Paola Di Donato
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View article: Characterization of two GH10 enzymes with ability to hydrolyze pretreated Sorghum bicolor bagasse
Characterization of two GH10 enzymes with ability to hydrolyze pretreated Sorghum bicolor bagasse Open
In this study, we characterized two novel enzymes of the glycoside hydrolase family 10 (GH10), Xyl10 C and Xyl10E, identified in the termite gut microbiome. The activities of both enzymes were assayed using beechwood xylan, barley β-glucan…
View article: Soft bottom benthic communities under potentially anthropic and natural pressures in Terra Nova Bay (Ross Sea, Antarctica)
Soft bottom benthic communities under potentially anthropic and natural pressures in Terra Nova Bay (Ross Sea, Antarctica) Open
Benthic communities have a key function in the Antarctic marine ecosystem since they play a central role in the food web pathway and represent the main “environmental biological memory”. The goal of the study is to evaluate differences in …
View article: Physico-Chemical Properties and Valorization of Biopolymers Derived from Food Processing Waste
Physico-Chemical Properties and Valorization of Biopolymers Derived from Food Processing Waste Open
The widespread use of synthetic plastics, as well as the waste produced at the end of their life cycle, poses serious environmental issues. In this context, bio-based plastics, i.e., natural polymers produced from renewable resources, repr…
View article: Inhibition of Enzymes Involved in Neurodegenerative Disorders and Aβ1–40 Aggregation by Citrus limon Peel Polyphenol Extract
Inhibition of Enzymes Involved in Neurodegenerative Disorders and Aβ1–40 Aggregation by Citrus limon Peel Polyphenol Extract Open
Alzheimer’s (AD) and Parkinson’s diseases (PD) are multifactorial neurogenerative disorders of the Central Nervous System causing severe cognitive and motor deficits in elderly people. Because treatment of AD and PD by synthetic drugs alle…
View article: Exploring the Development of Astrobiology Scientific Research through Bibliometric Network Analysis: A Focus on Biomining and Bioleaching
Exploring the Development of Astrobiology Scientific Research through Bibliometric Network Analysis: A Focus on Biomining and Bioleaching Open
Our understanding of the diversity of life on our planet and the possibility of finding or sustaining life elsewhere in the universe plays a central role in supporting human space settlement and exploration. Astrobiology and its outcomes r…
View article: Exploring the Development of Astrobiology Scientific Research Through Bibliometric Network Analysis: A Focus on Biomining and Bioleaching
Exploring the Development of Astrobiology Scientific Research Through Bibliometric Network Analysis: A Focus on Biomining and Bioleaching Open
Our understanding of the diversity of life on our planet and the possibility of finding or sustaining life elsewhere in the universe plays a central role in supporting human space settling and exploration. Astrobiology and its outcomes req…
View article: Approaches for the sustainable management of the Apulian coastal areas: the potential of a geoportal
Approaches for the sustainable management of the Apulian coastal areas: the potential of a geoportal Open
In order to identify the most suitable strategies and to support territorial decision- making processes, it is necessary to operate with an integrated vision of coastal systems, considering the complex phenomena of sediment production, ero…
View article: Thermophilic bacteria and their thermozymes in composting processes: a review
Thermophilic bacteria and their thermozymes in composting processes: a review Open
In this review, the composting process of organic waste is discussed through an in-depth exploring of its thermophilic phase. It starts with the highlight on the thermodynamic evolution, which needs to be assessed when deciding to use reac…
View article: Revealing Angiopep-2/LRP1 Molecular Interaction for Optimal Delivery to Glioblastoma (GBM)
Revealing Angiopep-2/LRP1 Molecular Interaction for Optimal Delivery to Glioblastoma (GBM) Open
Background: The family of synthetic peptide angiopeps, and particularly angiopep-2 (ANG-2) demonstrated the ability preclinically and clinically to shuttle active molecules across the blood–brain barrier (BBB) and selectively toward brain …
View article: Extremophilic Microorganisms for the Green Synthesis of Antibacterial Nanoparticles
Extremophilic Microorganisms for the Green Synthesis of Antibacterial Nanoparticles Open
The biogenic synthesis of nanomaterials, i.e., synthesis carried out by means of living organisms, is an emerging technique in nanotechnology since it represents a greener and more eco-friendly method for the production of nanomaterials. I…
