Paolo Ciana
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View article: Metabolic reprogramming and altered ATP content impair neuroprotective functions of microglia in β-glucocerebrosidase deficiency models
Metabolic reprogramming and altered ATP content impair neuroprotective functions of microglia in β-glucocerebrosidase deficiency models Open
Mutations in the GBA gene, which reduce β-glucocerebrosidase (GCase) activity, represent the most significant genetic risk factor for Parkinson’s disease (PD). Decreased GCase activity has also been observed in sporadic PD cases, supportin…
View article: Editor’s Note: RIP1–HAT1–SIRT Complex Identification and Targeting in Treatment and Prevention of Cancer
Editor’s Note: RIP1–HAT1–SIRT Complex Identification and Targeting in Treatment and Prevention of Cancer Open
View article: Metabolic reprogramming and altered ATP content impair neuroprotective functions of microglia in β-glucocerebrosidase deficiency models
Metabolic reprogramming and altered ATP content impair neuroprotective functions of microglia in β-glucocerebrosidase deficiency models Open
Mutations in the GBA gene, which reduce β-glucocerebrosidase (GCase) activity, represent the most significant genetic risk factor for Parkinson’s disease (PD). Decreased GCase activity has also been observed in sporadic PD cases, supportin…
View article: MyoRep: a novel reporter system to detect early muscle atrophy <i>in vitro</i> and <i>in vivo</i>
MyoRep: a novel reporter system to detect early muscle atrophy <i>in vitro</i> and <i>in vivo</i> Open
Muscle atrophy occurs during physiological (i.e., fasting, aging) and pathological (i.e., amyotrophic lateral sclerosis, cancer) conditions and anticipates death. Since not all patients will undergo muscle wasting, it would be highly usefu…
View article: A Novel Approach for In Vitro Testing and Hazard Evaluation of Nanoformulated RyR2-Targeting siRNA Drugs Using Human PBMCs
A Novel Approach for In Vitro Testing and Hazard Evaluation of Nanoformulated RyR2-Targeting siRNA Drugs Using Human PBMCs Open
Nucleic acid (NA)-based drugs are promising therapeutics agents. Beyond efficacy, addressing safety concerns—particularly those specific to this class of drugs—is crucial. Here, we propose an in vitro approach to screen for potential adver…
View article: Isolation of Tumour‐Derived Extracellular Vesicles From the Plasma of Dogs Affected by Intracranial Tumours Showing Heterologous and Cross‐Species Tropism: A Pilot Study
Isolation of Tumour‐Derived Extracellular Vesicles From the Plasma of Dogs Affected by Intracranial Tumours Showing Heterologous and Cross‐Species Tropism: A Pilot Study Open
Canine and human brain tumours exhibit similar incidence rates and prognoses. Recent studies have demonstrated that extracellular vesicles derived from human patients (PDEVs) can be loaded with contrast agents and exhibit tumour tropism in…
View article: Discovery and characterization of a new class of NAD+-independent SIRT1 activators
Discovery and characterization of a new class of NAD+-independent SIRT1 activators Open
View article: Design and validation of a reporter mouse to study the dynamic regulation of TFEB and TFE3 activity through <i>in vivo</i> imaging techniques
Design and validation of a reporter mouse to study the dynamic regulation of TFEB and TFE3 activity through <i>in vivo</i> imaging techniques Open
TFEB and TFE3 belong to the MiT/TFE family of transcription factors that bind identical DNA responsive elements in the regulatory regions of target genes. They are involved in regulating lysosomal biogenesis, function, exocytosis, autophag…
View article: Canine glioblastoma-derived extracellular vesicles as precise carriers for glioblastoma imaging: Targeting across the blood-brain barrier
Canine glioblastoma-derived extracellular vesicles as precise carriers for glioblastoma imaging: Targeting across the blood-brain barrier Open
The treatment of glioblastoma (GBM) faces significant challenges due to the difficulty of delivering drugs through the blood-brain barrier (BBB). Extracellular vesicles (EVs) have emerged as potential carriers for targeted drug delivery to…
View article: ERα-independent NRF2-mediated immunoregulatory activity of tamoxifen
ERα-independent NRF2-mediated immunoregulatory activity of tamoxifen Open
Background and Purpose: Sex differences in immune-mediated diseases are linked to the activity of estrogens on innate immunity cells, including macrophages. Tamoxifen (TAM) is a selective estrogen receptor modulator (SERM) used in estrogen…
View article: Preclinical pharmacology of patient-derived extracellular vesicles for the intraoperative imaging of tumors
Preclinical pharmacology of patient-derived extracellular vesicles for the intraoperative imaging of tumors Open
Extracellular vesicles (EVs) derived from the plasma of oncological patients exhibit significant tumor-targeting properties, unlike those from healthy individuals. We have previously shown the feasibility of formulating the near-infrared (…
View article: Discovery and Characterization of a New Class of NAD,sup&gt; -Independent SIRT1 Activators
Discovery and Characterization of a New Class of NAD,sup> -Independent SIRT1 Activators Open
View article: Data from RIP1–HAT1–SIRT Complex Identification and Targeting in Treatment and Prevention of Cancer
Data from RIP1–HAT1–SIRT Complex Identification and Targeting in Treatment and Prevention of Cancer Open
Purpose: Alteration in cell death is a hallmark of cancer. A functional role regulating survival, apoptosis, and necroptosis has been attributed to RIP1/3 complexes.Experimental Design: We have investigated the role of RIP1 a…
View article: Supplementary Tables from RIP1–HAT1–SIRT Complex Identification and Targeting in Treatment and Prevention of Cancer
Supplementary Tables from RIP1–HAT1–SIRT Complex Identification and Targeting in Treatment and Prevention of Cancer Open
