Pedram Panahi
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View article: Therapeutic anticoagulation in patients with acute pancreatitis and splanchnic vein thrombosis: a best evidence topic
Therapeutic anticoagulation in patients with acute pancreatitis and splanchnic vein thrombosis: a best evidence topic Open
A best evidence topic in general surgery was written according to a structured protocol. The clinical question addressed was: in adult patients with splanchnic vein thrombosis in acute pancreatitis, would administration of therapeutic anti…
View article: Postoperative packing of perianal abscesses following incision and drainage
Postoperative packing of perianal abscesses following incision and drainage Open
A best evidence topic in general surgery was written according to a structured protocol, to address the question: in adult patients with perianal abscesses, should postoperative wound packing be undertaken considering the rates of pain exp…
View article: The impact of COVID-19 prevention measures on surgical wound infection rates post-cardiac surgery
The impact of COVID-19 prevention measures on surgical wound infection rates post-cardiac surgery Open
The COVID-19 pandemic had a huge impact on medical services. Several measures have been implemented to reduce the risk of viral transmission. In this paper, we assessed the impact of these measures on surgical wound infection rates in pati…
View article: A review of the best method of leg wound closure following open harvesting of the long saphenous vein for coronary artery bypass grafting
A review of the best method of leg wound closure following open harvesting of the long saphenous vein for coronary artery bypass grafting Open
Uncertainty exists around the optimal method of leg wound closure following open long saphenous vein harvesting in adults undergoing coronary artery bypass graft surgery (CABG). Such is evident from the variety observed in the closure appr…
View article: The Fractalkine Receptor CX3CR1 Links Lymphocyte Kinetics in CMV-Seropositive Patients and Acute Myocardial Infarction With Adverse Left Ventricular Remodeling
The Fractalkine Receptor CX3CR1 Links Lymphocyte Kinetics in CMV-Seropositive Patients and Acute Myocardial Infarction With Adverse Left Ventricular Remodeling Open
Aims Latent cytomegalovirus (CMV) infection is associated with adverse cardiovascular outcomes. Virus-specific CX 3 CR1 + effector memory T-cells may be instrumental in this process due to their pro-inflammatory properties. We investigated…
View article: Antimicrobial prophylaxis in adult cardiac surgery in the United Kingdom and Republic of Ireland
Antimicrobial prophylaxis in adult cardiac surgery in the United Kingdom and Republic of Ireland Open
Background: Deep sternal wound infections are a financially costly complication of cardiac surgery with serious implications for patient morbidity and mortality. Prophylactic antimicrobials have been shown to reduce the incidence of infect…
View article: Role of CMV-serostatus and CX3CR1 on lymphocyte kinetics and left ventricular remodelling in patients with acute myocardial infarction
Role of CMV-serostatus and CX3CR1 on lymphocyte kinetics and left ventricular remodelling in patients with acute myocardial infarction Open
Background Patients with latent cytomegalovirus (CMV) infection have higher rates of adverse cardiovascular outcomes, but the reasons for this remain elusive. CMV-induced changes to T-lymphocyte populations, with a proliferation of CMV-spe…
View article: Early versus interval appendicectomy for localised perforated appendicitis in children: A best evidence review
Early versus interval appendicectomy for localised perforated appendicitis in children: A best evidence review Open
A best evidence topic in general surgery was written according to a structured protocol. The question addressed was whether early or interval appendicectomy provides a superior clinical outcome for children presenting with localised perfor…
View article: Best evidence topic: Can acute appendicitis manifest with normal inflammatory markers?
Best evidence topic: Can acute appendicitis manifest with normal inflammatory markers? Open
A best evidence topic has been constructed using a described protocol. The three-part question addressed was: for patients with suspected acute appendicitis can normal inflammatory markers rule out the diagnosis? Altogether 151 papers were…
View article: Appendiceal phlegmon in adults: Do we know how to manage it yet?
Appendiceal phlegmon in adults: Do we know how to manage it yet? Open
A Best Evidence Topic in general surgery was written according to a structured protocol. The question addressed was 'Appendiceal phlegmon in adults: Do we know how to manage it yet?'. Altogether 217 papers were found on Ovid Embase and Med…
View article: Effect of ciclosporin on safety, lymphocyte kinetics and left ventricular remodelling in acute myocardial infarction
Effect of ciclosporin on safety, lymphocyte kinetics and left ventricular remodelling in acute myocardial infarction Open
Aims Following a favourable pilot trial using a single bolus of ciclosporin, it has been unclear why 2 large studies (CYCLE and CIRCUS) failed to prevent reperfusion injury and reduce infarct size in STEMI (ST elevation myocardial infarcti…
View article: Kinetics Analysis of Circulating MicroRNAs Unveils Markers of Failed Myocardial Reperfusion
Kinetics Analysis of Circulating MicroRNAs Unveils Markers of Failed Myocardial Reperfusion Open
BACKGROUND Failed myocardial reperfusion occurs in approximately 50% of patients with ST-elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (PPCI). It manifests as microvascular obstruction (MVO…