Explanipedia

Development of a submicron emulsion-based delivery system to improve the anti-inflammatory activity of urolithin A Open

Elisabetta Esposito, Valentyn Dzyhovskyi, Francisco Santamaría, Lorenza Marvelli, Paola Boldrini , et al. · 2025

Objective Despite the antioxidant, anti-inflammatory, and anti-cellular-aging activities of urolithin A (UroA), a naturally occurring postbiotic, its high lipophilicity hampers its pharmaceutical application. To overcome this limitation im…

Small-angle scattering characterization of magnetosomes from Magnetospirillum gryphiswaldense MSR-1 Open

Adnan Khan, Paolo Moretti, Valentina Notarstefano, Paolo Mariani, Najet Mahmoudi , et al. · 2025

Beneath the Surface: Investigating Perovskite Solar Cells Under Water Open

Jessica Barichello, Peyman Amiri, Sebastiano Bellani, Cosimo Anichini, Marilena Isabella Zappia , et al. · 2025

Beyond traditional rooftop and building‐integrated photovoltaics (BIPV), photovoltaic (PV) devices find applications in agrivoltaics, space, and indoor settings. However, the underwater (UW) environment remains largely unexplored. Below 50…

Nanovesicles and Human Skin Interaction: A Comparative Ex-Vivo Study Open

Elisabetta Esposito, Valentyn Dzyhovski, Francisco Santamaría, Catia Contado, Cinzia Brenna , et al. · 2025

The topical administration of drugs on the skin by nanovesicular systems can represent a tool to treat skin pathologies. The study of nanovesicle biodistribution after skin administration is crucial to understanding their transdermal poten…

Transport Properties of Self-Assembling G-Hydrogels: Evidence for a Tunable Fickian Diffusivity Open

Alessia Pepe, Paolo Moretti, Paolo Mariani, Valentina Notarstefano, Francesca Ripanti · 2025

The mixing of Guanosine (Gua) and Guanosine 5'-monophosphate (GMP) in water in selected compositions yields highly hydrated, transparent, and self-healing self-assembled supramolecular G-hydrogels, attractive for biomedical applications. T…

Gossypin-Loaded Ethosome Gel for Cutaneous Administration: A Preliminary Study on Melanoma Cells Open

Agnese Bondi, Walter Pula, Mascia Benedusi, Giulia Trinchera, Anna Baldisserotto , et al. · 2025

A preformulative study was conducted to produce and characterize ethosomes for the transdermal delivery of gossypin. This plant-derived compound possesses many pharmacological properties, including antitumoral potential. Ethosome dispersio…

In situ forming gels as subcutaneous delivery systems of curcumin and piperine Open

Walter Pula, Alessia Pepe, Francesca Ferrara, Agnese Bondi, Paolo Mariani , et al. · 2025

Small-Angle Scattering Characterization of Magnetosomes from Magnetospirillum Gryphiswaldense Msr-1 Open

Adnan Khan, Paolo Moretti, Valentina Notarstefano, Paolo Mariani, Najet Mahmoudi , et al. · 2025

Comprehensive Structural Investigation of Magnetosomes for Potential Biomedical Applications Open

Adnan Khan, Paolo Moretti, Valentina Notarstefano, Paolo Mariani, Najet Mahmoudi , et al. · 2025

Spongosome-based co-delivery of curcumin and Piperine: A novel strategy for mitigating pollution-induced skin damage Open

Agnese Bondi, Francesca Ferrara, Walter Pula, Paolo Mariani, Alessia Pepe , et al. · 2024

The present study aims to explore the potential role of curcumin and piperine loaded spongosomes to protect the skin against pollution-induced damage. The hydration of a glyceryl monooleate and sodium cholate thin film, followed by homogen…

A new approach to assess post-mortem interval: A machine learning-assisted label-free ATR-FTIR analysis of human vitreous humor Open

Valentina Notarstefano, Chiara Santoni, Eva Montanari, Francesco Paolo Busardò, Angelo Montana , et al. · 2024

Guanosine hydrogels in focus: A comprehensive analysis through mid-infrared spectroscopy Open

Valentina Notarstefano, Alessia Pepe, Francesca Ripanti, Federica Piccirilli, Lisa Vaccari , et al. · 2024

Dimeric and monomeric conformation of SARS-CoV-2 main protease: New technical approaches based on IR radiation Open

Federica Piccirilli, Hendrik Vondracek, Lucia Silvestrini, Pietro Parisse, Francesco Spinozzi , et al. · 2024

Self-assembling properties of mono and di-rhamnolipids characterized using small-angle X-ray scattering Open

Alessandra Marega Motta, Paolo Mariani, Rosângela Itri, Francesco Spinozzi · 2024

Rhamnolipids are glycolipid surfactants composed by a hydrophilic head of either one (mono-RL) or two (di-RL) rhamnose moieties coupled to hydroxyaliphatic chains that can be of different lengths. In spite of their importance in different …

Self-Assembling Properties of Mono and Di-Rhamnolipids Characterized Using Small-Angle X-Ray Scattering Open

Alessandra Marega Motta, Paolo Mariani, Rosângela Itri, Francesco Spinozzi · 2024

A New Approach to Assess Post-Mortem Interval: A Label-Free Machine Learning-Assisted Atr-Ftir Analysis of Human Vitreous Humor Open

Valentina Notarstefano, Chiara Santoni, Eva Montanari, Francesco Paolo Busardò, Angelo Montana , et al. · 2024

