Paolo Nichelli
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View article: Olfactory Testing and Gray Matter Volume: A Combined Approach to Predict the Conversion to Alzheimer
Olfactory Testing and Gray Matter Volume: A Combined Approach to Predict the Conversion to Alzheimer Open
Background/Objectives: Olfactory decline is common in normal aging and frequent in neurodegenerative diseases such as Alzheimer’s disease (AD). Therefore, it has been suggested as a marker for the Mild Cognitive Impairment (MCI) progressio…
View article: Understanding basic and social emotions in Alzheimer's disease and frontotemporal dementia
Understanding basic and social emotions in Alzheimer's disease and frontotemporal dementia Open
Introduction Recent developments in the field of social cognition have led to a renewed interest in basic and social emotion recognition in early stages of Alzheimer's Disease (AD) and FrontoTemporal Dementia (FTD). Despite the growing att…
View article: Sensitivity and specificity of the action observation network to kinematics, target object, and gesture meaning
Sensitivity and specificity of the action observation network to kinematics, target object, and gesture meaning Open
Hierarchical models have been proposed to explain how the brain encodes actions, whereby different areas represent different features, such as gesture kinematics, target object, action goal, and meaning. The visual processing of action‐rel…
View article: “When You’re Smiling”: How Posed Facial Expressions Affect Visual Recognition of Emotions
“When You’re Smiling”: How Posed Facial Expressions Affect Visual Recognition of Emotions Open
Facial imitation occurs automatically during the perception of an emotional facial expression, and preventing it may interfere with the accuracy of emotion recognition. In the present fMRI study, we evaluated the effect of posing a facial …
View article: Uncover the Offensive Side of Disparagement Humor: An fMRI Study
Uncover the Offensive Side of Disparagement Humor: An fMRI Study Open
Disparagement humor is a kind of humor that denigrates, belittles an individual or a social group. In the aim to unveil the offensive side of these kinds of jokes, we have run an event-related fMRI study asking 30 healthy volunteers to jud…
View article: Safety and outcomes of routine endovascular thrombectomy in large artery occlusion recorded in the SITS Register: An observational study
Safety and outcomes of routine endovascular thrombectomy in large artery occlusion recorded in the SITS Register: An observational study Open
Background and objective We aimed to evaluate the safety and outcomes of thrombectomy in anterior circulation acute ischaemic stroke recorded in the SITS–International Stroke Thrombectomy Register (SITS‐ISTR) and compare them with pooled r…
View article: The Effect of Dopaminergic Replacement Therapy on Creative Thinking and Insight Problem-Solving in Parkinson's Disease Patients
The Effect of Dopaminergic Replacement Therapy on Creative Thinking and Insight Problem-Solving in Parkinson's Disease Patients Open
Parkinson's disease (PD) patients receiving dopaminergic treatment may experience bursts of creativity. Although this phenomenon is sometimes recognized among patients and their clinicians, the association between dopamine replacement ther…
View article: Intravenous thrombolysis in stroke mimics: results from the <scp>SITS</scp> International Stroke Thrombolysis Register
Intravenous thrombolysis in stroke mimics: results from the <span>SITS</span> International Stroke Thrombolysis Register Open
Background and purpose Patients with stroke mimics (SM), i.e. conditions with stroke‐like symptoms, may risk harm if treated with intravenous thrombolysis ( IVT ). Current guidelines state low risk of intracerebral hemorrhage based on stud…
View article: Primary progressive aphasia and the FTD-MND spectrum disorders: clinical, pathological, and neuroimaging correlates
Primary progressive aphasia and the FTD-MND spectrum disorders: clinical, pathological, and neuroimaging correlates Open
Objective: Behavioral variant frontotemporal dementia (bvFTD), is commonly considered the cognitive presentation of the frontotemporal dementia-motor neuron disease (FTD-MND) spectrum disorder. We evaluated the prevalence of primary progre…
View article: Eight Weddings and Six Funerals: An fMRI Study on Autobiographical Memories
Eight Weddings and Six Funerals: An fMRI Study on Autobiographical Memories Open
"Autobiographical memory" (AM) refers to remote memories from one's own life. Previous neuroimaging studies have highlighted that voluntary retrieval processes from AM involve different forms of memory and cognitive functions. Thus, a comp…
