Pascal Cosette
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View article: Regional and temporal dynamics of DNA methylation and epigenetic gene regulation in response to binge-like alcohol exposure in the adolescent mouse brain
Regional and temporal dynamics of DNA methylation and epigenetic gene regulation in response to binge-like alcohol exposure in the adolescent mouse brain Open
Adolescence is a critical late phase of the neurodevelopment, characterized by marked brain plasticity and increased vulnerability to environmental challenges such as alcohol exposure. This study examined the impact of binge-like alcohol e…
View article: Proteomic Insights Into the Mitigating Effects of Grape Seed Extract on High‐Fat Diet‐Induced Cardiac Metabolic Alterations
Proteomic Insights Into the Mitigating Effects of Grape Seed Extract on High‐Fat Diet‐Induced Cardiac Metabolic Alterations Open
Prevention and treatment of obesity using nutritional supplements became a realistic and effective approach. The present work aims at the assessment of the potential protection afforded by grape seed extract (GSE) on the rat cardiac proteo…
View article: PROTEOMIC PROFILES AND CLINICOPATHOLOGICAL FACTORS OF OROPHARYNGEAL CANCER IN SENEGAL.
PROTEOMIC PROFILES AND CLINICOPATHOLOGICAL FACTORS OF OROPHARYNGEAL CANCER IN SENEGAL. Open
Background: The early diagnosis of cancers around the world represents a major challenge. Among the most common cancers, those affecting the upper aerodigestive tract (UADT) are on the rise in Senegal with a very high mortality rate. To de…
View article: IFNγ causes mitochondrial dysfunction and oxidative stress in myositis
IFNγ causes mitochondrial dysfunction and oxidative stress in myositis Open
Idiopathic inflammatory myopathies (IIMs) are severe autoimmune diseases with poorly understood pathogenesis and unmet medical needs. Here, we examine the role of interferon γ (IFNγ) using NOD female mice deficient in the inducible T cell …
View article: BacA: a possible regulator that contributes to the biofilm formation of Pseudomonas aeruginosa
BacA: a possible regulator that contributes to the biofilm formation of Pseudomonas aeruginosa Open
Previously, we pointed out in P. aeruginosa PAO1 biofilm cells the accumulation of a hypothetical protein named PA3731 and showed that the deletion of the corresponding gene impacted its biofilm formation capacity. PA3731 belongs to a clus…
View article: Extracellular vesicles from Nurse-Like Cells and THP1-derived Type-2 macrophages transfer aggressiveness to chronic lymphocytic leukemia cells
Extracellular vesicles from Nurse-Like Cells and THP1-derived Type-2 macrophages transfer aggressiveness to chronic lymphocytic leukemia cells Open
The resistance of leukemic B cells to cell death is mainly associated with interactions within the tumor microenvironment, where they interact with various types of cells. Within this microenvironment, CLL B cells produce and bind cytokine…
View article: <i>Icos</i> gene disruption in non‐obese diabetic mice elicits myositis associated with anti‐troponin T3 autoantibodies
<i>Icos</i> gene disruption in non‐obese diabetic mice elicits myositis associated with anti‐troponin T3 autoantibodies Open
Aims Idiopathic inflammatory myopathies (IIM) are autoimmune inflammatory disorders leading to skeletal muscle weakness and disability. The pathophysiology of IIM is poorly understood due to the scarcity of animal disease models. Genetic d…
View article: Hepatoprotective Effect of Grape Seed and Skin Extract Against Lithium Exposure Examined by the Window of Proteomics
Hepatoprotective Effect of Grape Seed and Skin Extract Against Lithium Exposure Examined by the Window of Proteomics Open
Context The liver is the organ by which the majority of substances are metabolized, including psychotropic drugs. Lithium (Li) used as drug for many neurological disorders such as bipolar disorders. Objective This study aims to assess lith…
View article: Elicitation of Roots and AC-DC with PEP-13 Peptide Shows Differential Defense Responses in Multi-Omics
