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View article: Leishmania major centrin knock-out parasites reprogram tryptophan metabolism to induce a pro-inflammatory response
Leishmania major centrin knock-out parasites reprogram tryptophan metabolism to induce a pro-inflammatory response Open
View article: Toll-like Receptor-9 (TLR-9) Signaling Is Crucial for Inducing Protective Immunity following Immunization with Genetically Modified Live Attenuated Leishmania Parasites
Toll-like Receptor-9 (TLR-9) Signaling Is Crucial for Inducing Protective Immunity following Immunization with Genetically Modified Live Attenuated Leishmania Parasites Open
No human vaccine is available for visceral leishmaniasis (VL). Live attenuated centrin gene-deleted L. donovani (LdCen−/−) parasite vaccine has been shown to induce robust innate immunity and provide protection in animal models. Toll-like …
View article: <i>Leishmania major centrin</i>knock-out parasites alter the kynurenine- aryl hydrocarbon receptor signaling to produce a pro-inflammatory response
<i>Leishmania major centrin</i>knock-out parasites alter the kynurenine- aryl hydrocarbon receptor signaling to produce a pro-inflammatory response Open
Summary Leishmaniasis is a parasitic disease that is prevalent in approximately 88 countries, and yet no licensed human vaccine exists against it. Towards control of leishmaniasis, we have developed Leishmania major centrin gene deletion m…
View article: Dual scRNA-Seq analysis reveals rare and uncommon parasitized cell populations in chronic <i>L. donovani</i> infection
Dual scRNA-Seq analysis reveals rare and uncommon parasitized cell populations in chronic <i>L. donovani</i> infection Open
Although phagocytic cells are documented targets of Leishmania parasites, it is unclear whether these parasites can infect other cell types. In this study, we describe a computational approach that exploits scRNA-seq to simultaneously anal…
View article: Leishmania Major Centrin Gene-Deleted Parasites Generate Skin Resident Memory T-Cell Immune Response Analogous to Leishmanization
Leishmania Major Centrin Gene-Deleted Parasites Generate Skin Resident Memory T-Cell Immune Response Analogous to Leishmanization Open
Leishmaniasis is a vector-borne parasitic disease transmitted through the bite of a sand fly with no available vaccine for humans. Recently, we have developed a live attenuated Leishmania major centrin gene-deleted parasite strain ( LmCen …
View article: Neutrophil-dendritic cell interaction plays an important role in live attenuated Leishmania vaccine induced immunity
Neutrophil-dendritic cell interaction plays an important role in live attenuated Leishmania vaccine induced immunity Open
Background Neutrophils are involved in the initial host responses to pathogens. Neutrophils can activate T cell responses either independently or through indirect involvement of Dendritic cells (DCs). Recently we have demonstrated direct n…
View article: Skin resident memory cells generated by the <i>L. major</i> centrin gene deleted parasites mediate protective immune response analogous to leishmanization
Skin resident memory cells generated by the <i>L. major</i> centrin gene deleted parasites mediate protective immune response analogous to leishmanization Open
Leishmaniasis is a vector-borne parasitic disease transmitted through the bite of a sand fly with no available vaccine for humans. Recently, we have developed a live attenuated Leishmania major centrin gene deleted parasite strain ( LmCen …
View article: Determinants of Innate Immunity in Visceral Leishmaniasis and Their Implication in Vaccine Development
Determinants of Innate Immunity in Visceral Leishmaniasis and Their Implication in Vaccine Development Open
Leishmaniasis is endemic to the tropical and subtropical regions of the world and is transmitted by the bite of an infected sand fly. The multifaceted interactions between Leishmania , the host innate immune cells, and the adaptive immunit…
View article: From infection to vaccination: reviewing the global burden, history of vaccine development, and recurring challenges in global leishmaniasis protection
From infection to vaccination: reviewing the global burden, history of vaccine development, and recurring challenges in global leishmaniasis protection Open
Despite advances in pre-clinical vaccine research, approval of a human leishmaniasis vaccine still faces major challenges - including manufacturing of candidate vaccines under Good Manufacturing Practices, developing well-designed clinical…
View article: Preclinical validation of a live attenuated dermotropic Leishmania vaccine against vector transmitted fatal visceral leishmaniasis
Preclinical validation of a live attenuated dermotropic Leishmania vaccine against vector transmitted fatal visceral leishmaniasis Open
Visceral Leishmaniasis (VL), a potentially fatal disease is caused by Leishmania donovani parasites with no vaccine available. Here we produced a dermotropic live attenuated centrin gene deleted Leishmania major ( LmCen −/− ) vaccine under…
View article: Revival of Leishmanization and Leishmanin
Revival of Leishmanization and Leishmanin Open
Leishmaniasis includes a spectrum of diseases ranging from debilitating cutaneous to fatal visceral infections. This disease is caused by the parasitic protozoa of the genus Leishmania that is transmitted by infected sandflies. Over 1 bill…
View article: Preclinical validation of a second generation leishmanization vaccine against vector transmitted fatal visceral leishmaniasis
Preclinical validation of a second generation leishmanization vaccine against vector transmitted fatal visceral leishmaniasis Open
Visceral Leishmaniasis (VL) is fatal if untreated. There is no licensed vaccine available against human leishmaniasis. We recently demonstrated protection in mice against L. major infection using a CRISPR genome edited attenuated Leishmani…
View article: Essential Role of Neutrophils in the Protective Immune Response Induced by a Live Attenuated <i>Leishmania</i> Vaccine
Essential Role of Neutrophils in the Protective Immune Response Induced by a Live Attenuated <i>Leishmania</i> Vaccine Open
No licensed vaccine exists against visceral leishmaniasis (VL), a disease caused by the Leishmania donovani parasite. We have previously reported both macrophages and dendritic cells play important role in the protection induced by a live …
View article: miR-21 Expression Determines the Early Vaccine Immunity Induced by LdCen−/− Immunization
miR-21 Expression Determines the Early Vaccine Immunity Induced by LdCen−/− Immunization Open
Role of miR-21 in vaccine induced immunity.
