Parul Sahu
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View article: The extracellular vesicle transcriptome provides tissue-specific functional genomic annotation relevant to disease susceptibility in obesity
The extracellular vesicle transcriptome provides tissue-specific functional genomic annotation relevant to disease susceptibility in obesity Open
We characterized circulating extracellular vesicles (EVs) in obese and lean humans, identifying transcriptional cargo differentially expressed in obesity (277 unique genes; false discovery rate < 10%). Since circulating EVs may have broad …
View article: Obesity and Heart Failure: Mechanistic Insights and the Regulatory Role of MicroRNAs
Obesity and Heart Failure: Mechanistic Insights and the Regulatory Role of MicroRNAs Open
Heart failure (HF) remains a leading cause of morbidity and mortality worldwide, driven by diverse pathophysiological mechanisms. Among its major risk factors, obesity has emerged as a lobal public health concern affecting individuals acro…
View article: The extracellular vesicle transcriptome provides tissue-specific functional genomic annotation relevant to disease susceptibility in obesity
The extracellular vesicle transcriptome provides tissue-specific functional genomic annotation relevant to disease susceptibility in obesity Open
We characterized circulating extracellular vesicles (EVs) in obese and lean humans, identifying transcriptional cargo differentially expressed in obesity. Since circulating EVs may have broad origin, we compared this obesity EV transcripto…
View article: Cardiomyocyte-derived circulating extracellular vesicles allow a non-invasive liquid biopsy of myocardium in health and disease
Cardiomyocyte-derived circulating extracellular vesicles allow a non-invasive liquid biopsy of myocardium in health and disease Open
SUMMARY The ability to track disease without tissue biopsy in patients is a major goal in biology and medicine. Here, we identify and characterize cardiomyocyte-derived extracellular vesicles in circulation (EVs; “cardiovesicles”) through …
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View article: <scp>MicroRNA</scp> ‐409‐3p/ <scp>BTG2</scp> signaling axis improves impaired angiogenesis and wound healing in obese mice
<span>MicroRNA</span> ‐409‐3p/ <span>BTG2</span> signaling axis improves impaired angiogenesis and wound healing in obese mice Open
Wound healing is facilitated by neoangiogenesis, a complex process that is essential to tissue repair in response to injury. MicroRNAs are small, noncoding RNAs that can regulate the wound healing process including stimulation of impaired …
View article: Human red blood cells release microvesicles with distinct sizes and protein composition that alter neutrophil phagocytosis
Human red blood cells release microvesicles with distinct sizes and protein composition that alter neutrophil phagocytosis Open
Extracellular vesicles (EVs) are membrane‐bound structures released by cells and tissues into biofluids, involved in cell‐cell communication. In humans, circulating red blood cells (RBCs), represent the most common cell‐type in the body, g…
View article: The collagen metabolism, disrupted endothelium, the endothelial progenitor cells and their microvesicles in acute rheumatic fever
The collagen metabolism, disrupted endothelium, the endothelial progenitor cells and their microvesicles in acute rheumatic fever Open
Background Acute rheumatic fever (ARF) and its chronic sequelae, rheumatic heart disease (RHD) contributes to valvular dysfunction and significant cardiovascular disability and endocardial damage is considered the primary pathophysiologica…
View article: Identification of post-transcriptional modifications in nucleic acid sequences using purpose-designed molecular beacons
Identification of post-transcriptional modifications in nucleic acid sequences using purpose-designed molecular beacons Open
Post-transcriptional RNA modifications (PTxMs) present in small RNA species, specifically circulating extracellular RNAs, were recently identified as clinically relevant readouts, often more indicative of disease severity than the classica…
View article: Immunological consequences of compromised ocular immune privilege accelerate retinal degeneration in retinitis pigmentosa
Immunological consequences of compromised ocular immune privilege accelerate retinal degeneration in retinitis pigmentosa Open
View article: Cardiac troponin T in extracellular vesicles as a novel biomarker in human cardiovascular disease
Cardiac troponin T in extracellular vesicles as a novel biomarker in human cardiovascular disease Open
Dear Editor, Soluble cardiac troponin T (cTnT), an indicator of myocardial injury and stress, is used in decision management for patients with cardiovascular disease (CVD). As highly sensitive assays can detect elevated concentrations of c…
View article: A nanoparticle probe for the imaging of autophagic flux in live mice via magnetic resonance and near-infrared fluorescence
A nanoparticle probe for the imaging of autophagic flux in live mice via magnetic resonance and near-infrared fluorescence Open
View article: Process design and economic evaluation for cyclopentane (CP)-based hydrate desalination
Process design and economic evaluation for cyclopentane (CP)-based hydrate desalination Open
View article: TRACE-seq: A transgenic system for unbiased and non-invasive transcriptome profiling of living cells
TRACE-seq: A transgenic system for unbiased and non-invasive transcriptome profiling of living cells Open
View article: The safety and efficacy of BCG encapsulated alginate particle (BEAP) against M.tb H37Rv infection in Macaca mulatta : A pilot study
The safety and efficacy of BCG encapsulated alginate particle (BEAP) against M.tb H37Rv infection in Macaca mulatta : A pilot study Open
View article: Peripheral blood-derived monocytes show neuronal properties and integration in immune-deficient rd1 mouse model upon phenotypic differentiation and induction with retinal growth factors
Peripheral blood-derived monocytes show neuronal properties and integration in immune-deficient rd1 mouse model upon phenotypic differentiation and induction with retinal growth factors Open
Background Cell therapy is one of the most promising therapeutic interventions for retinitis pigmentosa. In the current study, we aimed to assess if peripheral blood-derived monocytes which are highly abundant and accessible could be utili…
View article: Aerosol immunization by alginate coated mycobacterium (BCG/MIP) particles provide enhanced immune response and protective efficacy than aerosol of plain mycobacterium against M.tb. H37Rv infection in mice
Aerosol immunization by alginate coated mycobacterium (BCG/MIP) particles provide enhanced immune response and protective efficacy than aerosol of plain mycobacterium against M.tb. H37Rv infection in mice Open
View article: Intrasplenic Transplantation of Hepatocytes After Partial Hepatectomy in NOD.SCID Mice
Intrasplenic Transplantation of Hepatocytes After Partial Hepatectomy in NOD.SCID Mice Open
Partial hepatectomy is a versatile and reproducible method to study liver regeneration and the effect of cell based therapeutics in various pathological conditions. Partial hepatectomy also facilitates the increased engraftment and prolife…
View article: Novel immunodeficient <i>Pde6b</i> rd1 mouse model of retinitis pigmentosa to investigate potential therapeutics and pathogenesis of retinal degeneration
Novel immunodeficient <i>Pde6b</i> rd1 mouse model of retinitis pigmentosa to investigate potential therapeutics and pathogenesis of retinal degeneration Open
Retinitis pigmentosa (RP) is a common retinal degeneration disease caused by mutation in any gene of the photo transduction cascade and results in photoreceptor dystrophy. Over decades, several animal models have been used to address the n…