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EV-mediated asymmetrical crosstalk between CAFs and cancer cells in the tumor microenvironment Open

Alice Santi, Annalisa Moccia, Anna Caselli, Paolo Cirri · 2025

Tumor is a complex tissue composed of both genetically transformed cancer cells and the cells of the tumor microenvironment, including connective cells, immune cells, and endothelial cells that actively contribute to the maintenance of the…

Limiting serine availability during tumor progression promotes muscle wasting in cancer cachexia Open

Erica Pranzini, Livio Muccillo, Ilaria Nesi, Alice Santi, Caterina Mancini , et al. · 2024

Targeting of tumor cells by custom antigen transfer: a novel approach for immunotherapy of cancer Open

Ilaria Nesi, Chiara Della Bella, Maria Letizia Taddei, Alice Santi, Erica Pranzini , et al. · 2023

In the early stages of carcinogenesis, the transformed cells become “invisible” to the immune system. From this moment on, the evolution of the tumor depends essentially on the genotype of the primitive cancer cells and their subsequent ge…

Supplementary Figure 3 from Reciprocal Metabolic Reprogramming through Lactate Shuttle Coordinately Influences Tumor-Stroma Interplay Open

Tania Fiaschi, Alberto Marini, Elisa Giannoni, Maria Letizia Taddei, Paolo Gandellini , et al. · 2023

PDF file - 385K, 8.Lactate up-load by HPFs and PCa-AFs; 10000 HPFs were treated with serum-free medium or with CM-PCa for 24 hours (PCa-AFs). U-14Clactate were added to the culture media for 30 minutes, then cells were lysated and incorpor…

Data from Reciprocal Metabolic Reprogramming through Lactate Shuttle Coordinately Influences Tumor-Stroma Interplay Open

Tania Fiaschi, Alberto Marini, Elisa Giannoni, Maria Letizia Taddei, Paolo Gandellini , et al. · 2023

Cancer-associated fibroblasts (CAF) engage in tumor progression by promoting the ability of cancer cells to undergo epithelial–mesenchymal transition (EMT), and also by enhancing stem cells traits and metastatic dissemination. Here we show…

Supplementary Table 1 from Reciprocal Metabolic Reprogramming through Lactate Shuttle Coordinately Influences Tumor-Stroma Interplay Open

Tania Fiaschi, Alberto Marini, Elisa Giannoni, Maria Letizia Taddei, Paolo Gandellini , et al. · 2023

PDF file - 3MB, Pathological parameters of individuals from which CAFs have isolated; CAFs have been isolated from surgical biopsy from nine individuals with prostate carcinoma. Table reports the pathological parameters of the patients bef…

Data from Reciprocal Metabolic Reprogramming through Lactate Shuttle Coordinately Influences Tumor-Stroma Interplay Open

Tania Fiaschi, Alberto Marini, Elisa Giannoni, Maria Letizia Taddei, Paolo Gandellini , et al. · 2023

Cancer-associated fibroblasts (CAF) engage in tumor progression by promoting the ability of cancer cells to undergo epithelial–mesenchymal transition (EMT), and also by enhancing stem cells traits and metastatic dissemination. Here we show…

Supplementary Figure 1 from Reciprocal Metabolic Reprogramming through Lactate Shuttle Coordinately Influences Tumor-Stroma Interplay Open

Tania Fiaschi, Alberto Marini, Elisa Giannoni, Maria Letizia Taddei, Paolo Gandellini , et al. · 2023

PDF file - 54K, The Biochemical Recurrence (BCR) free survival was estimated using the Kaplan-Meier method; In figure is represented the BCR free survival curve of patients treated with Radical Prostatectomy for Prostate Cancer. Among all,…

Supplementary Figure 1 from Reciprocal Metabolic Reprogramming through Lactate Shuttle Coordinately Influences Tumor-Stroma Interplay Open

Tania Fiaschi, Alberto Marini, Elisa Giannoni, Maria Letizia Taddei, Paolo Gandellini , et al. · 2023

PDF file - 54K, The Biochemical Recurrence (BCR) free survival was estimated using the Kaplan-Meier method; In figure is represented the BCR free survival curve of patients treated with Radical Prostatectomy for Prostate Cancer. Among all,…

Supplementary Table 1 from Reciprocal Metabolic Reprogramming through Lactate Shuttle Coordinately Influences Tumor-Stroma Interplay Open