View article: Leptin Functions in Infectious Diseases
Leptin Functions in Infectious Diseases Open
Leptin, a pleiotropic protein has long been recognized to play an important role in the regulation of energy homeostasis, metabolism, neuroendocrine function, and other physiological functions through its effects on the central nervous sys…
View article: Gut Microbiota Egested During Bites of Infected Sand flies Augments Severity of Leishmaniasis via Inflammasome-Derived IL-11
Gut Microbiota Egested During Bites of Infected Sand flies Augments Severity of Leishmaniasis via Inflammasome-Derived IL-11 Open
View article: Gut Microbes Egested during Bites of Infected Sand Flies Augment Severity of Leishmaniasis via Inflammasome-Derived IL-1β
Gut Microbes Egested during Bites of Infected Sand Flies Augment Severity of Leishmaniasis via Inflammasome-Derived IL-1β Open
View article: Immunization with Live Attenuated Leishmania donovani Centrin−/− Parasites Is Efficacious in Asymptomatic Infection
Immunization with Live Attenuated Leishmania donovani Centrin−/− Parasites Is Efficacious in Asymptomatic Infection Open
Currently, there is no vaccine against visceral leishmaniasis (VL). Toward developing an effective vaccine, we have reported extensively on the immunogenicity of live attenuated LdCentrin-/- mutants in naive animal models…
View article: Live Attenuated <i>Leishmania donovani</i> Centrin Gene–Deleted Parasites Induce IL-23–Dependent IL-17–Protective Immune Response against Visceral Leishmaniasis in a Murine Model
Live Attenuated <i>Leishmania donovani</i> Centrin Gene–Deleted Parasites Induce IL-23–Dependent IL-17–Protective Immune Response against Visceral Leishmaniasis in a Murine Model Open
No vaccine exists against visceral leishmaniasis. To develop effective vaccines, we have previously reported protective role of live attenuated centrin gene–deleted Leishmania donovani (LdCen−/−) parasites through induction of Th1 type imm…
View article: Live Attenuated Leishmania donovani Centrin Knock Out Parasites Generate Non-inferior Protective Immune Response in Aged Mice against Visceral Leishmaniasis
Live Attenuated Leishmania donovani Centrin Knock Out Parasites Generate Non-inferior Protective Immune Response in Aged Mice against Visceral Leishmaniasis Open
Taken together, LdCen-/- immunization induced a significant but diminished host protective response in aged mice after challenge with virulent L. donovani parasites compared to young mice.
View article: Modulation of Innate Immune Mechanisms to Enhance Leishmania Vaccine-Induced Immunity: Role of Coinhibitory Molecules
Modulation of Innate Immune Mechanisms to Enhance Leishmania Vaccine-Induced Immunity: Role of Coinhibitory Molecules Open
No licensed human vaccines are currently available against any parasitic disease including leishmaniasis. Several antileishmanial vaccine formulations have been tested in various animal models, including genetically modified live-attenuate…
View article: Differential Role of Leptin as an Immunomodulator in Controlling Visceral Leishmaniasis in Normal and Leptin-Deficient Mice
Differential Role of Leptin as an Immunomodulator in Controlling Visceral Leishmaniasis in Normal and Leptin-Deficient Mice Open
Visceral leishmaniasis (VL) is caused by the protozoan parasite Leishmania donovani . There are no vaccines and available drugs against leishmaniasis are toxic. Immunomodulators that specifically boost the anti-microbial activities of the …
View article: Genetically Modified Live Attenuated Leishmania donovani Parasites Induce Innate Immunity through Classical Activation of Macrophages That Direct the Th1 Response in Mice
Genetically Modified Live Attenuated Leishmania donovani Parasites Induce Innate Immunity through Classical Activation of Macrophages That Direct the Th1 Response in Mice Open
Visceral leishmaniasis (VL) causes significant mortality and there is no effective vaccine. Previously, we have shown that genetically modified Leishmania donovani parasites, here described as live attenuated parasites, induce a host prote…
View article: TACI deficiency leads to alternatively activated macrophage phenotype and susceptibility to<i>Leishmania</i>infection
TACI deficiency leads to alternatively activated macrophage phenotype and susceptibility to<i>Leishmania</i>infection Open
Significance Here, we described a novel role for transmembrane activator and calcium-modulator and cyclophilin ligand interactor (TACI) in determining Mϕ phenotype, a molecule that is previously known to be important in B-cell responses. W…