Parash Prasad
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View article: Bone Marrow Adipokine Mediates Hematopoietic Regeneration and Stem Cell Fitness
Bone Marrow Adipokine Mediates Hematopoietic Regeneration and Stem Cell Fitness Open
Summary Bone marrow (BM) hematopoietic stem cells (HSCs) are exquisitely sensitive to cues from the BM microenvironment (ME), which is critical for their engraftment and regeneration following myeloablative stress. Retinoic acid signaling,…
View article: From Marrow to Bone and Fat: Exploring the Multifaceted Roles of Leptin Receptor Positive Bone Marrow Mesenchymal Stromal Cells
From Marrow to Bone and Fat: Exploring the Multifaceted Roles of Leptin Receptor Positive Bone Marrow Mesenchymal Stromal Cells Open
The bone marrow (BM) stromal cell microenvironment contains non-hematopoietic stromal cells called mesenchymal stromal cells (MSCs). MSCs are plastic adherent, form CFU-Fs, and give rise to osteogenic, adipogenic, chondrogenic progenitors,…
View article: Metallo-protease Peptidase M84 from Bacillus altitudinis induces ROS-dependent apoptosis in ovarian cancer cells by targeting PAR-1
Metallo-protease Peptidase M84 from Bacillus altitudinis induces ROS-dependent apoptosis in ovarian cancer cells by targeting PAR-1 Open
We have purified Peptidase M84 from Bacillus altitudinis in an effort to isolate anticancer proteases from environmental microbial isolates. This metallo-protease had no discernible impact on normal cell survival, but it specificall…
View article: Experimental type 1 diabetes metabolically rejuvenates CD8<sup>+</sup>T cells for improved control of tumor growth through an IGF1-IGF1R axis
Experimental type 1 diabetes metabolically rejuvenates CD8<sup>+</sup>T cells for improved control of tumor growth through an IGF1-IGF1R axis Open
Epidemiological studies suggest that patients with pre-existing type 1 diabetes (T1D) have a decreased risk of developing melanoma, prostate cancer, and breast cancer, although the underlying mechanism remains to be elucidated. In translat…
View article: Mesenchymal stromal cells, metabolism, and mitochondrial transfer in bone marrow normal and malignant hematopoiesis
Mesenchymal stromal cells, metabolism, and mitochondrial transfer in bone marrow normal and malignant hematopoiesis Open
Hematopoietic stem cell (HSC) transplantation-based treatments are in different phases of clinical development, ranging from current therapies to a promise in the repair and regeneration of diseased tissues and organs. Mesenchymal stromal/…
View article: Metallo-protease Peptidase M84 from<i>Bacillus altitudinis</i>induces ROS dependent apoptosis in ovarian cancer cells by targeting PAR-1
Metallo-protease Peptidase M84 from<i>Bacillus altitudinis</i>induces ROS dependent apoptosis in ovarian cancer cells by targeting PAR-1 Open
In pursuit of isolating novel anticancer proteases from environmental microbial isolates, we have purified and identified an extracellular metallo-protease from Bacillus altitudinis named Peptidase M84. This protease selectively triggered …
View article: Metallo-Protease Peptidase M84 from <i>Bacillus altitudinis</i> Induces ROS Dependent Apoptosis in Ovarian Cancer Cells by Targeting PAR-1
Metallo-Protease Peptidase M84 from <i>Bacillus altitudinis</i> Induces ROS Dependent Apoptosis in Ovarian Cancer Cells by Targeting PAR-1 Open
View article: Rodent model preclinical assessment of PEGylated block copolymer targeting cognition and oxidative stress insults of Alzheimer’s disease
Rodent model preclinical assessment of PEGylated block copolymer targeting cognition and oxidative stress insults of Alzheimer’s disease Open
Misfolded peptide amyloid beta (A β 42 ), neurofibrillary tangles of hyper-phosphorylated tau, oxidative damage to the brain, neuroinflammation are distinguished determinants of Alzheimer’s disease (AD) responsible for disease progression.…
View article: <scp>SIRT6</scp> promotes mitochondrial fission and subsequent cellular invasion in ovarian cancer
<span>SIRT6</span> promotes mitochondrial fission and subsequent cellular invasion in ovarian cancer Open
Ovarian cancer ranks fifth in terms of cancer mortality in women due to lack of early diagnosis and poor clinical management. Characteristics like high cellular proliferation, EMT and metabolic alterations contribute to oncogenicity. Cance…
View article: Murine model preclinical assessment of PEGylated block copolymer targeting cognition and oxidative stress insults of Alzheimer’s disease
Murine model preclinical assessment of PEGylated block copolymer targeting cognition and oxidative stress insults of Alzheimer’s disease Open
Misfolded peptide amyloid beta (A β 42 ), neurofibrillary tangles of hyper-phosphorylated tau, oxidative damage to the brain, neuroinflammation are distinguished determinants of Alzheimer’s disease (AD) responsible for disease progression.…
View article: Glutamine regulates ovarian cancer cell migration and invasion through ETS1
Glutamine regulates ovarian cancer cell migration and invasion through ETS1 Open
View article: Glutamine deficiency promotes stemness and chemoresistance in tumor cells through DRP1-induced mitochondrial fragmentation
Glutamine deficiency promotes stemness and chemoresistance in tumor cells through DRP1-induced mitochondrial fragmentation Open
View article: Blast Response of Steel and Cast Iron Circular Pipe Sections Under Explosive Impact using ls - Dyna
Blast Response of Steel and Cast Iron Circular Pipe Sections Under Explosive Impact using ls - Dyna Open
There has been an immense significance of sparing structures like pipe structures which exchange oil and gas, blasts on these pipe lines may intrude on the transmission. In the current decades a lot of research is done to think about the a…