Supplementary Tables
View article: On line Materials and Methods from RIP1–HAT1–SIRT Complex Identification and Targeting in Treatment and Prevention of Cancer
On line Materials and Methods from RIP1–HAT1–SIRT Complex Identification and Targeting in Treatment and Prevention of Cancer Open
On line Materials and Methods
View article: On line Materials and Methods from RIP1–HAT1–SIRT Complex Identification and Targeting in Treatment and Prevention of Cancer
On line Materials and Methods from RIP1–HAT1–SIRT Complex Identification and Targeting in Treatment and Prevention of Cancer Open
On line Materials and Methods
View article: Supplementary note from RIP1–HAT1–SIRT Complex Identification and Targeting in Treatment and Prevention of Cancer
Supplementary note from RIP1–HAT1–SIRT Complex Identification and Targeting in Treatment and Prevention of Cancer Open
supplementary chemistry
View article: Supplementary note from RIP1–HAT1–SIRT Complex Identification and Targeting in Treatment and Prevention of Cancer
Supplementary note from RIP1–HAT1–SIRT Complex Identification and Targeting in Treatment and Prevention of Cancer Open
supplementary chemistry
View article: Supplementary Figures from RIP1–HAT1–SIRT Complex Identification and Targeting in Treatment and Prevention of Cancer
Supplementary Figures from RIP1–HAT1–SIRT Complex Identification and Targeting in Treatment and Prevention of Cancer Open
Supplementary Figures
View article: Data from RIP1–HAT1–SIRT Complex Identification and Targeting in Treatment and Prevention of Cancer
Data from RIP1–HAT1–SIRT Complex Identification and Targeting in Treatment and Prevention of Cancer Open
Purpose: Alteration in cell death is a hallmark of cancer. A functional role regulating survival, apoptosis, and necroptosis has been attributed to RIP1/3 complexes.Experimental Design: We have investigated the role of RIP1 a…
View article: Supplementary Figures from RIP1–HAT1–SIRT Complex Identification and Targeting in Treatment and Prevention of Cancer
Supplementary Figures from RIP1–HAT1–SIRT Complex Identification and Targeting in Treatment and Prevention of Cancer Open
Supplementary Figures
View article: Supplementary Tables from RIP1–HAT1–SIRT Complex Identification and Targeting in Treatment and Prevention of Cancer
Supplementary Tables from RIP1–HAT1–SIRT Complex Identification and Targeting in Treatment and Prevention of Cancer Open
Supplementary Tables
View article: Sex-Specific Microglial Responses to Glucocerebrosidase Inhibition: Relevance to GBA1-Linked Parkinson’s Disease
Sex-Specific Microglial Responses to Glucocerebrosidase Inhibition: Relevance to GBA1-Linked Parkinson’s Disease Open
Microglia are heterogenous cells characterized by distinct populations each contributing to specific biological processes in the nervous system, including neuroprotection. To elucidate the impact of sex-specific microglia heterogenicity to…
View article: Increased Sensitivity of Computed Tomography Scan for Neoplastic Tissues Using the Extracellular Vesicle Formulation of the Contrast Agent Iohexol
Increased Sensitivity of Computed Tomography Scan for Neoplastic Tissues Using the Extracellular Vesicle Formulation of the Contrast Agent Iohexol Open
Computed tomography (CT) is a diagnostic medical imaging modality commonly used to detect disease and injury. Contrast agents containing iodine, such as iohexol, are frequently used in CT examinations to more clearly differentiate anatomic…
View article: Sex-specific microglial responses to glucocerebrosidase inhibition: relevance to GBA1-linked Parkinson disease
Sex-specific microglial responses to glucocerebrosidase inhibition: relevance to GBA1-linked Parkinson disease Open
Microglia are heterogenous cells characterized by distinct populations each contributing to specific biological processes in the nervous system, including neuroprotection. To elucidate the impact of sex-specific microglia heterogenicity to…
View article: Sex-specific microglial responses to glucocerebrosidase inhibition
Sex-specific microglial responses to glucocerebrosidase inhibition Open
Morpho-dynamic analysis occurring in primary cells derived from female and male mice in response to proinflammatory stimulations and glucocerebrosidase inhibition. The work was supported by the EU Joint Programme - Neurodegenerative Diseas…
View article: Sex-specific microglial responses to glucocerebrosidase inhibition
Sex-specific microglial responses to glucocerebrosidase inhibition Open
Morpho-dynamic analysis occurring in primary cells derived from female and male mice in response to proinflammatory stimulations and glucocerebrosidase inhibition. The work was supported by the EU Joint Programme - Neurodegenerative Diseas…
View article: Indocyanine Green Fluorescence-Guided Surgery for Gastrointestinal Tumors: A Systematic Review
Indocyanine Green Fluorescence-Guided Surgery for Gastrointestinal Tumors: A Systematic Review Open
Objective: To conduct a systematic review of the currently available literature on the use of ICG to guide surgical dissection in gastrointestinal (GI) cancer surgery. Background: Real-time indocyanine green (ICG) fluorescence-guided surge…
View article: Infrared and Raman spectroscopy for purity assessment of extracellular vesicles
Infrared and Raman spectroscopy for purity assessment of extracellular vesicles Open
Extracellular vesicles (EVs) are a complex and heterogeneous population of nanoparticles involved in cell-to-cell communication. Recently, numerous studies have indicated the potential of EVs as therapeutic agents, drug carriers and diagno…
View article: The Use of ERE-Luc Reporter Mice to Monitor Estrogen Receptor Transcriptional Activity in a Spatio-Temporal Dimension
The Use of ERE-Luc Reporter Mice to Monitor Estrogen Receptor Transcriptional Activity in a Spatio-Temporal Dimension Open