View article: Outcomes in AB0 Incompatible Living Donor Kidney Transplantation: A Case – Control Study
Outcomes in AB0 Incompatible Living Donor Kidney Transplantation: A Case – Control Study Open
Background Patients waiting for a kidney transplant by far exceed available organs. AB0 incompatible living donor kidney transplantation (AB0i LDKT) represents an additional therapeutic strategy, but with higher risk for complications. We …
View article: Effects of Ionizing Radiation and Long-Term Storage on Hydrated vs. Dried Cell Samples of Extremophilic Microorganisms
Effects of Ionizing Radiation and Long-Term Storage on Hydrated vs. Dried Cell Samples of Extremophilic Microorganisms Open
A main factor hampering life in space is represented by high atomic number nuclei and energy (HZE) ions that constitute about 1% of the galactic cosmic rays. In the frame of the “STARLIFE” project, we accessed the Heavy Ion Medical Acceler…
View article: Antarctic Special Protected Area 161 as a Reference to Assess the Effects of Anthropogenic and Natural Impacts on Meiobenthic Assemblages
Antarctic Special Protected Area 161 as a Reference to Assess the Effects of Anthropogenic and Natural Impacts on Meiobenthic Assemblages Open
The Antarctic region is usually considered a pristine area. Nevertheless, regional warming effects and increasing human activities, including the presence of several research stations, are inducing considerable environmental changes that m…
View article: Inhibition of Interleukin-6-Induced Matrix Metalloproteinase-2 Expression and Invasive Ability of Lemon Peel Polyphenol Extract in Human Primary Colon Cancer Cells
Inhibition of Interleukin-6-Induced Matrix Metalloproteinase-2 Expression and Invasive Ability of Lemon Peel Polyphenol Extract in Human Primary Colon Cancer Cells Open
Among matrix metalloproteinases (MMPs), MMP-9/2 are key enzymes involved in the proteolysis of extracellular matrices in the inflammatory process and in cancer. Since MMP-9/2 expression levels, activity, and secretion is up-regulated durin…
View article: Biomass Valorization: Sustainable Methods for the Production of Hemicellulolytic Catalysts from Thermoanaerobacterium thermostercoris strain BUFF
Biomass Valorization: Sustainable Methods for the Production of Hemicellulolytic Catalysts from Thermoanaerobacterium thermostercoris strain BUFF Open
Processing and selection of fruits and vegetables generate high quantities of wastes that represent an economic and environmental issue for the agroindustry sector. According to the so-called “biorefinery” approach, this biomass can be exp…
View article: How Poloxamer Addition in Hyaluronic-Acid-Decorated Biodegradable Microparticles Affects Polymer Degradation and Protein Release Kinetics
How Poloxamer Addition in Hyaluronic-Acid-Decorated Biodegradable Microparticles Affects Polymer Degradation and Protein Release Kinetics Open
Polymeric microparticles (MPs) designed for the intravitreal administration of therapeutic proteins result in a prolonged half-life in the vitreous and can delay or discourage the onset of adverse effects inevitably related to this route o…
View article: Catching the Main Ethiopian Rift Evolving Towards Plate Divergence
Catching the Main Ethiopian Rift Evolving Towards Plate Divergence Open
Magmatism accompanies rifting along divergent plate boundaries, although its role before continental breakup remains poorly understood. For example, the magma-assisted Northern Main Ethiopian Rift (NMER) lacks current volcanism and clear t…
View article: Transcript Regulation of the Recoded Archaeal α-l-Fucosidase In Vivo
Transcript Regulation of the Recoded Archaeal α-l-Fucosidase In Vivo Open
Genetic decoding is flexible, due to programmed deviation of the ribosomes from standard translational rules, globally termed “recoding”. In Archaea, recoding has been unequivocally determined only for termination codon readthrough events …
View article: Novel Psychrophiles and Exopolymers from Permafrost Thaw Lake Sediments
Novel Psychrophiles and Exopolymers from Permafrost Thaw Lake Sediments Open
Thermokarst lakes are one of the most abundant types of microbial ecosystems in the circumpolar North. These shallow basins are formed by the thawing and collapse of ice-rich permafrost, with subsequent filling by snow and ice melt. Until …
View article: Hetero-exopolysaccharide from the extremely halophilic Halomonas smyrnensis K2: production, characterization and functional properties in vitro
Hetero-exopolysaccharide from the extremely halophilic Halomonas smyrnensis K2: production, characterization and functional properties in vitro Open
View article: Graphene-Based and Surface-Enhanced Raman Spectroscopy for Monitoring the Physio-Chemical Response of Thermophilic Bacterial Spores to Low Temperatures Exposure