Jovan Kratohvil's monument dedicated to the Yugoslav fallen in central Italy in Sansepolcro, Tuscany Open

Paolo Mariani · 2024

The article aims to analyse the morphological and spatial characteristics and the historical reasons that led to the construction of the monument dedicated to the Yugoslav fallen of the Second World War in central Italy. The monument, desi…

Small-angle scattering from flat bilayers containing correlated scattering length density inhomogeneities Open

Francesco Spinozzi, Leandro R.S. Barbosa, Giacomo Corucci, Paolo Mariani, Rosângela Itri · 2023

Model lipid bilayers have been widely employed as a minimal system to investigate the structural properties of biological membranes by small-angle X-ray (SAXS) and neutron scattering (SANS) techniques. These have nanometre resolution and c…

Stabilization of the Dimeric State of SARS-CoV-2 Main Protease by GC376 and Nirmatrelvir Open

Alessandro Paciaroni, Valeria Libera, Francesca Ripanti, A. Orecchini, C. Petrillo , et al. · 2023

The main protease (Mpro or 3CLpro) is an enzyme that is evolutionarily conserved among different genera of coronaviruses. As it is essential for processing and maturing viral polyproteins, Mpro has been identified as a promising target for…

Niosomes for Topical Application of Antioxidant Molecules: Design and In Vitro Behavior Open

Maddalena Sguizzato, Alessia Pepe, Anna Baldisserotto, Riccardo Barbari, Leda Montesi , et al. · 2023

In the present study, gels based on xanthan gum and poloxamer 407 have been developed and characterized in order to convey natural antioxidant molecules included in niosomes. Specifically, the studies were conducted to evaluate how the ves…

Multivariate curve Resolution-Alternating least squares coupled with Raman microspectroscopy: new insights into the kinetic response of primary oral squamous carcinoma cells to cisplatin Open

Valentina Notarstefano, Alessia Belloni, Paolo Mariani, Giulia Orilisi, Giovanna Orsini , et al. · 2023

Raman MicroSpectroscopy (RMS) is a powerful label-free tool to probe the effects of drugs at a cellular/subcellular level.

Self-oriented anisotropic structure of G-hydrogels as a delicate balance between attractive and repulsive forces Open

Alessia Pepe, Paolo Moretti, Juliana Sakamoto Yoneda, Federica Carducci, Rosângela Itri , et al. · 2023

Guanine (G) hydrogels are very attractive materials made by the supramolecular organization of G-derivatives in water.

Ex Vivo Evaluation of Ethosomes and Transethosomes Applied on Human Skin: A Comparative Study Open

Elisabetta Esposito, Laura Calderan, Andrea Galvan, Enrica Cappellozza, Markus Drechsler , et al. · 2022

In this study, the transdermal fate of vesicular nanosystems was investigated. Particularly, ethosomes based on phosphatidylcholine 0.9% w/w and transethosomes based on phosphatidylcholine 0.9 or 2.7% w/w plus polysorbate 80 0.3% w/w as an…

Unveiling the mono-rhamnolipid and di-rhamnolipid mechanisms of action upon plasma membrane models Open

Alessandra Marega Motta, Maressa Donato, Giovanna Mobbili, Paolo Mariani, Rosângela Itri , et al. · 2022

SAXS Reveals the Stabilization Effects of Modified Sugars on Model Proteins Open

Astra Piccinini, Eva C. Lourenço, Osvaldo S. Ascenso, M. Rita Ventura, Heinz Amenitsch , et al. · 2022

Many proteins are usually not stable under different stresses, such as temperature and pH variations, mechanical stresses, high concentrations, and high saline contents, and their transport is always difficult, because they need to be main…

Natural Polyphenol-Containing Gels against HSV-1 Infection: A Comparative Study Open

Mariaconcetta Sicurella, Maddalena Sguizzato, Paolo Mariani, Alessia Pepe, Anna Baldisserotto , et al. · 2022

Herpes simplex virus type 1 infection commonly affects many people, causing perioral sores, as well as severe complications including encephalitis in immunocompromised patients. The main pharmacological approach involves synthetic antivira…

Tuning curvature and phase behavior of monoolein bilayers by epigallocatechin-3-gallate: Structural insight and cytotoxicity Open

Cristina Minnelli, Paolo Moretti, Emiliano Laudadio, Yuri Gerelli, Andrea Pigozzo , et al. · 2021

“Plurethosome” as Vesicular System for Cutaneous Administration of Mangiferin: Formulative Study and 3D Skin Tissue Evaluation Open

Maddalena Sguizzato, Francesca Ferrara, Paolo Mariani, Alessia Pepe, Rita Cortesi , et al. · 2021

Human skin is dramatically exposed to toxic pollutants such as ozone. To counteract the skin disorders induced by the air pollution, natural antioxidants such as mangiferin could be employed. A formulative study for the development of vesi…

Practical development of efficient thermoelectric – Photovoltaic hybrid systems based on wide-gap solar cells Open

Bruno Lorenzi, Paolo Mariani, Andrea Reale, Aldo Di Carlo, Gang Chen , et al. · 2021

The dimer-monomer equilibrium of SARS-CoV-2 main protease is affected by small molecule inhibitors Open

Lucia Silvestrini, Norhan Belhaj, Lucia Comez, Yuri Gerelli, Antonino Lauria , et al. · 2021

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