Parkash S. Gill
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View article: EphB4-ephrin-B2 are targets in castration resistant prostate cancer
EphB4-ephrin-B2 are targets in castration resistant prostate cancer Open
Background PI3K pathway activation is a common and early event in prostate cancer, from loss of function mutations in PTEN , or activating mutations in PIK3Ca or AKT leading to constitutive activation, induction of growth factor-receptors …
View article: Improved efficacy of pembrolizumab combined with soluble EphB4-albumin in HPV-negative EphrinB2 positive head neck squamous cell carcinoma
Improved efficacy of pembrolizumab combined with soluble EphB4-albumin in HPV-negative EphrinB2 positive head neck squamous cell carcinoma Open
The combination of sEphB4-HSA and pembrolizumab has a favorable toxicity profile and favorable activity particularly among HPV-negative EphrinB2 positive patients with HNSCC.
View article: EphrinB2: Expression of a novel potential target in renal cell carcinoma
EphrinB2: Expression of a novel potential target in renal cell carcinoma Open
Introduction: Renal cell carcinoma (RCC) is primarily managed by surgery with the use of systemic targeted therapy in a metastatic setting. Newer targeted therapeutic options are evolving; Eph-ephrin is a potential new pathway. The therape…
View article: Supplementary Tables 1 - 2 from Monoclonal Antibody against Cell Surface GRP78 as a Novel Agent in Suppressing PI3K/AKT Signaling, Tumor Growth, and Metastasis
Supplementary Tables 1 - 2 from Monoclonal Antibody against Cell Surface GRP78 as a Novel Agent in Suppressing PI3K/AKT Signaling, Tumor Growth, and Metastasis Open
PDF file - 62K, Table S1. Humanized MAb159 Pharmacokinetics in mouse. Table S2. Toxicology study of humanized MAb159 in mouse.
View article: Supplementary Methods from Monoclonal Antibody against Cell Surface GRP78 as a Novel Agent in Suppressing PI3K/AKT Signaling, Tumor Growth, and Metastasis
Supplementary Methods from Monoclonal Antibody against Cell Surface GRP78 as a Novel Agent in Suppressing PI3K/AKT Signaling, Tumor Growth, and Metastasis Open
PDF file - 121K
View article: Supplementary Methods from Monoclonal Antibody against Cell Surface GRP78 as a Novel Agent in Suppressing PI3K/AKT Signaling, Tumor Growth, and Metastasis
Supplementary Methods from Monoclonal Antibody against Cell Surface GRP78 as a Novel Agent in Suppressing PI3K/AKT Signaling, Tumor Growth, and Metastasis Open
PDF file - 121K
View article: Supplementary Tables 1 - 2 from Monoclonal Antibody against Cell Surface GRP78 as a Novel Agent in Suppressing PI3K/AKT Signaling, Tumor Growth, and Metastasis
Supplementary Tables 1 - 2 from Monoclonal Antibody against Cell Surface GRP78 as a Novel Agent in Suppressing PI3K/AKT Signaling, Tumor Growth, and Metastasis Open
PDF file - 62K, Table S1. Humanized MAb159 Pharmacokinetics in mouse. Table S2. Toxicology study of humanized MAb159 in mouse.
View article: Supplementary Figures 1 - 9 from Monoclonal Antibody against Cell Surface GRP78 as a Novel Agent in Suppressing PI3K/AKT Signaling, Tumor Growth, and Metastasis
Supplementary Figures 1 - 9 from Monoclonal Antibody against Cell Surface GRP78 as a Novel Agent in Suppressing PI3K/AKT Signaling, Tumor Growth, and Metastasis Open
PDF file - 736K, Fig. S1. Generation and characterization of MAb159. Fig. S2. MAb159 induces GRP78 endocytosis through clathrin mediated pathway. Fig. S3. MAb159 induces apoptosis of tumor cells in vitro. Fig. S4. Surface GRP78 Forms Compl…
View article: Data from Monoclonal Antibody against Cell Surface GRP78 as a Novel Agent in Suppressing PI3K/AKT Signaling, Tumor Growth, and Metastasis
Data from Monoclonal Antibody against Cell Surface GRP78 as a Novel Agent in Suppressing PI3K/AKT Signaling, Tumor Growth, and Metastasis Open
Purpose: The ER chaperone GRP78 translocates to the surface of tumor cells and promotes survival, metastasis, and resistance to therapy. An oncogenic function of cell surface GRP78 has been attributed to the activation of the phosph…
View article: Data from Converging Evidence for Efficacy from Parallel EphB4-Targeted Approaches in Ovarian Carcinoma
Data from Converging Evidence for Efficacy from Parallel EphB4-Targeted Approaches in Ovarian Carcinoma Open
EphB4 is a transmembrane receptor tyrosine kinase that plays an important role in neural plasticity and angiogenesis. EphB4 is overexpressed in ovarian cancer and is predictive of poor clinical outcome. However, the biological significance…
