine-tunes TORC1 signaling in response to glucose starvation Open
status: Published
View article: Snf1/AMPK fine-tunes TORC1 signaling in response to glucose starvation
Snf1/AMPK fine-tunes TORC1 signaling in response to glucose starvation Open
The AMP-activated protein kinase (AMPK) and the target of rapamycin complex 1 (TORC1) are central kinase modules of two opposing signaling pathways that control eukaryotic cell growth and metabolism in response to the availability of energ…
View article: Anti-Aging and Neuroprotective Properties of Grifola frondosa and Hericium erinaceus Extracts
Anti-Aging and Neuroprotective Properties of Grifola frondosa and Hericium erinaceus Extracts Open
Nutrition has relevant consequences for human health and increasing pieces of evidence indicate that medicinal mushrooms have several beneficial effects. One of the main issues in Western countries is represented by the challenges of aging…
View article: AMPK Phosphorylation Is Controlled by Glucose Transport Rate in a PKA-Independent Manner
AMPK Phosphorylation Is Controlled by Glucose Transport Rate in a PKA-Independent Manner Open
To achieve growth, microbial organisms must cope with stresses and adapt to the environment, exploiting the available nutrients with the highest efficiency. In Saccharomyces cerevisiae, Ras/PKA and Snf1/AMPK pathways regulate cellular meta…
View article: Methionine Supplementation Affects Metabolism and Reduces Tumor Aggressiveness in Liver Cancer Cells
Methionine Supplementation Affects Metabolism and Reduces Tumor Aggressiveness in Liver Cancer Cells Open
Liver cancer is one of the most common cancer worldwide with a high mortality. Methionine is an essential amino acid required for normal development and cell growth, is mainly metabolized in the liver, and its role as an anti-cancer supple…
View article: Protective effect of <i>Vigna unguiculata</i> extract against aging and neurodegeneration
Protective effect of <i>Vigna unguiculata</i> extract against aging and neurodegeneration Open
Aging and age-related neurodegeneration are among the major challenges in modern medicine because of the progressive increase in the number of elderly in the world population. Nutrition, which has important long-term consequences for healt…
View article: The Regulatory Role of Key Metabolites in the Control of Cell Signaling
The Regulatory Role of Key Metabolites in the Control of Cell Signaling Open
Robust biological systems are able to adapt to internal and environmental perturbations. This is ensured by a thick crosstalk between metabolism and signal transduction pathways, through which cell cycle progression, cell metabolism and gr…
View article: Conventional and emerging roles of the energy sensor Snf1/AMPK in Saccharomyces cerevisiae
Conventional and emerging roles of the energy sensor Snf1/AMPK in Saccharomyces cerevisiae Open
All proliferating cells need to match metabolism, growth and cell cycle progression with nutrient availability to guarantee cell viability in spite of a changing environment. In yeast, a signaling pathway centered on the effector kinase Sn…
View article: Synthesis and biological evaluation of new 3-amino-2-azetidinone derivatives as anti-colorectal cancer agents
Synthesis and biological evaluation of new 3-amino-2-azetidinone derivatives as anti-colorectal cancer agents Open
Several synthetic combretastatin A4 (CA-4) derivatives were recently prepared to increase the drug efficacy and stability of the natural product isolated from the South African tree Combretum caffrum.
View article: Azole resistance in a Candida albicans mutant lacking the ABC transporter CDR6/ROA1 depends on TOR signaling
Azole resistance in a Candida albicans mutant lacking the ABC transporter CDR6/ROA1 depends on TOR signaling Open
ATP-binding cassette (ABC) transporters help export various substrates across the cell membrane and significantly contribute to drug resistance. However, a recent study reported an unusual case in which the loss of an ABC transporter in Ca…