Paromita Das
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View article: IUC24417-83 Correlation of circulating tumor DNA with oncological endpoints in metastatic urothelial cancer: a systematic review and meta-analysis of phase II/III clinical trials
IUC24417-83 Correlation of circulating tumor DNA with oncological endpoints in metastatic urothelial cancer: a systematic review and meta-analysis of phase II/III clinical trials Open
Background Metastatic urothelial cancer (mUC) bears a poor prognosis, with current surveillance strategies offering limited precision. Biomarkers such as circulating tumor DNA (ctDNA) are emerging tools to monitor treatment response in ear…
View article: IUC24418-84 Biomarkers detecting minimal residual disease for predicting risk of relapse in operable urothelial cancer: a systematic review and meta-analysis of phase II/III clinical trials
IUC24418-84 Biomarkers detecting minimal residual disease for predicting risk of relapse in operable urothelial cancer: a systematic review and meta-analysis of phase II/III clinical trials Open
Background Non-metastatic urothelial cancers (UC), whether non-muscle-invasive bladder cancer (NMIBC) (Tis/Ta/T1) or MIBC (T2/T3/T4), are known for high recurrence and variable treatment response, henceforth warranting reliable biomarkers …
View article: SPINK1-COL18A1 Crosstalk Shapes Epigenome and Drives Cancer Stemness in Pancreatic Ductal Adenocarcinoma
SPINK1-COL18A1 Crosstalk Shapes Epigenome and Drives Cancer Stemness in Pancreatic Ductal Adenocarcinoma Open
Pancreatic ductal adenocarcinoma (PDAC) is a devastating cancer with an increasing incidence and extremely dismal prognosis. Discovery and mechanistic understanding of the genetic and epigenetic drivers of PDAC is therefore of critical imp…
View article: Translation of Epigenetics in Cell-Free DNA Liquid Biopsy Technology and Precision Oncology
Translation of Epigenetics in Cell-Free DNA Liquid Biopsy Technology and Precision Oncology Open
Technological advancements in cell-free DNA (cfDNA) liquid biopsy have triggered exponential growth in numerous clinical applications. While cfDNA-based liquid biopsy has made significant strides in personalizing cancer treatment, the expl…
View article: Histone deacetylase (Rpd3) regulates <i>Drosophila</i> early brain development via regulation of Tailless
Histone deacetylase (Rpd3) regulates <i>Drosophila</i> early brain development via regulation of Tailless Open
Tailless is a committed transcriptional repressor and principal regulator of the brain and eye development in Drosophila . Rpd3, the histone deacetylase, is an established repressor that interacts with co-repressors like Sin3a, Prospero, B…