View article: Data from Converging Evidence for Efficacy from Parallel EphB4-Targeted Approaches in Ovarian Carcinoma
Data from Converging Evidence for Efficacy from Parallel EphB4-Targeted Approaches in Ovarian Carcinoma Open
EphB4 is a transmembrane receptor tyrosine kinase that plays an important role in neural plasticity and angiogenesis. EphB4 is overexpressed in ovarian cancer and is predictive of poor clinical outcome. However, the biological significance…
View article: Data from Monoclonal Antibody against Cell Surface GRP78 as a Novel Agent in Suppressing PI3K/AKT Signaling, Tumor Growth, and Metastasis
Data from Monoclonal Antibody against Cell Surface GRP78 as a Novel Agent in Suppressing PI3K/AKT Signaling, Tumor Growth, and Metastasis Open
Purpose: The ER chaperone GRP78 translocates to the surface of tumor cells and promotes survival, metastasis, and resistance to therapy. An oncogenic function of cell surface GRP78 has been attributed to the activation of the phosph…
View article: Supplementary Figures 1 - 9 from Monoclonal Antibody against Cell Surface GRP78 as a Novel Agent in Suppressing PI3K/AKT Signaling, Tumor Growth, and Metastasis
Supplementary Figures 1 - 9 from Monoclonal Antibody against Cell Surface GRP78 as a Novel Agent in Suppressing PI3K/AKT Signaling, Tumor Growth, and Metastasis Open
PDF file - 736K, Fig. S1. Generation and characterization of MAb159. Fig. S2. MAb159 induces GRP78 endocytosis through clathrin mediated pathway. Fig. S3. MAb159 induces apoptosis of tumor cells in vitro. Fig. S4. Surface GRP78 Forms Compl…
View article: Supplementary Table 1 from Critical Role for the Receptor Tyrosine Kinase EPHB4 in Esophageal Cancers
Supplementary Table 1 from Critical Role for the Receptor Tyrosine Kinase EPHB4 in Esophageal Cancers Open
PDF file - 66K, This table contains the detailed immunohistochemical data scoring depicted in Figure A and B
View article: Data from Preferential Induction of EphB4 over EphB2 and Its Implication in Colorectal Cancer Progression
Data from Preferential Induction of EphB4 over EphB2 and Its Implication in Colorectal Cancer Progression Open
The receptor tyrosine kinase EphB2 is expressed by colon progenitor cells; however, only 39% of colorectal tumors express EphB2 and expression levels decline with disease progression. Conversely, EphB4 is absent in normal colon but is expr…
View article: Data from Critical Role for the Receptor Tyrosine Kinase EPHB4 in Esophageal Cancers
Data from Critical Role for the Receptor Tyrosine Kinase EPHB4 in Esophageal Cancers Open
Esophageal cancer incidence is increasing and has few treatment options. In studying receptor tyrosine kinases associated with esophageal cancers, we have identified EPHB4 to be robustly overexpressed in cell lines and primary tumor tissue…
View article: Data from Critical Role for the Receptor Tyrosine Kinase EPHB4 in Esophageal Cancers
Data from Critical Role for the Receptor Tyrosine Kinase EPHB4 in Esophageal Cancers Open
Esophageal cancer incidence is increasing and has few treatment options. In studying receptor tyrosine kinases associated with esophageal cancers, we have identified EPHB4 to be robustly overexpressed in cell lines and primary tumor tissue…
View article: Data from Cancer Angiogenesis Induced by Kaposi Sarcoma–Associated Herpesvirus Is Mediated by EZH2
Data from Cancer Angiogenesis Induced by Kaposi Sarcoma–Associated Herpesvirus Is Mediated by EZH2 Open
EZH2 is a component of the epigenetic regulator PRC2 that suppresses gene expression. Elevated expression of EZH2 is common in human cancers and is associated with tumor progression and poor prognosis. In this study, we show that EZH2 elev…
View article: Supplementary Methods and Figure Legends 1-11 from Preferential Induction of EphB4 over EphB2 and Its Implication in Colorectal Cancer Progression
Supplementary Methods and Figure Legends 1-11 from Preferential Induction of EphB4 over EphB2 and Its Implication in Colorectal Cancer Progression Open
Supplementary Methods and Figure Legends 1-11 from Preferential Induction of EphB4 over EphB2 and Its Implication in Colorectal Cancer Progression
View article: Supplementary Table 1 from Critical Role for the Receptor Tyrosine Kinase EPHB4 in Esophageal Cancers
Supplementary Table 1 from Critical Role for the Receptor Tyrosine Kinase EPHB4 in Esophageal Cancers Open
