Parham Ramezani-Rad
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View article: HIV broadly neutralizing antibody precursors to the Apex epitope induced in nonhuman primates
HIV broadly neutralizing antibody precursors to the Apex epitope induced in nonhuman primates Open
An effective prophylactic HIV vaccine will likely need to induce broadly neutralizing antibodies (bnAbs). bnAbs to the Apex region of the HIV envelope glycoprotein (Env) are promising targets for vaccination because of their relatively low…
View article: Vaccination with an mRNA-encoded membrane-bound HIV envelope trimer induces neutralizing antibodies in animal models
Vaccination with an mRNA-encoded membrane-bound HIV envelope trimer induces neutralizing antibodies in animal models Open
A protective vaccine against human immunodeficiency virus (HIV) will likely need to induce broadly neutralizing antibodies (bnAbs) that engage relatively conserved epitopes on the HIV envelope glycoprotein (Env) trimer. Nearly all vaccine …
View article: Regnase-1 is essential for B cell homeostasis to prevent immunopathology
Regnase-1 is essential for B cell homeostasis to prevent immunopathology Open
Regnase-1 is an emerging regulator of immune responses with essential roles in the posttranscriptional control of immune cell activation. Regnase-1 is expressed in B cells; however, its B cell–specific functions remain unknown. Here, we de…
View article: Quick and easy purification of murine untouched naive B cells or germinal center B cells by MACS
Quick and easy purification of murine untouched naive B cells or germinal center B cells by MACS Open
View article: Cyclin D3 Governs Clonal Expansion of Dark Zone Germinal Center B Cells
Cyclin D3 Governs Clonal Expansion of Dark Zone Germinal Center B Cells Open
View article: E3 Ubiquitin Ligase Fbw7 Regulates the Survival of Mature B Cells
E3 Ubiquitin Ligase Fbw7 Regulates the Survival of Mature B Cells Open
Mature naive B cells expressing BCRs of the IgM and IgD isotypes respond to Ag in secondary lymphoid organs. However, the vast majority of B cells do not undergo productive Ag encounter and have finite life spans dependent on survival sign…
View article: Cutting Edge: The RNA-Binding Protein Ewing Sarcoma Is a Novel Modulator of Lymphotoxin β Receptor Signaling
Cutting Edge: The RNA-Binding Protein Ewing Sarcoma Is a Novel Modulator of Lymphotoxin β Receptor Signaling Open
Lymphotoxin β receptor (LTβR) signaling is crucial for lymphoid tissue organogenesis and immune homeostasis. To identify novel regulatory mechanisms for signaling, we implemented a two-step screen that uses coexpression analysis of human f…
View article: The AKT isoforms 1 and 2 drive B cell fate decisions during the germinal center response
The AKT isoforms 1 and 2 drive B cell fate decisions during the germinal center response Open
The PI3K pathway is integral for the germinal center (GC) response. However, the contribution of protein kinase B (AKT) as a PI3K effector in GC B cells remains unknown. Here, we show that mice lacking the AKT1 and AKT2 isoforms in B cells…
View article: Murine models of germinal center derived-lymphomas
Murine models of germinal center derived-lymphomas Open
View article: Gsk3 is a metabolic checkpoint regulator in B cells
Gsk3 is a metabolic checkpoint regulator in B cells Open