Paolo Severi
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View article: Anticancer activity of MDM2 inhibition in 2D and bioprinted 3D retinoblastoma cell models
Anticancer activity of MDM2 inhibition in 2D and bioprinted 3D retinoblastoma cell models Open
Retinoblastoma is the most common childhood tumor affecting the retina. Pharmacological resistance or delayed intervention leads to the loss of vision. Therefore, novel therapeutic strategies need to be assessed in preclinical models that …
View article: The heat, the heart and beyond: a narrative review of the many ways climate change impacts human health
The heat, the heart and beyond: a narrative review of the many ways climate change impacts human health Open
This article provides a narrative review of recent literature on the health impacts of climate change, synthesizing epidemiological findings, mechanistic insights, and policy implications across major exposure domains. Anthropogenic climat…
View article: Highly differentiated T cells link systemic and vascular inflammation in a mouse model of recurrent psoriasis
Highly differentiated T cells link systemic and vascular inflammation in a mouse model of recurrent psoriasis Open
Psoriasis is a chronic inflammatory skin-disease associated with cardiovascular comorbidities. In patients, T cells with a skin-primed phenotype are expanded in peripheral blood, indicating a role for skin to blood T cell recirculation in …
View article: <scp>ErbB2</scp>‐<scp>NOTCH1</scp> axis controls autophagy in cardiac cells
<span>ErbB2</span>‐<span>NOTCH1</span> axis controls autophagy in cardiac cells Open
Although the epidermal growth factor receptor 2 (ErbB2) and Notch1 signaling pathways have both significant roles in regulating cardiac biology, their interplay in the heart remains poorly investigated. Here, we present evidence of a cross…
View article: Hypertensive Pressure Mechanosensing Alone Triggers Lipid Droplet Accumulation and Transdifferentiation of Vascular Smooth Muscle Cells to Foam Cells (Adv. Sci. 9/2024)
Hypertensive Pressure Mechanosensing Alone Triggers Lipid Droplet Accumulation and Transdifferentiation of Vascular Smooth Muscle Cells to Foam Cells (Adv. Sci. 9/2024) Open
Vascular Smooth Muscle Cells Arterial vascular smooth muscle cells (VSMCs) play a central role in the onset and progression of atherosclerosis. In article 2308686, Thomas Iskratsch and co‐workers report that hypertensive pressure transform…
View article: Hypertensive Pressure Mechanosensing Alone Triggers Lipid Droplet Accumulation and Transdifferentiation of Vascular Smooth Muscle Cells to Foam Cells
Hypertensive Pressure Mechanosensing Alone Triggers Lipid Droplet Accumulation and Transdifferentiation of Vascular Smooth Muscle Cells to Foam Cells Open
Arterial Vascular smooth muscle cells (VSMCs) play a central role in the onset and progression of atherosclerosis. Upon exposure to pathological stimuli, they can take on alternative phenotypes that, among others, have been described as ma…
View article: Transcriptomic profiling of calcified aortic valves in clonal hematopoiesis of indeterminate potential carriers
Transcriptomic profiling of calcified aortic valves in clonal hematopoiesis of indeterminate potential carriers Open
View article: Occupational Exposure Assessment to Antineoplastic Drugs in Nine Italian Hospital Centers over a 5-Year Survey Program
Occupational Exposure Assessment to Antineoplastic Drugs in Nine Italian Hospital Centers over a 5-Year Survey Program Open
In the present study, surface contamination where antineoplastic drugs (ADs) are present was investigated, as occupational exposure risk is still an open debate. Despite recommendations and safety standard procedures being in place in heal…
View article: Fermentation of Vaccinium floribundum Berries with Lactiplantibacillus plantarum Reduces Oxidative Stress in Endothelial Cells and Modulates Macrophages Function
Fermentation of Vaccinium floribundum Berries with Lactiplantibacillus plantarum Reduces Oxidative Stress in Endothelial Cells and Modulates Macrophages Function Open
Accumulating evidence suggests that high consumption of natural antioxidants promotes health by reducing oxidative stress and, thus, the risk of developing cardiovascular diseases. Similarly, fermentation of natural compounds with lactic a…
View article: Cardiac Calcifications: Phenotypes, Mechanisms, Clinical and Prognostic Implications
Cardiac Calcifications: Phenotypes, Mechanisms, Clinical and Prognostic Implications Open
There is a growing interest in arterial and heart valve calcifications, as these contribute to cardiovascular outcome, and are leading predictors of cardiovascular and kidney diseases. Cardiovascular calcifications are often considered as …
View article: Looking for a Tailored Therapy for Heart Failure: Are We Capable of Treating the Patient Instead of the Disease?
