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Endoplasmic reticulum quality control and metal tolerance: reduced activity of glucosidase II enzyme affects positively cadmium tolerance in Arabidopsis thaliana Open
The Endoplasmic Reticulum Quality Control (ERQC) machinery is highly conserved among eukaryotes and assists the newly synthetized proteins in the folding process. Previous works have reported the involvement of ERQC in plant immunity and b…
View article: Reactive Behaviour of Platinum(II) Salts with Ethylenediamine in Sustainable Water/Choline Chloride-Based Deep Eutectic Solvents Mixtures
Reactive Behaviour of Platinum(II) Salts with Ethylenediamine in Sustainable Water/Choline Chloride-Based Deep Eutectic Solvents Mixtures Open
Deep eutectic solvents (DESs) are environmentally friendly solvents formed by combining hydrogen bond donors and acceptors, resulting in a eutectic mixture with a lower melting point than the individual components. While there is extensive…
View article: Opportunistic omnivory impairs the use of the Atlantic blue crab Callinectes sapidus as a trace metal biomonitor in invaded Mediterranean coastal waters
Opportunistic omnivory impairs the use of the Atlantic blue crab Callinectes sapidus as a trace metal biomonitor in invaded Mediterranean coastal waters Open
[EN] The contribution of non-indigenous species to the transfer of contaminants in invaded food webs represents an active research area. Here we measured trace metals and CN stable isotopes in five populations of the invasive Atlantic blue…
View article: Interactions with DNA Models of the Oxaliplatin Analog (cis-1,3-DACH)PtCl2
Interactions with DNA Models of the Oxaliplatin Analog (cis-1,3-DACH)PtCl2 Open
It is generally accepted that adjacent guanine residues in DNA are the primary target for platinum antitumor drugs and that differences in the conformations of the Pt-DNA adducts can play a role in their antitumor activity. In this study, …
Correction: Anglana et al. Dittrichia viscosa Selection Strategy Based on Stress Produces Stable Clonal Lines for Phytoremediation Applications. Plants 2023, 12, 2499 Open
In the original publication [...]
Quantification of Arsenic in Soil Samples Collected in an Industrial Area of Brindisi (Apulia, Italy): Speciation Analysis and Availability Open
Arsenic (As) is a well-known toxic metalloid, but environmental risks due to excessive As content in soils or sediments depend on the chemical forms present and their relative mobility. Long-term exposure to arsenic may cause several disea…
Dittrichia viscosa Selection Strategy Based on Stress Produces Stable Clonal Lines for Phytoremediation Applications Open
Dittrichia viscosa uptake and translocation of the metalloid As is not fully understood and some data are contradictory, but its adaptability to this pollutant is known and is dependent on its genetic variability. D. viscosa is not a hyper…
View article: 5-(4-Chlorophenyl)-N,1-di-o-tolyl-1H-imidazole-2-amine
5-(4-Chlorophenyl)-N,1-di-o-tolyl-1H-imidazole-2-amine Open
A new 2-amino imidazole derivative, 5-(4-chlorophenyl)-N,1-di-o-tolyl-1H-imidazole-2-amine (3), has been synthesized using a green approach. The reaction was conducted in a ChCl (cholinium chloride)/urea eutectic mixture, which is a nature…
Cadmium treatment induces endoplasmic reticulum stress and unfolded protein response in <i>Arabidopsis thaliana</i> Open
We report about the response of Arabidopsis thaliana to chronic and temporary Cd 2+ stress, and the Cd 2+ induced activation of ER stress and unfolded protein response (UPR). Cd 2+ -induced UPR proceeds mainly through the bZIP60 arm, which…
View article: Enhanced Bioactivity of Pomegranate Peel Extract following Controlled Release from CaCO<sub>3</sub> Nanocrystals
Enhanced Bioactivity of Pomegranate Peel Extract following Controlled Release from CaCO<sub>3</sub> Nanocrystals Open
Pomegranate peel extract is rich of interesting bioactive chemicals, principally phenolic compounds, which have shown antimicrobial, anticancer, and antioxidative properties. The aim of this work was to improve extract’ bioactivity through…
View article: New Oxaliplatin-Pyrophosphato Analogs with Improved In Vitro Cytotoxicity
New Oxaliplatin-Pyrophosphato Analogs with Improved In Vitro Cytotoxicity Open
