Paola Tononi
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View article: Kinetics of circulating multiple myeloma cells (CMMCs) in patients undergoing standard-of-care anti-BCMA chimeric antigen receptor T cell therapy for Relapsed/Refractory multiple myeloma
Kinetics of circulating multiple myeloma cells (CMMCs) in patients undergoing standard-of-care anti-BCMA chimeric antigen receptor T cell therapy for Relapsed/Refractory multiple myeloma Open
Chimeric antigen receptor (CAR) T cell therapies against B-cell Maturation Antigen (BCMA) are a highly effective therapy in patients with relapsed/refractory multiple myeloma. However, assessing response in the early period after cell infu…
View article: 25P Genomic ground truth for AI-based image classification of CELLSEARCH® circulating multiple myeloma cells
25P Genomic ground truth for AI-based image classification of CELLSEARCH® circulating multiple myeloma cells Open
View article: Circulating Multiple Myeloma Cells (CMMCs) as Prognostic and Predictive Markers in Multiple Myeloma and Smouldering MM Patients
Circulating Multiple Myeloma Cells (CMMCs) as Prognostic and Predictive Markers in Multiple Myeloma and Smouldering MM Patients Open
In recent years, liquid biopsy has emerged as a promising alternative to the bone marrow (BM) examination, since it is a minimally invasive technique allowing serial monitoring. Circulating multiple myeloma cells (CMMCs) enumerated using C…
View article: Cellular and transcriptional responses of SH-SY5Y human neurocytes following in vitro exposure to Gelsemium sempervirens
Cellular and transcriptional responses of SH-SY5Y human neurocytes following in vitro exposure to Gelsemium sempervirens Open
Background: Gelsemium sempervirens (Gelsemium s.) is a highly toxic plant but is employed at low doses and/or high dilutions as an anxiolytic and antidepressant. Previous investigations in our laboratory [1,2] have shown a significant anxi…
View article: Genetic Characterization of Cancer of Unknown Primary Using Liquid Biopsy Approaches
Genetic Characterization of Cancer of Unknown Primary Using Liquid Biopsy Approaches Open
Cancers of unknown primary (CUPs) comprise a heterogeneous group of rare metastatic tumors whose primary site cannot be identified after extensive clinical–pathological investigations. CUP patients are generally treated with empirical chem…
View article: Whole-Transcriptome Analysis Unveils the Synchronized Activities of Genes for Fructans in Developing Tubers of the Jerusalem Artichoke
Whole-Transcriptome Analysis Unveils the Synchronized Activities of Genes for Fructans in Developing Tubers of the Jerusalem Artichoke Open
Helianthus tuberosus L., known as the Jerusalem artichoke, is a hexaploid plant species, adapted to low-nutrient soils, that accumulates high levels of inulin in its tubers. Inulin is a fructose-based polysaccharide used either as d…
View article: Precise detection of genomic imbalances at single-cell resolution reveals intra-patient heterogeneity in Hodgkin’s lymphoma
Precise detection of genomic imbalances at single-cell resolution reveals intra-patient heterogeneity in Hodgkin’s lymphoma Open
View article: A chromosome-anchored eggplant genome sequence reveals key events in Solanaceae evolution
A chromosome-anchored eggplant genome sequence reveals key events in Solanaceae evolution Open
View article: A streamlined workflow for single-cells genome-wide copy-number profiling by low-pass sequencing of LM-PCR whole-genome amplification products
A streamlined workflow for single-cells genome-wide copy-number profiling by low-pass sequencing of LM-PCR whole-genome amplification products Open
Chromosomal instability and associated chromosomal aberrations are hallmarks of cancer and play a critical role in disease progression and development of resistance to drugs. Single-cell genome analysis has gained interest in latest years …
View article: Whole-genome sequencing and SNV genotyping of ‘Nebbiolo’ (Vitis vinifera L.) clones
Whole-genome sequencing and SNV genotyping of ‘Nebbiolo’ (Vitis vinifera L.) clones Open
View article: Interference with ethylene perception at receptor level sheds light on auxin and transcriptional circuits associated with the climacteric ripening of apple fruit (<i>Malus x domestica</i> Borkh.)
Interference with ethylene perception at receptor level sheds light on auxin and transcriptional circuits associated with the climacteric ripening of apple fruit (<i>Malus x domestica</i> Borkh.) Open
Summary Apple ( Malus x domestica Borkh.) is a model species for studying the metabolic changes that occur at the onset of ripening in fruit crops, and the physiological mechanisms that are governed by the hormone ethylene. In this study, …
View article: Physical Mapping of Bread Wheat Chromosome 5A: An Integrated Approach
Physical Mapping of Bread Wheat Chromosome 5A: An Integrated Approach Open
The huge size, redundancy, and highly repetitive nature of the bread wheat [ Triticum aestivum (L.)] genome, makes it among the most difficult species to be sequenced. To overcome these limitations, a strategy based on the separation of in…
View article: DNA methylation and gene expression profiles show novel regulatory pathways in hepatocellular carcinoma
DNA methylation and gene expression profiles show novel regulatory pathways in hepatocellular carcinoma Open
View article: 'OMICS' AND CHEMICAL APPROACHES USED TO MONITOR IRON-DEFICIENCY IN CITRUS ROOTSTOCKS
'OMICS' AND CHEMICAL APPROACHES USED TO MONITOR IRON-DEFICIENCY IN CITRUS ROOTSTOCKS Open
Two different 'omics' approaches were performed to a better comprehension of biological mechanisms involved in citrus iron (Fe) deficiency. Tips roots from Swingle citrumelo and Carrizo citrange (sensitive and tolerant rootstocks, respecti…