Pascal G.P. Martin
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View article: Treatment evolution in spinal muscular atrophy: insights from the SMArtCARE registry
Treatment evolution in spinal muscular atrophy: insights from the SMArtCARE registry Open
Real world treatments for 5q-spinal muscular atrophy (SMA) have evolved rapidly following the sequential approval of three disease-modifying treatments (DMT): nusinersen, onasemnogene abeparvovec (OA) and risdiplam. The aim of this study w…
View article: Molecular mechanisms underlying the determination of axillary bud fate and outgrowth into branch crown in strawberry
Molecular mechanisms underlying the determination of axillary bud fate and outgrowth into branch crown in strawberry Open
Summary ▪ In strawberry, the axillary bud (AXB) can produce either an elongated stem called stolon giving a daughter-plant (asexual reproduction) or an inflorescence-bearing branch crown (BC) (sexual reproduction). The fate of the AXB depe…
View article: The Zinc Finger protein<i>Sl</i>ZFP2 is essential for tomato fruit locular tissue morphogenesis
The Zinc Finger protein<i>Sl</i>ZFP2 is essential for tomato fruit locular tissue morphogenesis Open
In tomato ( Solanum lycopersicum L .) fruit, the locular tissue (LT) is a unique jelly-like tissue that differentiates from the central axis of the fruit after ovule fertilization. LT is essential for seed development and dispersal by prev…
View article: Ploidy‐specific transcriptomes shed light on the heterogeneous identity and metabolism of developing tomato pericarp cells
Ploidy‐specific transcriptomes shed light on the heterogeneous identity and metabolism of developing tomato pericarp cells Open
SUMMARY Endoreduplication, during which cells increase their DNA content through successive rounds of full genome replication without cell division, is the major source of endopolyploidy in higher plants. Endoreduplication plays pivotal ro…
View article: eLife Assessment: Genetic and pharmacologic alterations of claudin9 levels suffice to induce functional and mature inner hair cells
eLife Assessment: Genetic and pharmacologic alterations of claudin9 levels suffice to induce functional and mature inner hair cells Open
Hearing loss is the most common form of sensory deficit. It occurs predominantly due to hair cell (HC) loss. Mammalian HCs are terminally differentiated by birth, making HC loss incurable. Here, we show the pharmacogenetic downregulation o…
View article: Ploidy-specific transcriptomes shed light on the heterogeneous identity and metabolism of developing pericarp cells
Ploidy-specific transcriptomes shed light on the heterogeneous identity and metabolism of developing pericarp cells Open
Summary Endoreduplication, during which cells increase their DNA content through successive rounds of full genome replication without cell division, is the major source of endopolyploidy in higher plants. Endoreduplication plays pivotal ro…
View article: Widespread premature transcription termination of Arabidopsis thaliana NLR genes by the spen protein FPA
Widespread premature transcription termination of Arabidopsis thaliana NLR genes by the spen protein FPA Open
Genes involved in disease resistance are some of the fastest evolving and most diverse components of genomes. Large numbers of nucleotide-binding, leucine-rich repeat (NLR) genes are found in plant genomes and are required for disease resi…
View article: The 7SK/P-TEFb snRNP controls ultraviolet radiation-induced transcriptional reprogramming
The 7SK/P-TEFb snRNP controls ultraviolet radiation-induced transcriptional reprogramming Open
Conversion of promoter-proximally paused RNA polymerase II (RNAPII) into elongating polymerase by the positive transcription elongation factor b (P-TEFb) is a central regulatory step of mRNA synthesis. The activity of P-TEFb is controlled …
View article: Widespread premature transcription termination of<i>Arabidopsis thaliana</i>NLR genes by the spen protein FPA
Widespread premature transcription termination of<i>Arabidopsis thaliana</i>NLR genes by the spen protein FPA Open
Genes involved in disease resistance are some of the fastest evolving and most diverse components of genomes. Large numbers of n ucleotide-binding, l eucine-rich repeat r eceptor (NLR) genes are found in plant genomes and are required for …
View article: Co-Occurrence of DON and Emerging Mycotoxins in Worldwide Finished Pig Feed and Their Combined Toxicity in Intestinal Cells
Co-Occurrence of DON and Emerging Mycotoxins in Worldwide Finished Pig Feed and Their Combined Toxicity in Intestinal Cells Open
Food and feed can be naturally contaminated by several mycotoxins, and concern about the hazard of exposure to mycotoxin mixtures is increasing. In this study, more than 800 metabolites were analyzed in 524 finished pig feed samples collec…
View article: Dietary oleic acid regulates hepatic lipogenesis through a liver X receptor-dependent signaling
Dietary oleic acid regulates hepatic lipogenesis through a liver X receptor-dependent signaling Open
Olive oil consumption is beneficial for health as it is associated with a decreased prevalence of cancer and cardiovascular diseases. Oleic acid is, by far, the most abundant component of olive oil. Since it can be made through de novo syn…
View article: The Extent of mRNA Editing Is Limited in Chicken Liver and Adipose, but Impacted by Tissular Context, Genotype, Age, and Feeding as Exemplified with a Conserved Edited Site in COG3
The Extent of mRNA Editing Is Limited in Chicken Liver and Adipose, but Impacted by Tissular Context, Genotype, Age, and Feeding as Exemplified with a Conserved Edited Site in COG3 Open
RNA editing is a posttranscriptional process leading to differences between genomic DNA and transcript sequences, potentially enhancing transcriptome diversity. With recent advances in high-throughput sequencing, many efforts have been mad…
View article: <i>In vivo</i> intestinal permeability to oral FD4 during development.