Two new Pt(II)-pyrophosphato complexes containing the carrier ligands cis-1,3-diaminocyclohexane (cis-1,3-DACH) and trans-1,2-diamine-4-cyclohexene (1,2-DACHEX), variants of the 1R,2R-diaminocyclohexane ligand present in the clinically use…
Trace Metals Do Not Accumulate Over Time in The Edible Mediterranean Jellyfish Rhizostoma pulmo (Cnidaria, Scyphozoa) from Urban Coastal Waters Open
Jellyfish as food represent a millennial tradition in Asia. Recently, jellyfish have also been proposed as a valuable source of protein in Western countries. To identify health risks associated with the potential human consumption of jelly…
Sequential Extraction Analysis of Arsenic in Soil Samples Collected in an Agricultural Area of Brindisi, Apulia (Italy), in the Proximity of a Coal-Burning Power Plant Open
In order to evaluate the local environmental risk deriving from coal transport and burning, 30 soil samples were collected along the coal conveyor belt and around the coal-burning power plant Federico II of Brindisi (Apulia, southern Italy…
Aquatic Mosses as Adaptable Bio-Filters for Heavy Metal Removal from Contaminated Water Open
Heavy metals (HMs) are released into the environment by many human activities and persist in water even after remediation. The efficient filtration of solubilized HMs is extremely difficult. Phytoremediation appears a convenient tool to re…
View article: Platinum(IV) Complexes of trans-1,2-diamino-4-cyclohexene: Prodrugs Affording an Oxaliplatin Analogue that Overcomes Cancer Resistance
Platinum(IV) Complexes of trans-1,2-diamino-4-cyclohexene: Prodrugs Affording an Oxaliplatin Analogue that Overcomes Cancer Resistance Open
Six platinum(IV) compounds derived from an oxaliplatin analogue containing the unsaturated cyclic diamine trans-1,2-diamino-4-cyclohexene (DACHEX), in place of the 1,2-diaminocyclohexane, and a range of axial ligands, were synthesized and …
View article: CaCO3 as an Environmentally Friendly Renewable Material for Drug Delivery Systems: Uptake of HSA-CaCO3 Nanocrystals Conjugates in Cancer Cell Lines
CaCO3 as an Environmentally Friendly Renewable Material for Drug Delivery Systems: Uptake of HSA-CaCO3 Nanocrystals Conjugates in Cancer Cell Lines Open
Chemical and biochemical functionalization of nanoparticles (NPs) can lead to an active cellular uptake enhancing their efficacy thanks to the targeted localization in tumors. In the present study calcium carbonate nano-crystals (CCNs), st…
View article: Variation in Membrane Trafficking Linked to SNARE AtSYP51 Interaction With Aquaporin NIP1;1
Variation in Membrane Trafficking Linked to SNARE AtSYP51 Interaction With Aquaporin NIP1;1 Open
SYP51 and 52 are the two members of the SYP5 Qc-SNARE gene family in Arabidopsis thaliana. These two proteins, besides their high level of sequence identity (85%), have shown to have differential functional specificity and possess a differ…
View article: A minimal structural variation can overcome tumour resistance of oxaliplatin: the case of 4,5-dehydrogenation of the cyclohexane ring
A minimal structural variation can overcome tumour resistance of oxaliplatin: the case of 4,5-dehydrogenation of the cyclohexane ring Open
A new family of anticancer compounds has been derived from oxaliplatin by inserting a double-bond between carbons 4 and 5 of the 1,2-diaminocyclohexane ring.
Cisplatin, Oxaliplatin, and Kiteplatin Subcellular Effects Compared in a Plant Model Open
The immediate visual comparison of platinum chemotherapeutics’ effects in eukaryotic cells using accessible plant models of transgenic Arabidopsis thaliana is reported. The leading anticancer drug cisplatin, a third generation drug used fo…
View article: Harvest year effects on Apulian EVOOs evaluated by <sup>1</sup> H NMR based metabolomics
Harvest year effects on Apulian EVOOs evaluated by <sup>1</sup> H NMR based metabolomics Open
Nine hundred extra virgin olive oils (EVOO) were extracted from individual olive trees of four olive cultivars (Coratina, Cima di Mola, Ogliarola, Peranzana), originating from the provinces of Bari and Foggia (Apulia region, Southern Italy…
Peer Review #1 of "Harvest year effects on Apulian EVOOs evaluated by 1H NMR based metabolomics (v0.1)" Open
Nine hundred extra virgin olive oils (EVOO) were extracted from individual olive trees of four olive cultivars (Coratina, Cima di Mola, Ogliarola, Peranzana), originating from the provinces of Bari and Foggia (Apulia region, Southern Italy…