PDF file - 66K, This table contains the detailed immunohistochemical data scoring depicted in Figure A and B
View article: Supplementary Methods and Figure Legends 1-11 from Preferential Induction of EphB4 over EphB2 and Its Implication in Colorectal Cancer Progression
Supplementary Methods and Figure Legends 1-11 from Preferential Induction of EphB4 over EphB2 and Its Implication in Colorectal Cancer Progression Open
Supplementary Methods and Figure Legends 1-11 from Preferential Induction of EphB4 over EphB2 and Its Implication in Colorectal Cancer Progression
View article: Supplementary Figure 1 from Cancer Angiogenesis Induced by Kaposi Sarcoma–Associated Herpesvirus Is Mediated by EZH2
Supplementary Figure 1 from Cancer Angiogenesis Induced by Kaposi Sarcoma–Associated Herpesvirus Is Mediated by EZH2 Open
PDF file - 101K, KSHV infection converts BOEC cells into spindle shape, and upregulates the expression of lymphatic endothelial markers
View article: The Impact of Facility Surgical Caseload Volumes on Survival Outcomes in Patients Undergoing Radical Cystectomy
The Impact of Facility Surgical Caseload Volumes on Survival Outcomes in Patients Undergoing Radical Cystectomy Open
The role of surgical experience and its impact on the survival requires further investigation. A cohort of patients undergoing radical cystectomy or anterior pelvic exenteration for localized bladder cancer between 2006 and 2013 at 1143 fa…
View article: PD-1 Blockade on Tumor Microenvironment-Resident ILC2s Promotes TNF-α Production and Restricts Progression of Metastatic Melanoma
PD-1 Blockade on Tumor Microenvironment-Resident ILC2s Promotes TNF-α Production and Restricts Progression of Metastatic Melanoma Open
While pulmonary ILC2s represent one of the major tissue-resident innate lymphoid cell populations at steady state and are key drivers of cytokine secretion in their occupational niche, their role in pulmonary cancer progression remains unc…
View article: Quantitative Tyrosine Phosphoproteome Profiling of AXL Receptor Tyrosine Kinase Signaling Network
Quantitative Tyrosine Phosphoproteome Profiling of AXL Receptor Tyrosine Kinase Signaling Network Open
Overexpression and amplification of AXL receptor tyrosine kinase (RTK) has been found in several hematologic and solid malignancies. Activation of AXL can enhance tumor-promoting processes such as cancer cell proliferation, migration, inva…
View article: Tyrosine Phosphoproteomics of Patient-Derived Xenografts Reveals Ephrin Type-B Receptor 4 Tyrosine Kinase as a Therapeutic Target in Pancreatic Cancer
Tyrosine Phosphoproteomics of Patient-Derived Xenografts Reveals Ephrin Type-B Receptor 4 Tyrosine Kinase as a Therapeutic Target in Pancreatic Cancer Open
Pancreatic ductal adenocarcinoma is a recalcitrant tumor with minimal response to conventional chemotherapeutic approaches. Oncogenic signaling by activated tyrosine kinases has been implicated in cancers resulting in activation of diverse…
View article: A Novel DNA Methylation Signature as an Independent Prognostic Factor in Muscle-Invasive Bladder Cancer
A Novel DNA Methylation Signature as an Independent Prognostic Factor in Muscle-Invasive Bladder Cancer Open
Background Muscle-invasive bladder cancer (MIBC) accounts for approximately 20% of all urothelial bladder carcinomas (UBC) at time of diagnosis, and up to 30% of patients with non-muscle invasive UBC will progress to MIBC over time. An inc…
View article: The chaperone GRP78 is a host auxiliary factor for SARS-CoV-2 and GRP78 depleting antibody blocks viral entry and infection
The chaperone GRP78 is a host auxiliary factor for SARS-CoV-2 and GRP78 depleting antibody blocks viral entry and infection Open
View article: 455 Impact of EphB4 and PD-1 treatment on immune infiltrate in advanced bladder cancer
455 Impact of EphB4 and PD-1 treatment on immune infiltrate in advanced bladder cancer Open
Background Bladder cancer is the fourth most common cancer in American men with chances of 1 in 27 developing this form of cancer. Despite the progress in treating these patients with immunomodulatory agents, the vast majority of patients …
View article: Reply by Authors
Reply by Authors Open
You have accessJournal of UrologyReview Article1 Oct 2020Reply by Authorsis a reply to letterEditorial Comment G. E. Cacciamani, S. Ghodoussipour, A. Mari, K. S. Gill, M. Desai, W. Artibani, P. S. Gill, S. F. Shariat, I. S. Gill, and H. Dj…