View article: Neural Correlates of Anosognosia in Alzheimer's Disease and Mild Cognitive Impairment: A Multi-Method Assessment
Neural Correlates of Anosognosia in Alzheimer's Disease and Mild Cognitive Impairment: A Multi-Method Assessment Open
Patients with Alzheimer's Disease (AD) and Mild Cognitive Impairment (MCI) may present anosognosia for their cognitive deficits. Three different methods have been usually used to measure anosognosia in patients with AD and MCI, but no stud…
View article: Acute coronary syndrome associated with alemtuzumab infusion in multiple sclerosis
Acute coronary syndrome associated with alemtuzumab infusion in multiple sclerosis Open
no abstract available
View article: Modulation of neural circuits underlying temporal production by facial expressions of pain
Modulation of neural circuits underlying temporal production by facial expressions of pain Open
According to the Scalar Expectancy Theory, humans are equipped with a biological internal clock, possibly modulated by attention and arousal. Both emotions and pain are arousing and can absorb attentional resources, thus causing distortion…
View article: Mechanical knowledge does matter to tool use even when assessed with a non‐production task: Evidence from left brain‐damaged patients
Mechanical knowledge does matter to tool use even when assessed with a non‐production task: Evidence from left brain‐damaged patients Open
In the literature on apraxia of tool use, it is now accepted that using familiar tools requires semantic and mechanical knowledge. However, mechanical knowledge is nearly always assessed with production tasks, so one may assume that mechan…
View article: [P3–514]: NAMING IMPROVEMENT IN PRIMARY PROGRESSIVE APHASIA FOLLOWING LEXICAL TRAINING
[P3–514]: NAMING IMPROVEMENT IN PRIMARY PROGRESSIVE APHASIA FOLLOWING LEXICAL TRAINING Open
the effect of rehabilitation of naming difficulties in patients with Primary Progressive Aphasia (PPA) is difficult to test due to the heterogeneity and progressive nature of the disease. We set up a novel 12-week rehabilitation programme …
View article: Factors affecting outcome in ocular myasthenia gravis
Factors affecting outcome in ocular myasthenia gravis Open
Sex, later onset and anti-AChR Ab positivity were significantly associated with clinical worsening.
View article: Stress and brain functional changes in patients with Crohn's disease: A functional magnetic resonance imaging study
Stress and brain functional changes in patients with Crohn's disease: A functional magnetic resonance imaging study Open
Background In Crohn's disease ( CD ) patients, stress is believed to influence symptoms generation. Stress may act via central nervous system pathways to affect visceral sensitivity and motility thus exacerbating gastrointestinal symptoms.…
View article: The In-Flight Affective Brain: Decision Making Under Uncertainty and Safety Implications in Aviation
The In-Flight Affective Brain: Decision Making Under Uncertainty and Safety Implications in Aviation Open
Understanding the relation betweenmotivation and pilot impulsive decision-making is extremely important in the context of aviation human factors.One way to operationalize motivation is by presentingparticipantswith different reinforces, ei…
View article: Long-term disability and prognostic factors in polyneuropathy associated with anti-myelin-associated glycoprotein (MAG) antibodies
Long-term disability and prognostic factors in polyneuropathy associated with anti-myelin-associated glycoprotein (MAG) antibodies Open
Our study provides evidence that electrophysiologic pattern, age of onset and absence of treatment are strong predictor of prognosis in anti-MAG polyneuropathy.
View article: The Brain Correlates of Laugh and Cataplexy in Childhood Narcolepsy
The Brain Correlates of Laugh and Cataplexy in Childhood Narcolepsy Open
In this study we reported for the first time in humans the brain structures whose neural activity is specifically and consistently associated with emotion-induced cataplexy. To reach this goal drug-naive children and adolescents with recen…
View article: An EEG-fMRI Study on the Termination of Generalized Spike-And-Wave Discharges in Absence Epilepsy
An EEG-fMRI Study on the Termination of Generalized Spike-And-Wave Discharges in Absence Epilepsy Open
The role of the decreased neural activity of lateral prefrontal cortex at GSWD termination deserve future investigations to ascertain if it has a role in promoting the discharge offset, as well as in the determination of the cognitive defi…