Looking for a Tailored Therapy for Heart Failure: Are We Capable of Treating the Patient Instead of the Disease? Open
After almost a decade of stagnation in clinical research for HF treatment, five large randomized trials recently published have supported the use of four new classes of drugs, namely: angiotensin receptor/neprilysin inhibitor, sodium–gluco…
View article: Adding a “Notch” to Cardiovascular Disease Therapeutics: A MicroRNA-Based Approach
Adding a “Notch” to Cardiovascular Disease Therapeutics: A MicroRNA-Based Approach Open
Dysregulation of the Notch pathway is implicated in the pathophysiology of cardiovascular diseases (CVDs), but, as of today, therapies based on the re-establishing the physiological levels of Notch in the heart and vessels are not availabl…
View article: A Smartphone-Based Chemosensor to Evaluate Antioxidants in Agri-Food Matrices by In Situ AuNP Formation
A Smartphone-Based Chemosensor to Evaluate Antioxidants in Agri-Food Matrices by In Situ AuNP Formation Open
In recent years, there has been a continuously growing interest in antioxidants by both customers and food industry. The beneficial health effects of antioxidants led to their widespread use in fortified functional foods, as dietary supple…
View article: Well-Known and Novel Players in Endothelial Dysfunction: Updates on a Notch(ed) Landscape
Well-Known and Novel Players in Endothelial Dysfunction: Updates on a Notch(ed) Landscape Open
Endothelial dysfunction characterizes every aspect of the so-called cardiovascular continuum, a series of events ranging from hypertension to the development of atherosclerosis and, finally, to coronary heart disease, thrombus formation, m…
View article: An Early Increase of Blood Leukocyte Subsets in Aneurysmal Subarachnoid Hemorrhage Is Predictive of Vasospasm
An Early Increase of Blood Leukocyte Subsets in Aneurysmal Subarachnoid Hemorrhage Is Predictive of Vasospasm Open
Objective: Vasospasm is a severe complication in patients with aneurysmal subarachnoid hemorrhage (aSAH) and cannot be reliably predicted. Its pathophysiology remains elusive with the current body of evidence suggesting inflammation as one…
View article: Paper-based smartphone chemosensor for reflectometric on-site total polyphenols quantification in olive oil
Paper-based smartphone chemosensor for reflectometric on-site total polyphenols quantification in olive oil Open
View article: Infection with spinal instrumentation: A 20-year, single-institution experience with review of pathogenesis, diagnosis, prevention, and management
Infection with spinal instrumentation: A 20-year, single-institution experience with review of pathogenesis, diagnosis, prevention, and management Open
Objective and Importance: Instrumentation has become an integral component in the management of various spinal pathologies. The rate of infection varies from 2% to 20% of all instrumented spinal procedures. Postoperative spinal implant inf…
View article: The Role of Physical Activity in the New 2017 American College of Cardiology/American Heart Association Blood Pressure Guidelines
The Role of Physical Activity in the New 2017 American College of Cardiology/American Heart Association Blood Pressure Guidelines Open
View article: Exercise dose in clinical practice: Right is better than more
Exercise dose in clinical practice: Right is better than more Open
View article: Pacemaker-detected severe sleep apnoea predicts new-onset atrial fibrillation
Pacemaker-detected severe sleep apnoea predicts new-onset atrial fibrillation Open
View article: Management of oral anticoagulation in patients with atrial fibrillation: newer agents, newer conundrums?
Management of oral anticoagulation in patients with atrial fibrillation: newer agents, newer conundrums? Open
Click here to view the Original article by Dr. Staerk et al .
View article: Hypertensive response to exercise and exercise training in hypertension: odd couple no more
Hypertensive response to exercise and exercise training in hypertension: odd couple no more Open
The diagnostic and prognostic implication of exaggerated blood pressure response to exercise has been controversial, with opinions ranging from a benign process to a harbinger of potential cardiovascular morbidity. Nonetheless, lowering of…