Elicitation of Roots and AC-DC with PEP-13 Peptide Shows Differential Defense Responses in Multi-Omics Open
The root extracellular trap (RET) has emerged as a specialized compartment consisting of root AC-DC and mucilage. However, the RET’s contribution to plant defense is still poorly understood. While the roles of polysaccharides and glycoprot…
View article: Pathogenesis of Enamel-Renal Syndrome Associated Gingival Fibromatosis: A Proteomic Approach
Pathogenesis of Enamel-Renal Syndrome Associated Gingival Fibromatosis: A Proteomic Approach Open
The enamel renal syndrome (ERS) is a rare disorder featured by amelogenesis imperfecta , gingival fibromatosis and nephrocalcinosis. ERS is caused by bi-allelic mutations in the secretory pathway pseudokinase FAM20A. How mutations in FAM20…
View article: Anti-Carbamylated Fibrinogen Antibodies Might Be Associated With a Specific Rheumatoid Phenotype and Include a Subset Recognizing In Vivo Epitopes of Its γ Chain One of Which Is Not Cross Reactive With Anti-Citrullinated Protein Antibodies
Anti-Carbamylated Fibrinogen Antibodies Might Be Associated With a Specific Rheumatoid Phenotype and Include a Subset Recognizing In Vivo Epitopes of Its γ Chain One of Which Is Not Cross Reactive With Anti-Citrullinated Protein Antibodies Open
To identify the targets recognized by anti-carbamylated protein antibodies (anti-CarP) in patients with early Rheumatoid Arthritis (RA), to study the cross-reactivity between anti-CarP and anti-citrullinated protein antibodies (ACPA) and t…
View article: Phosphorylation of Extracellular Proteins in Acinetobacter baumannii in Sessile Mode of Growth
Phosphorylation of Extracellular Proteins in Acinetobacter baumannii in Sessile Mode of Growth Open
Acinetobacter baumannii is a problematic nosocomial pathogen owing to its increasing resistance to antibiotics and its great ability to survive in the hospital environment, which is linked to its capacity to form biofilms. Structural and f…
View article: 3-Benzoylquinoxalinone as a photoaffinity labelling derivative with fluorogenic properties allowing reaction monitoring under “no-wash” conditions
3-Benzoylquinoxalinone as a photoaffinity labelling derivative with fluorogenic properties allowing reaction monitoring under “no-wash” conditions Open
In this communication, we report a fluorogenic 3-benzoylquinoxalinone derivative for photoaffinity labelling applications.
View article: Bioinformatics in tear fluid proteomics – connecting proteomic and clinical data
Bioinformatics in tear fluid proteomics – connecting proteomic and clinical data Open
maintained expression of ITGAV, ITGB5, PEDF and CONNEXIN43, as well as 100% pigmentation of the cells was achieved.TEM could show the cell-to-cell and cell-to-ECM adhesions.Conclusions: Standardized expansion of hRPE cells with spontaneous…
View article: Proteomic and transcriptomic study of brain microvessels in neonatal and adult mice
Proteomic and transcriptomic study of brain microvessels in neonatal and adult mice Open
Infants born before 29 weeks gestation incur a major risk of preterm encephalopathy and subependymal/intracerebral/intraventricular haemorrhage. In mice, an ontogenic window of haemorrhage risk was recorded up to 5 days after birth in serp…
View article: The aliphatic amidase AmiE is involved in regulation of Pseudomonas aeruginosa virulence
The aliphatic amidase AmiE is involved in regulation of Pseudomonas aeruginosa virulence Open
We have previously shown that the eukaryotic C-type natriuretic peptide hormone (CNP) regulates Pseudomonas aeruginosa virulence and biofilm formation after binding on the AmiC sensor, triggering the amiE transcription. Herein, the involve…
View article: Major remodeling of brain microvessels during neonatal period in the mouse: A proteomic and transcriptomic study
Major remodeling of brain microvessels during neonatal period in the mouse: A proteomic and transcriptomic study Open
Preterm infants born before 29 gestation weeks incur major risk of subependymal/intracerebral/intraventricular hemorrhage. In mice, neonate brain endothelial cells are more prone than adult cells to secrete proteases under glutamate challe…