Explanipedia

Short Review on Treatment of Superficial Bladder Cancer (Ta, Tis, T1) Open

Phalguni Gupta · 2019

Type 1-programmed dendritic cells drive antigen-specific latency reversal and immune elimination of persistent HIV-1 Open

Jan Kristoff, Mariana L. Palma, Tatiana M. García-Bates, Chengli Shen, Nicolas Sluis‐Cremer , et al. · 2019

Neisseria gonorrhoeae uses cellular proteins CXCL10 and IL8 to enhance HIV‐1 transmission across cervical mucosa Open

Anwesha Sanyal, Chengli Shen, Ming Ding, Todd A. Reinhart, Yue Chen , et al. · 2019

Problem Neisseria gonorrhoeae (NG) infection has been shown to increase sexual transmission of HIV‐1. However, the mechanism of NG‐induced enhanced HIV‐1 transmission is unknown. Methods (a) The cervical tissues were exposed to NG, and cyt…

TZA, a sensitive reporter cell-based assay to accurately and rapidly quantify inducible, replication-competent latent HIV-1 from resting CD4 T cells Open

Anwesha Sanyal, Vatsala Rangachar, Phalguni Gupta · 2019

The latent HIV-1 viral reservoir in resting CD4⁺ (rCD4⁺) T cells represents a major barrier to an HIV-1 cure. There is an ongoing effort to identify therapeutic approaches that will eliminate or reduce the size of thi…

Inhibitors of Signaling Pathways That Block Reversal of HIV-1 Latency Open

Benni Vargas, Nicholas S. Giacobbi, Anwesha Sanyal, Narasimhan J. Venkatachari, Feng Han , et al. · 2018

Signaling pathways play a key role in HIV-1 latency. In this study, we used the 24ST1NLESG cell line of HIV-1 latency to screen a library of structurally diverse, medicinally active, cell permeable kinase inhibitors, which target a wide ra…

Human immunodeficiency virus infection induces lymphoid fibrosis in the BM-liver-thymus-spleen humanized mouse model Open

Jasmine Samal, Samantha Kelly, Ali Na-Shatal, Abdalla Elhakiem, Antu Das , et al. · 2018

A major pathogenic feature associated with HIV infection is lymphoid fibrosis, which persists during antiretroviral therapy (ART). Lymphoid tissues play critical roles in the generation of antigen-specific immune response, and fibrosis dis…

TZA: a novel assay for measuring the latent HIV-1 reservoir Open

Phalguni Gupta, Anwesha Sanyal, Robbie B. Mailliard · 2017

Combination antiretroviral therapy (cART) has significantly reduced mortality and morbidity of those infected with HIV-1 [1,2]. During cART, the plasma virus levels become undetectable by standard ...

Novel assay reveals a large, inducible, replication-competent HIV-1 reservoir in resting CD4+ T cells Open

Anwesha Sanyal, Robbie B. Mailliard, Charles R. Rinaldo, Deena Ratner, Ming Ding , et al. · 2017

Effect of prolonged freezing of semen on exosome recovery and biologic activity Open

Jennifer L. Welch, Marisa Nia Madison, Joseph B. Margolick, Shannon Galvin, Phalguni Gupta , et al. · 2017

Exosomes are important vehicles of intercellular communication that shape host responses to physiologic, tumorigenic, and pathogenic conditions. The composition and function of exosomes are dynamic and depends on the state and condition of…

Identification of the transcripts associated with spontaneous HCV clearance in individuals co-infected with HIV and HCV Open

Yue Chen, Chengli Shen, Debjani Guha, Ming Ding, Scott Kulich , et al. · 2016

These results suggest that subjects who spontaneously clear HCV may express these unique genes associated with innate immune functions.

Erratum for Smith et al., Effective Cytotoxic T Lymphocyte Targeting of Persistent HIV-1 during Antiretroviral Therapy Requires Priming of Naive CD8 + T Cells Open

Kellie N. Smith, Robbie B. Mailliard, Paolo Piazza, Will Fischer, Bette Korber , et al. · 2016

Volume 7, no. 3, doi:10.1128/mBio.00473-16, 2016. For transparency, the legend to Fig. 7 has been revised to include additional information that was inadvertently omitted. Below is the corrected version.

Placental Mechanics in the Zika-Microcephaly Relationship Open

Jennifer J. Adibi, Yaqi Zhao, Abigail R. Cartus, Phalguni Gupta, Lance A. Davidson · 2016

28 Dendritic cells programmed by inflammatory mediators can effectively induce both the immunologic ‘kick’ and ‘kill’ of latent HIV-1 Open

Jan Kristoff, Robbie B. Mailliard, Jennifer M. Zerbato, N. Sluis-Cremer, Mackenzie Carlson , et al. · 2016

Effective Cytotoxic T Lymphocyte Targeting of Persistent HIV-1 during Antiretroviral Therapy Requires Priming of Naive CD8 + T Cells Open

Kellie N. Smith, Robbie B. Mailliard, Paolo Piazza, Will Fischer, Bette Korber , et al. · 2016

Curing HIV-1 infection will require elimination of persistent cellular reservoirs that harbor latent virus in the face of combination antiretroviral therapy (cART). Proposed immunotherapeutic strategies to cure HIV-1 infection include enha…

HIV Exposure to the Epithelia in Ectocervical and Colon Tissues Induces Inflammatory Cytokines Without Tight Junction Disruption Open

Soni Ramachandra Sankapal, Phalguni Gupta, Deena Ratner, Ming Ding, Chengli Shen , et al. · 2016

Epithelial cells in human cervical and colonic mucosa do not express HIV receptor. However, HIV transmission occurs across the unbreached epithelia by an unknown mechanism. In this study, the effect of HIV exposure on tight junction (TJ) a…

Colposcopy of the cervicovagina reveals no adverse effects of RC-101 films. Open

Alexander M. Cole, Dorothy L. Patton, Lisa C. Rohan, Amy L. Cole, Yvonne Cosgrove-Sweeney , et al. · 2015

Images from colposcopic examination of cervicovaginal mucosa of a representative pigtailed macaque obtained prior to film insertion, at the time of insertion (Time 0), and 30 min and 24 hr after film insertion. Note the absence of mucosal …

Dendritic cell induced “kick” of latent HIV-1 in vitro during cART Open

Robbie B. Mailliard, Jan Kristoff, Jennifer M. Zerbato, Nicolas Sluis‐Cremer, Phalguni Gupta , et al. · 2015

Optimum utilization of megavoltage teletherapy machine in developing countries Open

Phalguni Gupta, Ranen Kanti Aich, Asit Ranjan Deb, Poulami Gupta · 2015

Objectives: Radiotherapy is an integral part of Cancer management. The unavailability of adequate number of teletherapy machines in developing countries like India has compounded upon the increasing incidence of Cancer, leading to a huge d…

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