<i>In vivo</i> intestinal permeability to oral FD4 during development. Open
Data show the progressive decrease of IP to FITC-Dextran 4 kDa (FD4) every 10 days from the mild-lactation period (postnatal day (PND) 10) to adulthood (PND50). Data are expressed as the mean of plasma FITC-Dextran concentration (µg/ml)±SE…
View article: Expanding Duplication of Free Fatty Acid Receptor-2 (GPR43) Genes in the Chicken Genome
Expanding Duplication of Free Fatty Acid Receptor-2 (GPR43) Genes in the Chicken Genome Open
Free fatty acid receptors (FFAR) belong to a family of five G-protein coupled receptors that are involved in the regulation of lipid metabolism, so that their loss of function increases the risk of obesity. The aim of this study was to det…
View article: Additional file 2: of Exploring transcriptomic diversity in muscle revealed that cellular signaling pathways mainly differentiate five Western porcine breeds
Additional file 2: of Exploring transcriptomic diversity in muscle revealed that cellular signaling pathways mainly differentiate five Western porcine breeds Open
Annotation of the regulated genes. This list of probes corresponds to the differential probes from the linear mixed model, the pairwise analysis and the discriminating analysis. From this list, 1,394 probes were localized on porcine chromo…
View article: Additional file 1: of Exploring transcriptomic diversity in muscle revealed that cellular signaling pathways mainly differentiate five Western porcine breeds
Additional file 1: of Exploring transcriptomic diversity in muscle revealed that cellular signaling pathways mainly differentiate five Western porcine breeds Open
1,859 genes were identified to be differentially expressed between five breeds according to statistical analysis. 1,703 were differentially expressed with a linear mixed model (FDR
View article: Additional file 4: of Exploring transcriptomic diversity in muscle revealed that cellular signaling pathways mainly differentiate five Western porcine breeds
Additional file 4: of Exploring transcriptomic diversity in muscle revealed that cellular signaling pathways mainly differentiate five Western porcine breeds Open
70 pathways enriched to explain the biologically diversity of five pig breeds. These pathways have been identified with the free software GeneCodis. These pathways concerned the KEGG (Kyoto Encyclopedia of Genes and Genomes) pathways which…
View article: Additional file 3: of Exploring transcriptomic diversity in muscle revealed that cellular signaling pathways mainly differentiate five Western porcine breeds
Additional file 3: of Exploring transcriptomic diversity in muscle revealed that cellular signaling pathways mainly differentiate five Western porcine breeds Open
Differentially expressed genes on autosomes. Only probes with an alignment on the porcine genome Sscrofa10.2 are reported with the corresponding annotation from Ensembl. The global and pairwise statistics are given for all the comparisons.…
View article: Additional file 6: of Exploring transcriptomic diversity in muscle revealed that cellular signaling pathways mainly differentiate five Western porcine breeds
Additional file 6: of Exploring transcriptomic diversity in muscle revealed that cellular signaling pathways mainly differentiate five Western porcine breeds Open
EASE systematic functional annotation for the 683 unique differentially expressed genes. Detailed functional information were obtained from EASE (Expression Analysis Systematic Explorer) from DAVID (Database for Annotation, Visualization a…
View article: Additional file 5: of Exploring transcriptomic diversity in muscle revealed that cellular signaling pathways mainly differentiate five Western porcine breeds
Additional file 5: of Exploring transcriptomic diversity in muscle revealed that cellular signaling pathways mainly differentiate five Western porcine breeds Open
228 spots (171 unique genes) allow the discrimination between the five lines. These genes were identified as differentially expressed from one line against the others or were identified in the sPLS-DA or Random Forest analysis. The 15 disc…