Pascal Demange
YOU?
Author Swipe
View article: Coarse-Graining the Recognition of a Glycolipid by the C-Type Lectin Mincle Receptor
Coarse-Graining the Recognition of a Glycolipid by the C-Type Lectin Mincle Receptor Open
Macrophage inducible Ca2+-dependent lectin (Mincle) receptor recognizes Mycobacterium tuberculosis glycolipids to trigger an immune response. This host membrane receptor is thus a key player in the modulation of the immune response to infe…
View article: Coarse-graining the recognition of a glycolipid by the C-type lectin Mincle receptor
Coarse-graining the recognition of a glycolipid by the C-type lectin Mincle receptor Open
Macrophage inducible Ca 2+ -dependent lectin (Mincle) receptor recognizes Mycobacterium tuberculosis glycolipids to trigger an immune response. This host membrane receptor is thus a key player in the modulation of the immune response to in…
View article: The human and mouse dendritic cell receptor DCIR binds to LRP1 N-glycans containing terminal galactoses, including the α-Gal antigen
The human and mouse dendritic cell receptor DCIR binds to LRP1 N-glycans containing terminal galactoses, including the α-Gal antigen Open
SUMMARY The dendritic cell immunoreceptor (DCIR) is a C-type lectin receptor expressed by myeloid cells that plays a key immunoregulatory role in a wide range of diseases, from inflammation to cancer. However, the ligand(s) of DCIR remain(…
View article: Use of energy dispersive X-ray spectroscopy as a convenient technique for estimation of quartz purity in geological samples subject to surface exposure dating with 10Be and 26Al
Use of energy dispersive X-ray spectroscopy as a convenient technique for estimation of quartz purity in geological samples subject to surface exposure dating with 10Be and 26Al Open
Accelerator Mass Spectrometry (AMS) and cosmogenic nuclides techniques are used in quantitative geomorphological studies on large time scale.In order to accurately date surface exposure to cosmic rays, the amount of pure quartz taken into …
View article: SDR enzymes oxidize specific lipidic alkynylcarbinols into cytotoxic protein-reactive species
SDR enzymes oxidize specific lipidic alkynylcarbinols into cytotoxic protein-reactive species Open
Hundreds of cytotoxic natural or synthetic lipidic compounds contain chiral alkynylcarbinol motifs, but the mechanism of action of those potential therapeutic agents remains unknown. Using a genetic screen in haploid human cells, we discov…
View article: Author response: SDR enzymes oxidize specific lipidic alkynylcarbinols into cytotoxic protein-reactive species
Author response: SDR enzymes oxidize specific lipidic alkynylcarbinols into cytotoxic protein-reactive species Open
Article Figures and data Abstract Editor's evaluation Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Hundreds of cytotoxic …
View article: SDR enzymes oxidize specific lipidic alkynylcarbinols into cytotoxic protein-reactive species
SDR enzymes oxidize specific lipidic alkynylcarbinols into cytotoxic protein-reactive species Open
Hundreds of cytotoxic natural or synthetic lipidic compounds contain chiral alkynylcarbinol motifs, but the mechanism of action of those potential therapeutic agents remains unknown. Using a genetic screen in haploid human cells, we discov…
View article: Defining the function of OmpA in the Rcs stress response
Defining the function of OmpA in the Rcs stress response Open
OmpA, a protein commonly found in the outer membrane of Gram-negative bacteria, has served as a paradigm for the study of β-barrel proteins for several decades. In Escherichia coli , OmpA was previously reported to form complexes with RcsF…
View article: Defining the function of OmpA in the Rcs stress response
Defining the function of OmpA in the Rcs stress response Open
OmpA, a protein commonly found in the outer membrane of Gram-negative bacteria, has served as a paradigm for the study of β-barrel proteins for several decades. In Escherichia coli , OmpA was previously reported to form complexes with RcsF…
View article: Structure and dynamics of G protein-coupled receptor–bound ghrelin reveal the critical role of the octanoyl chain
Structure and dynamics of G protein-coupled receptor–bound ghrelin reveal the critical role of the octanoyl chain Open
Ghrelin plays a central role in controlling major biological processes. As for other G protein-coupled receptor (GPCR) peptide agonists, the structure and dynamics of ghrelin bound to its receptor remain obscure. Using a combination of sol…
View article: Structure and dynamics of dynorphin peptide and its receptor
Structure and dynamics of dynorphin peptide and its receptor Open
Dynorphin is a neuropeptide involved in pain, addiction and mood regulation. It exerts its activity by binding to the kappa opioid receptor (KOP) which belongs to the large family of G-protein coupled receptors. The dynorphin peptide was d…
View article: A protein nanocontainer targeting epithelial cancers: rational engineering, biochemical characterization, drug loading and cell delivery
A protein nanocontainer targeting epithelial cancers: rational engineering, biochemical characterization, drug loading and cell delivery Open
An original protein nanocontainer for drug vectorization and imaging device open new exciting perspectives in nano-theranostic approaches.
View article: Local and Global Dynamics in <i>Klebsiella pneumoniae</i> Outer Membrane Protein a in Lipid Bilayers Probed at Atomic Resolution
Local and Global Dynamics in <i>Klebsiella pneumoniae</i> Outer Membrane Protein a in Lipid Bilayers Probed at Atomic Resolution Open
The role of membrane proteins in cellular mechanism strongly depends on their dynamics, and solid-state magic-angle spinning (MAS) nuclear magnetic resonance (NMR) is a unique method to exhaustively characterize motions of proteins in a li…