Tania Fiaschi, Alberto Marini, Elisa Giannoni, Maria Letizia Taddei, Paolo Gandellini , et al. · 2023

PDF file - 3MB, Pathological parameters of individuals from which CAFs have isolated; CAFs have been isolated from surgical biopsy from nine individuals with prostate carcinoma. Table reports the pathological parameters of the patients bef…

Supplementary Figure 2 from Reciprocal Metabolic Reprogramming through Lactate Shuttle Coordinately Influences Tumor-Stroma Interplay Open

Tania Fiaschi, Alberto Marini, Elisa Giannoni, Maria Letizia Taddei, Paolo Gandellini , et al. · 2023

PDF file - 3.3K, Enrichment of glycolitic enzymes among genes up-regulated in prostatic CAFs; Gene expression profiles were analyzed using an Illumina microarray platform (unpublished data) on paired CAFs and HPFs isolated respectively fro…

Supplementary Figure 3 from Reciprocal Metabolic Reprogramming through Lactate Shuttle Coordinately Influences Tumor-Stroma Interplay Open

Tania Fiaschi, Alberto Marini, Elisa Giannoni, Maria Letizia Taddei, Paolo Gandellini , et al. · 2023

PDF file - 385K, 8.Lactate up-load by HPFs and PCa-AFs; 10000 HPFs were treated with serum-free medium or with CM-PCa for 24 hours (PCa-AFs). U-14Clactate were added to the culture media for 30 minutes, then cells were lysated and incorpor…

Supplementary Figure 2 from Reciprocal Metabolic Reprogramming through Lactate Shuttle Coordinately Influences Tumor-Stroma Interplay Open

Tania Fiaschi, Alberto Marini, Elisa Giannoni, Maria Letizia Taddei, Paolo Gandellini , et al. · 2023

PDF file - 3.3K, Enrichment of glycolitic enzymes among genes up-regulated in prostatic CAFs; Gene expression profiles were analyzed using an Illumina microarray platform (unpublished data) on paired CAFs and HPFs isolated respectively fro…

Supplementary Figure 4 from Reciprocal Metabolic Reprogramming through Lactate Shuttle Coordinately Influences Tumor-Stroma Interplay Open

Tania Fiaschi, Alberto Marini, Elisa Giannoni, Maria Letizia Taddei, Paolo Gandellini , et al. · 2023

PDF file - 818K, MCT1 transporter is important for PCa cell growth; A) MCT1 transporter is up-regulated in PCa cells. PCa cells were cultivated alone or in co-colture with CAFs (3:1 CAFs:PCa cells proportion). Cells were then treated with …

Supplementary Figure 4 from Reciprocal Metabolic Reprogramming through Lactate Shuttle Coordinately Influences Tumor-Stroma Interplay Open

Tania Fiaschi, Alberto Marini, Elisa Giannoni, Maria Letizia Taddei, Paolo Gandellini , et al. · 2023

PDF file - 818K, MCT1 transporter is important for PCa cell growth; A) MCT1 transporter is up-regulated in PCa cells. PCa cells were cultivated alone or in co-colture with CAFs (3:1 CAFs:PCa cells proportion). Cells were then treated with …

Immunological Targeting of Tumor Cells: A Novel Approach Open

Ilaria Nesi, Chiara Della Bella, Maria Letizia Taddei, Alice Santi, Erica Pranzini , et al. · 2023

Therapy-Induced Stromal Senescence Promoting Aggressiveness of Prostate and Ovarian Cancer Open

Elisa Pardella, Erica Pranzini, Ilaria Nesi, Matteo Parri, Pietro Spatafora , et al. · 2022

Cancer progression is supported by the cross-talk between tumor cells and the surrounding stroma. In this context, senescent cells in the tumor microenvironment contribute to the development of a pro-inflammatory milieu and the acquisition…

SHMT2-mediated mitochondrial serine metabolism drives 5-FU resistance by fueling nucleotide biosynthesis Open

Erica Pranzini, Elisa Pardella, Livio Muccillo, Angela Leo, Ilaria Nesi , et al. · 2022

Differential impact of cold and hot tea extracts on tyrosine phosphatases regulating insulin receptor activity: a focus on PTP1B and LMW-PTP Open

Massimo Genovese, Simone Luti, Elisa Pardella, Mirella Vivoli, Luigia Pazzagli , et al. · 2022

Claisened Hexafluoro Inhibits Metastatic Spreading of Amoeboid Melanoma Cells Open

