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View article: Balcinrenone plus dapagliflozin in patients with heart failure and chronic kidney disease: Results from the phase 2b <scp>MIRACLE</scp> trial
Balcinrenone plus dapagliflozin in patients with heart failure and chronic kidney disease: Results from the phase 2b <span>MIRACLE</span> trial Open
Aims Many patients with heart failure (HF) have chronic kidney disease (CKD) and may not tolerate mineralocorticoid receptor antagonists. We investigated the efficacy and safety of the novel mineralocorticoid receptor modulator balcinrenon…
View article: Spleen contributes significantly to increased circulating levels of fibroblast growth factor 23 in response to lipopolysaccharide-induced inflammation
Spleen contributes significantly to increased circulating levels of fibroblast growth factor 23 in response to lipopolysaccharide-induced inflammation Open
Acute on chronic exposure to LPS stimulates FGF23 production in a normal mouse model of inflammation. We provide the first evidence that the spleen, under these conditions, contributes substantially to elevated circulating FGF23 levels.