Graphene-Based and Surface-Enhanced Raman Spectroscopy for Monitoring the Physio-Chemical Response of Thermophilic Bacterial Spores to Low Temperatures Exposure Open
Monitoring the spore life cycle is one of the main issues in several fields including environmental control, sustainable ecosystems, food security, and healthcare systems. In this framework, the study of the living organism resistance to e…
View article: The Italian National Project of Astrobiology—Life in Space—Origin, Presence, Persistence of Life in Space, from Molecules to Extremophiles
The Italian National Project of Astrobiology—Life in Space—Origin, Presence, Persistence of Life in Space, from Molecules to Extremophiles Open
The Italian National Project of Astrobiology—Life in Space—Origin, Presence, Persistence of Life in Space, from Molecules to Extremophiles
View article: Tuning Functional Behavior of Humic Acids through Interactions with Stöber Silica Nanoparticles
Tuning Functional Behavior of Humic Acids through Interactions with Stöber Silica Nanoparticles Open
Humic acids (HA) exhibit fascinating multifunctional features, yet degradation phenomena as well as poor stability in aqueous environments strongly limit their use. Inorganic nanoparticles are emerging as a powerful interface for the devel…
View article: Lemon Peel Polyphenol Extract Reduces Interleukin-6-Induced Cell Migration, Invasiveness, and Matrix Metalloproteinase-9/2 Expression in Human Gastric Adenocarcinoma MKN-28 and AGS Cell Lines
Lemon Peel Polyphenol Extract Reduces Interleukin-6-Induced Cell Migration, Invasiveness, and Matrix Metalloproteinase-9/2 Expression in Human Gastric Adenocarcinoma MKN-28 and AGS Cell Lines Open
Among plant polyphenols, lemon peels extract (LPE) from the residues of the industrial processing of lemon (Citrus limon) shows anti-proliferative properties in cancer cells and anticholinesterase activity. In this study, we analyze the an…
View article: Bioprospecting of exopolysaccharide-producing bacteria from different natural ecosystems for biopolymer synthesis from vinasse
Bioprospecting of exopolysaccharide-producing bacteria from different natural ecosystems for biopolymer synthesis from vinasse Open
Background Exopolysaccharides (EPSs) belong to a family of organic thickeners or alternative hydrocolloids of microbial origin. Because the chemical structure offers beneficial bioactive functions, biocompatibility and biodegradability, EP…
View article: Titanium based complexes with melanin precursors as a tool for directing melanogenic pathways
Titanium based complexes with melanin precursors as a tool for directing melanogenic pathways Open
Bioinspired melanin based hybrid materials hold huge promise for developing multifunctional systems for a considerable set of applications. Yet, control of melanogenic pathway is a big challenge to allow rational design of nanostructured s…
View article: Parageobacillus thermantarcticus, an Antarctic Cell Factory: From Crop Residue Valorization by Green Chemistry to Astrobiology Studies
Parageobacillus thermantarcticus, an Antarctic Cell Factory: From Crop Residue Valorization by Green Chemistry to Astrobiology Studies Open
Knowledge of Antarctic habitat biodiversity, both marine and terrestrial, has increased considerably in recent years, causing considerable development in the studies of life science related to Antarctica. In the Austral summer 1986–1987, a…
View article: Exploring Marine Environments for the Identification of Extremophiles and Their Enzymes for Sustainable and Green Bioprocesses
Exploring Marine Environments for the Identification of Extremophiles and Their Enzymes for Sustainable and Green Bioprocesses Open
Sea environments harbor a wide variety of life forms that have adapted to live in hard and sometimes extreme conditions. Among the marine living organisms, extremophiles represent a group of microorganisms that attract increasing interest …
View article: Production and Biotechnological Potential of Extracellular Polymeric Substances from Sponge-Associated Antarctic Bacteria
Production and Biotechnological Potential of Extracellular Polymeric Substances from Sponge-Associated Antarctic Bacteria Open
Four sponge-associated Antarctic bacteria (i.e., Winogradskyella sp. strains CAL384 and CAL396, Colwellia sp. strain GW185, and Shewanella sp. strain CAL606) were selected for the highly mucous appearance of their colonies on agar plates. …
View article: Pb2+ Effects on Growth, Lipids, and Protein and DNA Profiles of the Thermophilic Bacterium Thermus Thermophilus
Pb2+ Effects on Growth, Lipids, and Protein and DNA Profiles of the Thermophilic Bacterium Thermus Thermophilus Open
Extremophiles are organisms able to thrive in extreme environmental conditions and some of them show the ability to survive high doses of heavy metals thanks to defensive mechanisms provided by primary and secondary metabolic products, i.e…