Pascal Champéroux
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View article: Modelling of clinical TQT studies outcomes from preclinical cardiovascular safety pharmacology studies using the one-step QTc model
Modelling of clinical TQT studies outcomes from preclinical cardiovascular safety pharmacology studies using the one-step QTc model Open
Introduction Retrospective translational analyses have shown a high rate of false negatives between clinical thorough QT studies (TQT) and preclinical cardiovascular safety pharmacology studies. The aim of this work was to model the result…
View article: Reconsidering CPR protocols: Exploring hypernatremia's role in ventricular tachycardia from a case report
Reconsidering CPR protocols: Exploring hypernatremia's role in ventricular tachycardia from a case report Open
Introduction: This study delves into the mechanisms through which severe hypernatremia may precipitate ventricular tachycardia, drawing from a clinical case involving a 14-year-old patient presenting with ventricular tachycardia in the con…
View article: Simultaneous assessment of central nervous and respiratory systems using jacketed telemetry in socially-housed rats: Application of the “3Rs” principles in core battery safety pharmacology studies
Simultaneous assessment of central nervous and respiratory systems using jacketed telemetry in socially-housed rats: Application of the “3Rs” principles in core battery safety pharmacology studies Open
Central nervous (CNS) and respiratory systems are routinely investigated in safety pharmacology core battery studies. For small molecules, the assessment of both vital organ systems is frequently done in rats in two distinct studies. With …
View article: ERBC telemetry database 24 drugs V2.3
ERBC telemetry database 24 drugs V2.3 Open
This new version of the ERBC telemetry database includes analysis of telemetry data for 24 drugs including 15 torsadogenic drugs This database reports drug-induced cardiovascular effects on blood pressure (abdominal aortic pressure), heart…
View article: ERBC telemetry database 24 drug V2.2
ERBC telemetry database 24 drug V2.2 Open
This new version of the ERBC telemetry database includes analysis of telemetry data for 24 drugs including 15 torsadogenic drugs This database reports drug-induced cardiovascular effects on blood pressure (abdominal aortic pressure), heart…
View article: Contribution of haemodynamic side effects and associated autonomic reflexes to ventricular arrhythmias triggering by torsadogenic hERG blocking drugs
Contribution of haemodynamic side effects and associated autonomic reflexes to ventricular arrhythmias triggering by torsadogenic hERG blocking drugs Open
Background and Purpose HERG blocking drugs known for their propensity to trigger Torsades de Pointes (TdP) were reported to induce a sympatho‐vagal coactivation and to enhance High Frequency heart rate (HFHR) and QT oscillations (HFQT) in …
View article: Raw data 22 reference compounds by telemetry
Raw data 22 reference compounds by telemetry Open
The version V2.1 is the last update of raw data of the ERBC telemetry database in beagle dogs This new version is is accrued from 22 reference compounds including 15 herg blockers. The list of reference drugs is: astemizole, atenolol, atro…
View article: Reflex sympatho-vagal coactivation and concealed QTc prolongation: Lessons from hERG-blockers and long QT syndromes type 1 and type 2
Reflex sympatho-vagal coactivation and concealed QTc prolongation: Lessons from hERG-blockers and long QT syndromes type 1 and type 2 Open
Background and Purposes: Several hERG blocking molecules known for their propensity in triggering Torsades de Pointes (TdP) were reported as increasing High Frequency QT oscillations (HFQT). This effect was found as reflecting a sympatho-v…
View article: High‐frequency autonomic modulation: a new model for analysis of autonomic cardiac control
High‐frequency autonomic modulation: a new model for analysis of autonomic cardiac control Open
Background and Purpose Increase in high‐frequency beat‐to‐beat heart rate oscillations by torsadogenic hERG blockers appears to be associated with signs of parasympathetic and sympathetic co‐activation which cannot be assessed directly usi…
View article: Correction: Corrigendum: Inter-individual variability and modeling of electrical activity: a possible new approach to explore cardiac safety?
Correction: Corrigendum: Inter-individual variability and modeling of electrical activity: a possible new approach to explore cardiac safety? Open
Scientific Reports 6: Article number: 37948; published online: 30 November 2016; updated: 16 February 2017 This Article contains an error in the plot for Verapamil in Figure 5, where the red and black lines representing simulations of huma…
View article: Social housing of non-rodents during cardiovascular recordings in safety pharmacology and toxicology studies
Social housing of non-rodents during cardiovascular recordings in safety pharmacology and toxicology studies Open
Although the majority of the industry does not yet socially house animals during telemetry recordings in safety pharmacology and toxicology studies, there is support to implement this refinement. Continued discussions, sharing of best prac…
View article: The high frequency relationship: implications for torsadogenic hERG blockers
The high frequency relationship: implications for torsadogenic hERG blockers Open
Background and Purpose Ventricular arrhythmias induced by human ether‐a‐go‐go related gene (hERG; K v 11.1 channel) blockers are a consequence of alterations in ventricular repolarisation in association with high‐frequency (HF) oscillation…