Paolo Suating
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View article: Peptide recognition by a synthetic receptor at subnanomolar concentrations
Peptide recognition by a synthetic receptor at subnanomolar concentrations Open
The synthetic receptor cucurbit[8]uril (Q8) binds the N-terminal dipeptide site Lys-Phe with subnanomolar affinity in neutral aqueous buffer.
View article: Molecular recognition of peptides and proteins by cucurbit[<i>n</i>]urils: systems and applications
Molecular recognition of peptides and proteins by cucurbit[<i>n</i>]urils: systems and applications Open
The molecular recognition of peptides and proteins by cucurbit[ n ]uril synthetic receptors in aqueous solution occurs with high affinity and with selectivity that is predictive from the sequence of amino acids and has enabled many applica…
View article: Semisynthesis of Aminomethyl-Insulin: An Atom-Economic Strategy to Increase the Affinity and Selectivity of a Protein for Recognition by a Synthetic Receptor
Semisynthesis of Aminomethyl-Insulin: An Atom-Economic Strategy to Increase the Affinity and Selectivity of a Protein for Recognition by a Synthetic Receptor Open
Advancements in the molecular recognition of insulin by nonantibody-based means would facilitate the development of methodology for the continuous detection of insulin for the management of diabetes mellitus. Herein, we report a novel insu…
View article: CCDC 2127617: Experimental Crystal Structure Determination
CCDC 2127617: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: On the Nature of Guest Complexation in Water: Triggered Wetting–Water-Mediated Binding
On the Nature of Guest Complexation in Water: Triggered Wetting–Water-Mediated Binding Open
The complexity of macromolecular surfaces means that there are still many open questions regarding how specific areas are solvated and how this might affect the complexation of guests. Contributing to the identification and classification …
View article: Cavitand Complexes in Aqueous Solution: Collaborative Experimental and Computational Studies of the Wetting, Assembly, and Function of Nanoscopic Bowls in Water
Cavitand Complexes in Aqueous Solution: Collaborative Experimental and Computational Studies of the Wetting, Assembly, and Function of Nanoscopic Bowls in Water Open
Water is the dominant liquid on Earth. Despite this, the main focus of supramolecular chemistry research has been on binding and assembly events in organic solvents. This arose because it is more straightforward to synthesize organic-media…
View article: Proximal charge effects on guest binding to a non-polar pocket
Proximal charge effects on guest binding to a non-polar pocket Open
Science still does not have the ability to accurately predict changes in ligand affinity induced by proximal charged groups.
View article: Front Cover: 1‐Hydrosilatrane: A Locomotive for Efficient Ketone Reductions (Eur. J. Org. Chem. 2/2017)
Front Cover: 1‐Hydrosilatrane: A Locomotive for Efficient Ketone Reductions (Eur. J. Org. Chem. 2/2017) Open
The cover picture shows artist Jesse Mai's imagination of the reduction of ketones to alcohols by 1-hydrosilatrane. The accompanying work describes this mild method for reduction, which makes use of a cheap, safe, easy-to-handle, and envir…