Angela Leo, Erica Pranzini, Laura Pietrovito, Elisa Pardella, Matteo Parri , et al. · 2021

Metastatic melanoma is characterized by poor prognosis and a low free-survival rate. Thanks to their high plasticity, melanoma cells are able to migrate exploiting different cell motility strategies, such as the rounded/amoeboid-type motil…

Activated fibroblasts enhance cancer cell migration by microvesicles-mediated transfer of Galectin-1 Open

Alessandra Toti, Alice Santi, Elisa Pardella, Ilaria Nesi, Richard Tomasini , et al. · 2021

Cancer-associated fibroblasts (CAFs) are one of the main components of the stromal compartment in the tumor microenvironment (TME) and the crosstalk between CAFs and cancer cells is essential for tumor progression and aggressiveness. Cance…

Metabolic cell communication within tumour microenvironment: models, methods and perspectives Open

Matteo Parri, Luigi Ippolito, Paolo Cirri, Matteo Ramazzotti, Paola Chiarugi · 2020

PreImplantation Factor immunohistochemical expression correlates with prostate cancer aggressiveness Open

Maria Rosaria Raspollini, Ilaria Montagnani, Paolo Cirri, Gianna Baroni, Alessia Cimadamore , et al. · 2020

Background: The PreImplantation Factor (PIF)—a peptide secreted by viable embryos—exerts autotrophic protective effects, promotes endometrial receptivity and controls trophoblast invasion. Synthetic PIF (sPIF) has both immune-protective an…

Nutritional Exchanges Within Tumor Microenvironment: Impact for Cancer Aggressiveness Open

Giuseppina Comito, Luigi Ippolito, Paola Chiarugi, Paolo Cirri · 2020

Neoplastic tissues are composed not only by tumor cells but also by several non-transformed stromal cells, such as cancer-associated fibroblasts, endothelial and immune cells, that actively participate to tumor progression. Starting from t…

miR‐210‐3p mediates metabolic adaptation and sustains DNA damage repair of resistant colon cancer cells to treatment with 5‐fluorouracil Open

Erica Pranzini, Angela Leo, Elena Rapizzi, Matteo Ramazzotti, Francesca Magherini , et al. · 2019

Chemoresistance is the primary cause of chemotherapy failure. Compelling evidence shows that micro RNAs (miRNAs) contribute to reprogram cancer cells toward a resistant phenotype. We investigate the role of miRNAs in the response to acute …

Honey extracts inhibit PTP1B, upregulate insulin receptor expression, and enhance glucose uptake in human HepG2 cells Open

Giulia Lori, Lorenzo Cecchi, Nádia Mulinacci, F Melani, Anna Caselli , et al. · 2019

Honey is a food known for its medical properties. In this work, we have studied the impact of different types of honey on insulin signalling pathway. We found that honey extracts inhibit the enzyme PTP1B, one of the main negative regulator…

Targeting <span>LMW</span>‐<span>PTP</span> to sensitize melanoma cancer cells toward chemo‐ and radiotherapy Open

Giulia Lori, Paolo Paoli, Anna Caselli, Paolo Cirri, Riccardo Marzocchini , et al. · 2018

Tumor resistance to apoptosis is one the main causes of anticancer treatment failure. Previous studies showed that LMW ‐ PTP overexpression enhances resistance of cancer cells to traditional anticancer drugs. Today, the role of LMW ‐ PTP i…

Modeled Microgravity Affects Fibroblast Functions Related to Wound Healing Open

Francesca Cialdai, Leonardo Vignali, Lucia Morbidelli, Alessandra Colciago, F. Celotti , et al. · 2017

Morin: A Promising Natural Drug Open

Anna Caselli, Paolo Cirri, Alice Santi, Paolo Paoli · 2016

Morin is a natural polyphenol, originally isolated from members of the Moraceae family that can be extracted from leaves, fruits, stems and branches of numerous plants. Several evidence have demonstrated that Morin could have a beneficial …

5-Fluorouracil resistant colon cancer cells are addicted to OXPHOS to survive and enhance stem-like traits Open

Denise Corti, Paolo Paoli, Maura Calvani, Maria Letizia Taddei, Elisa Giannoni , et al. · 2015

Despite marked tumor shrinkage after 5-FU treatment, the frequency of colon cancer relapse indicates that a fraction of tumor cells survives treatment causing tumor recurrence. The majority of cancer cells divert metabolites into anabolic …

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